Name: STIM1 Antibody (5A2)
Brand: Novus Biologicals
SKU: H00006786-M01
Price: 519 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, Mu, RtSpecies Glossary
Applications	WB, ELISA, ICC/IF, IHC, IP
Clone	5A2
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Description	Quality control test: Antibody Reactive Against Recombinant Protein.
Immunogen	STIM1 (AAH21300, 24 a.a. ~ 685 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SHSHSEKATGTSSGANSEESTAAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVVQWLITYVELPQYEETFRKLQLSGHAMPRLAVTNTTMTGAVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAEKQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQHGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMSRAADEALNAMTSNGSHRLIEGVHPGSLVEKLPDSPALAKKALLALNHGLDKAHSLMELSPSAPPGGSPHLDSSRSHSPSSPDPDTPSPVGDSRALQASRNTRIPHLAGKKAVAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
Specificity	STIM1 (5A2)
Isotype	IgG2a Kappa
Clonality	Monoclonal
Host	Mouse
Gene	STIM1
Purity	IgG purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer	In 1x PBS, pH 7.4
Preservative	No Preservative
Purity	IgG purified

Publications using H00006786-M01	Applications	Species
Lisak D, Schacht T, Gawlitza A et al. BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival. Cell Death Differ. 2015-10-16 [PMID: 26470731]
Hong CH, Chang KL, Wang HJ et al. IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis. J Dermatol Sci. 2015-03-16 [PMID: 25840641]
Duquette M, Nadler M, Okuhara D et al. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biol. 2014-05-16 [PMID: 24845346] (IP, Human)	IP	Human
Ferdaus MZ, Xiao B, Ohara H et al. Identification of stim1 as a candidate gene for exaggerated sympathetic response to stress in the stroke-prone spontaneously hypertensive rat. PLoS One. 2014-04-15 [PMID: 24736434]
Umemura M, Baljinnyam E, Feske S et al. Store-Operated Ca(2) (+) Entry (SOCE) Regulates Melanoma Proliferation and Cell Migration. PLoS One. 2014-02-21 [PMID: 24586666]
Schmid E, Bhandaru M, Nurbaeva MK et al. SGK3 Regulates Ca Entry and Migration of Dendritic Cells. Cell Physiol Biochem. 2012-11-22 [PMID: 23171960]
Jans R, Mottram L, Johnson DL et al. Lysophosphatidic Acid Promotes Cell Migration through STIM1- and Orai1-Mediated Ca(2+)(i) Mobilization and NFAT2 Activation. J Invest Dermatol. 2012-10-25 [PMID: 23096711]
Henke N, Albrecht P, Pfeiffer A et al. Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress. J Biol Chem. 2012-12-07 [PMID: 23076152] (Mouse)		Mouse
Elvers M, Herrmann A, Seizer P et al. Intracellular cyclophilin A is an important Ca2+ regulator in platelets and critically involved in arterial thrombus formation. Blood. 2012-06-27 [PMID: 22740452]
Eylenstein A, Schmidt S, Gu S et al. Transcription factor NF-kB regulates the expressions of a pore-forming unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem. 2011-11-21 [PMID: 22110130]
Steinbeck JA, Henke N, Opatz J et al. Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Exp Neurol. 2011-08-30 [PMID: 21906591]
Kiviluoto S, Decuypere JP, De Smedt H et al. STIM1 as a key regulator for Ca2+ homeostasis in skeletal-muscle development and function. Skelet Muscle. 2011-04-04 [PMID: 21798093]
Saitoh N, Oritani K, Saito K et al. Identification of functional domains and novel binding partners of STIM proteins. J Cell Biochem 112(1):147-56. 2011-01-01 [PMID: 21053360]
Schuhmann MK, Stegner D, Berna-Erro A et al. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. J Immunol 184(3):1536-42. 2010-02-01 [PMID: 20028655]
Pani B, Ong HL, Brazer SC et al. Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1. Proc Natl Acad Sci U S A 106(47):20087-20092. 2009-11-24 [PMID: 19897728]
Beyersdorf N, Braun A, Vogtle T et al. STIM1-Independent T Cell Development Effector Function In Vivo. J Immunol;182(6):3390-7. 2009-03-15 [PMID: 19265116]
Wu F, Wang P, Young LC et al. Proteome-Wide Identification of Novel Binding Partners to the Oncogenic Fusion Gene Protein, NPM-ALK, using Tandem Affinity Purification and Mass Spectrometry. Am J Pathol 2009-01-08 [PMID: 19131589]
Braun A, Gessner JE, Varga-Szabo D et al. STIM1 is essential for Fc{gamma} receptor activation autoimmune inflammation. Blood. 2008-10-21 [PMID: 18941110]
Varga-Szabo D, Braun A, Kleinschnitz C et al. The calcium sensor STIM1 is an essential mediator of arterial thrombosis ischemic brain infarction. J Exp Med;205(7):1583-91. 2008-07-07 [PMID: 18559454]
Pani B, Ong HL, Liu X et al. Lipid rafts determine clustering of STIM1 in ER-plasma membrane junctions regulation of SOCE. J Biol Chem;283(25):17333-40. 2008-06-20 [PMID: 18430726]
1 Alicia S, Angelica Z, Carlos S et al. STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: Moving TRPC1 in out of lipid rafts. Cell Calcium;44(5):479-91. 2008-11-01 [PMID: 18420269]
Grosse J, Braun A, Varga-Szabo D et al. An EF h mutation in Stim1 causes premature platelet activation bleeding in mice. J Clin Invest;117(11):3540-3550. 2007-11-01 [PMID: 17965774]
Prakash,YS et al. Caveolins intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 293(5):L1118-26. 2007-11-01 [PMID: 17704188]
Show All 23 Publications. Collapse Publications.

STIM1 Antibody (5A2)

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Bioinformatics

Gene Symbol	STIM1
Entrez	6786(Human)
OMIM	605921(Human)
Uniprot	AAH21300(Human)