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Recombinant Mouse TGF-beta 1 Protein

Name: Recombinant Mouse TGF-beta 1 Protein
Brand: Novus Biologicals
SKU: 7666-MB
Price: 408 USD

(364 Publications)

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Recombinant mouse TGF-beta 1 (7666-MB) inhibits IL-4-dependent proliferation in the HT-2 mouse T cell line. The ED50 for this effect is 0.04-0.2 ng/mL.

Product Details

Summary

Reactivity	MuSpecies Glossary
Applications	Bioactivity

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Carrier Free 7666-MB-005/CF

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Recombinant Mouse TGF-beta 1 Protein Summary

Details of Functionality	Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED₅₀ for this effect is 0.04-0.2 ng/mL.
Source	Chinese Hamster Ovary cell line, CHO-derived mouse TGF-beta 1 protein Ala279-Ser390
Accession #	P04202
N-terminal Sequence	Ala279
Structure / Form	Disulfide-linked homodimer
Protein/Peptide Type	Recombinant Proteins
Gene	Tgfb1
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

12.8 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

10.5 kDa, reducing conditions

Publications

Read Publications using
7666-MB in the following applications:

Bioassay
318 publications
Cell Culture
31 publications
ELISA Developmet
1 publication
ELISA Standard
1 publication
In Vivo
8 publications
Stimulation
1 publication
Surface Plasmon Resonance
1 publication
Tissue Culture
1 publication

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in HCl with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute at 50 μg/mL in 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse TGF-beta 1 Protein

CEDLAP
DPD1
latency-associated peptide
TGF beta
TGF beta1
TGFB
TGFB1
TGF-beta 1 protein
TGFbeta 1
TGF-beta 1
TGFbeta
TGF-beta-1
transforming growth factor beta-1
transforming growth factor, beta 1

Background

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF‑ beta superfamily that share a characteristic cystine knot structure (1‑7). TGF‑ beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial‑mesenchymal transition (1‑4). Each TGF‑ beta isoform has some non‑redundant functions; for TGF‑ beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human or mouse TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature mouse TGF‑ beta 1 shares 99‑100% aa sequence identity with human, rat, equine, porcine, canine and bovine TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
Wahl, S.M. (2006) Immunol. Rev. 213:213.
Chang, H. et al. (2002) Endocr. Rev. 23:787.
Lin, J.S. et al. (2006) Reproduction 132:179.
Hinck, A.P. et al. (1996) Biochemistry 35:8517.
Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
Derynck, R. et al. (1985) Nature 316:701.
Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.

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Recombinant Mouse
TGF-beta 1 Protein

7666-MB

Species: Mu

Applications: Bioactivity

Publications for TGF-beta 1 (7666-MB)(364)

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Canine, N/A, Transgenic Mouse.

We have publications tested in 8 applications: Bioassay, Cell Culture, ELISA Developmet, ELISA Standard, In Vivo, Stimulation, Surface Plasmon Resonance, Tissue Culture.

Showing Publications 1 - 10 of 364. Show All 364 Publications.

