Recombinant Porcine IFN-gamma Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interferon-gamma (IFN-gamma ), also known as type II or immune interferon, exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine (1, 2). Mature porcine IFN-gamma exists as a noncovalently linked homodimer of 20-25 kDa variably glycosylated subunits (3). It shares 72%-79% amino acid sequence identity with bovine, canine, equine, and feline IFN-gamma and 41%-57% with cotton rat, human, mouse, rat, and rhesus IFN-gamma . IFN-gamma dimers bind to IFN-gamma RI ( alpha  subunits) which then interact with IFN-gamma RII ( beta  subunits) to form the functional receptor complex of two alpha  and two beta  subunits. Inclusion of IFN-gamma RII increases the binding affinity for ligand and the efficiency of signal transduction (4, 5). IFN-gamma is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells (6). It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, anti-proliferative, and apoptotic effects (6, 7). In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation (8, 9). The pleiotropic effects of IFN-gamma contribute to the development of multiple aspects of atherosclerosis (7).

We have publications tested in 1 confirmed species: Porcine.

We have publications tested in 3 applications: Bioassay, Cell Culture, In Vivo.

Showing Publications 1 - 10 of 17. Show All 17 Publications. Collapse Publications.

Publications using 985-PI	Applications	Species
Ba, C;Tian, C;Bo, X;Xu, C;Zhang, Y;Sun, X;Nan, Y;Wu, C; Porcine HERC6 acts as major E3 ligase for ISGylation and is auto-ISGylated for effective ISGylation in porcine Microbial pathogenesis 2024-03-29 [PMID: 38554778] (Bioassay, Porcine)	Bioassay	Porcine
Z Oreskovic, L Levá, K Chlebová, K Hlavová, R Tesa?ík, J Gebauer, M Faldyna Effects of IFNgamma and IL4 rich microenvironment on porcine monocyte-derived dendritic cell activation in vitro Research in Veterinary Science, 2022-02-06;145(0):54-62. 2022-02-06 [PMID: 35168110] (Bioassay, Porcine)	Bioassay	Porcine
P Li, JR Walsh, K Lopez, A Isidan, W Zhang, AM Chen, WC Goggins, NG Higgins, J Liu, RR Brutkiewic, LJ Smith, H Hara, DKC Cooper, B Ekser Genetic engineering of porcine endothelial cell lines for evaluation of human-to-pig xenoreactive immune responses Scientific Reports, 2021-06-23;11(1):13131. 2021-06-23 [PMID: 34162938] (Cell Culture, Porcine)	Cell Culture	Porcine
T Cao, X Li, Y Xu, S Zhang, Z Wang, Y Shan, J Sun, W Fang, X Li Npro of Classical Swine Fever Virus Suppresses Type III Interferon Production by Inhibiting IRF1 Expression and Its Nuclear Translocation Viruses, 2019-10-31;11(11):. 2019-10-31 [PMID: 31683525] (Cell Culture, Porcine)	Cell Culture	Porcine
T Huang, X Huang, W Chen, J Yin, B Shi, F Wang, W Feng, M Yao MicroRNA responses associated with Salmonella enterica serovar typhimurium challenge in peripheral blood: effects of miR-146a and IFN-gamma in regulation of fecal bacteria shedding counts in pig BMC Vet. Res., 2019-06-11;15(1):195. 2019-06-11 [PMID: 31186019] (In Vivo, Porcine)	In Vivo	Porcine
G Ogno, CA Sautter, E Canelli, O García-Nic, T Stadejek, P Martelli, P Borghetti, A Summerfiel In vitro characterization of PRRSV isolates with different in vivo virulence using monocyte-derived macrophages Vet. Microbiol., 2019-03-11;231(0):139-146. 2019-03-11 [PMID: 30955801] (Bioassay, Porcine)	Bioassay	Porcine
