Recombinant Mouse Flt-3 Ligand/FLT3L Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Flt-3 Ligand, also known as FLT3L, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages (1-3). Mature mouse Flt‑3 Ligand consists of a 161 amino acid (aa) extracellular domain (ECD) with a cytokine-like domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 22 aa cytoplasmic tail (4-6). Within the ECD, mouse Flt-3 Ligand shares 71% and 81% aa sequence identity with human and rat Flt-3 Ligand, respectively. The mouse and human Flt-3 Ligand proteins show cross-species activity (4, 5, 7). Flt-3 Ligand is also structurally related to M-CSF and SCF. Flt-3 Ligand is widely expressed in various mouse and human tissues. Flt-3 Ligand is expressed as a noncovalently-linked dimer by T cells and bone marrow and thymic fibroblasts (1, 8). Each 36 kDa chain of the Flt-3 Ligand dimer carries approximately 12 kDa of N- and O‑linked carbohydrates (8). Alternate splicing and proteolytic cleavage of the transmembrane form of the Flt-3 Ligand protein can generate a soluble 30 kDa fragment that includes the cytokine-like domain (4, 8). Alternate splicing of mouse Flt-3 Ligand also generates a membrane-associated isoform with a 57 aa substitution following the cytokine-like domain in the ECD of the Flt-3 Ligand protein (4, 5, 8, 9). Both transmembrane and soluble Flt-3 Ligand signal through the tyrosine kinase receptor Flt-3/Flk-2 (3 - 6). Flt-3 Ligand induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation (2, 10). Additionally, Flt-3 Ligand synergizes with IL-3, GM‑CSF, and SCF to promote the mobilization and myeloid differentiation of hematopoietic stem cells (4, 5, 7). Flt-3 Ligand also cooperates with IL‑2, IL-6, IL-7, and IL-15 to induce NK cell development and with IL-3, IL-7, and IL‑11 to induce terminal B cell maturation (1, 11). Animal studies also show that Flt-3 Ligand reduces the severity of experimentally induced allergic inflammation (12).

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Cotton Rat, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 8 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), ELISA Developmet, In Vivo, Multiplex Assay, Western Blot.

Showing Publications 1 - 10 of 88. Show All 88 Publications. Collapse Publications.

Publications using 427-FL/CF	Applications	Species
X Cui, C Zhang, F Wang, X Zhao, S Wang, J Liu, D He, C Wang, FC Yang, S Tong, Y Liang Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1 Cell Reports, 2023-03-16;42(3):112274. 2023-03-16 [PMID: 36933218] (Bioassay, Mouse)	Bioassay	Mouse
J Liu, Y Cheng, X Zhang, Y Chen, H Zhu, K Chen, S Liu, Z Li, X Cao Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity Cell Reports, 2023-01-18;42(1):111991. 2023-01-18 [PMID: 36656709] (Bioassay, Mouse)	Bioassay	Mouse
X Liu, N Sato, T Yabushita, J Li, Y Jia, M Tamura, S Asada, T Fujino, T Fukushima, T Yonezawa, Y Tanaka, T Fukuyama, A Tsuchiya, S Shikata, H Iwamura, C Kinouchi, K Komatsu, S Yamasaki, T Shibata, AT Sasaki, J Schibler, M Wunderlich, E O'Brien, B Mizukawa, JC Mulloy, Y Sugiura, H Takizawa, T Shibata, K Miyake, T Kitamura, S Goyama IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia Embo Molecular Medicine, 2022-12-01;0(0):e15631. 2022-12-01 [PMID: 36453131] (Cell Culture, Human)	Cell Culture	Human
M Uslu, E Albayrak, F Kocaba? Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content International immunopharmacology, 2022-07-11;110(0):109035. 2022-07-11 [PMID: 35834953] (Bioassay, Mouse)	Bioassay	Mouse
