Recombinant Mouse IL-6 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, 22 - 28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1 - 5). Mature mouse IL-6 is 187 amino acids (aa) in length and shares 39% and 85% aa sequence identity with human and rat IL-6, respectively (6 - 8). IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha , triggering IL-6 R alpha association with gp130 and gp130 dimerization (9). gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM (10). Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage (5). In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha (5). Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes (2, 5). Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor (5, 11). IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease (1 - 5). When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis (1, 2, 5). IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise (2). In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells (1, 12).

We have publications tested in 5 confirmed species: Human, Mouse, Rat, N/A, Transgenic Mouse.

We have publications tested in 8 applications: Bioassay, Cell Culture, ELISA (Standard), ELISA Control, ELISA Standard, IHC, In Vivo, Western Blot.

Showing Publications 1 - 10 of 364. Show All 364 Publications. Collapse Publications.

Publications using 406-ML	Applications	Species
Davaanyam, D;Seol, SI;Oh, SA;Lee, H;Lee, JK; Hepatocyte activation and liver injury following cerebral ischemia promote HMGB1-mediated hepcidin upregulation in hepatocytes and regulation of systemic iron levels Experimental & molecular medicine 2024-10-01 [PMID: 39349828] (Bioassay, Mouse)	Bioassay	Mouse
Takacs, GP;Garcia, JS;Hodges, CA;Kreiger, CJ;Sherman, A;Harrison, JK; CSF1R Ligands Expressed by Murine Gliomas Promote M-MDSCs to Suppress CD8+ T Cells in a NOS-Dependent Manner Cancers 2024-09-01 [PMID: 39272914] (Bioassay, Mouse)	Bioassay	Mouse
Chang, YH;Yamamoto, K;Fujino, T;Wang, TW;Sugimoto, E;Zhang, W;Yabushita, T;Suzaki, K;Pietsch, EC;Weir, BA;Crescenzo, R;Cowley, GS;Attar, R;Philippar, U;Wunderlich, M;Mizukawa, B;Zheng, Y;Enomoto, Y;Imai, Y;Kitamura, T;Goyama, S; SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation Cell reports 2024-07-30 [PMID: 39096901] (Bioassay, Mouse)	Bioassay	Mouse
Lim, YJ;Park, SA;Wang, D;Jin, W;Ku, WL;Zhang, D;Xu, J;Patiño, LC;Liu, N;Chen, W;Kazmi, R;Zhao, K;Zhang, YE;Sun, L;Chen, W; MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells Cell reports 2024-07-30 [PMID: 39083380] (Bioassay, Mouse)	Bioassay	Mouse
Thakore, PI;Schnell, A;Huang, L;Zhao, M;Hou, Y;Christian, E;Zaghouani, S;Wang, C;Singh, V;Singaraju, A;Krishnan, RK;Kozoriz, D;Ma, S;Sankar, V;Notarbartolo, S;Buenrostro, JD;Sallusto, F;Patsopoulos, NA;Rozenblatt-Rosen, O;Kuchroo, VK;Regev, A; BACH2 regulates diversification of regulatory and proinflammatory chromatin states in TH17 cells Nature immunology 2024-07-15 [PMID: 39009838] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Donahue, KL;Watkoske, HR;Kadiyala, P;Du, W;Brown, K;Scales, MK;Elhossiny, AM;Espinoza, CE;Lasse Opsahl, EL;Griffith, BD;Wen, Y;Sun, L;Velez-Delgado, A;Renollet, NM;Morales, J;Nedzesky, NM;Baliira, RK;Menjivar, RE;Medina-Cabrera, PI;Rao, A;Allen, B;Shi, J;Frankel, TL;Carpenter, ES;Bednar, F;Zhang, Y;Pasca di Magliano, M; Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth Cancer discovery 2024-07-03 [PMID: 38958646] (Bioassay, Mouse)	Bioassay	Mouse
Li, Y;Ramírez-Suástegui, C;Harris, R;Castañeda-Castro, FE;Ascui, G;Pérez-Jeldres, T;Diaz, A;Morong, C;Giles, DA;Chai, J;Seumois, G;Sanchez-Elsner, T;Cummings, F;Kronenberg, M;Vijayanand, P; Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans Nature immunology 2024-07-01 [PMID: 38898157] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Takacs, GP;Garcia, JS;Hodges, CA;Kreiger, CJ;Sherman, A;Harrison, JK; Glioma-derived M-CSF and IL-34 license M-MDSCs to suppress CD8+ T cells in a NOS-dependent manner bioRxiv : the preprint server for biology 2024-06-06 [PMID: 38895268] (Bioassay, Mouse)	Bioassay	Mouse
Castro-Pando, S;Howell, RM;Li, L;Mascaro, M;Faraoni, EY;Le Roux, O;Romanin, D;Tahan, V;Riquelme, E;Zhang, Y;Kolls, JK;Allison, JP;Lozano, G;Moghaddam, SJ;McAllister, F; Pancreatic epithelial IL-17/IL-17RA signaling drives B7-H4 expression to promote tumorigenesis Cancer immunology research 2024-06-06 [PMID: 38842383] (Bioassay, Mouse)	Bioassay	Mouse
