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Thyroid Peroxidase Antibody (TPO/6417R) [DyLight 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clone
TPO/6417R
Clonality
Monoclonal
Host
Rabbit
Conjugate
DyLight 594

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP3-08762AF350
Alexa Fluor 405
NBP3-08762AF405
Alexa Fluor 488
NBP3-08762AF488
Alexa Fluor 532
NBP3-08762AF532
Alexa Fluor 594
NBP3-08762AF594
Alexa Fluor 647
NBP3-08762AF647
Alexa Fluor 700
NBP3-08762AF700
Alexa Fluor 750
NBP3-08762AF750
Allophycocyanin
NBP3-08762APC
Biotin
NBP3-08762B
CoraFluor 1
NBP3-08762CL1
DyLight 350
NBP3-08762UV
DyLight 405
NBP3-08762V
DyLight 488
NBP3-08762G
DyLight 550
NBP3-08762R
DyLight 650
NBP3-08762C
DyLight 680
NBP3-08762FR
DyLight 755
NBP3-08762IR
FITC
NBP3-08762F
HRP
NBP3-08762H
Janelia Fluor 525
NBP3-08762JF525
Janelia Fluor 549
NBP3-08762JF549
Janelia Fluor 585
NBP3-08762JF585
Janelia Fluor 635
NBP3-08762JF635
Janelia Fluor 646
NBP3-08762JF646
Janelia Fluor 669
NBP3-08762JF669
PE
NBP3-08762PE
PerCP
NBP3-08762PCP
Unconjugated
NBP3-08762
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP3-08762
Azide and BSA Free
NBP3-08762
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Thyroid Peroxidase Antibody (TPO/6417R) [DyLight 594] Summary

Additional Information
Recombinant Monoclonal Antibody
Immunogen
Recombinant fragment of human Thyroid Peroxidase (around aa 685-804) (Exact sequence is proprietary) (Uniprot: P07202 )
Localization
Cytoplasm, Cell surface
Marker
Thyroid Marker
Specificity
Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
TPO
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Thyroid Peroxidase Antibody (TPO/6417R) [DyLight 594]

  • EC 1.11.1
  • MSA
  • TDH2A
  • thyroid microsomal antigen
  • thyroid peroxidase
  • thyroperoxidase
  • TPXEC 1.11.1.8

Background

Thyroid Peroxidase encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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IL-11 [HRP]
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Species: Hu
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Bioinformatics

Gene Symbol TPO