Publications using 7666-MB	Applications	Species
Liu, C;Zhang, Q;Zhou, H;Jin, L;Liu, C;Yang, M;Zhao, X;Ding, W;Xie, W;Kong, H; GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation Journal of translational medicine 2024-10-21 [PMID: 39434134] (Bioassay, Mouse)	Bioassay	Mouse
Scafidi, A;Lind-Holm Mogensen, F;Campus, E;Pailas, A;Neumann, K;Legrave, N;Bernardin, F;Pereira, SL;Antony, PMA;Nicot, N;Mittelbronn, M;Grünewald, A;Nazarov, PV;Poli, A;Van Dyck, E;Michelucci, A; Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity Heliyon 2024-09-30 [PMID: 39315158] (Bioassay, Mouse)	Bioassay	Mouse
Yoshida, S;Yoshida, T;Inukai, K;Kato, K;Yura, Y;Hattori, T;Enomoto, A;Ohashi, K;Okumura, T;Ouchi, N;Kawase, H;Wettschureck, N;Offermanns, S;Murohara, T;Takefuji, M; Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion Nature communications 2024-09-12 [PMID: 39266515] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Sokolova, D;Ghansah, SA;Puletti, F;Georgiades, T;De Schepper, S;Zheng, Y;Crowley, G;Wu, L;Rueda-Carrasco, J;Koutsiouroumpa, A;Muckett, P;Freeman, OJ;Khakh, BS;Hong, S; Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models bioRxiv : the preprint server for biology 2024-09-01 [PMID: 39257734] (Bioassay, Mouse)	Bioassay	Mouse
Dipali, SS;Gowett, MQ;Kamat, P;Converse, A;Zaniker, EJ;Fennell, A;Chou, T;Pritchard, MT;Zelinski, M;Phillip, JM;Duncan, FE; Self-organizing ovarian somatic organoids preserve cellular heterogeneity and reveal cellular contributions to ovarian aging bioRxiv : the preprint server for biology 2024-08-10 [PMID: 39211064] (Bioassay, Mouse)	Bioassay	Mouse
Malone, K;Dugas, M;Earl, N;Alain, T;LaCasse, EC;Beug, ST; Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds Cell death & disease 2024-08-15 [PMID: 39147758] (Bioassay, Mouse)	Bioassay	Mouse
Lebas, M;Chinigò, G;Courmont, E;Bettaieb, L;Machmouchi, A;Goveia, J;Beatovic, A;Van Kerckhove, J;Robil, C;Angulo, FS;Vedelago, M;Errerd, A;Treps, L;Gao, V;Delgado De la Herrán, HC;Mayeuf-Louchart, A;L'homme, L;Chamlali, M;Dejos, C;Gouyer, V;Garikipati, VNS;Tomar, D;Yin, H;Fukui, H;Vinckier, S;Stolte, A;Conradi, LC;Infanti, F;Lemonnier, L;Zeisberg, E;Luo, Y;Lin, L;Desseyn, JL;Pickering, J;Kishore, R;Madesh, M;Dombrowicz, D;Perocchi, F;Staels, B;Pla, AF;Gkika, D;Cantelmo, AR; Integrated single-cell RNA-seq analysis reveals mitochondrial calcium signaling as a modulator of endothelial-to-mesenchymal transition Science advances 2024-08-09 [PMID: 39121218] (Bioassay, Mouse)	Bioassay	Mouse
Assayag, M;Obedeyah, T;Abutbul, A;Berkman, N; The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice Respiratory research 2024-07-12 [PMID: 38997751] (Bioassay, Mouse)	Bioassay	Mouse
Cremin, M;Ramirez, VT;Sanchez, K;Tay, E;Murray, K;Brust-Mascher, I;Reardon, C; Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection bioRxiv : the preprint server for biology 2024-06-27 [PMID: 38979288] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Amargant, F;Vieira, C;Pritchard, MT;Duncan, FE; Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse bioRxiv : the preprint server for biology 2024-06-25 [PMID: 38979191] (Bioassay, Mouse)	Bioassay	Mouse
Zewdie, EY;Edwards, GM;Hunter, DM;Earp, HS;Holtzhausen, A; MerTK Induces Dysfunctional Dendritic Cells by Metabolic Reprogramming Cancer immunology research 2024-07-08 [PMID: 38976507] (Bioassay, Mouse)	Bioassay	Mouse
Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Bioassay, Mouse)	Bioassay	Mouse
Frey, HC;Sun, X;Oudeif, F;Corona, DL;He, Z;Won, T;Schultz, TL;Carruthers, VB;Laouar, A;Laouar, Y; A Membrane Lipid Signature Unravels the Dynamic Landscape of Group 1 ILCs bioRxiv : the preprint server for biology 2024-04-20 [PMID: 38659946] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Llorián-Salvador, M;de Fuente, AG;McMurran, CE;Dashwood, A;Dooley, J;Liston, A;Penalva, R;Dombrowski, Y;Stitt, AW;Fitzgerald, DC; Regulatory T cells limit age-associated retinal inflammation and neurodegeneration Molecular neurodegeneration 2024-04-05 [PMID: 38581053] (Mouse)		Mouse
Hao, J;Liu, C;Gu, Z;Yang, X;Lan, X;Guo, X; Dysregulation of Wnt/?-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells Nature communications 2024-04-01 [PMID: 38561332] (Mouse)		Mouse
Zhang, Z;Zhao, C;Sun, L;Cheng, C;Tian, Q;Wu, C;Xu, Y;Dong, X;Zhang, B;Zhang, L;Zhao, Y; Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice European journal of immunology 2024-01-17 [PMID: 38234007] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
King, A;Reichl, P;Metson, JS;Parker, R;Munro, D;Oliveira, C;Becker, JR;Biggs, D;Preece, C;Davies, B;Chapman, JR; Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice bioRxiv : the preprint server for biology 2023-12-21 [PMID: 38187711] (Bioassay, Mouse)	Bioassay	Mouse
Wang, M;Mequanint, K; Preparation and Microscopic Mechanical Characterization of L-Methionine-Based Polyphosphazene Fibrous Mats for Vascular Tissue Engineering Pharmaceutics 2023-10-28 [PMID: 38004526] (Bioassay, Mouse)	Bioassay	Mouse
Li, D;Zhou, J;Wang, L;Gong, Z;Le, H;Huang, Y;Xu, C;Tian, C;Cai, W;Wu, J; Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation Cell & bioscience 2023-10-03 [PMID: 37789469] (Bioassay, Mouse)	Bioassay	Mouse