Ma, L;Li, M;Lv, J;Yuan, Q;Yin, X;Lu, W;Lin, W;Wang, P;Cui, J;Lv, Q;Liu, J;Hu, L; Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities European journal of medicinal chemistry 2024-06-05 [PMID: 38718622] (Bioassay, Mouse)	Bioassay	Mouse
Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B; Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice Nature communications 2024-02-26 [PMID: 38409097] (Bioassay, Mouse)	Bioassay	Mouse
Scherlinger, M;Li, H;Pan, W;Li, W;Karino, K;Vichos, T;Boulougoura, A;Yoshida, N;Tsokos, MG;Tsokos, GC; CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses Nature communications 2024-01-29 [PMID: 38287012] (Bioassay, Mouse)	Bioassay	Mouse
Zhang, Z;Zhao, C;Sun, L;Cheng, C;Tian, Q;Wu, C;Xu, Y;Dong, X;Zhang, B;Zhang, L;Zhao, Y; Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice European journal of immunology 2024-01-17 [PMID: 38234007] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Chen, Y;Bounds, SE;Ma, X;Karmoker, JR;Liu, Y;Ma, JX;Cai, J; Interleukin-17-mediated protective cytokine signaling against degeneration of the retinal pigment epithelium Proceedings of the National Academy of Sciences of the United States of America 2023-12-19 [PMID: 38085785] (Bioassay, Mouse)	Bioassay	Mouse
Hong, J;Son, M;Sin, J;Kim, H;Chung, DK; Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation Nutrients 2023-11-09 [PMID: 38004123] (ELISA Control, Mouse)	ELISA Control	Mouse
Rahman, SM;Buchholz, DW;Imbiakha, B;Jager, MC;Leach, J;Osborn, RM;Birmingham, AO;Dewhurst, S;Aguilar, HC;Luebke, AE; SARS-CoV-2 induces acute neurological signs while Calcitonin Gene-Related Peptide (CGRP) signaling blockade reduces interleukin 6 (IL-6) release and weight loss in mouse models bioRxiv : the preprint server for biology 2023-11-08 [PMID: 37965203] (ELISA Standard, N/A)	ELISA Standard	N/A
Adrian, M;Weber, M;Tsai, MC;Glock, C;Kahn, OI;Phu, L;Cheung, TK;Meilandt, WJ;Rose, CM;Hoogenraad, CC; Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release Nature communications 2023-10-09 [PMID: 37813836] (Bioassay, Mouse)	Bioassay	Mouse
Li, D;Zhou, J;Wang, L;Gong, Z;Le, H;Huang, Y;Xu, C;Tian, C;Cai, W;Wu, J; Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation through modulating cholesterol biosynthesis and participates in high-fat diet-associated colonic inflammation Cell & bioscience 2023-10-03 [PMID: 37789469] (Bioassay, Mouse)	Bioassay	Mouse
Jindal, K;Adil, MT;Yamaguchi, N;Yang, X;Wang, HC;Kamimoto, K;Rivera-Gonzalez, GC;Morris, SA; Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Nature biotechnology 2023-09-25 [PMID: 37749269] (Bioassay, Mouse)	Bioassay	Mouse
Wu, S;Zhang, X;Hu, C;Zhong, Y;Chen, J;Chong, WP; CD8+ T cells reduce neuroretina inflammation in mouse by regulating autoreactive Th1 and Th17 cells through IFN-? European journal of immunology 2023-09-09 [PMID: 37689974] (Bioassay, Mouse)	Bioassay	Mouse
van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E; CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1 European journal of immunology 2023-09-08 [PMID: 37683186] (Bioassay, Mouse)	Bioassay	Mouse
Lee, JY;Lee, JH;Lim, HJ;Kim, E;Kim, DK;Choi, JK; Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism Frontiers in pharmacology 2023-08-15 [PMID: 37649889] (Bioassay, Mouse)	Bioassay	Mouse
Lara-Astiaso, D;Goñi-Salaverri, A;Mendieta-Esteban, J;Narayan, N;Del Valle, C;Gross, T;Giotopoulos, G;Beinortas, T;Navarro-Alonso, M;Aguado-Alvaro, LP;Zazpe, J;Marchese, F;Torrea, N;Calvo, IA;Lopez, CK;Alignani, D;Lopez, A;Saez, B;Taylor-King, JP;Prosper, F;Fortelny, N;Huntly, BJP; In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis Nature genetics 2023-08-14 [PMID: 37580596] (Bioassay, Mouse)	Bioassay	Mouse
Goulart, A;Boko, MMM;Martins, NS;Gembre, AF;de Oliveira, RS;Palma-Albornoz, SP;Bertolini, T;Ribolla, PEM;Ramalho, LNZ;Fraga-Silva, TFC;Bonato, VLD; IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia International journal of molecular sciences 2023-06-21 [PMID: 37445595] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
Li, TT;Lin, CL;Chiang, M;He, JT;Hung, CH;Hsieh, CC; Cytokine-Induced Myeloid-Derived Suppressor Cells Demonstrate Their Immunoregulatory Functions to Prolong the Survival of Diabetic Mice Cells 2023-05-29 [PMID: 37296628] (Bioassay, Mouse)	Bioassay	Mouse
