Sodium Potassium ATPase Alpha 3 Antibody (XVIF9-G10) - BSA Free

The sodium/potassium ATPase is an integral membrane enzyme found in all cells of higher organisms and is responsible for the ATP-dependent transport of sodium and potassium across the cell membrane. This membrane-bound enzyme is related to a number of other ATPases including sarcoplasmic and endoplasmic reticulum calcium ATPase (SERCA) and plasma membrane calcium ATPase (PMCA). The sodium/potassium ATPase consists of a large, multipass, transmembrane catalytic subunit, termed the alpha subunit, and an associated smaller glycoprotein, termed the beta subunit. Studies indicate that there are three isoforms of the alpha subunit (alpha 1, alpha 2, alpha 3) and two isoforms of the beta subunit (beta 1 and beta 2) encoded by two multigene families. The different isoforms of the sodium/potassium ATPase exhibit tissue-specific and developmental patterns of expression. The alpha 1 and beta mRNAs are present in all cell types examined, whereas the alpha 2 and alpha 3 mRNAs exhibit a more restricted pattern of cell-specific expression. The alpha-3 subunit has been found in neuronal and to skeletal and cardiac muscle, lung and stomach tissues.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 8 applications: Block/Neutralize, FLOW, ICC/IF, IF/IHC, IHC, Immunohistochemistry-Frozen, WB, Western Blot.

Showing Publications 1 - 10 of 21. Show All 21 Publications. Collapse Publications.