Kitamura, F;Semba, T;Yasuda-Yoshihara, N;Yamada, K;Nishimura, A;Yamasaki, J;Nagano, O;Yasuda, T;Yonemura, A;Tong, Y;Wang, H;Akiyama, T;Matsumura, K;Uemura, N;Itoyama, R;Bu, L;Fu, L;Hu, X;Wei, F;Mima, K;Imai, K;Hayashi, H;Yamashita, YI;Miyamoto, Y;Baba, H;Ishimoto, T; Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer JCI insight 2023-10-23 [PMID: 37733442] (Bioassay, Mouse)	Bioassay	Mouse
Kweon, B;Kim, DU;Oh, JY;Park, SJ;Bae, GS; Catechin hydrate ameliorates cerulein?induced chronic pancreatitis via the inactivation of TGF??/Smad2 signaling Molecular medicine reports 2023-11-01 [PMID: 37732516] (Bioassay, Mouse)	Bioassay	Mouse
Wu, S;Zhang, X;Hu, C;Zhong, Y;Chen, J;Chong, WP; CD8+ T cells reduce neuroretina inflammation in mouse by regulating autoreactive Th1 and Th17 cells through IFN-? European journal of immunology 2023-09-09 [PMID: 37689974] (Bioassay, Mouse)	Bioassay	Mouse
van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Mouse)	Bioassay	Mouse
Li, Y;Chen, Y;Xiao, X;Deng, S;Kuang, J;Wang, Y; CX3CL1 represses autophagy via CX3CR1/ CaMKII?/HDAC4/Rubicon axis and exacerbates chronic intermittent hypoxia induced Kupffer cell apoptosis Cellular signalling 2023-08-26 [PMID: 37640194] (Cell Culture, Mouse)	Cell Culture	Mouse
Sweeney, M;O'Fee, K;Villanueva-Hayes, C;Rahman, E;Lee, M;Vanezis, K;Andrew, I;Lim, WW;Widjaja, A;Barton, PJR;Cook, SA; Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction International journal of molecular sciences 2023-08-20 [PMID: 37629170] (Bioassay, Mouse)	Bioassay	Mouse
Yin, J;Zidan, A;Zhu, S;Elbasiony, E;Najafi, S;Lin, Z;Singh, RB;Naderi, A; Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury Research square 2023-08-07 [PMID: 37609298] (Bioassay, Mouse)	Bioassay	Mouse
Miyamoto, K;Sujino, T;Harada, Y;Ashida, H;Yoshimatsu, Y;Yonemoto, Y;Nemoto, Y;Tomura, M;Melhem, H;Niess, JH;Suzuki, T;Suzuki, T;Suzuki, S;Koda, Y;Okamoto, R;Mikami, Y;Teratani, T;Tanaka, K;Yoshimura, A;Sato, T;Kanai, T; The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis Cell reports 2023-08-16 [PMID: 37590143] (Bioassay, Mouse)	Bioassay	Mouse
Elmarsafawi, AG;Hesterberg, RS;Fernandez, MR;Yang, C;Darville, LN;Liu, M;Koomen, JM;Phanstiel Iv, O;Atkins, R;Mullinax, JE;Pilon-Thomas, SA;Locke, FL;Epling-Burnette, PK;Cleveland, JL; Modulating the polyamine-hypusine axis controls generation of CD8+ tissue resident memory T cells JCI insight 2023-08-15 [PMID: 37581943] (Cell Culture, Mouse)	Cell Culture	Mouse
Santiago, JV;Natu, A;Ramelow, CC;Rayaprolu, S;Xiao, H;Kumar, V;Seyfried, NT;Rangaraju, S; Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles bioRxiv : the preprint server for biology 2023-07-29 [PMID: 37546899] (Mouse)		Mouse
Lee, JY;Chou, NL;Yu, YR;Shih, HA;Lin, HW;Lee, CK;Chang, MS; PHRF1 promotes the class switch recombination of IgA in CH12F3-2A cells PloS one 2023-08-04 [PMID: 37540725] (Bioassay, Mouse)	Bioassay	Mouse
Rondeaux, J;Groussard, D;Renet, S;Tardif, V;Dumesnil, A;Chu, A;Di Maria, L;Lemarcis, T;Valet, M;Henry, JP;Badji, Z;Vézier, C;Béziau-Gasnier, D;Neele, AE;de Winther, MPJ;Guerrot, D;Brand, M;Richard, V;Durand, E;Brakenhielm, E;Fraineau, S; Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI Nature communications 2023-07-25 [PMID: 37491334] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Chauvin, M;Meinsohn, MC;Dasari, S;May, P;Iyer, S;Nguyen, NMP;Oliva, E;Lucchini, Z;Nagykery, N;Kashiwagi, A;Mishra, R;Maser, R;Wells, J;Bult, CJ;Mitra, AK;Donahoe, PK;Pépin, D; Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis Cell reports 2023-07-13 [PMID: 37453057] (Human)		Human
Goulart, A;Boko, MMM;Martins, NS;Gembre, AF;de Oliveira, RS;Palma-Albornoz, SP;Bertolini, T;Ribolla, PEM;Ramalho, LNZ;Fraga-Silva, TFC;Bonato, VLD; IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia International journal of molecular sciences 2023-06-21 [PMID: 37445595] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Vinod, N;Hwang, D;Fussell, SC;Owens, TC;Tofade, OC;Copling, S;Ramsey, JD;Rädler, PD;Atkins, HM;Livingston, EE;Ashley Ezzell, J;Papkov, MS;Yuan, H;Perou, CM;Kabanov, AV; Combination of Polymeric Micelle Formulation of TGF beta Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC bioRxiv : the preprint server for biology 2023-06-14 [PMID: 37398150] (Bioassay, Mouse)	Bioassay	Mouse
Alber, AB;Marquez, HA;Ma, L;Kwong, G;Thapa, BR;Villacorta-Martin, C;Lindstrom-Vautrin, J;Bawa, P;Wang, F;Luo, Y;Ikonomou, L;Shi, W;Kotton, DN; Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme Nature communications 2023-06-13 [PMID: 37311756] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Suzuki, K;Kunisada, Y;Miyamura, N;Eikawa, S;Hurtado de Mendoza, T;Mose, ES;Lu, C;Kuroda, Y;Ruoslahti, E;Lowy, AM;Sugahara, KN; Tumor-resident regulatory T cells in pancreatic cancer express the ?v?5 integrin as a targetable activation marker bioRxiv : the preprint server for biology 2023-05-24 [PMID: 37292693] (Bioassay, Mouse)	Bioassay	Mouse
Zhou, W;Zhang, H;Huang, L;Sun, C;Yue, Y;Cao, X;Jia, H;Wang, C;Gao, Y; Disulfiram with Cu2+ alleviates dextran sulfate sodium-induced ulcerative colitis in mice Theranostics 2023-05-08 [PMID: 37284442] (Bioassay, Mouse)	Bioassay	Mouse
Werner, F;Prentki Santos, E;Michel, K;Schrader, H;V�lker, K;Potapenko, T;Krebes, L;Abesser, M;M�llmann, D;Schlattjan, M;Schmidt, H;Skryabin, BV;�piranec Spes, K;Schuh, K;Denton, CP;Baba, HA;Kuhn, M; Ablation of C-type natriuretic peptide/cGMP signaling in fibroblasts exacerbates adverse cardiac remodeling in mice JCI insight 2023-05-25 [PMID: 37227779] (Bioassay, Mouse)	Bioassay	Mouse