Cheemalavagu, N;Shoger, KE;Cao, YM;Michalides, BA;Botta, SA;Faeder, JR;Gottschalk, RA; Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework bioRxiv : the preprint server for biology 2023-05-20 [PMID: 37292918] (Bioassay, Mouse)	Bioassay	Mouse
Laragione, T;Harris, C;Azizgolshani, N;Beeton, C;Bongers, G;Gulko, PS; Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome EBioMedicine 2023-05-16 [PMID: 37201335] (Bioassay, Mouse)	Bioassay	Mouse
Alvarez, F;Istomine, R;Da Silva Lira Filho, A;Al-Aubodah, TA;Huang, D;Okde, R;Olivier, M;Fritz, JH;Piccirillo, CA; IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections Mucosal immunology 2023-05-12 [PMID: 37182738] (Bioassay, Mouse)	Bioassay	Mouse
Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S; EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia Nature 2023-05-01 [PMID: 37165186] (Bioassay, Mouse)	Bioassay	Mouse
O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Bioassay, Mouse)	Bioassay	Mouse
H Huang, Y Li, G Zhang, GX Ruan, Z Zhu, W Chen, J Zou, R Zhang, J Wang, Y Ouyang, S Xu, X Ou The RNA-binding protein hnRNP F is required for the germinal center B cell response Nature Communications, 2023-03-30;14(1):1731. 2023-03-30 [PMID: 36997512] (Bioassay, Mouse)	Bioassay	Mouse
KA Read, DM Jones, S Pokhrel, EDS Hales, A Varkey, JA Tuazon, CD Eisele, O Abdouni, A Saadey, MR Leonard, RT Warren, MD Powell, JM Boss, EA Hemann, JS Yount, G Xin, HE Ghoneim, CJ Lio, AG Freud, PL Collins, KJ Oestreich Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity Nature Communications, 2023-03-24;14(1):1652. 2023-03-24 [PMID: 36964178] (Bioassay, Mouse)	Bioassay	Mouse
X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 Cell Reports, 2023-03-16;42(3):112274. 2023-03-16 [PMID: 36933218] (Bioassay, Mouse)	Bioassay	Mouse
H Koizumi, W Fujii, C Sanjoba, Y Goto BAFF induces CXCR5 expression during B cell differentiation in bone marrow Biochemistry and Biophysics Reports, 2023-03-07;34(0):101451. 2023-03-07 [PMID: 36926279] (Bioassay, Mouse)	Bioassay	Mouse
Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang Modulation of Skin Inflammatory Responses by Aluminum Adjuvant Pharmaceutics, 2023-02-08;15(2):. 2023-02-08 [PMID: 36839900] (Bioassay, Mouse)	Bioassay	Mouse
AT Obi, SB Sharma, MA Elfline, CE Luke, AR Dowling, Q Cai, AS Kimball, M Hollinstat, L Stanger, BB Moore, FA Jaffer, PK Henke Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions Scientific Reports, 2023-02-24;13(1):3253. 2023-02-24 [PMID: 36828892] (Bioassay, Mouse)	Bioassay	Mouse
S Ma, Q Yang, N Chen, A Zheng, N Abbasi, G Wang, PR Patel, BS Cho, BA Yee, L Zhang, H Chu, SM Evans, GW Yeo, Y Zheng, WJM Huang RNA binding protein DDX5 restricts RORgammat+ Treg suppressor function to promote intestine inflammation Science Advances, 2023-02-01;9(5):eadd6165. 2023-02-01 [PMID: 36724232] (Bioassay, Mouse)	Bioassay	Mouse
X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Mouse)	Cell Culture	Mouse
M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity Science Advances, 2022-11-30;8(48):eadc9657. 2022-11-30 [PMID: 36449620] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Bioassay, Mouse)	Bioassay	Mouse
JS Park, SC Yang, HY Jeong, SY Lee, JG Ryu, JW Choi, HY Kang, SM Kim, SH Hwang, ML Cho, SH Park EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis Arthritis Research & Therapy, 2022-11-17;24(1):254. 2022-11-17 [PMID: 36397156] (Bioassay, Mouse)	Bioassay	Mouse
X Hu, Y Zou, DA Copland, LP Schewitz-B, Y Li, PJP Lait, M Stimpson, Z Zhang, S Guo, J Liang, T Chen, JJ Li, S Yuan, S Li, P Zhou, Y Liu, AD Dick, X Wen, RWJ Lee, L Wei Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 2022-11-03;86(0):104333. 2022-11-03 [PMID: 36335665] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Mouse)	Bioassay	Mouse
EC Freckmann, E Sandilands, E Cumming, M Neilson, A Román-Fern, K Nikolatou, M Nacke, TRM Lannagan, A Hedley, D Strachan, M Salji, JP Morton, L McGarry, HY Leung, OJ Sansom, CJ Miller, DM Bryant Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging Nature Communications, 2022-09-09;13(1):5317. 2022-09-09 [PMID: 36085324] (Bioassay, Mouse)	Bioassay	Mouse
