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Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [mFluor Violet 500 SE]

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Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [mFluor Violet 500 SE] - Vial of mFluor Violet 500 conjugated antibody. mFluor Violet 500 is optimally excited at 410 nm by the Violet laser (405 nm) and has an emission maximum ...read more

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, IHC
Clone
4D8.2C6
Clonality
Monoclonal
Host
Rat
Conjugate
mFluor Violet 500 SE

Order Details

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Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [mFluor Violet 500 SE] Summary

Immunogen
Two synthetic peptides made to internal portions of the mouse Thrombomodulin protein (between residues 25-150 and 400-550) [UniProt P07204]
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
THBD
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (4D8.2C6) [mFluor Violet 500 SE]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

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Research Areas for Thrombomodulin/BDCA-3 Antibody (NBP2-36496MFV500)

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Blogs on Thrombomodulin/BDCA-3.

Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.

mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol THBD