Laragione, T;Harris, C;Azizgolshani, N;Beeton, C;Bongers, G;Gulko, PS; Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome EBioMedicine 2023-05-16 [PMID: 37201335] (Bioassay, Mouse)	Bioassay	Mouse
Plebanek, MP;Xue, Y;Nguyen, YV;DeVito, NC;Wang, X;Holtzhausen, A;Beasley, GM;Yarla, N;Thievanthiran, B;Hanks, BA; A SREBF2-dependent gene program drives an immunotolerant dendritic cell population during cancer progression bioRxiv : the preprint server for biology 2023-04-28 [PMID: 37162965] (Bioassay, Mouse)	Bioassay	Mouse
Ni, Z;Lyu, L;Gong, H;Du, L;Wen, Z;Jiang, H;Yang, H;Hu, Y;Zhang, B;Xu, Q;Guo, X;Chen, T; Multilineage commitment of Sca-1+ cells in reshaping vein grafts Theranostics 2023-04-01 [PMID: 37153747] (Bioassay, Mouse)	Bioassay	Mouse
Heyer, V;Reina-San-Martin, B; Optimal AID expression and efficient immunoglobulin class switch recombination are dependent on the Hypoxia-Inducible Factor European journal of immunology 2023-05-04 [PMID: 37143384] (Bioassay, Mouse)	Bioassay	Mouse
D Irala, S Wang, K Sakers, L Nagendren, FP Ulloa-Seve, DS Bindu, C Eroglu Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066164] (Bioassay, Mouse)	Bioassay	Mouse
X Che, X Jin, NR Park, HJ Kim, HS Kyung, HJ Kim, JB Lian, JL Stein, GS Stein, JY Choi Cbfbeta Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-beta Signaling Cells, 2023-03-31;12(7):. 2023-03-31 [PMID: 37048137] (Bioassay, Mouse)	Bioassay	Mouse
Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)	Bioassay	Mouse
C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu Old age promotes retinal fibrosis in choroidal neovascularization through circulating fibrocytes and profibrotic macrophages Journal of Neuroinflammation, 2023-02-23;20(1):45. 2023-02-23 [PMID: 36823538] (Bioassay, Mouse)	Bioassay	Mouse
S De Scheppe, JZ Ge, G Crowley, LSS Ferreira, D Garceau, CE Toomey, D Sokolova, J Rueda-Carr, SH Shin, JS Kim, T Childs, T Lashley, JJ Burden, M Sasner, C Sala Frige, S Jung, S Hong Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease Nature Neuroscience, 2023-02-06;0(0):. 2023-02-06 [PMID: 36747024] (Bioassay, Mouse)	Bioassay	Mouse
RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu Crosstalk between ILC2s and Th2 cells varies among mouse models Cell Reports, 2023-02-02;42(2):112073. 2023-02-02 [PMID: 36735533] (Bioassay, Mouse)	Bioassay	Mouse
T Kasuya, S Tanaka, J Tamura, K Etori, J Shoda, K Hattori, Y Endo, M Kitajima, T Kageyama, T Iwamoto, M Yokota, A Iwata, A Suto, K Suzuki, H Suzuki, SF Ziegler, H Nakajima Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake Scientific Reports, 2023-01-30;13(1):1653. 2023-01-30 [PMID: 36717741] (Cell Culture, Mouse)	Cell Culture	Mouse
TT Li, XW Su, LL Chen, WN Zhang, JP Zhang, Y Wang, WH Xu Roxarsone inhibits hepatic stellate cell activation and ameliorates liver fibrosis by blocking TGF-beta1/Smad signaling pathway International immunopharmacology, 2022-12-19;114(0):109527. 2022-12-19 [PMID: 36700762] (Cell Culture, Human)	Cell Culture	Human
L Tang, M Zhu, X Che, X Yang, Y Xu, Q Ma, M Zhang, Z Ni, X Shao, S Mou Astragaloside IV Targets Macrophages to Alleviate Renal Ischemia-Reperfusion Injury via the Crosstalk between Hif-1alpha and NF-kappaB (p65)/Smad7 Pathways Journal of personalized medicine, 2022-12-27;13(1):. 2022-12-27 [PMID: 36675720] (Bioassay, Mouse)	Bioassay	Mouse
T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival Mucosal Immunology, 2023-01-13;0(0):. 2023-01-13 [PMID: 36642378] (Bioassay, Mouse)	Bioassay	Mouse
J Li, Z Yao, X Liu, R Duan, X Yi, A Ayoub, JO Sanders, A Mesfin, L Xing, BF Boyce TGFbeta1+CCR5+ neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice Nature Communications, 2023-01-11;14(1):159. 2023-01-11 [PMID: 36631487] (Bioassay, Mouse)	Bioassay	Mouse
D Shore, N Griggs, V Graffeo, ARMR Amin, XM Zha, Y Xu, JP McAleer GPR68 limits the severity of chemical-induced oral epithelial dysplasia Scientific Reports, 2023-01-07;13(1):353. 2023-01-07 [PMID: 36611126] (Cell Culture, Mouse)	Cell Culture	Mouse
B Wang, Y Tan, Y Zhang, S Zhang, X Duan, Y Jiang, T Li, Q Zhou, X Liu, Z Zhan Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression Experimental & Molecular Medicine, 2022-12-08;0(0):. 2022-12-08 [PMID: 36481938] (Mouse)		Mouse
M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Mouse)	Bioassay	Mouse
M Schmitt, F Ceteci, J Gupta, M Pesic, TW Böttger, AM Nicolas, KB Kennel, E Engel, M Schewe, A Callak Kir, V Petrocelli, Y Dabiri, J Varga, M Ramakrishn, M Karimova, A Ablasser, T Sato, MC Arkan, FJ de Sauvage, FR Greten Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation Nature, 2022-11-16;0(0):. 2022-11-16 [PMID: 36385525] (Bioassay, Mouse)	Bioassay	Mouse
S Munakarmi, Y Gurau, J Shrestha, P Risal, HS Park, HB Shin, YJ Jeong Hepatoprotective Effects of a Natural Flavanol 3,3'-Diindolylmethane against CCl4-Induced Chronic Liver Injury in Mice and TGFbeta1-Induced EMT in Mouse Hepatocytes via Activation of Nrf2 Cascade International Journal of Molecular Sciences, 2022-09-27;23(19):. 2022-09-27 [PMID: 36232707] (Cell Culture, Mouse)	Cell Culture	Mouse
WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022-09-22;112(0):109261. 2022-09-22 [PMID: 36155282] (Bioassay, Mouse)	Bioassay	Mouse
