Home » Thrombomodulin/BDCA-3 » Thrombomodulin/BDCA-3 Antibodies » Thrombomodulin/BDCA-3 Antibody (THBD/1591) [Janelia Fluor® 549]
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Thrombomodulin/BDCA-3 Antibody (THBD/1591) [Janelia Fluor® 549]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, IHC, MA, CyTOF-ready
Clone
THBD/1591
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 549

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-54490AF350
Alexa Fluor 405
NBP2-54490AF405
Alexa Fluor 488
NBP2-54490AF488
Alexa Fluor 532
NBP2-54490AF532
Alexa Fluor 594
NBP2-54490AF594
Alexa Fluor 647
NBP2-54490AF647
Alexa Fluor 700
NBP2-54490AF700
Alexa Fluor 750
NBP2-54490AF750
Biotin
NBP2-54490B
DyLight 350
NBP2-54490UV
DyLight 405
NBP2-54490V
DyLight 488
NBP2-54490G
DyLight 550
NBP2-54490R
DyLight 594
NBP2-54490DL594
DyLight 650
NBP2-54490C
DyLight 680
NBP2-54490FR
DyLight 755
NBP2-54490IR
FITC
NBP2-54490F
HRP
NBP2-54490H
Janelia Fluor 646
NBP2-54490JF646
Unconjugated
NBP2-54490-100ug
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-54490-100ug
Azide and BSA Free
NBP2-54490-100ug
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Thrombomodulin/BDCA-3 Antibody (THBD/1591) [Janelia Fluor® 549] Summary

Immunogen
Recombinant fragment (around aa 69-194) of human Thrombomodulin/BDCA-3 protein (exact sequence is proprietary) (Uniprot: P07204)
Localization
Cell Surface & Cytoplasmic
Marker
Endothelial Cell Marker
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
THBD
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Protein Array
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (THBD/1591) [Janelia Fluor® 549]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.
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Bioinformatics

Gene Symbol THBD