L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani IL-3 regulates the differentiation of pathogenic Th17 cells European Journal of Immunology, 2022-09-26;0(0):. 2022-09-26 [PMID: 36074916] (Bioassay, Mouse)	Bioassay	Mouse
M Plana-Carm, G Stik, R Bulteau, C Segura-Mor, N Alcázar, CDR Wyatt, A Klonizakis, L de Andrés-, M Gasnier, TV Tian, G Torcal Gar, M Vila-Casad, N Plachta, M Serrano, M Francescon, T Graf The trophectoderm acts as a niche for the inner cell mass through C/EBPalpha-regulated IL-6 signaling Stem Cell Reports, 2022-08-11;0(0):. 2022-08-11 [PMID: 35961310] (Cell Culture, Mouse)	Cell Culture	Mouse
Y Su, X Sun, X Liu, Q Qu, L Yang, Q Chen, F Liu, Y Li, Q Wang, B Huang, XJ Huang, XH Zhang hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Journal of hematology & oncology, 2022-07-21;15(1):99. 2022-07-21 [PMID: 35864538] (Bioassay, Mouse)	Bioassay	Mouse
C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury Journal of Neuroinflammation, 2022-07-09;19(1):177. 2022-07-09 [PMID: 35810304] (Bioassay, Mouse)	Bioassay	Mouse
LM Fan, YQ Zhang, YP Chen, LL Chen, WH Xu, LH Nan, W Xu, B Lu, Y Wang, KD Chu, JP Zhang Cryptotanshinone ameliorates dextran sulfate sodium-induced murine acute and chronic ulcerative colitis via suppressing STAT3 activation and Th17 cell differentiation Oncogene, 2022-05-31;108(0):108894. 2022-05-31 [PMID: 35729830] (Bioassay, Mouse)	Bioassay	Mouse
HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis Oncogene, 2022-12-01;17(12):2765-2770. 2022-12-01 [PMID: 35662227] (Bioassay, Mouse)	Bioassay	Mouse
H Kamei, T Ishii, Y Nishii Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement Oncogene, 2022-06-02;12(1):9243. 2022-06-02 [PMID: 35654941] (Bioassay, Mouse)	Bioassay	Mouse
YS Zhang, DE Xin, Z Wang, W Peng, Y Zeng, J Liang, M Xu, N Chen, J Zhang, J Yue, M Cao, C Zhang, Y Wang, Z Chang, XM Lu, L Chang, YE Chinn Acetylation licenses Th1 cell polarization to constrain Listeria monocytogenes infection Cell Death and Differentiation, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614130] (Bioassay, Mouse)	Bioassay	Mouse
LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program Cell Reports, 2022-05-24;39(8):110838. 2022-05-24 [PMID: 35613599] (Bioassay, Mouse)	Bioassay	Mouse
R Mary, F Chalmin, T Accogli, M Bruchard, C Hibos, J Melin, C Truntzer, E Limagne, V Derangère, M Thibaudin, E Humblin, R Boidot, S Chevrier, L Arnould, C Richard, Q Klopfenste, A Bernard, Y Urade, JA Harker, L Apetoh, F Ghiringhel, F Végran Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects Cancer Immunology Research, 2022-07-01;0(0):OF1-OF17. 2022-07-01 [PMID: 35612500] (Bioassay, Mouse)	Bioassay	Mouse
Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Mouse)	Bioassay	Mouse
FA Graca, M Rai, LC Hunt, A Stephan, YD Wang, B Gordon, R Wang, G Quarato, B Xu, Y Fan, M Labelle, F Demontis The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy Nature Communications, 2022-05-02;13(1):2370. 2022-05-02 [PMID: 35501350] (Bioassay, Mouse)	Bioassay	Mouse
N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival Cell Reports, 2022-03-29;38(13):110565. 2022-03-29 [PMID: 35354043] (Bioassay, Mouse)	Bioassay	Mouse
B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling Elife, 2022-03-18;11(0):. 2022-03-18 [PMID: 35302487] (Cell Culture, Mouse)	Cell Culture	Mouse
S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)	Cell Culture	Mouse
Q Zhang, L Zhao, Y Yang, S Li, Y Liu, C Chen Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis JCI Insight, 2022-02-08;7(3):. 2022-02-08 [PMID: 35132955]
A Okubo, Y Uchida, Y Higashi, T Sato, Y Ogawa, A Ryuge, K Kadomatsu, T Kanekura CD147 Is Essential for the Development of Psoriasis via the Induction of Th17 Cell Differentiation International Journal of Molecular Sciences, 2021-12-24;23(1):. 2021-12-24 [PMID: 35008603] (Bioassay, Mouse)	Bioassay	Mouse
V Patel, A Jayaraman, S Jayaraman Epigenetic drug ameliorated type 1 diabetes via decreased generation of Th1 and Th17 subsets and restoration of self-tolerance in CD4+ T cells International immunopharmacology, 2021-12-23;103(0):108490. 2021-12-23 [PMID: 34954557] (Bioassay, Mouse)	Bioassay	Mouse
FJ Velloso, A Wadhwa, E Kumari, I Carcea, O Gunal, SW Levison Modestly increasing systemic interleukin-6 perinatally disturbs secondary germinal zone neurogenesis and gliogenesis and produces sociability deficits Brain, Behavior, and Immunity, 2021-12-23;101(0):23-36. 2021-12-23 [PMID: 34954074] (Bioassay, Mouse)	Bioassay	Mouse