BA Dos Santos, AC Anauate, E Maquigussa, MA Boim, A da Silva N Determination of reference genes as a quantitative standard for gene expression analysis in mouse mesangial cells stimulated with TGF-beta Scientific Reports, 2022-09-17;12(1):15626. 2022-09-17 [PMID: 36115882] (Cell Culture, Mouse)	Cell Culture	Mouse
M Bobowski-G, C Boulet, FP Zummo, J Dubois-Che, C Gheeraert, M Bou Saleh, JM Strub, A Farce, M Ploton, L Guille, J Vandel, A Bongiovann, N Very, E Woitrain, A Deprince, F Lalloyer, E Bauge, L Ferri, LC Ntandja-Wa, AK Cotte, C Grangette, E Vallez, S Cianférani, V Raverdy, R Caiazzo, V Gnemmi, E Leteurtre, B Pourcet, R Paumelle, K Ravnskjaer, G Lassailly, JT Haas, P Mathurin, F Pattou, L Dubuquoy, B Staels, P Lefebvre, J Eeckhoute Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis Nature Communications, 2022-09-10;13(1):5324. 2022-09-10 [PMID: 36088459] (Bioassay, Mouse)	Bioassay	Mouse
EC Freckmann, E Sandilands, E Cumming, M Neilson, A Román-Fern, K Nikolatou, M Nacke, TRM Lannagan, A Hedley, D Strachan, M Salji, JP Morton, L McGarry, HY Leung, OJ Sansom, CJ Miller, DM Bryant Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging Nature Communications, 2022-09-09;13(1):5317. 2022-09-09 [PMID: 36085324] (Bioassay, Mouse)	Bioassay	Mouse
L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)	Bioassay	Mouse
N Nishiyama, C Nakahashi-, A Shibuya Interferon-beta promotes the survival and function of induced regulatory T cells Cytokine, 2022-08-29;158(0):156009. 2022-08-29 [PMID: 36049243] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
SI Tsukumo, PG Subramani, N Seija, M Tabata, Y Maekawa, Y Mori, C Ishifune, Y Itoh, M Ota, K Fujio, JM Di Noia, K Yasutomo AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination Science Advances, 2022-08-24;8(34):eabq0008. 2022-08-24 [PMID: 36001653] (Cell Culture, Mouse)	Cell Culture	Mouse
JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation Theranostics, 2022-07-18;12(13):5744-5760. 2022-07-18 [PMID: 35966593] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Li, J Wang, C Chen, Q He, X Xu, Z Da, B Wang, M Wang, X Gao, G Zhang, Q Gao, X Si, Y Luo, X Ma Intratumoral IL-28B Gene Delivery Elicits Antitumor Effects by Remodeling of the Tumor Microenvironment in H22-Bearing Mice Journal of Immunology Research, 2022-07-28;2022(0):1345971. 2022-07-28 [PMID: 35935577] (Cell Culture, Mouse)	Cell Culture	Mouse
EG Vasquez, N Nasreddin, GN Valbuena, EJ Mulholland, HL Belnoue-Da, HR Eggington, RO Schenck, VM Wouters, P Wirapati, K Gilroy, TRM Lannagan, DJ Flanagan, AK Najumudeen, S Omwenga, AMB McCorry, A Easton, VH Koelzer, JE East, D Morton, L Trusolino, T Maughan, AD Campbell, MB Loughrey, PD Dunne, P Tsantoulis, DJ Huels, S Tejpar, OJ Sansom, SJ Leedham Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia Cell Stem Cell, 2022-08-04;29(8):1213-1228.e8. 2022-08-04 [PMID: 35931031] (Bioassay, Mouse)	Bioassay	Mouse
K Nishida-Ta, A Kimura, T Tsubata, S Takahashi, H Suzuki Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels PLoS ONE, 2022-07-29;17(7):e0272090. 2022-07-29 [PMID: 35905076] (Bioassay, Mouse)	Bioassay	Mouse
T Ahmed, PC Flores, CC Pan, HR Ortiz, YS Lee, PR Langlais, K Mythreye, NY Lee EPDR1 is a Non-canonical Effector of Insulin-mediated Angiogenesis Regulated by an Endothelial-specific TGF-beta Receptor Complex The Journal of Biological Chemistry, 2022-07-21;0(0):102297. 2022-07-21 [PMID: 35872017] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Y Su, X Sun, X Liu, Q Qu, L Yang, Q Chen, F Liu, Y Li, Q Wang, B Huang, XJ Huang, XH Zhang hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Journal of hematology & oncology, 2022-07-21;15(1):99. 2022-07-21 [PMID: 35864538] (Bioassay, Mouse)	Bioassay	Mouse
E Ledoult, M Jendoubi, A Collet, T Guerrier, A Largy, S Speca, S Vivier, F Bray, M Figeac, E Hachulla, M Labalette, F Leprêtre, S Sebda, S Sanges, C Rolando, V Sobanski, S Dubucquoi, D Launay Simple gene signature to assess murine fibroblast polarization Scientific Reports, 2022-07-11;12(1):11748. 2022-07-11 [PMID: 35817787] (Bioassay, Mouse)	Bioassay	Mouse
P Kim, J Park, DJ Lee, S Mizuno, M Shinohara, CP Hong, Y Jeong, R Yun, H Park, S Park, KM Yang, MJ Lee, SP Jang, HY Kim, SJ Lee, SU Song, KS Park, M Tanaka, H Ohshima, JW Cho, F Sugiyama, S Takahashi, HS Jung, SJ Kim Mast4 determines the cell fate of MSCs for bone and cartilage development Nature Communications, 2022-07-08;13(1):3960. 2022-07-08 [PMID: 35803931] (Bioassay, Mouse)	Bioassay	Mouse
Y Xia, K Inoue, Y Du, SJ Baker, E Premkumar, MB Greenblatt, B Zhao TGFbeta reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis Nature Communications, 2022-07-07;13(1):3920. 2022-07-07 [PMID: 35798734] (Bioassay, Mouse)	Bioassay	Mouse
P Lu, J Li, C Liu, J Yang, H Peng, Z Xue, Z Liu Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis Asian journal of pharmaceutical sciences, 2022-04-30;17(3):447-461. 2022-04-30 [PMID: 35782322] (Bioassay, Mouse)	Bioassay	Mouse
LM Fan, YQ Zhang, YP Chen, LL Chen, WH Xu, LH Nan, W Xu, B Lu, Y Wang, KD Chu, JP Zhang Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation Oncogene, 2022-05-31;108(0):108894. 2022-05-31 [PMID: 35729830] (Bioassay, Mouse)	Bioassay	Mouse
SPS Pandi, MJ Shattock, BM Hendry, CC Sharpe Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1 Oncogene, 2022-06-16;23(1):211. 2022-06-16 [PMID: 35710406] (Bioassay, Mouse)	Bioassay	Mouse
