SynGAP Antibody

Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Zebrafish.

We have publications tested in 1 application: WB.

Showing Publications 1 - 3 of 3.

Publications using NBP2-27541	Applications	Species
Sumathipala SH, Khan S, Kozol RA et al. Context-dependent hyperactivity in syngap1a and syngap1b zebrafish autism models bioRxiv : the preprint server for biology 2023-09-21 [PMID: 37786701] (WB, Zebrafish)	WB	Zebrafish
Gou G, Roca-Fernandez A, Kilinc M, Serrano E Syngap Splice Variants Display Heterogeneous Spatio-Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain J Neurochem 2020-02-19 [PMID: 32068252]
Rumbaugh G, Adams JP, Kim JH, Huganir RL. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc Natl Acad Sci U S A 2006-03-21 [PMID: 16537406]

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Mouse	02/23/2021	View Summary Application Western Blot Sample Tested Mouse brain synaptosomal membrane Species Mouse Lot P1 E160816 Comments Comments 1:2000

Array NBP2-27541

• SynGAP Antibodies
• SynGAP Proteins