Y Hayashi, KC Kawabata, Y Tanaka, Y Uehara, Y Mabuchi, K Murakami, A Nishiyama, S Kiryu, Y Yoshioka, Y Ota, T Sugiyama, K Mikami, M Tamura, T Fukushima, S Asada, R Takeda, Y Kunisaki, T Fukuyama, K Yokoyama, T Uchida, M Hagihara, N Ohno, K Usuki, A Tojo, Y Katayama, S Goyama, F Arai, T Tamura, T Nagasawa, T Ochiya, D Inoue, T Kitamura MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis Cell Reports, 2022-05-10;39(6):110805. 2022-05-10 [PMID: 35545056] (Bioassay, Mouse)	Bioassay	Mouse
J Jeong, I Jung, JH Kim, S Jeon, DY Hyeon, H Min, B Kang, J Nah, D Hwang, SJ Um, M Ko, RH Seong BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells Cell Death and Differentiation, 2022-04-26;0(0):. 2022-04-26 [PMID: 35473985] (Bioassay, Mouse)	Bioassay	Mouse
K Yamamoto, S Goyama, S Asada, T Fujino, T Yonezawa, N Sato, R Takeda, A Tsuchiya, T Fukuyama, Y Tanaka, A Yokoyama, H Toya, A Kon, Y Nannya, R Onoguchi-M, S Nakagawa, T Hirose, S Ogawa, N Akimitsu, T Kitamura A histone modifier, ASXL1, interacts with NONO and is involved in paraspeckle formation in hematopoietic cells Cell Reports, 2021-08-24;36(8):109576. 2021-08-24 [PMID: 34433054] (Bioassay, Mouse)	Bioassay	Mouse
N Ohashi, T Terashima, M Katagi, Y Nakae, J Okano, Y Suzuki, H Kojima GLT1 gene delivery based on bone marrow-derived cells ameliorates motor function and survival in a mouse model of ALS Scientific Reports, 2021-06-17;11(1):12803. 2021-06-17 [PMID: 34140581] (Cell Culture, Mouse)	Cell Culture	Mouse
F Herbst, TJL Lang, ESP Eckert, P Wünsche, AA Wurm, T Kindinger, K Laaber, S Hemmati, A Hotz-Wagen, O Zavidij, A Paruzynski, J Lu, C von Kalle, T Zenz, C Klein, M Schmidt, CR Ball, H Glimm The balance between the intronic miR-342 and its host gene Evl determines hematopoietic cell fate decision Leukemia, 2021-05-21;0(0):. 2021-05-21 [PMID: 34021250] (Bioassay, Mouse)	Bioassay	Mouse
J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging Aging Cell, 2021-03-29;0(0):e13353. 2021-03-29 [PMID: 33780118] (Bioassay, Mouse)	Bioassay	Mouse
V Tereshchen, A Bulygin, R Zavodskii, A Maksyutov, V Kurilin, M Fisher, N Semenyuk, S Aladev, S Sennikov The murine DCs transfected with DNA-plasmid encoding CCR9 demonstrate the increased migration to CCL25 and thymic cells in vitro and to the thymus in vivo Cytokine, 2021-02-26;142(0):155473. 2021-02-26 [PMID: 33647585] (Bioassay, Mouse)	Bioassay	Mouse
SP Fahl, AV Contreras, A Verma, X Qiu, C Harly, F Radtke, JC Zúñiga-Pfl, C Murre, HH Xue, JM Sen, DL Wiest The E protein-TCF1 axis controls &gamma&delta T�cell development and effector fate Cell Reports, 2021-02-02;34(5):108716. 2021-02-02 [PMID: 33535043] (Bioassay, Mouse)	Bioassay	Mouse
SJ Gurczynski, NL Pereira, SM Hrycaj, C Wilke, RL Zemans, BB Moore Stem cell transplantation uncovers TDO-AHR regulation of lung dendritic cells in herpesvirus-induced pathology JCI Insight, 2021-01-25;6(2):. 2021-01-25 [PMID: 33491663] (Bioassay, Mouse)	Bioassay	Mouse
NE Papaioanno, N Salei, S Rambichler, K Ravi, J Popovic, V Küntzel, CHK Lehmann, R Fiancette, J Salvermose, DW Gajdasik, R Mettler, D Messerer, J Carrelha, C Ohnmacht, D Haller, R Stumm, T Straub, SEW Jacobsen, C Schulz, DR Withers, G Schotta, D Dudziak, BU Schraml Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice Nature Communications, 2021-01-19;12(1):464. 2021-01-19 [PMID: 33469015] (Bioassay, Mouse)	Bioassay	Mouse
Y Hong, N Singh, S Bamopoulos, E Gjerga, LK Schmalbroc, K Balabanian, M Schick, U Keller, M Wirth Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System Biomedicines, 2020-12-09;8(12):. 2020-12-09 [PMID: 33317212] (Bioassay, Mouse)	Bioassay	Mouse
M Girotra, V Trachsel, A Roch, MP Lutolf In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci, 2020-11-03;21(21):. 2020-11-03 [PMID: 33153113] (Cell Culture, Mouse)	Cell Culture	Mouse