I Nanda, C Steinlein, T Haaf, EM Buhl, DG Grimm, SL Friedman, SK Meurer, SK Schröder, R Weiskirche Genetic Characterization of Rat Hepatic Stellate Cell Line HSC-T6 for In Vitro Cell Line Authentication Cells, 2022-05-29;11(11):. 2022-05-29 [PMID: 35681478] (Bioassay, Rat)	Bioassay	Rat
S Urbanczyk, OR Baris, J Hofmann, RV Taudte, N Guegen, F Golombek, K Castiglion, X Meng, A Bozec, J Thomas, L Weckwerth, D Mougiakako, SR Schulz, W Schuh, U Schlötzer-, TD Steinmetz, S Brodesser, RJ Wiesner, D Mielenz Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle Cell Reports, 2022-06-07;39(10):110912. 2022-06-07 [PMID: 35675769] (Bioassay, Mouse)	Bioassay	Mouse
F Wang, F Stappenbec, LY Tang, YE Zhang, ST Hui, AJ Lusis, F Parhami Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization International Journal of Molecular Sciences, 2022-05-13;23(10):. 2022-05-13 [PMID: 35628290] (Bioassay, Mouse)	Bioassay	Mouse
DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Mouse)	Bioassay	Mouse
YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)	Bioassay	Mouse
AP Leinroth, AJ Mirando, D Rouse, Y Kobayahsi, PR Tata, HE Rueckert, Y Liao, JT Long, JV Chakkalaka, MJ Hilton Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations Cell Reports, 2022-05-10;39(6):110785. 2022-05-10 [PMID: 35545045] (Bioassay, Mouse)	Bioassay	Mouse
Y Yoshimatsu, T Sujino, K Miyamoto, Y Harada, S Tanemoto, K Ono, S Umeda, K Yoshida, T Teratani, T Suzuki, Y Mikami, N Nakamoto, N Sasaki, K Takabayash, N Hosoe, H Ogata, K Sawada, T Imamura, A Yoshimura, T Kanai Aryl hydrocarbon receptor signals in epithelial cells govern the recruitment and location of Helios+ Tregs in the gut Cell Reports, 2022-05-10;39(6):110773. 2022-05-10 [PMID: 35545035] (Bioassay, Mouse)	Bioassay	Mouse
S Balasubram, M Andreani, JG Andrade, T Saha, D Sundaravin, J Garzón, W Zhang, O Popp, SI Hiraga, A Rahjouei, DB Rosen, P Mertins, BT Chait, AD Donaldson, M Di Virgili Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region Elife, 2022-04-13;11(0):. 2022-04-13 [PMID: 35416772] (Stimulation, Mouse)	Stimulation	Mouse
C Yi, J Liu, W Deng, C Luo, J Qi, M Chen, H Xu Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis Journal of Neuroinflammation, 2022-04-05;19(1):78. 2022-04-05 [PMID: 35382832] (Bioassay, Mouse)	Bioassay	Mouse
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)	Bioassay	Human
H Kubota, H Yamada, T Sugimoto, N Wada, S Motoyama, M Saburi, D Miyawaki, N Wakana, D Kami, T Ogata, M Ibi, S Matoba Repeated Social Defeat Enhances CaCl2-Induced Abdominal Aortic Aneurysm Expansion by Inhibiting the Early Fibrotic Response via the MAPK-MKP-1 Pathway Cells, 2022-02-19;11(4):. 2022-02-19 [PMID: 35203381] (Bioassay, Mouse)	Bioassay	Mouse
GS Whitehead, SY Thomas, K Nakano, DJ Royer, CG Burke, H Nakano, DN Cook A neutrophil/TGF-beta axis limits the pathogenicity of allergen-specific CD4+ T cells JCI Insight, 2022-02-22;7(4):. 2022-02-22 [PMID: 35191395] (In Vivo, Mouse)	In Vivo	Mouse
H Ni, C Liu, Y Chen, Y Lu, Y Ji, M Xiang, Y Xie MGP Regulates Perivascular Adipose-Derived Stem Cells Differentiation Toward Smooth Muscle Cells Via BMP2/SMAD Pathway Enhancing Neointimal Formation Cell Transplantation, 2022-01-01;31(0):9636897221075. 2022-01-01 [PMID: 35168405] (Bioassay, Mouse)	Bioassay	Mouse
A Bartolomé, N Suda, J Yu, C Zhu, J Son, H Ding, A Califano, D Accili, UB Pajvani Notch-mediated Ephrin signaling disrupts islet architecture and beta cell function JCI Insight, 2022-03-22;0(0):. 2022-03-22 [PMID: 35167496] (Bioassay, Mouse)	Bioassay	Mouse
H Qin, Y Tang, Y Mao, X Zhou, T Xu, W Liu, X Su C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1 Cellular Signalling, 2022-02-03;0(0):110274. 2022-02-03 [PMID: 35122989] (Bioassay, Mouse)	Bioassay	Mouse
D Yang, P Xu, H Su, W Zhong, J Xu, Z Su, X Liu The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis Cell Death & Disease, 2022-01-17;13(1):60. 2022-01-17 [PMID: 35039472] (Bioassay, Mouse)	Bioassay	Mouse
A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22 PloS Pathogens, 2022-01-13;18(1):e1010200. 2022-01-13 [PMID: 35025968] (Bioassay, Mouse)	Bioassay	Mouse
BY Nam, JH Jhee, J Park, S Kim, G Kim, JT Park, TH Yoo, SW Kang, JW Yu, SH Han PGC-1alpha inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis Cell Death & Disease, 2022-01-10;13(1):31. 2022-01-10 [PMID: 35013155] (Bioassay, Mouse)	Bioassay	Mouse
Y Liu, W Zhong, J Zhang, W Chen, Y Lu, Y Qiao, Z Zeng, H Huang, S Cai, H Dong Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis Frontiers in Pharmacology, 2021-11-22;12(0):739220. 2021-11-22 [PMID: 34880752] (Bioassay, Mouse)	Bioassay	Mouse
J Chatterjee, S Sanapala, O Cobb, A Bewley, AK Goldstein, E Cordell, X Ge, JR Garbow, MJ Holtzman, DH Gutmann Asthma reduces glioma formation by T cell decorin-mediated inhibition of microglia Nature Communications, 2021-12-08;12(1):7122. 2021-12-08 [PMID: 34880260] (Bioassay, Mouse)	Bioassay	Mouse
KM Deng, XS Yang, Q Luo, YX She, QY Yu, XX Tang Deleterious Role of Th9 Cells in Pulmonary Fibrosis Cells, 2021-11-17;10(11):. 2021-11-17 [PMID: 34831433] (Bioassay, Mouse)	Bioassay	Mouse
P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard Differential Cytokine-Induced Responses of Polarized Microglia Brain sciences, 2021-11-10;11(11):. 2021-11-10 [PMID: 34827481] (Bioassay, Mouse)	Bioassay	Mouse