I Yoo, J Han, S Lee, W Jung, JH Kim, YW Kim, HJ Kim, M Hong, H Ka Analysis of stage-specific expression of the toll-like receptor family in the porcine endometrium throughout the estrous cycle and pregnancy Theriogenology, 2018-11-11;125(0):173-183. 2018-11-11 [PMID: 30448720] (Bioassay, Porcine)	Bioassay	Porcine
H Singleton, SP Graham, JP Frossard, KB Bodman-Smi, F Steinbach Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10 Virology, 2018-03-02;0(0):. 2018-03-02 [PMID: 29502802] (Bioassay, Porcine)	Bioassay	Porcine
MD de Smet, JL Lynch, NS Dejneka, M Keane, IJ Khan A Subretinal Cell Delivery Method via Suprachoroidal Access in Minipigs: Safety and Surgical Outcomes Invest. Ophthalmol. Vis. Sci., 2018-01-01;59(1):311-320. 2018-01-01 [PMID: 29346488] (Bioassay, Porcine)	Bioassay	Porcine
J Nau, SK Eller, J Wenning, KH Spekker-Bo, H Schroten, C Schwerk, A Hotop, U Gro beta , W Däubener Experimental Porcine Toxoplasma gondii Infection as a Representative Model for Human Toxoplasmosis Mediators Inflamm., 2017-08-13;2017(0):3260289. 2017-08-13 [PMID: 28883687] (Bioassay, Porcine)	Bioassay	Porcine
Hakhyun Ka Characterization of interferon ? and ? receptor IFNAR1 and IFNAR2 expression and regulation in the uterine endometrium during the estrous cycle and pregnancy in pigs Theriogenology, 2016-09-22;88(0):166-173. 2016-09-22 [PMID: 27769575] (Bioassay, Porcine)	Bioassay	Porcine
Sang Y, Brichalli W, Rowland R, Blecha F Genome-wide analysis of antiviral signature genes in porcine macrophages at different activation statuses. PLoS ONE, 2014-02-05;9(2):e87613. 2014-02-05 [PMID: 24505295] (Bioassay, Porcine)	Bioassay	Porcine
Lannes N, Summerfield A Regulation of porcine plasmacytoid dendritic cells by cytokines. PLoS ONE, 2013-04-08;8(4):e60893. 2013-04-08 [PMID: 23577175] (Bioassay, Porcine)	Bioassay	Porcine
Delputte PL, Van Breedam W, Barbe F, Van Reeth K, Nauwynck HJ IFN-alpha treatment enhances porcine Arterivirus infection of monocytes via upregulation of the porcine Arterivirus receptor sialoadhesin. J. Interferon Cytokine Res., 2007-09-01;27(9):757-66. 2007-09-01 [PMID: 17892397] (Bioassay, Porcine)	Bioassay	Porcine
Poncelet AJ, Vercruysse J, Saliez A, Gianello P Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo. Transplantation, 2007-03-27;83(6):783-90. 2007-03-27 [PMID: 17414713] (Bioassay, Porcine)	Bioassay	Porcine
Tambuyzer BR, Nouwen EJ Inhibition of microglia multinucleated giant cell formation and induction of differentiation by GM-CSF using a porcine in vitro model. Cytokine, 2005-08-21;31(4):270-9. 2005-08-21 [PMID: 16009563] (Bioassay, Porcine)	Bioassay	Porcine
Seo SH, Hoffmann E, Webster RG The NS1 gene of H5N1 influenza viruses circumvents the host anti-viral cytokine responses. Virus Res., 2004-07-01;103(1):107-13. 2004-07-01 [PMID: 15163498] (Bioassay, Porcine)	Bioassay	Porcine
Show All 17 Publications. Collapse Publications.

Array 985-PI

• IFN-gamma Antibodies
• IFN-gamma Antibody Pairs
• IFN-gamma ELISA Kits
• IFN-gamma Kits
• IFN-gamma Lysate
• IFN-gamma Proteins
• IFN-gamma ELISAs
• IFN-gamma Proteins and Enzymes