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N Funk, M Munz, T Ott, K Brockmann, A Wenninger-, R Kühn, D Vogt-Weise, F Giesert, W Wurst, T Gasser, S Biskup The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4 Sci Rep, 2019-03-14;9(1):4515. 2019-03-14 [PMID: 30872638] (Bioassay, Mouse)	Bioassay	Mouse
KL Graham, BJ Werner, KM Moyer, AK Patton, CR Krois, HS Yoo, M Tverskoy, M LaJevic, JL Napoli, RA Sobel, BA Zabel, EC Butcher DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis Proc. Natl. Acad. Sci. U.S.A., 2019-02-04;0(0):. 2019-02-04 [PMID: 30718413] (Bioassay, Mouse)	Bioassay	Mouse
K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)	Bioassay	Mouse
F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben, PA Olofsen, A Henic, MV Ferreira, S Chen, USA Stalmann, G Buesche, RM Hoogenboez, R Kramann, U Platzbecke, MHGP Raaijmaker, BL Ebert, RK Schneider Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651631] (Bioassay, Mouse)	Bioassay	Mouse
S Das, D Bar-Sagi BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis Oncogene, 2019-01-11;0(0):. 2019-01-11 [PMID: 30635655] (Cell Culture, Mouse)	Cell Culture	Mouse
E Minakova, J Lang, JS Medel-Matu, GG Gould, A Reynolds, D Shin, A Mazarati, R Sankar Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism PLoS ONE, 2019-01-10;14(1):e0210389. 2019-01-10 [PMID: 30629642] (Mouse)		Mouse
M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse)	Bioassay	Mouse
CM Percopo, M Ma, TA Brenner, JO Krumholz, TJ Break, K Laky, HF Rosenberg Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection J. Immunol., 2018-12-21;0(0):. 2018-12-21 [PMID: 30578308] (In Vivo, Mouse)	In Vivo	Mouse
J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance Cell Rep, 2018-12-18;25(12):3329-3341.e5. 2018-12-18 [PMID: 30566860] (Bioassay, Mouse)	Bioassay	Mouse
F Dou, X Chu, B Zhang, L Liang, G Lu, J Ding, S Chen EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway Mol Brain, 2018-12-18;11(1):75. 2018-12-18 [PMID: 30563578] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller IL-23R Signaling Plays No Role in Myocardial Infarction Sci Rep, 2018-11-20;8(1):17078. 2018-11-20 [PMID: 30459442] (Bioassay, Mouse)	Bioassay	Mouse
KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism Cell Death Dis, 2018-11-13;9(11):1130. 2018-11-13 [PMID: 30425241] (Bioassay, Mouse)	Bioassay	Mouse
B Zwarycz, AD Gracz, KR Rivera, IA Williamson, LA Samsa, J Starmer, MA Daniele, L Salter-Cid, Q Zhao, ST Magness IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model Cell Mol Gastroenterol Hepatol, 2018-07-04;7(1):1-17. 2018-07-04 [PMID: 30364840] (Bioassay, Mouse)	Bioassay	Mouse
A Badamchi-Z, KD Moynihan, RA Larocca, M Aid, NM Provine, MJ Iampietro, E Kinnear, P Penaloza-M, P Abbink, E Blass, JS Tregoning, DJ Irvine, DH Barouch Combined HDAC and BET Inhibition Enhances Melanoma Vaccine Immunogenicity and Efficacy J. Immunol., 2018-09-24;0(0):. 2018-09-24 [PMID: 30249811] (In Vivo, Mouse)	In Vivo	Mouse
HC Chuang, CY Tsai, CH Hsueh, TH Tan GLK-IKK? signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease Sci Adv, 2018-09-12;4(9):eaat5401. 2018-09-12 [PMID: 30214937] (Bioassay, Mouse)	Bioassay	Mouse
HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection Mucosal Immunol, 2018-07-23;0(0):. 2018-07-23 [PMID: 30038214] (Bioassay, Mouse)	Bioassay	Mouse
CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice Stem Cell Res Ther, 2018-07-04;9(1):183. 2018-07-04 [PMID: 29973247] (Bioassay, Mouse)	Bioassay	Mouse
E Archer-Lah, C Lan, RT Jagoe Physiological culture conditions alter myotube morphology and responses to atrophy treatments: implications for in�vitro research on muscle wasting Physiol Rep, 2018-06-01;6(12):e13726. 2018-06-01 [PMID: 29932505] (Bioassay, Mouse)	Bioassay	Mouse
Y Nam, SM Jung, YA Rim, H Jung, K Lee, N Park, J Kim, Y Jang, YB Park, SH Park, JH Ju Intraperitoneal infusion of mesenchymal stem cell attenuates severity of collagen antibody induced arthritis PLoS ONE, 2018-06-07;13(6):e0198740. 2018-06-07 [PMID: 29879214] (Bioassay, Mouse)	Bioassay	Mouse
JA Johnson, JK Watson, MZ Nikoli?, EL Rawlins Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium Biol Open, 2018-04-16;7(4):. 2018-04-16 [PMID: 29661797] (Bioassay, Mouse)	Bioassay	Mouse