M Rogier, J Moritz, I Robert, C Lescale, V Heyer, A Abello, O Martin, K Capitani, M Thomas, AS Thomas-Cla, B Laffleur, F Jouan, E Pinaud, K Tarte, M Cogné, SG Conticello, E Soutoglou, L Deriano, B Reina-San- Fam72a enforces error-prone DNA repair during antibody diversification Nature, 2021-11-24;0(0):. 2021-11-24 [PMID: 34819671] (Bioassay, Mouse)	Bioassay	Mouse
Y Feng, C Li, JA Stewart, P Barbulescu, NS Desivo, A Álvarez-Qu, RC Pezo, MLW Perera, K Chan, AHY Tong, R Mohamad-Ra, M Berru, D Nakib, G Li, GA Kardar, JR Carlyle, J Moffat, D Durocher, JM Di Noia, AS Bhagwat, A Martin FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation Nature, 2021-11-24;0(0):. 2021-11-24 [PMID: 34819670] (Bioassay, Mouse)	Bioassay	Mouse
Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons Journal of Neuroinflammation, 2021-11-08;18(1):261. 2021-11-08 [PMID: 34749758] (Bioassay, Mouse)	Bioassay	Mouse
HM Shih, SY Pan, CJ Wu, YH Chou, CY Chen, FC Chang, YT Chen, WC Chiang, HC Tsai, YM Chen, SL Lin Transforming growth factor-beta1 decreases erythropoietin production through repressing hypoxia-inducible factor 2alpha in erythropoietin-producing cells Journal of Biomedical Science, 2021-11-02;28(1):73. 2021-11-02 [PMID: 34724959] (Bioassay, Mouse)	Bioassay	Mouse
W Chen, J Zhang, W Zhong, Y Liu, Y Lu, Z Zeng, H Huang, X Wan, X Meng, F Zou, S Cai, H Dong Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis Frontiers in Pharmacology, 2021-09-16;12(0):744826. 2021-09-16 [PMID: 34603058] (Bioassay, Mouse)	Bioassay	Mouse
S Yamada, K Tsushima, M Kinoshita, H Sakashita, T Kajikawa, C Fujihara, H Yuan, S Suzuki, T Morisaki, S Murakami Mouse Model of Loeys-Dietz Syndrome Shows Elevated Susceptibility to Periodontitis via Alterations in Transforming Growth Factor-Beta Signaling Frontiers in Physiology, 2021-08-11;12(0):715687. 2021-08-11 [PMID: 34456753] (Bioassay, Mouse)	Bioassay	Mouse
A Agasing, JL Quinn, G Kumar, RC Axtell Interferon-beta Intensifies Interleukin-23-Driven Pathogenicity of T Helper Cells in Neuroinflammatory Disease Cells, 2021-08-20;10(8):. 2021-08-20 [PMID: 34440908] (Bioassay, Mouse)	Bioassay	Mouse
Y Choi, S Sim, DH Lee, HR Lee, GY Ban, YS Shin, YK Kim, HS Park Effect of TGF-beta1 on eosinophils to induce cysteinyl leukotriene E4 production in aspirin-exacerbated respiratory disease PLoS ONE, 2021-08-26;16(8):e0256237. 2021-08-26 [PMID: 34437574] (Bioassay, Mouse)	Bioassay	Mouse
SM Kim, WH Hur, BY Kang, SW Lee, PR Roh, DJ Park, PS Sung, SK Yoon Death-Associated Protein 6 (Daxx) Alleviates Liver Fibrosis by Modulating Smad2 Acetylation Cells, 2021-07-09;10(7):. 2021-07-09 [PMID: 34359912] (Bioassay, Mouse)	Bioassay	Mouse
Y Yokozeki, A Kawakubo, M Miyagi, A Kuroda, H Sekiguchi, G Inoue, M Takaso, K Uchida Reduced TGF-beta Expression and CD206-Positive Resident Macrophages in the Intervertebral Discs of Aged Mice BioMed Research International, 2021-07-12;2021(0):7988320. 2021-07-12 [PMID: 34337052] (Bioassay, Mouse)	Bioassay	Mouse
J Basu, BS Reis, S Peri, J Zha, X Hua, L Ge, K Ferchen, E Nicolas, P Czyzewicz, KQ Cai, Y Tan, JI Fuxman Bas, AJM Walhout, HL Grimes, SI Grivenniko, D Mucida, DJ Kappes Essential role of a ThPOK autoregulatory loop in the maintenance of mature CD4+ T cell identity and function Nature Immunology, 2021-07-26;22(8):969-982. 2021-07-26 [PMID: 34312548] (Bioassay, Mouse)	Bioassay	Mouse
Y Yokozeki, K Uchida, A Kawakubo, M Nakawaki, T Okubo, M Miyagi, G Inoue, M Itakura, H Sekiguchi, M Takaso TGF-beta regulates nerve growth factor expression in a mouse intervertebral disc injury model Bmc Musculoskeletal Disorders, 2021-07-23;22(1):634. 2021-07-23 [PMID: 34301215] (Bioassay, Mouse)	Bioassay	Mouse
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RA Contreras-, R Elizondo-V, MJ Torres, AM Vega-Lette, N Luque-Camp, MJ Paredes-Ma, C Pradenas, G Tejedor, K Oyarce, M Salgado, C Jorgensen, M Khoury, G Kronke, MA Garcia-Rob, C Altamirano, P Luz-Crawfo, F Djouad PPAR&beta/&delta-dependent MSC metabolism determines their immunoregulatory properties Sci Rep, 2020-07-10;10(1):11423. 2020-07-10 [PMID: 32651456] (Bioassay, Mouse)	Bioassay	Mouse
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Li S, Huang P, Yang A, Tarng D, Yang W, Lin C, Chen J, Schmid-Schonbein G, Lin S Matrix metalloproteinase-9 deficiency attenuates diabetic nephropathy by modulation of podocyte functions and dedifferentiation. Kidney Int, 2014-03-26;86(2):358-69. 2014-03-26 [PMID: 24670409] (Bioassay, Mouse)	Bioassay	Mouse
Rebhandl S, Huemer M, Zaborsky N, Gassner F, Catakovic K, Felder T, Greil R, Geisberger R Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia. Eur J Immunol, 2014-04-15;44(7):2175-87. 2014-04-15 [PMID: 24668151] (Bioassay, Mouse)	Bioassay	Mouse
Uslu K, Coleman A, Allman W, Katsenelson N, Bram R, Alugupalli K, Akkoyunlu M Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-linked immunodeficient mice. J Immunol, 2014-03-19;192(8):3582-95. 2014-03-19 [PMID: 24646744] (Bioassay, Mouse)	Bioassay	Mouse
McSorley H, Blair N, Smith K, McKenzie A, Maizels R Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy. Mucosal Immunol, 2014-02-05;7(5):1068-78. 2014-02-05 [PMID: 24496315] (In Vivo, Mouse)	In Vivo	Mouse
Yoshida Y, Yoshimi R, Yoshii H, Kim D, Dey A, Xiong H, Munasinghe J, Yazawa I, O'Donovan M, Maximova O, Sharma S, Zhu J, Wang H, Morse H, Ozato K The transcription factor IRF8 activates integrin-mediated TGF-beta signaling and promotes neuroinflammation. Immunity, 2014-01-30;40(2):187-98. 2014-01-30 [PMID: 24485804] (Bioassay, Mouse)	Bioassay	Mouse
