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Thrombomodulin/BDCA-3 Antibody (461714) [DyLight 755]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB, Flow, IHC, CyTOF-ready, ICC/IF
Clone
461714
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 755

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB3894U-100UG
Alexa Fluor 405
FAB3894V-100UG
Alexa Fluor 488
FAB3894G-100UG
Alexa Fluor 532
FAB3894X
Alexa Fluor 594
FAB3894T-100UG
Alexa Fluor 647
FAB3894R-100UG
Alexa Fluor 700
FAB3894N-100UG
Alexa Fluor 750
FAB3894S-100UG
Allophycocyanin
FAB3894A
Allophycocyanin/Cy7
FAB3894APCCY7
Biotin
FAB3894B
CoraFluor 1
FAB3894CL1
DyLight 350
FAB3894D
DyLight 405
FAB3894E
DyLight 488
FAB3894K
DyLight 550
FAB3894L
DyLight 594
FAB3894M
DyLight 650
FAB3894W
DyLight 680
FAB3894Y
HRP
FAB3894H
Janelia Fluor 525
FAB3894JF525
Janelia Fluor 549
FAB3894I
Janelia Fluor 585
FAB3894JF585
Janelia Fluor 635
FAB3894JF635
Janelia Fluor 646
FAB3894J
Janelia Fluor 669
FAB3894JF669
PE/Atto594
FAB3894PEATT594
PE/Cy5.5
FAB3894PECY55
PE/Cy7
FAB3894PECY7
PerCP
FAB3894C
Phycoerythrin
FAB3894P
Unconjugated
MAB3894
mFluor Violet 450 SE
FAB3894MFV450
mFluor Violet 500 SE
FAB3894MFV500
mFluor Violet 610 SE
FAB3894MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB3894
Carrier Free
MAB3894
Carrier Free
FAB3894A
Carrier Free
FAB3894P
Carrier Free
MAB3894-SP
Carrier Free
FAB3894V-100UG
Carrier Free
FAB3894U-100UG
Carrier Free
FAB3894T-100UG
Carrier Free
FAB3894S-100UG
Carrier Free
FAB3894R-100UG
Carrier Free
FAB3894N-100UG
Carrier Free
FAB3894G-100UG
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Thrombomodulin/BDCA-3 Antibody (461714) [DyLight 755] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Thrombomodulin/BDCA-3
Leu17-Ser517
Accession # P15306
Specificity
Detects mouse Thrombomodulin/BDCA-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) Thrombomodulin is observed.
Isotype
IgG2b
Clonality
Monoclonal
Host
Rat
Gene
THBD
Purity
Protein A or G purified from hybridoma culture supernatant
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Thrombomodulin/BDCA-3 Antibody (461714) [DyLight 755]

  • BDCA3
  • BDCA-3
  • CD141 antigen
  • CD141
  • Fetomodulin
  • THBD
  • THRM
  • Thrombomodulin
  • TM

Background

CD141/Thrombomodulin is an exclusively endothelial cell surface glycoprotein that forms a 1:1 complex with thrombin. Binding of thrombin to this high affinity receptor alters its specificity toward several substrates. The complex activates protein C approximately 1000 times faster than thrombin alone. Activated protein C degrades clotting factors V and VIII; thus, thrombomodulin converts thrombin into a physiologic anticoagulant. Thrombomodulin is also found in the circulatory and urinary systems, the physiologic significance of this is obscure.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Blogs on Thrombomodulin/BDCA-3.

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Thrombomodulin - A multifunctional protein with roles in inflammation and coagulation
Thrombomodulin, also known as BDCA-3, is a glycosylated transmembrane protein present on the surface of vascular endothelial cells. Thrombomodulin is a high-affinity receptor for thrombin, a key protein in the coagulation cascade. Formation of the...  Read full blog post.
mFluor Violet Conjugated Antibodies

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Bioinformatics

Gene Symbol THBD