SMAC/Diablo Antibody (78-1-118)

Smac/DIABLO, a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enters the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms (2,3).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: ICC/IF, WB.

Showing Publications 1 - 10 of 10.

Publications using NB500-213	Applications	Species
Hwang HJ, Dornbos P, Steidemann M et al. Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. Toxicol. Appl. Pharmacol. 2016-04-20 [PMID: 27105554] (WB, Mouse)	WB	Mouse
Sirianni AC, Jiang J, Zeng J et al. N-acetyl-L-tryptophan, but not N-acetyl-D-tryptophan, Rescues Neuronal Cell Death in Models of Amyotrophic Lateral Sclerosis J. Neurochem. 2015-05-30 [PMID: 26031348] (WB, Mouse)	WB	Mouse
Zhang Y, Chen LY, Han X et al. Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol Dis 2013-03-26 [PMID: 23537713] (WB, Mouse)	WB	Mouse
Wang X, Sirianni A, Pei Z et al. The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience;31(41):14496-14507. 2011-10-12 [PMID: 21994366]
Zhang Yi, Wang Xin, Baranov Sergei V et al. Dipyrone inhibits neuronal cell death and diminishes hypoxic/ischemic brain injury. Neurosurgery 2011-01-01 [PMID: 21552169] (WB, Mouse)	WB	Mouse
Wang X et al. Inhibitors of cytochrome c release with therapeutic potential for Huntington's disease. J Neurosci;28(38):9473-85. 2008-09-17 [PMID: 18799679] (WB, Rat, Mouse)	WB	Rat, Mouse
Zhang, WH et al. Nortriptyline protects mitochondria and reduces cerebral ischemia/hypoxia injury. Stroke;39(2):455-62. 2008-02-01 [PMID: 18174477]
Liu, JC et al. CELL, TUMOR, STEM CELL BIOLOGY: Identification of Tumorsphere- Tumor-Intiating Cells in HER2/Neu-Induced Mammary Tumors. Cancer Res 67:8671-8681. 2007-09-01 [PMID: 17875707]
Zhang, WH et al. Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death. Proc Natl Acad Sci U S A;100(26):16012-7. 2003-12-23 [PMID: 14663141] (WB, Mouse)	WB	Mouse
Wang, X et al. Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease. Proc Natl Acad Sci U S A;100(18):10483-7. 2003-09-02 [PMID: 12930891] (WB, ICC/IF, Rat, Mouse)	WB, ICC/IF	Rat, Mouse

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: PRAVEEN Dubey	WB	Rat	02/07/2022	View Summary Application Western Blot Sample Tested H9c2 whole cell lysate Species Rat Lot A1
	5 reviewed by: Verified Customer	WB	Human	04/20/2021	View Summary Application Western Blot Sample Tested AC!6,AC16 Species Human Lot A1
Enlarge	5 reviewed by: Verified Customer	WB	Mouse	05/15/2019	View Summary Application Western Blot Sample Tested AC16 Species Mouse Lot A1
Enlarge	5 reviewed by: Verified Customer	WB	Human	05/06/2019	View Summary Application Western Blot Sample Tested AC16 Species Human Lot A1

Array NB500-213

• SMAC/Diablo Antibodies
• SMAC/Diablo ELISA Kits
• SMAC/Diablo Lysate
• SMAC/Diablo Proteins
• SMAC/Diablo Proteins and Enzyme