TIMP-4 Antibody (SB30c) - Azide and BSA Free

Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (approx. 23kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7. (1-9)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-P.

Showing Publication 1 - 1 of 1.

Publication using NBP1-28619	Applications	Species
Solga R, Behrens J, Ziemann A et al. CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells European Journal of Cell Biology 2019-10-01 [PMID: 31677819] (IHC-P, Mouse)	IHC-P	Mouse

Array NBP1-28619

• TIMP-4 Antibodies
• TIMP-4 ELISA Kits
• TIMP-4 Lysate
• TIMP-4 ELISAs
• TIMP-4 Proteins and Enzymes