Hagiwara , Kunie, Obayashi , Takeshi, Sakayori , Nobuyuki, Yamanishi , Emiko, Hayashi , Ryuhei, Osumi , Noriko, Nakazawa , Toru, Nishida , Kohji Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells. PLoS ONE, 2014-01-20;9(1):e84072. 2014-01-20 [PMID: 24465393] (Bioassay, Mouse)	Bioassay	Mouse
Chrobak P, Afkhami S, Priceputu E, Poudrier J, Meunier C, Hanna Z, Sparwasser T, Jolicoeur P HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. J Immunol, 2014-01-24;192(4):1681-92. 2014-01-24 [PMID: 24465014] (Bioassay, Mouse)	Bioassay	Mouse
Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, Cordi S, Brindle P, Lemaigre F, Kaestner K, Sosa-Pineda B Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development, 2014-02-01;141(3):538-47. 2014-02-01 [PMID: 24449835] (Bioassay, Mouse)	Bioassay	Mouse
Suga H, Rennert R, Rodrigues M, Sorkin M, Glotzbach J, Januszyk M, Fujiwara T, Longaker M, Gurtner G Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing. Stem Cells, 2014-05-01;32(5):1347-60. 2014-05-01 [PMID: 24446236] (Bioassay, Mouse)	Bioassay	Mouse
Rodgers B, Wiedeback B, Hoversten K, Jackson M, Walker R, Thompson T Myostatin stimulates, not inihibits, C2C12 myoblast proliferation. Endocrinology, 2014-01-01;155(3):670-5. 2014-01-01 [PMID: 24424069] (Bioassay, Mouse)	Bioassay	Mouse
Sun Y, Qu X, Li X, Nikolic-Paterson D, Li J Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. PLoS ONE, 2013-12-31;8(12):e84063. 2013-12-31 [PMID: 24391884] (Cell Culture, Rat)	Cell Culture	Rat
Veremeyko , Tatyana, Siddiqui , Shafiudd, Sotnikov , Ilya, Yung , Amanda, Ponomarev , Eugene D IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE, 2013-12-16;8(12):e81774. 2013-12-16 [PMID: 24358127] (Bioassay, Mouse)	Bioassay	Mouse
van Voorhis , Michael, Knopp , Samantha, Julliard , Walker, Fechner , John H, Zhang , Xiaoji, Schauer , James J, Mezrich , Joshua D Exposure to atmospheric particulate matter enhances Th17 polarization through the aryl hydrocarbon receptor. PLoS ONE, 2013-12-11;8(12):e82545. 2013-12-11 [PMID: 24349309] (Cell Culture, Mouse)	Cell Culture	Mouse
Kowalczyk A, D'Souza C, Zhang L Cell-extrinsic CTLA4-mediated regulation of dendritic cell maturation depends on STAT3. Eur J Immunol, 2014-01-22;44(4):1143-55. 2014-01-22 [PMID: 24338929] (Bioassay, Mouse)	Bioassay	Mouse
Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S, Hoshino T, Yagita H, Ohteki T, Iwata M Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol, 2013-11-13;7(4):786-801. 2013-11-13 [PMID: 24220301] (Bioassay, Mouse)	Bioassay	Mouse
Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee D, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis N Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res, 2013-09-30;113(12):1331-44. 2013-09-30 [PMID: 24081879] (Bioassay, Mouse)	Bioassay	Mouse
Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity, 2013-09-26;39(4):722-32. 2013-09-26 [PMID: 24076050] (Bioassay, Mouse)	Bioassay	Mouse
Kim H, Claps G, Moller A, Bowtell D, Lu X, Ronai Z Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability. Oncogene, 2013-05-06;33(15):2004-10. 2013-05-06 [PMID: 23644657] (Bioassay, Mouse)	Bioassay	Mouse
Lee J, Lee J, Park M, Lim M, Park E, Kim E, Yang E, Lee S, Jhun J, Park S, Kim H, Cho M Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS ONE, 2013-04-16;8(4):e60900. 2013-04-16 [PMID: 23613752] (Bioassay, Mouse)	Bioassay	Mouse
Szewczyk K, Fuller K, Chambers T Distinctive subdomains in the resorbing surface of osteoclasts. PLoS ONE, 2013-03-21;8(3):e60285. 2013-03-21 [PMID: 23555944] (Bioassay, Mouse)	Bioassay	Mouse
Gui T, Sun Y, Gai Z, Shimokado A, Muragaki Y, Zhou G The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-beta signaling. Dev Biol, 2013-03-26;377(2):415-27. 2013-03-26 [PMID: 23537899] (Bioassay, Mouse)	Bioassay	Mouse
Li S, Meyer N, Quarto N, Longaker M Integration of multiple signaling regulates through apoptosis the differential osteogenic potential of neural crest-derived and mesoderm-derived Osteoblasts. PLoS ONE, 2013-03-25;8(3):e58610. 2013-03-25 [PMID: 23536803] (Bioassay, Mouse)	Bioassay	Mouse
Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis. Am J Pathol, 2013-03-14;182(5):1572-84. 2013-03-14 [PMID: 23499373] (Bioassay, Mouse)	Bioassay	Mouse
Tigges U, Boroujerdi A, Welser-Alves J, Milner R TNF-alpha promotes cerebral pericyte remodeling in vitro, via a switch from alpha1 to alpha2 integrins. J Neuroinflammation, 2013-03-01;10(0):33. 2013-03-01 [PMID: 23448258] (Bioassay, Mouse)	Bioassay	Mouse
Lien S, Wei S, Chang S, Chang M, Chang J, Chiu J Activation of PPAR-alpha induces cell cycle arrest and inhibits transforming growth factor-beta1 induction of smooth muscle cell phenotype in 10T1/2 mesenchymal cells. Cell Signal, 2013-02-04;25(5):1252-63. 2013-02-04 [PMID: 23385087] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
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TGF-beta 1 - a versatile signaling molecule with roles in development and disease
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Gene Symbol	Tgfb1
Uniprot	P04202()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

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