JP Ingram, S Tursi, T Zhang, W Guo, C Yin, M A Wynosky-, J van der He, KQ Cai, M Yamamoto, BB Finlay, IE Brodsky, SI Grivenniko, Ç Tükel, S Balachandr A Nonpyroptotic IFN-?-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo J. Immunol., 2018-04-13;0(0):. 2018-04-13 [PMID: 29654208] (Bioassay, Mouse)	Bioassay	Mouse
R Nagase, D Inoue, A Pastore, T Fujino, HA Hou, N Yamasaki, S Goyama, M Saika, A Kanai, Y Sera, S Horikawa, Y Ota, S Asada, Y Hayashi, KC Kawabata, R Takeda, HF Tien, H Honda, O Abdel-Waha, T Kitamura Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation J. Exp. Med., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643185] (Bioassay, Mouse)	Bioassay	Mouse
G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1 Immunity, 2018-03-20;48(3):556-569.e7. 2018-03-20 [PMID: 29562202] (Bioassay, Mouse)	Bioassay	Mouse
YY Wang, S Ma, Q Chen, D Jiao, Y Yang In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87Amutant in hematopoietic stem cell-transplanted mice Gene Ther., 2018-03-09;0(0):. 2018-03-09 [PMID: 29523881] (Bioassay, Mouse)	Bioassay	Mouse
R Yang, T Yu, D Liu, S Shi, Y Zhou Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 2018-03-09;9(1):62. 2018-03-09 [PMID: 29523215] (Bioassay, Mouse)	Bioassay	Mouse
KL Garner, VMS Betin, V Pinto, M Graham, E Abgueguen, M Barnes, DC Bedford, CA McArdle, RJM Coward Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress Sci Rep, 2018-03-02;8(1):3902. 2018-03-02 [PMID: 29500363] (Bioassay, Mouse)	Bioassay	Mouse
K Lee, N Park, H Jung, YA Rim, Y Nam, J Lee, SH Park, JH Ju Mesenchymal stem cells ameliorate experimental arthritis via expression of interleukin-1 receptor antagonist PLoS ONE, 2018-02-26;13(2):e0193086. 2018-02-26 [PMID: 29481574] (Bioassay, Mouse)	Bioassay	Mouse
J Zhang, J Shan, X Chen, S Li, D Long, Y Li Celastrol mediates Th17 and Treg cell generation via metabolic signaling Biochem. Biophys. Res. Commun., 2018-02-21;0(0):. 2018-02-21 [PMID: 29476742] (Bioassay, Mouse)	Bioassay	Mouse
QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro Evid Based Complement Alternat Med, 2017-12-31;2017(0):8134321. 2017-12-31 [PMID: 29456573] (Bioassay, Mouse)	Bioassay	Mouse
W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018-02-09;0(0):. 2018-02-09 [PMID: 29432809] (Cell Culture, Mouse)	Cell Culture	Mouse
SK Varanasi, U Jaggi, N Hay, BT Rouse Hexokinase II may be dispensable for CD4 T cell responses against a virus infection PLoS ONE, 2018-01-19;13(1):e0191533. 2018-01-19 [PMID: 29352298] (Bioassay, Mouse)	Bioassay	Mouse
JE Draper, P Sroczynska, MZH Fadlullah, R Patel, G Newton, W Breitwiese, V Kouskoff, G Lacaud A novel prospective isolation of murine fetal liver progenitors to study in utero hematopoietic defects PLoS Genet., 2018-01-04;14(1):e1007127. 2018-01-04 [PMID: 29300724] (Bioassay, Mouse)	Bioassay	Mouse
X Sun, K Gupta, B Wu, D Zhang, B Yuan, X Zhang, HC Chiang, C Zhang, TJ Curiel, MP Bendeck, S Hursting, Y Hu, R Li Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulatingadipose stromal interleukin 6 production in mice J. Biol. Chem., 2018-01-03;0(0):. 2018-01-03 [PMID: 29298894] (Bioassay, Mouse)	Bioassay	Mouse
P Barragán-I, TF Lou, VD Bhat, S Megat, MD Burton, TJ Price, ZT Campbell Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice Nat Commun, 2018-01-02;9(1):10. 2018-01-02 [PMID: 29295980] (In Vivo, Mouse)	In Vivo	Mouse
X Jiang, C Hu, K Ferchen, J Nie, X Cui, CH Chen, L Cheng, Z Zuo, W Seibel, C He, Y Tang, JR Skibbe, M Wunderlich, WC Reinhold, L Dong, C Shen, S Arnovitz, B Ulrich, J Lu, H Weng, R Su, H Huang, Y Wang, C Li, X Qin, J Mulloy, Y Zheng, J Diao, J Jin, C Li, PP Liu, C He, Y Chen, J Chen Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia Nat Commun, 2017-12-13;8(1):2099. 2017-12-13 [PMID: 29235481] (Bioassay, Mouse)	Bioassay	Mouse
S Ollila, E Domènech-M, K Laajanen, IP Wong, S Tripathi, N Pentinmikk, Y Gao, Y Yan, EH Niemelä, TC Wang, B Viollet, G Leone, P Katajisto, K Vaahtomeri, TP Mäkelä Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway J. Clin. Invest., 2017-12-04;0(0):. 2017-12-04 [PMID: 29202476] (Bioassay, Mouse)	Bioassay	Mouse
W Eichler, H Savkovi?-C, S Bürger, M Beck, M Schmidt, P Wiedemann, A Reichenbac, JD Unterlauft M�ller Cell-Derived PEDF Mediates Neuroprotection via STAT3 Activation Cell. Physiol. Biochem., 2017-11-30;44(4):1411-1424. 2017-11-30 [PMID: 29186716] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
