TLR5 Antibody (624915) [Alexa Fluor® 488]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TLR5 is an ~100 kDa type I transmembrane glycoprotein of the Toll-like receptor family. It is expressed on mucosal epithelia in the gastrointestinal tract, airways, and other areas of potential bacterial contact and recognizes bacterial flagellin. Expression is also reported on monocytes, immature dendritic cells, and CD4⁺ T lymphocytes. The region of human TLR5 used as an immunogen includes the first 2 of 16 leucine-rich repeats and shares 72% amino acid identity with mouse and rat TLR5. This region is outside of the flagellin binding region. Flagellin engagement induces dimerization and intracellular signaling via MyD88.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publication 1 - 1 of 1.

Publication using FAB6704G	Applications	Species
Shen, P;Serve, S;Wu, P;Liu, X;Dai, Y;Durán-Hernández, N;Nguyen, DTM;Fuchs, M;Maleitzke, T;Reisener, MJ;Dzamukova, M;Nussbaumer, K;Brunner, TM;Li, Y;Holecska, V;Heinz, GA;Heinrich, F;Durek, P;Katsoula, G;Gwinner, C;Jung, T;Zeggini, E;Winkler, T;Mashreghi, MF;Pumberger, M;Perka, C;Löhning, M; NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis Proceedings of the National Academy of Sciences of the United States of America 2023-07-18 [PMID: 37428931] (Flow Cytometry, Human)	Flow Cytometry	Human

Array FAB6704G

• TLR5 Antibodies
• TLR5 ELISA Kits
• TLR5 Lysate
• TLR5 Protein
• TLR5 Proteins and Enzyme