TLR5 Products

Description

The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.

Bioinformatics

Entrez	53791 Mouse 7100 Human
Uniprot	NM_003268 Human NP_003259 Human NP_003259.2 Human O60602 Human
Product By Gene ID	7100
Alternate Names	MGC126430 MGC126431 SLEB1FLJ10052 TIL3Toll/interleukin-1 receptor-like protein 3 toll-like receptor 5

Research Areas for TLR5

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Innate Immunity
Prostate Cancer
Toll-Like Receptors

Related TLR5 Blog Posts

Check out the latest blog posts on TLR5.

The role of TLR4 in breast cancer Toll like receptors (TLRs) are highly conserved proteins that are first known for their role in pathogen recognition and immune response activation.  In order to elicit the necessary immune response in reaction to a foreign pathogen, TLRs trigger cy...    Read more.

Toll-like receptors in the intestinal epithelial cells By Jamshed Arslan, Pharm. D., PhD. Toll-like receptors (TLRs) are microbe-sensing proteins that act as first responders to danger signals. TLRs help the intestinal epithelial cells (IECs) recognize commensal bacteria ...    Read more.

Read more TLR5 related blogs.