A Hammer, A Schliep, S Jörg, A Haghikia, R Gold, M Kleinewiet, DN Müller, RA Linker Impact of combined sodium chloride and saturated long-chain fatty acid challenge on the differentiation of T helper cells in neuroinflammation J Neuroinflammation, 2017-09-12;14(1):184. 2017-09-12 [PMID: 28899400] (Bioassay, Mouse)	Bioassay	Mouse
T Oike, Y Sato, T Kobayashi, K Miyamoto, S Nakamura, Y Kaneko, S Kobayashi, K Harato, H Saya, M Matsumoto, M Nakamura, Y Niki, T Miyamoto Stat3 as a potential therapeutic target for rheumatoid arthritis Sci Rep, 2017-09-08;7(1):10965. 2017-09-08 [PMID: 28887478] (Bioassay, Mouse)	Bioassay	Mouse
N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2017-09-07;2(17):. 2017-09-07 [PMID: 28878126] (Bioassay, Mouse)	Bioassay	Mouse
SH Lee, JY Kwon, SY Kim, K Jung, ML Cho Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis Sci Rep, 2017-08-31;7(1):10133. 2017-08-31 [PMID: 28860618] (Bioassay, Mouse)	Bioassay	Mouse
A Muschaweck, F Petermann, T Korn IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells J. Immunol., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855314] (Bioassay, Mouse)	Bioassay	Mouse
MH Ross, AK Esser, GC Fox, AH Schmieder, X Yang, G Hu, D Pan, X Su, Y Xu, DV Novack, T Walsh, GA Colditz, GH Lukaszewic, E Cordell, JS Novack, JAJ Fitzpatric, DL Waning, KS Mohammad, TA Guise, GM Lanza, KN Weilbaeche Bone-induced expression of integrin ?3 enables targeted nanotherapy of breast cancer metastases Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855208] (Bioassay, Mouse)	Bioassay	Mouse
KA Read, MD Powell, CE Baker, BK Sreekumar, VM Ringel-Sca, H Bachus, RE Martin, ID Cooley, IC Allen, A Ballestero, KJ Oestreich Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4(+) Th Cells J. Immunol., 2017-08-28;0(0):. 2017-08-28 [PMID: 28848064] (Bioassay, Mouse)	Bioassay	Mouse
T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function J. Immunol., 2017-08-02;0(0):. 2017-08-02 [PMID: 28768723] (Bioassay, Mouse)	Bioassay	Mouse
M Fernández, EM Monsalve, S López-Lópe, A Ruiz-Garcí, S Mellado, E Caminos, JJ García-Ram, J Laborda, P Tranque, MJM Díaz-Guerr Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming Eur. J. Immunol., 2017-08-31;0(0):. 2017-08-31 [PMID: 28762472] (Bioassay, Mouse)	Bioassay	Mouse
TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath The Role of Inflammation in ?-cell Dedifferentiation Sci Rep, 2017-07-24;7(1):6285. 2017-07-24 [PMID: 28740254] (Bioassay, Mouse)	Bioassay	Mouse
W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells Parasit Vectors, 2017-07-21;10(1):348. 2017-07-21 [PMID: 28732522] (Bioassay, Mouse)	Bioassay	Mouse
X Li, AR Cannon, AM Hammer, NL Morris, MA Choudhry IL-23 restoration of Th17 effector function is independent of IL-6 and TGF-? in a mouse model of alcohol and burn injury J. Leukoc. Biol., 2017-07-06;0(0):. 2017-07-06 [PMID: 28684599] (Bioassay, Mouse)	Bioassay	Mouse
Z You, M Timilshina, BS Jeong, JH Chang BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway Eur. J. Immunol., 2017-07-26;0(0):. 2017-07-26 [PMID: 28681958] (Bioassay, Mouse)	Bioassay	Mouse
JK Moy, A Khoutorsky, MN Asiedu, BJ Black, JL Kuhn, P Barragán-I, S Megat, MD Burton, CC Burgos-Veg, OK Melemedjia, S Boitano, J Vagner, CG Gkogkas, JJ Pancrazio, JS Mogil, G Dussor, N Sonenberg, TJ Price The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain J. Neurosci., 2017-07-03;0(0):. 2017-07-03 [PMID: 28674170] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
M Hara, K Kobayakawa, Y Ohkawa, H Kumamaru, K Yokota, T Saito, K Kijima, S Yoshizaki, K Harimaya, Y Nakashima, S Okada Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury Nat. Med., 2017-06-19;0(0):. 2017-06-19 [PMID: 28628111] (Bioassay, Mouse)	Bioassay	Mouse
HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity Biochem. Biophys. Res. Commun., 2017-06-12;0(0):. 2017-06-12 [PMID: 28619514] (Bioassay, Mouse)	Bioassay	Mouse
J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease Mol Ther Methods Clin Dev, 2017-05-12;5(0):241-258. 2017-05-12 [PMID: 28603745] (Bioassay, Mouse)	Bioassay	Mouse
K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor Cell Mol Gastroenterol Hepatol, 2017-04-11;4(1):135-151. 2017-04-11 [PMID: 28593185] (Bioassay, Mouse)	Bioassay	Mouse
