Synaptophysin Antibody (SP11)

Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non chromaffin paragangliomas.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ICC/IF, IHC-P.

Showing Publications 1 - 9 of 9.

Publications using NB120-16659	Applications	Species
Iworima DG, Baker RK, Ellis C et Al. Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells Stem Cell Res Ther 2024-01-02 [PMID: 38167219]
Saber N, Ellis CE, Iworima DG et al. The impact of different implantation sites and sex on the differentiation of human pancreatic endoderm cells into insulin-secreting cells in vivo Diabetes 2023-02-06 [PMID: 36745576]
A Ramzy, DM Thompson, KA Ward-Harts, S Ivison, L Cook, RV Garcia, J Loyal, PTW Kim, GL Warnock, MK Levings, TJ Kieffer Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes Cell Stem Cell, 2021-12-02;28(12):2047-2061.e5. 2021-12-02 [PMID: 34861146]
Saber N, Bruin JE, O'Dwyer S, Schuster H. Sex differences in maturation of human embryonic stem cell-derived beta cells in mice. Endocrinology. 2018-02-05 [PMID: 29420708] (Human)		Human
Yu N, Wang S, Song X, Gao L. Low-Dose Radiation Promotes Dendritic Cell Migration and IL-12 Production via the ATM/NF-kappaB Pathway. Radiat. Res. 2018-02-08 [PMID: 29420126] (Mouse)		Mouse
Ramzy A, Mojibian M, Kieffer TJ. Insulin deficient mouse b-cells do not fully mature but can be remedied through insulin replacement by islet transplantation. Endocrinology. 2017-09-27 [PMID: 29029025]
Bruin JE, Saber N, O'Dwyer S et al. Hypothyroidism impairs human stem cell-derived pancreatic progenitor cell maturation in mice. Diabetes. 2016-01-06 [PMID: 26740603]
Bruin JE, Asadi A, Fox JK et al. Accelerated Maturation of Human Stem Cell-Derived Pancreatic Progenitor Cells into Insulin-Secreting Cells in Immunodeficient Rats Relative to Mice. Stem Cell Reports. 2015-12-08 [PMID: 26677767] (IHC-P, Human)	IHC-P	Human
Gage BK, Baker RK, Kieffer TJ. Overexpression of PAX4 reduces glucagon expression in differentiating hESCs. Islets. 2014-06-17 [PMID: 25483960] (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human

Array NB120-16659

• Synaptophysin Antibodies
• Synaptophysin ELISA Kits
• Synaptophysin Lysate
• Synaptophysin Proteins