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Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, Flow, IHC
Clone
6C8.2F9
Clonality
Monoclonal
Host
Mouse
Conjugate
Janelia Fluor 646

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-42213AF350
Alexa Fluor 405
NBP2-42213AF405
Alexa Fluor 488
NBP2-42213AF488
Alexa Fluor 532
NBP2-42213AF532
Alexa Fluor 594
NBP2-42213AF594
Alexa Fluor 647
NBP2-42213AF647
Alexa Fluor 700
NBP2-42213AF700
Alexa Fluor 750
NBP2-42213AF750
Allophycocyanin
NBP2-42213APC
Biotin
NBP2-42213B
CoraFluor 1
NBP2-42213CL1
DyLight 350
NBP2-42213UV
DyLight 405
NBP2-42213V
DyLight 488
NBP2-42213G
DyLight 550
NBP2-42213R
DyLight 594
NBP2-42213DL594
DyLight 650
NBP2-42213C
DyLight 680
NBP2-42213FR
DyLight 755
NBP2-42213IR
FITC
NBP2-42213F
HRP
NBP2-42213H
Janelia Fluor 525
NBP2-42213JF525
Janelia Fluor 549
NBP2-42213JF549
Janelia Fluor 585
NBP2-42213JF585
Janelia Fluor 635
NBP2-42213JF635
Janelia Fluor 669
NBP2-42213JF669
PE
NBP2-42213PE
PerCP
NBP2-42213PCP
Unconjugated
NBP2-42213
mFluor Violet 450 SE
NBP2-42213MFV450
mFluor Violet 500 SE
NBP2-42213MFV500
mFluor Violet 610 SE
NBP2-42213MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-42213
BSA Free
NBP2-42213SS
BSA Free
NBP2-42213
Azide and BSA Free
NBP2-80979
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Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646] Summary

Immunogen
Partial recombinant human CD141 protein (between amino acids 200-400) [UniProt P07204].
Localization
Transmembrane protein with Extracellular, Helical and Cytoplasmic domains.
Marker
Endothelial Cells Damage Marker
Isotype
IgG1 Lambda
Clonality
Monoclonal
Host
Mouse
Gene
THBD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [Janelia Fluor® 646]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol THBD