L Liu, C Zhao, Y Yang, X Kong, T Shao, L Ren, X Zhuang, B Yin, G Dryden, C McClain, W Luan, W Feng Fibroblast Growth Factor 21 Deficiency Attenuates Experimental Colitis-Induced Adipose Tissue Lipolysis Gastroenterol Res Pract, 2017-05-11;2017(0):3089378. 2017-05-11 [PMID: 28584524] (Bioassay, Mouse)	Bioassay	Mouse
Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse)	Bioassay	Mouse
CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp TNF? drives mitochondrial stress in POMC neurons in obesity Nat Commun, 2017-05-10;8(0):15143. 2017-05-10 [PMID: 28489068] (Bioassay, Mouse)	Bioassay	Mouse
E Xu, MMA Pereira, I Karakasili, S Theurich, M Al-Maarri, G Rappl, A Waisman, FT Wunderlich, JC Brüning Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance Nat Commun, 2017-05-03;8(0):14803. 2017-05-03 [PMID: 28466852] (Bioassay, Mouse)	Bioassay	Mouse
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K Timper, JL Denson, SM Steculorum, C Heilinger, L Engström-R, CM Wunderlich, S Rose-John, FT Wunderlich, JC Brüning IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling Cell Rep, 2017-04-11;19(2):267-280. 2017-04-11 [PMID: 28402851] (In Vivo, Mouse)	In Vivo	Mouse
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S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Mouse)	Bioassay	Mouse
M Ouzounova, E Lee, R Piranliogl, A El Andalou, R Kolhe, MF Demirci, D Marasco, I Asm, A Chadli, KA Hassan, M Thangaraju, G Zhou, AS Arbab, JK Cowell, H Korkaya Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade Nat Commun, 2017-04-06;8(0):14979. 2017-04-06 [PMID: 28382931] (Bioassay, Mouse)	Bioassay	Mouse
C Zhang, S Wang, J Li, W Zhang, L Zheng, C Yang, T Zhu, R Rong The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury Cell Death Dis, 2017-03-23;8(3):e2695. 2017-03-23 [PMID: 28333137] (Bioassay, Mouse)	Bioassay	Mouse
S Downs-Cann, S Berkey, GM Delgoffe, RP Edwards, T Curiel, K Odunsi, DL Bartlett, N Obermajer Suppressive IL-17A(+)Foxp3(+) and ex-Th17 IL-17A(neg)Foxp3(+) Treg cells are a source of tumour-associated Treg cells Nat Commun, 2017-03-14;8(0):14649. 2017-03-14 [PMID: 28290453] (Bioassay, Mouse)	Bioassay	Mouse
H Chen, L Zhang, P Wang, H Su, W Wang, Z Chu, L Zhang, X Zhang, Y Zhao mTORC2 controls Th9 polarization and allergic airway inflammation Allergy, 2017-03-29;0(0):. 2017-03-29 [PMID: 28273354] (Bioassay, Mouse)	Bioassay	Mouse
L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis J. Immunol, 2017-02-27;0(0):. 2017-02-27 [PMID: 28242647] (Bioassay, Mouse)	Bioassay	Mouse
Y Kang, M Timilshina, TG Nam, BS Jeong, JH Chang BJ-1108, a 6-Amino-2,4,5-trimethylpyridin-3-ol analogue, regulates differentiation of Th1 and Th17 cells to ameliorate experimental autoimmune encephalomyelitis Biol. Res, 2017-02-28;50(1):8. 2017-02-28 [PMID: 28241881] (Bioassay, Mouse)	Bioassay	Mouse
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Ellaban E, Bolgos G, Remick D Selective macrophage suppression during sepsis. Cell. Immunol., 2005-02-26;231(1):103-11. 2005-02-26 [PMID: 15919375] (ELISA (Standard))	ELISA (Standard)
Fredj S, Bescond J, Louault C, Delwail A, Potreau D Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation. J. Cell. Physiol., 2005-08-01;204(2):428-36. 2005-08-01 [PMID: 15717324] (ELISA (Standard))	ELISA (Standard)
Gard AL, Gavin E, Solodushko V, Pennica D Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 2004-01-01;127(1):43-52. 2004-01-01 [PMID: 15219667] (Western Blot)	Western Blot
Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT CXCR2-/- mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization. J. Immunol., 2004-01-15;172(2):1237-45. 2004-01-15 [PMID: 14707102] (In Vivo, Mouse)	In Vivo	Mouse
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001-11-01;293(10):508-14. 2001-11-01 [PMID: 11820727] (Bioassay, Mouse)	Bioassay	Mouse
Liu F, Poursine-Laurent J, Wu HY, Link DC Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation. Blood, 1997-10-01;90(7):2583-90. 1997-10-01 [PMID: 9326224] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
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Array 406-ML

• IL-6 Antibodies
• IL-6 Antibody Pair
• IL-6 ELISA Kits
• IL-6 Lysate
• IL-6 Proteins
• IL-6 Proteins and Enzymes
• IL-6 ELISAs