RHAMM/CD168 Antibody - BSA Free

The hyaluronan-mediated motility receptor, also known as RHAMM, was initially identified as a soluble protein that could be released by sub-confluent migrating cells, promoting cell motility and invasion via interactions with hyaluronan (HA) and the cell surface. While RHAMM is normally poorly expressed in most normal tissues and is not required for embryonic development or normal cell homeostasis functions, its expression is increased during wound repair in response to hypoxia and fibrogenic factors. However, its overexpression is transforming in multiple types of cancers and is required for maintaining RAS transformation. RHAMM associates with BRCA1 and BARD1, attenuating the mitotic-spindle-promoting activity of RHAMM, which may contribute to tumor progression by promoting genomic instability.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Porcine.

We have publications tested in 2 applications: FLOW, IF/IHC.

Showing Publications 1 - 3 of 3.

Publications using NBP1-76538	Applications	Species
G. Safarians, A. Sohrabi, I. Solomon, W. Xiao, S. Bastola, B.W. Rajput, M. Epperson, I. Rosenzweig, K. Tamura, B. Singer, J. Huang, M.J. Harrison, T. Sanazzaro, M.C. Condro, H.I. Kornblum, S.K. Seidlits Glioblastoma Spheroid Invasion Through Soft, Brain-like Matrices Depends on Hyaluronic Acid-CD44 Interactions Advanced healthcare materials 2023-06-03 [PMID: 36694362]
Moyra L, Arash S, Susanne B et al. Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells Sciences Advances 2022-02-16 [PMID: 35171685] (FLOW, Human)	FLOW	Human
Krishnamurthy VK, Stout AJ, Sapp MC et al. Dysregulation of hyaluronan homeostasis during aortic valve disease. Matrix Biol. 2016-11-15 [PMID: 27856308] (IF/IHC, Porcine, Human)	IF/IHC	Porcine, Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Flow	Mouse	01/25/2018	View Summary Application Flow Cytometry Sample Tested Hippocampal Cell Suspension Species Mouse Lot 6189-1502 Comments Comments Used antibody for FACS. 5 x 10^6 Mouse primary hippocampal cells suspended in complete neurosphere supplement media at 4' C. Cells are not permeabilized. Primary antibody used at 1:200 dilution for an hour on ice. Secondary goat antibody diluted to 1:2000 used. BD FACS Aria Fusion Sorter was used to analyze the sample. Excitation wavelength 488nm. Emission Filter 530/30. Events acquired ~70,000. Controls used were as follows: 1) No staining without Propidium Iodide. 2)No staining with Propidium Iodide. 3)Secondary only with Propidium Iodide. Rhamm only with Propidium Iodide.

Array NBP1-76538

• RHAMM/CD168 Antibodies
• RHAMM/CD168 ELISA Kits
• RHAMM/CD168 Lysate
• RHAMM/CD168 Proteins