Recombinant Mouse N-Cadherin Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neuronal Cadherin (N‑Cadherin or NCAD), also known as Cadherin‑2 (CDH2), is a 130 kDa type I membrane protein belonging to the Cadherin superfamily of calcium‑dependent adhesion molecules. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity (1, 2). Mouse N‑Cadherin is synthesized with a 25 amino acid (aa) signal peptide and a 134 aa N‑terminal propeptide. The mature cell surface‑expressed protein consists of a 565 amino acid (aa) extracellular domain (ECD) that contains five Cadherin repeats, a 21 aa transmembrane segment, and a 161 aa cytoplasmic domain (3). Within the ECD, mouse N‑Cadherin shares 98% and 99% aa sequence identity with human and rat N‑Cadherin, respectively. In the nervous system, N‑Cadherin mediates adhesion between the opposing faces of developing neuronal synapses and between Schwann cells and neuronal axons (4, 5). It interacts in cis or in trans homophilically and with the GluR2 subunit of neuronal AMPA receptors (1, 6). During synaptic maturation, its expression is lost from inhibitory terminals but maintained at excitatory terminals (5). ADAM10‑mediated shedding of the N‑Cadherin ECD alters cell‑cell adhesion, synaptic development, and AMPA receptor activity (7, 8). N‑Cadherin can also be cleaved at multiple additional sites within the intracellular or extracellular domains by Calpain, gamma ‑Secretase, and several MMPs (9 ‑ 13). Cleavage of N‑Cadherin in atherosclerotic plaques contributes alternatively to vascular smooth muscle cell proliferation (MMP‑9 and ‑12) or apoptosis (MMP‑7) (12, 13). Aberrant cell surface expression of the pro and mature forms of N‑Cadherin in cancer results in increased tumor progression and invasiveness (14, 15). N‑Cadherin also mediates the adhesion between hematopoeitic progenitor cells and mesenchymal stromal cells of the bone marrow (16).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, N/A.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 9 of 9.

Publications using 6626-NC	Applications	Species
Burmeister, M;Fraunenstein, A;Kahms, M;Arends, L;Gerwien, H;Deshpande, T;Kuhlmann, T;Gross, CC;Naik, VN;Wiendl, H;Klingauf, J;Meissner, F;Sorokin, L; Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function Science advances 2023-07-21 [PMID: 37467333] (Bioassay, Mouse)	Bioassay	Mouse
M Shoykhet, O Dervishi, P Menauer, M Hiermaier, S Moztarzade, C Osterloh, RJ Ludwig, T Williams, B Gerull, S Kaab, S Clauss, D Schüttler, J Waschke, S Yeruva EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation JCI Insight, 2023-03-22;0(0):. 2023-03-22 [PMID: 36795511] (Bioassay, Mouse)	Bioassay	Mouse
JS Pak, ZJ DeLoughery, J Wang, N Acharya, Y Park, A Jaworski, E Özkan NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance Nat Commun, 2020-03-20;11(1):1489. 2020-03-20 [PMID: 32198364] (Bioassay, Mouse)	Bioassay	Mouse
CG Silva, E Peyre, MH Adhikari, S Tielens, S Tanco, P Van Damme, L Magno, N Krusy, G Agirman, MM Magiera, N Kessaris, B Malgrange, A Andrieux, C Janke, L Nguyen Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis Cell, 2018-02-22;172(5):1063-1078.e19. 2018-02-22 [PMID: 29474907] (Bioassay, N/A)	Bioassay	N/A
B Libé-Phili, V Michel, J Boutet de, S Le Gal, T Dupont, P Avan, C Métin, N Michalski, C Petit Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction Proc. Natl. Acad. Sci. U.S.A., 2017-07-13;114(30):7765-7774. 2017-07-13 [PMID: 28705869] (Bioassay, Mouse)	Bioassay	Mouse
K Conant, S Daniele, PL Bozzelli, T Abdi, A Edwards, A Szklarczyk, I Olchefske, D Ottenheime, K Maguire-Ze Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation J Neuroinflammation, 2017-03-17;14(1):56. 2017-03-17 [PMID: 28302163] (Bioassay, Human)	Bioassay	Human
Y Matsunaga, M Noda, H Murakawa, K Hayashi, A Nagasaka, S Inoue, T Miyata, T Miura, KI Kubo, K Nakajima Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development Proc. Natl. Acad. Sci. U.S.A, 2017-02-07;114(8):2048-2053. 2017-02-07 [PMID: 28174271] (Bioassay, Mouse)	Bioassay	Mouse
Nanoscale architecture of cadherin-based cell�adhesions Nat. Cell Biol, 2016-12-19;19(1):28-37. 2016-12-19 [PMID: 27992406] (Bioassay)	Bioassay
Wiertz RW, Marani E, Rutten WL Neural cell-cell and cell-substrate adhesion through N-cadherin, N-CAM and L1. J Neural Eng, 2011-05-31;8(4):046004. 2011-05-31 [PMID: 21628769] (Bioassay, Rat)	Bioassay	Rat

Array 6626-NC

• N-Cadherin Antibodies
• N-Cadherin ELISA Kits
• N-Cadherin Lysate
• N-Cadherin Proteins
• N-Cadherin Proteins and Enzymes
• N-Cadherin ELISA