Publications using NB300-540	Applications	Species
Ferrer-Ferrer M, Jia S, Kaushik R et al. Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines Cellular and molecular life sciences : CMLS 2023-03-05 [PMID: 36871239] (Immunohistochemistry-Frozen, Mouse)	Immunohistochemistry-Frozen	Mouse
Zakharova IO, Bayunova LV, Zorina II et al. Insulin and ?-Tocopherol Enhance the Protective Effect of Each Other on Brain Cortical Neurons under Oxidative Stress Conditions and in Rat Two-Vessel Forebrain Ischemia/Reperfusion Injury International Journal of Molecular Sciences 2021-10-29 [PMID: 34769198] (Western Blot, Block/Neutralize)	Western Blot, Block/Neutralize
Lazar AM, Irannejad R, Baldwin TA et al. G protein-regulated endocytic trafficking of adenylyl cyclase type 9 eLife 2020-06-09 [PMID: 32515353]
Nordstrom CK, Danckwardt-Lilliestrom N, Liu W, Rask-Andersen H Reversed polarizationof Na/K-ATPase-a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study Cell Tissue Res. 2019-11-12 [PMID: 31713726]
Liu W, Luque M, Glueckert R et al. Expression of Na/K-ATPase subunits in the human cochlea: a confocal and super-resolution microscopy study with special reference to auditory nerve excitation and cochlear implantation Ups. J. Med. Sci. 2019-08-01 [PMID: 31460814]
Coleman LG, Zou J, Crews FT Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7 J Neuroinflammation Jan 25 2017 [PMID: 28118842] (FLOW, ELISA, Human) J Neuroinflammation. 2017-01-25 [PMID: 28118842] (FLOW, Human) Details: Citation using the Alexa Fluor 488 form of this antibody.	FLOW	Human
Vivek Mahadevan, Jessica C. Pressey, Brooke A. Acton, Pavel Uvarov, Michelle Y. Huang, Jonah Chevrier, Andrew Puchalski, Caiwei M. Li, Evgueni A. Ivakine, Matti S. Airaksinen, Eric Delpire, Roderick R. McInnes, Melanie A. Woodin Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons Cell reports 2019-01-14 [PMID: 24910435]
Ivakine EA, Acton BA, Mahadevan V et al. Neto2 is a KCC2 interacting protein required for neuronal Cl- regulation in hippocampal neurons. Proc Natl Acad Sci U S A 2013-02-26 [PMID: 23401525] (WB, Mouse)	WB	Mouse
Rose EM, Koo JCP, Antflick JE et al. Glutamate Transporter Coupling to Na,K-ATPase. J Neurosci;29(25):8143-8155. 2009-01-01 [PMID: 19553454]
Hou Z Matherly LH. Oligomeric Structure of the Human Reduced Folate Carrier: Identification of Homo-Oligomers Dominant-Negative Effects on Carrier Expression Function. J Biol Chem;284(5):3285-3293. 2009-01-01 [PMID: 19019821]
Molday LL, Wu WW, Molday RS. Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex. J Biol Chem;282(45):32792-801. 2007-11-09 [PMID: 17804407] (WB)	WB
Ferguson SM, Savchenko V, Apparsundaram S, Zwick M, Wright J, Heilman CJ, Yi H, Levey AI, Blakely RD. Vesicular localization and activity-dependent trafficking of presynaptic choline transporters. J Neurosci;23(30):9697-709. 2003-10-29 [PMID: 14585997] (IF/IHC)	IF/IHC
Hoffman JF, Wickrema A, Potapova O, Milanick M, Yingst DR. Na pump isoforms in human erythroid progenitor cells and mature erythrocytes. Proc Natl Acad Sci U S A;99(22):14572-7. 2002-10-29 [PMID: 12388775] (ICC/IF)	ICC/IF
Brickley DR, Mikosz CA, Hagan CR, Conzen SD. Ubiquitin modification of serum and glucocorticoid-induced protein kinase-1 (SGK-1). J Biol Chem;277(45):43064-70. 2002-11-08 [PMID: 12218062] (ICC/IF)	ICC/IF
Kong JQ, Meng J, Biser PS, Fleming WW, Taylor DA. Cellular depolarization of neurons in the locus ceruleus region of the guinea pig associated with the development of tolerance to opioids. J Pharmacol Exp Ther;298(3):909-16. 2001-09-01 [PMID: 11504784] (IF/IHC)	IF/IHC
Wetzel RK, Sweadner KJ. Immunocytochemical localization of NaK-ATPase isoforms in the rat and mouse ocular ciliary epithelium. Invest Ophthalmol Vis Sci. 42(3):763-9. 2001-03-01 [PMID: 11222539] (IF/IHC)	IF/IHC
Tao QF, Hollenberg NK, Graves SW. Sodium pump inhibition and regional expression of sodium pump alpha-isoforms in lens. Hypertension;34(5):1168-74. 1999-11-01 [PMID: 10567200] (WB)	WB
Ferrer-Ferrer M, Jia S, Kaushik R et al. Disturbance in Hebbian-like spinogenesis blunted learning-induced modulation in the number and spatial distribution of dendritic spines Research Square 2022-06-24 (IF/IHC, Mouse)	IF/IHC	Mouse
Ferrer-Ferrer M, Jia S, Kaushik R et al. Disturbance in Hebbian-like spinogenesis blunted learning-induced modulation in the number and spatial distribution of dendritic spines Research Square Jun 24 2022 (IHC, Mouse)	IHC	Mouse
Halbert D, Domenyuk V, Spetzler D et al. Aptamers and uses thereof United States Patent Application US 9958448 B2 2018-01-01
Pfeiffer R, Beron J, Verrey F. Regulation of Na+ pump function by aldosterone is alpha-subunit isoform specific. J Physiol 1999-04-14 [PMID: 10200415]
Show All 21 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	3 reviewed by: Verified Customer	WB	Human	08/22/2015	View Summary Application Western Blot Sample Tested Human cancer cell Species Human
	5 reviewed by: Vivek Mahadevan	WB	Mouse	08/21/2012	View Summary Application Western Blot Sample Tested Membrane fraction from whole brain Species Mouse Lot ME 158235

Array NB300-540

• Sodium Potassium ATPase Alpha 3 Antibodies
• Sodium Potassium ATPase Alpha 3 Lysate
• Sodium Potassium ATPase Alpha 3 Proteins