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TLR5 Antibody (624915) [DyLight 755]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, CyTOF-ready
Clone
624915
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB6704U-100UG
Alexa Fluor 405
FAB6704V-100UG
Alexa Fluor 488
FAB6704G
Alexa Fluor 532
FAB6704X
Alexa Fluor 594
FAB6704T-100UG
Alexa Fluor 647
FAB6704R-100UG
Alexa Fluor 700
FAB6704N-100UG
Alexa Fluor 750
FAB6704S-100UG
Allophycocyanin
FAB6704A
Allophycocyanin/Cy7
FAB6704APCCY7
Biotin
FAB6704B
CoraFluor 1
FAB6704CL1
DyLight 350
FAB6704D
DyLight 405
FAB6704E
DyLight 488
FAB6704K
DyLight 550
FAB6704L
DyLight 594
FAB6704M
DyLight 650
FAB6704W
DyLight 680
FAB6704Y
FITC
FAB6704F
HRP
FAB6704H
Janelia Fluor 525
FAB6704JF525
Janelia Fluor 549
FAB6704I
Janelia Fluor 646
FAB6704J
Janelia Fluor 669
FAB6704JF669
PE
FAB6704P
PE/Atto594
FAB6704PEATT594
PE/Cy5.5
FAB6704PECY55
PE/Cy7
FAB6704PECY7
PerCP
FAB6704C
Unconjugated
MAB6704
mFluor Violet 450 SE
FAB6704MFV450
mFluor Violet 500 SE
FAB6704MFV500
mFluor Violet 610 SE
FAB6704MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB6704
Carrier Free
MAB6704
Carrier Free
FAB6704G
Carrier Free
MAB6704-SP
Carrier Free
FAB6704V-100UG
Carrier Free
FAB6704U-100UG
Carrier Free
FAB6704T-100UG
Carrier Free
FAB6704S-100UG
Carrier Free
FAB6704R-100UG
Carrier Free
FAB6704N-100UG
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TLR5 Antibody (624915) [DyLight 755] Summary

Immunogen
E. coli-derived recombinant human TLR5
Ile21-Phe115
Accession # O60602
Specificity
Detects human TLR5 in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) TLR1, 2, 3, 4, 7, 8, recombinant mouse TLR5, 6, or rhTIRAP is observed.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TLR5
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TLR5 Antibody (624915) [DyLight 755]

  • MGC126430
  • MGC126431
  • SLEB1FLJ10052
  • TIL-3
  • TIL3Toll/interleukin-1 receptor-like protein 3
  • TLR5
  • toll-like receptor 5

Background

The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol TLR5