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RSK2 Antibody

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Western Blot: RSK2 Antibody [NBP2-29659] - HeLa lysate showing specific immunolabeling of the ~90k RSK2 protein.
Western Blot: RSK2 Antibody [NBP2-29659] - HeLa lysate showing specific immunolabeling of the ~90k RSK2 protein.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Ch, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

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RSK2 Antibody Summary

Immunogen
Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH. Accession # Q9WUT3
Specificity
Specific for endogenous levels of the ~90 kDa RSK2 protein.
Preparation
Method
Prepared from rabbit serum by affinity purification via chromatography on an affinity column made with the C-terminal peptide used as antigen.
Predicted Species
Mouse (100%), Rat (100%), Chicken (100%), Canine (100%), Primate (100%), Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RPS6KA3
Purity
Antigen Affinity-purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Theoretical MW
90 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

The antibody has been demonstrated to work in mouse, human and rat tissue. It is anticipated that the antibody will work in bovine, canine, chicken and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Antigen Affinity-purified

Alternate Names for RSK2 Antibody

  • 90 kDa ribosomal protein S6 kinase 3
  • CLS
  • Coffin-Lowry syndrome
  • EC 2.7.11
  • EC 2.7.11.1
  • HU-3
  • Insulin-stimulated protein kinase 1
  • ISPK1
  • ISPK-1
  • MAP kinase-activated protein kinase 1b
  • MAPK-activated protein kinase 1b
  • MAPKAP kinase 1b
  • MAPKAPK1B
  • MAPKAPK-1b
  • mental retardation, X-linked 19
  • MRX19
  • p90-RSK2
  • p90RSK3
  • pp90RSK2
  • ribosomal protein S6 kinase alpha-3
  • ribosomal protein S6 kinase, 90kD, polypeptide 3
  • ribosomal protein S6 kinase, 90kDa, polypeptide 3
  • Ribosomal S6 kinase 2
  • RPS6KA3
  • RSK
  • RSK2
  • RSK-2
  • RSK2p90-RSK 3
  • S6K-alpha3
  • S6K-alpha-3

Background

The p90 ribosomal S6 kinases (RSK)1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol RPS6KA3
Entrez
Uniprot