TCF7/TCF1 Antibody (812145) [Alexa Fluor® 647]

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TCF7 (Transcription factor 7), also called TCF1 (T cell factor 1) is a member of the lymphoid enhancer binding factor family of proteins that is expressed in thymocytes and mature T cells. In resting cells, TCF family members are transcriptional repressors, and are 25‑32 kDa in size. Following activation, the large TCF7/TCF1 isoform (isoform 2, chosen as 'canonical') predominates (419 amino acids, 42‑50 kDa), and serves a transcriptional activator function. The use of an alternate start site at Met116 seems to characterize repressor isoforms. Within aa 61-116 of the large form, mouse TCF7/TCF1 shares 77% aa sequence identity with human TCF7/TCF1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 4 of 4.

Publications using FAB8224R	Applications	Species
Marit J van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J C van Stigt Thans, Thorbald Van Hall et al. Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy Journal for ImmunoTherapy of Cancer 2023-03-13 [PMID: 36914207]
Brittany Fitzgerald, Kelli A. Connolly, Can Cui, Eric Fagerberg, Dylan L. Mariuzza, Noah I. Hornick et al. A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma Cell Reports Methods 2021-10-11 [PMID: 34632444]
Y Gong, T Suzuki, H Kozono, M Kubo, N Nakano Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor PLoS ONE, 2020-08-26;15(8):e0237646. 2020-08-26 [PMID: 32845913] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
SS Gupta, R Sharp, C Hofferek, L Kuai, GW Dorn, J Wang, M Chen NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells Cell Rep, 2019-11-12;29(7):1862-1877.e7. 2019-11-12 [PMID: 31722203] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse

Array FAB8224R

• TCF7/TCF1 Antibodies
• TCF7/TCF1 Proteins