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SH2D1A Antibody

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Western Blot: SH2D1A Antibody [NB100-40783] - Analysis of SH2D1A using NB100-40783 at 0.2 ug/ml in Human Lymph Node lysate (35ug protein in RIPA buffer).
Western Blot: SH2D1A Antibody [NB100-40783] - Analysis of SH2D1A using NB100-40783 at 0.2 ug/ml in Human Lymph Node lysate (35ug protein in RIPA buffer).
Western Blot: SH2D1A Antibody [NB100-40783] - HEK293 overexpressing SH2D1A and probed with (mock transfection in first lane).

Product Details

Summary
Reactivity Hu, PoSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

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SH2D1A Antibody Summary

Immunogen
Peptide with sequence C-QYPVEKKSSARSTQ corresponding to internal region according to NP_002342.1, NP_001108409.1.
Predicted Species
Porcine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SH2D1A
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 0.2 - 0.6 ug/ml
Application Notes
IP: An anonymous customer has reported usage under native conditions. WB: Approx. 16 kDa band observed in human lymph node lysates (calculated MW of 14.2 kDa band according to NP_002342.1). In transfected HEK293 transiently expressing SH2D1A a band of approx. 17 kDa is observed. This band is not observed in the non-transfected HEK293.
Control
SH2D1A Overexpression Lysate
Publications
Read Publication using NB100-40783.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SH2D1A Antibody

  • DSHP
  • DSHPLYP
  • Duncan disease SH2-protein
  • EBVS
  • FLJ92177
  • IMD5
  • LYP
  • MTCP1
  • SAP/SH2D1A
  • SAPlymphoproliferative syndrome
  • SH2 domain containing 1A
  • SH2 domain-containing protein 1A
  • SH2D1A
  • signaling lymphocyte activation molecule-associated protein
  • Signaling lymphocytic activation molecule-associated protein
  • SLAM associated protein/SH2 domain protein 1A
  • SLAM-associated protein
  • T cell signal transduction molecule SAP
  • T-cell signal transduction molecule SAP
  • XLP
  • XLPD
  • XLPDFLJ18687
  • XLPSH2 domain protein 1A

Background

The cytoplasmic protein encoded by the SH2D1A gene plays an essential role in controlling EBV infection. It is expressed in T and NK cells, but not in B cells or in granulocytes. SH2D1A is expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Defects in SH2D1A are a cause of X-linked lymphoproliferative disease (XLPD)also known as Duncan disease. XLPD is characterized by an immunodeficiency following Epstein-Barr virus (EBV)infection. Symptoms include fatal mononucleosis, hypogammaglobulinemia, pancytopenia or malignant lymphoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SH2D1A Antibody
NB100-40783
SH2D1A Antibody
Species: Hu, Po
Applications: WB, ELISA

Publications for SH2D1A Antibody (NB100-40783)(1)


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Control Lysate(s)

SH2D1A Overexpression Lysate

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SH2D1A
Entrez
Uniprot