Smoothelin Antibody

Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22. The distribution of smoothelin positive cells indicates a correlation between smoothelin expression and smooth muscle tissue contractility. Smoothelin is a useful tool in the evaluation of atherosclerotic lesions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Rat,  Human.

We have publications tested in 3 applications: ICC/IF, IHC-P, Simple Western.

Showing Publications 1 - 4 of 4.

Publications using NBP2-37931	Applications	Species
Kim YH, Lee YK, Park SS et al. Mid-old cells are a potential target for anti-aging interventions in the elderly Nature communications 2023-11-22 [PMID: 37993434] (IHC-P, Human)	IHC-P	Human
Salemi S, Schori L, Gerwinn T et al. Myostatin Overexpression and Smad Pathway in Detrusor Derived from Pediatric Patients with End-Stage Lower Urinary Tract Dysfunction International Journal of Molecular Sciences 2023-02-24 [PMID: 36901894] (IHC-P, Human)	IHC-P	Human
Gerwinn T, Salemi S, Krattiger L Et al. Spheroids of Bladder Smooth Muscle Cells for Bladder Tissue Engineering BioMed research international 2021-11-11 [PMID: 34805410] (ICC/IF, Simple Western, Rat)	ICC/IF, Simple Western	Rat
Yao D, Xu L, Xu O et al. O-Linked b-N-Acetylglucosamine Modification of A20 Enhances the Inhibition of NF-kB (Nuclear Factor-kB) Activation and Elicits Vascular Protection After Acute Endoluminal Arterial Injury. Arterioscler. Thromb. Vasc. Biol. 2018-04-05 [PMID: 29622561] (ICC/IF)	ICC/IF

Array NBP2-37931

• Smoothelin Antibodies
• Smoothelin ELISA Kits
• Smoothelin Lysates
• Smoothelin Proteins