RelA/NFkB p65 Transcription Factor Assay Kit (Colorimetric)

This product is produced by and distributed for Abnova, a company based in Taiwan.

In the canonical pathway of NF-kB activation, p65/p50 heterodimers are normally sequestered in the cytoplasm by binding to IkBa. Upon stimulus, such as TNFR1 activation, IkBa is phosphorylated, ubiquitinated and degraded, allowing the translocation of p65/p50 to the nucleus. There, the transcription factor binds to specific DNA sequences, called kB site, and stimulates transcription of target genes. Since NF-kB is a powerful activator of proinflammatory transcriptional programs, its activity is tightly regulated. IkBa is a transcriptional target of p65/p50, resulting in a negative feedback loop and 'turning off' NF-kB activation. The importance of Rel/NF-kB transcription factors in human inflammation and certain diseases makes them attractive targets for potential therapeutcs

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Kits are guaranteed for 6 months from date of receipt.

Showing Publications 1 - 6 of 6.

Publications using KA1341	Applications	Species
Lakshmi B, Prashant B, Paige M et al. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022-11-21 [PMID: 36410047]
Tian N, Shangguan W, Zhou Z et al. Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma. J Cancer. 2019-10-15 [PMID: 31762817]
Fu S, Lu W, Yu W et al. Protective effect of Cordyceps sinensis extract on lipopolysaccharide induced acute lung injury in mice. Biosci Rep. 2019-06-28 [PMID: 31186277]
Heun Y, Pircher J, Czermak T et al. Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in Sepsis. EBioMedicine. 2019-03-21 [PMID: 30905847]
Li Y, Hu C, Wang P et al. Indoor nanoscale particulate matter-induced coagulation abnormality based on a human 3D microvascular model on a microfluidic chip. J Nanobiotechnology. 2019-02-01 [PMID: 30709410]
Zhou M1, Li Z, Han Z, Tian N. Paclitaxel-sensitization enhanced by curcumin involves down-regulation of nuclear factor-iB and Lin28 in Hep3B cells. J Recept Signal Transduct Res. 2015-06-25 [PMID: 26108226]

Array KA1341

• RelA/NFkB p65 Antibodies
• RelA/NFkB p65 Antibody Pack
• RelA/NFkB p65 ELISA Kits
• RelA/NFkB p65 Inhibitors
• RelA/NFkB p65 Kit
• RelA/NFkB p65 Lysate
• RelA/NFkB p65 Proteins