Recombinant Mouse TfR (Transferrin R) Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The Transferrin Receptor (TfR or TfR-1, designated CD71) is a type II transmembrane glycoprotein expressed on erythroid progenitors, muscle cells and proliferating cells as a 188 kDa disulfide-linked homodimer of 95 kDa monomers (1-4). As the major mediator of cellular iron uptake, it binds and internalizes diferric transferrin, allowing iron release at the low pH of the endosome (2, 5). The mouse TfR cDNA encodes 763 amino acids (aa) including a 67 aa N-terminal intracellular domain, a 21 aa transmembrane domain, and a 675 aa extracellular domain (ECD) with helical, peptidase (nonfunctional), and ligand binding domains, including an RGD potential integrin binding site (5). Mouse TfR ECD shares 76% and 91% aa identity with human and rat, respectively. A cleaved and truncated 85 kDa soluble form of TfR (sTfR) arises from trypsin proteolysis at aa 100, producing the circulating form of TfR (3). sTfR concentration in plasma or serum is proportional to total TfR and can be increased by iron deficiency (3). Erythroid progenitors, which use iron for hemoglobin synthesis, normally account for the bulk of total body TfR production (3). Since rapidly growing cells require iron to replicate DNA, cancer cells can express up to 5-fold more TfR than quiescent cells in the surrounding tissue (2, 4). Antibody targeting of TfR can inhibit tumor cell proliferation and induce apoptosis (2, 4). The hereditary hemochromatosis protein HFE competes with diferric transferrin for binding to TfR, and targets TfR for degradation rather than recycling (2, 5). TfR has been reported to have ferritin-independent functions in T cell development, immunological synapse formation and galectin-3-mediated cell death, and to be a cell entry receptor for New World hemorrhagic fever arenaviruses (2, 4, 6).

We have publications tested in 3 confirmed species: Mouse, Hamster, N/A.

We have publications tested in 3 applications: Bioassay, ELISA Capture, Flow Ctyometry.

Showing Publications 1 - 3 of 3.

Publications using 9706-TR	Applications	Species
Crook, ZR;Sevilla, GP;Young, P;Girard, EJ;Phi, TD;Howard, M;Price, J;Olson, JM;Nairn, NW; CYpHER: Catalytic extracellular targeted protein degradation with high potency and durable effect bioRxiv : the preprint server for biology 2024-04-23 [PMID: 38712232] (Flow Ctyometry, Hamster)	Flow Ctyometry	Hamster
CA Desjardins, M Yao, J Hall, E O'Donnell, R Venkatesan, S Spring, A Wen, N Hsia, P Shen, R Russo, B Lan, T Picariello, K Tang, T Weeden, S Zanotti, R Subramania, O Ibraghimov Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice Nucleic Acids Research, 2022-11-11;0(0):. 2022-11-11 [PMID: 35944903] (ELISA Capture, N/A)	ELISA Capture	N/A
DM Castellano, J Sun, J Yang, W Ou, AC Zambon, WM Pardridge, RK Sumbria Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice Pharmaceutics, 2020-09-08;12(9):. 2020-09-08 [PMID: 32911688] (Bioassay, Mouse)	Bioassay	Mouse

Array 9706-TR

• TfR (Transferrin R) Antibodies
• TfR (Transferrin R) ELISA Kits
• TfR (Transferrin R) Lysates
• TfR (Transferrin R) Proteins
• TfR (Transferrin R) Proteins and Enzymes
• TfR (Transferrin R) ELISAs