TIMP-2 Antibody (89025) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases (MMPs). There are four members of the family, TIMP-1, TIMP-2, TIMP-3, and TIMP-4. TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa produced by a wide range of cell types, which inhibits MMPs non-covalently by the formation of binary complexes. TIMP-2 also has erythroid-potentiating and cell growth promoting activities.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 6 applications: Cell-based ELISA, Functional Assay, ICC, Immunocytochemistry, Immunoprecipitation, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using MAB971	Applications	Species
Lin, LL;Nayak, B;Osmulski, PA;Wang, E;Wang, CP;Valente, PT;Wang, CM;Tan, X;Santanam, N;Wang, TL;Gaczynska, ME;Kost, ER;Huang, TH;Kirma, NB; PAI-1 uncouples integrin-?1 from restrain by membrane-bound ?-catenin to promote collagen fibril remodeling in obesity-related neoplasms Cell reports 2024-07-23 [PMID: 39046873] (Western Blot, Immunocytochemistry, Functional Assay, Human)	Western Blot, Immunocytochemistry, Functional Assay	Human
Backe, SJ;Votra, SD;Stokes, MP;Sebesty�n, E;Castelli, M;Torielli, L;Colombo, G;Woodford, MR;Mollapour, M;Bourboulia, D; PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling Cell reports 2023-05-25 [PMID: 37243593] (Immunoprecipitation, Human)	Immunoprecipitation	Human
Gerwinn T, Salemi S, Schori LJ et al. Improved contractile potential in detrusor microtissues from pediatric patients with end stage lower urinary tract dysfunction Frontiers in Cell and Developmental Biology 2022-10-04 [PMID: 36268506]
Yang Wang, Qi Yang, Yanli Cheng, Meng Gao, Lei Kuang, Chun Wang Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/ beta -Catenin Pathway Medical Science Monitor 2018-12-15 [PMID: 30552850]
Y Yang, Q Li, L Guo MicroRNA?122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in�vitro Mol Med Rep, 2018-04-19;0(0):. 2018-04-19 [PMID: 29693120] (Western Blot, Human)	Western Blot	Human
Angela Armento, Elena I. Ilina, Tony Kaoma, Arnaud Muller, Laurent Vallar, Simone P. Niclou et al. Carboxypeptidase E transmits its anti-migratory function in glioma cells via transcriptional regulation of cell architecture and motility regulating factors International Journal of Oncology 2017-08-01 [PMID: 28656234]
Granule exocytosis is required for platelet spreading: differential sorting of alpha-granules expressing VAMP-7. Blood, 2012-05-15;120(1):199-206. 2012-05-15 [PMID: 22589474] (ICC, Human)	ICC	Human
Agnieszka Hałoń, Ewa Nowak-Markwitz, Piotr Donizy, Rafał Matkowski, Adam Maciejczyk, Tserenchunt Gansukh et al. Enhanced Immunoreactivity of TIMP-2 in the Stromal Compartment of Tumor as a Marker of Favorable Prognosis in Ovarian Cancer Patients Journal of Histochemistry & Cytochemistry 2012-07-01 [PMID: 22511598]
Yang SW, Cody JJ, Rivera AA, Waehler R, Wang M, Kimball KJ, Alvarez RA, Siegal GP, Douglas JT, Ponnazhagan S Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy. Clin. Cancer Res., 2010-11-29;17(3):538-49. 2010-11-29 [PMID: 21115652] (Western Blot, Human)	Western Blot	Human
Li MQ, Hou XF, Shao J, Tang CL, Li DJ The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy. Biol. Reprod., 2010-01-14;82(5):968-79. 2010-01-14 [PMID: 20075392] (Cell-based ELISA, Human)	Cell-based ELISA	Human
Villeneuve J, Block A, Le Bousse-Kerdiles MC, Lepreux S, Nurden P, Ripoche J, Nurden AT Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins. Exp. Hematol., 2009-05-03;37(7):849-56. 2009-05-03 [PMID: 19410025] (ICC, Human)	ICC	Human
Kong MY, Gaggar A, Li Y Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci, 2008-12-16;6(1):9-17. 2008-12-16 [PMID: 19159011] (Western Blot, Human)	Western Blot	Human
Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J. Immunol., 2007-05-01;178(9):5957-65. 2007-05-01 [PMID: 17442980] (Western Blot, Human)	Western Blot	Human
Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21. Gut, 2006-05-08;55(12):1774-80. 2006-05-08 [PMID: 16682426] (Western Blot, Human)	Western Blot	Human
Show All 14 Publications. Collapse Publications.

Array MAB971

• TIMP-2 Antibodies
• TIMP-2 ELISA Kits
• TIMP-2 Lysate
• TIMP-2 Proteins
• TIMP-2 ELISAs
• TIMP-2 Proteins and Enzymes