TPT1/TCTP Antibody (2C4) - Azide and BSA Free

This product is produced by and distributed for Abnova, a company based in Taiwan.

Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the central nervous, gastrointestinal, respiratory and immune systems. Histamine release is mediated by the stimulation of mast cells and basophils. Histamine-releasing factor (HRF) is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. HRF belongs to the translationally controlled tumor protein (TCTP) family and is detected as a protein of 21 kDa in mice and 23 kDa in human. It is expressed in several healthy and tumoral cells, including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas and lymphomas, and it is localized in the cytoplasm. HRF plays a pivotal role in allergic diseases, and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down Syndrome.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 3 of 3.

Publications using H00007178-M03	Applications	Species
Kazumi K, Yu K, Alain J et al. Histamine-Releasing Factor Is a Novel Alarmin Induced by House Dust Mite Allergen, Cytokines, and Cell Death. J Immunol. 2022-10-12 [PMID: 36223930]
Nusair SD, Joukhan AN, Rashaid AB, Rababa'h AM et al. Methomyl induced effect on fortilin and S100A1 in serum and cardiac tissue: Potential biomarkers of toxicity. Hum Exp Toxicol. 2018-11-25 [PMID: 30472887]
Sinthujaroen P, Wanachottrakul N, Pinkaew D et al. Elevation of serum fortilin levels is specific for apoptosis and signifies cell death in vivo. BBA Clinical. 2014-01-01 [PMID: 25558447]

Array H00007178-M03

• TPT1/TCTP Antibodies
• TPT1/TCTP ELISA Kits
• TPT1/TCTP Lysate
• TPT1/TCTP Proteins