TLR5 Antibody

The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Toll-like receptor 5 (TLR5) expression is upregulated following exposure to bacteria or to the TLR5 agonist, flagellin. Gram-negative bacteria, stimulate monocyte/macrophage cells in a TLR5-specific, CD14-independent manner. The TLR5 receptor thus appears to be the principal means by which the innate immune system recognizes flagellated bacterial pathogens.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Moose, Porcine.

We have publications tested in 5 applications: FLOW, Flow-CS, IF/IHC, IHC-P, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP2-24827	Applications	Species
Kapelouzou A, Kontogiannis C, Tsilimigras DI et al. Differential expression patterns of Toll Like Receptors and Interleukin-37 between calcific aortic and mitral valve cusps in humans Cytokine 2019-04-01 [PMID: 30716659] (IF/IHC, Human)	IF/IHC	Human
Liu H, Chen F, Wu W et al. TLR5 mediates CD172alpha(+) intestinal lamina propria dendritic cell induction of Th17 cells. Sci Rep. 2016-02-24 [PMID: 26907705] (FLOW, Mouse)	FLOW	Mouse
Bens M, Vimont S, Ben Mkaddem S et al. Flagellin/TLR5 signalling activates renal collecting duct cells and facilitates invasion and cellular translocation of uropathogenic Escherichia coli Cell Microbiol 2014-04-29 [PMID: 24779433] (WB, Mouse) Details: This citation used the PE version of this antibody.	WB	Mouse
Lacave-Lapalun JV, Benderitter M, Linard C Flagellin and LPS each restores rat lymphocyte populations after colorectal irradiation J Leukoc Biol. 2014-06-01 [PMID: 24532644] (Flow-CS, Rat) Details: Citation using the Azide Free format of this antibody.	Flow-CS	Rat
Muramatsu S, Tamada T, Nara M et al. Flagellin/TLR5 signaling potentiates airway serous secretion from swine tracheal submucosal glands. Am J Physiol Lung Cell Mol Physiol 2013-12-01 [PMID: 24097563] (IHC-P, WB, Porcine)	IHC-P, WB	Porcine
Brandon JA, Perez J, Jennings CD et al. Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease. Am J Physiol Gastrointest Liver Physiol. 2010-09-01 [PMID: 20634434] (FLOW, Moose) Details: TLR5 (IMG-580). Flow (cell surface & intracellular): Mouse liver associated mononuclear (LAM) cell line, Fig S2.	FLOW	Moose
Palladino Michael A, Savarese Michael A, Chapman Jessica L et al. Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa. Am J Reprod Immunol. 2008-12-01 [PMID: 19032616]
Palladino M A, Johnson T A, Gupta R et al. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod. 2007-06-01 [PMID: 17314314] (WB, Rat)	WB	Rat

Array NBP2-24827

• TLR5 Antibodies
• TLR5 Lysate
• TLR5 Protein
• TLR5 Proteins and Enzyme