![Immunohistochemistry-Paraffin: SOX11 Antibody (SOX11/3235R) - Azide and BSA Free [NBP3-08594] - Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).](http://images.novusbio.com/fullsize/SOX11-Antibody-SOX11-3235R-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP3-08594-img0001.jpg "Immunohistochemistry-Paraffin: SOX11 Antibody (SOX11/3235R) - Azide and BSA Free [NBP3-08594] - Formalin-fixed, paraffin-embedded human cervical carcinoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).")
| Reactivity | HuSpecies Glossary |
| Applications | IHC |
| Clone | SOX11/3235R |
| Clonality | Monoclonal |
| Host | Rabbit |
| Conjugate | Unconjugated |
| Format | Azide and BSA Free |
| Concentration | 1 mg/ml |
| Description | 1.0 mg/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS WITHOUT BSA & azide. Also available at 200 ug/ml WITH BSA & azide (NBP3-07688). Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. |
| Additional Information | Recombinant Monoclonal Antibody |
| Immunogen | Recombinant fragment (around aa300-400) of human SOX11 protein (Uniprot: P35716 ) |
| Localization | Nuclear (Cervix); Cytoplasmic (Melanoma) |
| Marker | Mantle Cell Lymphoma Marker |
| Specificity | Recognizes a protein of ~47kDa, identified as SOX11. This monoclonal antibody is highly specific and does not cross-react with other members of the SOX-family. Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of Cyclin D1. Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack Cyclin D1 expression and may be misdiagnosed. Almost all Cyclin D1-positive as well as Cyclin D1-negative MCL, show overexpression of SOX-11. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL. |
| Isotype | IgG |
| Clonality | Monoclonal |
| Host | Rabbit |
| Gene | SOX11 |
| Purity | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Dilutions |
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| Application Notes | Immunohistochemistry Formalin-fixed: 2-4ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined. |
| Theoretical MW | 47 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| Storage | Store at -20 to -80C. Avoid freeze-thaw cycles. |
| Buffer | 10 mM PBS |
| Preservative | No Preservative |
| Concentration | 1 mg/ml |
| Purity | Protein A or G purified |
![Western Blot SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Western_Blot_5161.jpg)
![Chromatin Immunoprecipitation (ChIP) SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Chromatin_Immunoprecipitation_11224.jpg)
![Simple Western SOX2 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX2_AF2018_Simple_Western_16676.jpg)
Secondary Antibodies |
Isotype Controls |
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SOX-11 seals your fate The SOX-11 transcription factor is a member of the SOX family known to be involved in embryonic development regulation and cell fate determination. The protein acts as a transcriptional regulator and appears to modulate fundamental aspects of normal e... Read full blog post. |
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
| Gene Symbol | SOX11 |
![Immunohistochemistry-Paraffin: SOX11 Antibody (SOX11/3235R) - Azide and BSA Free [NBP3-08594] - Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).](http://images.novusbio.com/fullsize/SOX11-Antibody-SOX11-3235R-Azide-and-BSA-Free-Immunohistochemistry-Paraffin-NBP3-08594-img0002.jpg "Immunohistochemistry-Paraffin: SOX11 Antibody (SOX11/3235R) - Azide and BSA Free [NBP3-08594] - Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained with SOX11 Recombinant Rabbit Monoclonal Antibody (SOX11/3235R).")
![Immunocytochemistry SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_15995.jpg)
![Western Blot SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Western_Blot_21580.jpg)
![Immunocytochemistry SOX9 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX9_AF3075_Immunocytochemistry_6490.jpg)
![Immunocytochemistry SOX3 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX3_AF2569_Immunocytochemistry_9767.jpg)
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![Western Blot SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX15_AF4070_Western_Blot_5397.jpg)
![Immunocytochemistry SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX15_AF4070_Immunocytochemistry__Immunofluorescence_19727.jpg)
![Immunocytochemistry SOX15 Antibody [Unconjugated]](https://images.novusbio.com/images2/af4070_human-sox15-affinity-purified-polyclonal-ab-immunocytochemistry-243202213427.jpg)
![Immunocytochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX10_AF2864_Immunocytochemistry__Immunofluorescence_17799.jpg)
![Immunocytochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/af2864_human-sox10-affinity-purified-polyclonal-ab-immunocytochemistry-3032021155556.jpg)
![Immunohistochemistry SOX10 Antibody [Unconjugated]](https://images.novusbio.com/images2/af2864_human-sox10-affinity-purified-polyclonal-ab-immunohistochemistry-303202115544.jpg)
![Immunocytochemistry SOX21 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX21_AF3538_Immunocytochemistry__Immunofluorescence_17801.jpg)
![Immunohistochemistry SOX21 Antibody [Unconjugated]](https://images.novusbio.com/images/antibody/af3538_human-sox21-affinity-purified-polyclonal-ab-immunohistochemistry-442024145721..jpg)
![Western Blot SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Western_Blot_21133.jpg)
![Simple Western SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Simple_Western_21134.jpg)
![Immunocytochemistry SOX1 Antibody [Unconjugated]](https://images.novusbio.com/images2/SOX1_AF3369_Immunocytochemistry_12364.jpg)
![Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).](https://images.novusbio.com/images/Goat-anti-Rabbit-IgG-H+L-Secondary-Antibody-HRP-Western-Blot-NB7160-img0001.jpg "Western Blot: Goat anti-Rabbit IgG (H+L) Secondary Antibody [HRP] [NB7160] - Western blot showing vemurafenib treatment in BRAFV600E CRC cells inhibits fission mediator DRP1 with no significant effect on fusion proteins (Mfn1 & 2) using MFN-1 antibody (NBP1-51841) and corresponding secondary antibody, goat anti-rabbit IgG-HRP (NB7160). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33738242).")
![Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.](https://images.novusbio.com/images/Rabbit--Mouse-IgG-Isotype-Control-Flow-Cytometry-NBP2-24891-img0001.jpg "Flow Cytometry: Rabbit IgG Isotype Control [NBP2-24891] - Intracellular FACS analysis of mouse TLR6 polyclonal antibody (red), rabbit isotype control (green), RAW cells alone (shaded). Two micrograms of antibodies were used. Goat anti-rabbit FITC (Novus, 20302) was used as secondary.")