Western blot shows lysates of human tonsil tissue and HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human TAP2 Monoclonal Antibody (Catalog # MAB2432) followed ...read more
TAP2 was detected in immersion fixed U-251 MG human glioblastoma cell line (left panel) and HL-60 human acute promyelocytic leukemia cell line (right panel, negative control) using Mouse Anti-Human TAP2 Monoclonal ...read more
TAP2 was detected in immersion fixed paraffin-embedded sections of human tonsil using Mouse Anti-Human TAP2 Monoclonal Antibody (Catalog # MAB2432) at 8 µg/mL for 1 hour at room temperature followed by ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for TAP2 Antibody (998524) [Unconjugated]
ABC18
ABCB3
ABCB3ABC18
antigen peptide transporter 2
APT2
ATP-binding cassette, sub-family B (MDR/TAP), member 3
D6S217E
MHC 2
Peptide transporter involved in antigen processing 2
Peptide transporter PSF2
Peptide transporter TAP2
PSF2
PSF2PSF-2
Really interesting new gene 11 protein
RING11
RING11ATP-binding cassette sub-family B member 3
TAP2
transporter 2, ABC (ATP binding cassette)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Y1
Background
TAP2 transports
antigens from the cytoplasm to the endoplasmic reticulum, where they can bind
to MHC class 1 molecules. It does this
translocation by selecting peptides based on both their length and their
sequence. The peptide selection occurs
during the first step of the translocation process. Transmembrane segments of TAP form a pore in
the membrane and the peptide binding site is formed by the cytosolic component
of the pore. Inherited deficiency in the
TAP transporter can lead to recurrent respiratory bacterial infections due to
HLA class I deficiency (BLS1).
Nijenjuis M., Hämmerling Journal of immunology; 1996
Dec 15;157(12):5467-5477
de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis SH, Donato L, Bausinger H, Laforet M, (1994), Science, Jul 8; 265(5169):237-241.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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