STIM1 Antibody (705129)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

STIM-1 (stromal interaction molecule 1), previously called GOK, is a 90 kDa type I transmembrane protein of the endoplasmic reticulum (ER). When STIM-1 senses depletion of calcium in the ER via its EF-hand domain (aa 63-98), it interacts with the plasma membrane Ca2⁺ release-activated Ca2⁺ (CRAC) channel Orai1, increasing Ca2⁺ influx. The human STIM-1 extracellular/lumenal domain (aa 23-213) contains an EF hand Ca2⁺-binding motif and a SAM (sterile a-motif) multimerization domain. A potential isoform is truncated at aa 491. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2). Within the region used as an immunogen, human STIM1 shares 95% amino acid identity with mouse and rat STIM1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB69761

• STIM1 Antibodies
• STIM1 Lysate
• STIM1 Proteins