M Wada, Y Shimada, S Iizuka, N Ishii, H Hiraki, T Tachibana, K Maeda, M Saito, S Arakawa, T Ishimoto, T Nakano, H Ida, T Ohashi, H Kobayashi Ex�Vivo Gene Therapy Treats Bone Complications of Mucopolysaccharidosis Type II Mouse Models through Bone Remodeling Reactivation Mol Ther Methods Clin Dev, 2020-09-20;19(0):261-274. 2020-09-20 [PMID: 33102618] (Bioassay, Mouse)	Bioassay	Mouse
NV Bogert, J Furkel, S Din, I Braren, V Eckstein, JA Müller, L Uhlmann, HA Katus, MH Konstandin A novel approach to genetic engineering of T-cell subsets by hematopoietic stem cell infection with a bicistronic lentivirus Sci Rep, 2020-08-13;10(1):13740. 2020-08-13 [PMID: 32792615] (Bioassay, Mouse)	Bioassay	Mouse
L Garcia-Per, M van Eggerm, L van Roon, SA Vloemans, M Cordes, A Schambach, M Rothe, D Berghuis, C Lagresle-P, M Cavazzana, F Zhang, AJ Thrasher, D Salvatori, P Meij, A Villa, JJM Van Dongen, JJ Zwaginga, M van der Bu, HB Gaspar, A Lankester, FJT Staal, K Pike-Overz Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID Mol Ther Methods Clin Dev, 2020-03-31;17(0):666-682. 2020-03-31 [PMID: 32322605] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhao, J Wang, Z Min, L Peng, S Qi, W Lin I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis Mediators Inflamm., 2020-03-10;2020(0):6947482. 2020-03-10 [PMID: 32256194] (Bioassay, Mouse)	Bioassay	Mouse
JM Bertho, D Kereselidz, L Manens, C Culeux, V Magneron, J Surette, M Blimkie, L Bertrand, H Wyatt, M Souidi, I Dublineau, N Priest, JR Jourdain Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism Sci Rep, 2019-12-27;9(1):19919. 2019-12-27 [PMID: 31882739] (Multiplex Assay, Mouse)	Multiplex Assay	Mouse
ELY Chen, PK Thompson, JC Zúñiga-Pfl RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors Nat. Immunol., 2019-10-21;0(0):. 2019-10-21 [PMID: 31636466] (Cell Culture, Mouse)	Cell Culture	Mouse
Z Gong, B Shang, Y Chu, X Chen, Q Li, K Liu, Y Chen, Y Huang, Y Han, Q Shang, Z Zheng, L Song, Y Li, R Liu, C Xu, X Zhang, B Liu, L Wang, C Shao, Y Wang, Y Shi Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development Cell Death Dis, 2019-06-05;10(6):440. 2019-06-05 [PMID: 31165736] (Bioassay, Mouse)	Bioassay	Mouse
P Huang, X Li, Y Meng, B Yuan, T Liu, M Jiao, X Wang, Y Liu, H Yin Interleukin-33 regulates hematopoietic stem cell regeneration after radiation injury Stem Cell Res Ther, 2019-04-18;10(1):123. 2019-04-18 [PMID: 30999922] (Bioassay, Mouse)	Bioassay	Mouse
N Vannini, V Campos, M Girotra, V Trachsel, S Rojas-Sutt, J Tratwal, S Ragusa, E Stefanidis, D Ryu, PY Rainer, G Nikitin, S Giger, TY Li, A Semilietof, A Oggier, Y Yersin, L Tauzin, E Pirinen, WC Cheng, J Ratajczak, C Canto, M Ehrbar, F Sizzano, TV Petrova, D Vanhecke, L Zhang, P Romero, A Nahimana, S Cherix, MA Duchosal, PC Ho, B Deplancke, G Coukos, J Auwerx, MP Lutolf, O Naveiras The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance Cell Stem Cell, 2019-03-07;24(3):405-418.e7. 2019-03-07 [PMID: 30849366] (Bioassay, Mouse)	Bioassay	Mouse
S Goossens, J Wang, C Tremblay, J De Medts, S T'Sas, T Nguyen, J Saw, K Haigh, DJ Curtis, P Van Vlierb, G Berx, T Taghon, JJ Haigh ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms Haematologica, 2019-01-24;0(0):. 2019-01-24 [PMID: 30679322] (Bioassay, Mouse)	Bioassay	Mouse
F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben, PA Olofsen, A Henic, MV Ferreira, S Chen, USA Stalmann, G Buesche, RM Hoogenboez, R Kramann, U Platzbecke, MHGP Raaijmaker, BL Ebert, RK Schneider Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome Leukemia, 2019-01-16;0(0):. 2019-01-16 [PMID: 30651631] (Bioassay, Mouse)	Bioassay	Mouse
F Boscolo Se, D Fox, A Sacco Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular Dystrophy Cell Rep, 2019-01-15;26(3):689-701.e6. 2019-01-15 [PMID: 30650360] (Bioassay, Mouse)	Bioassay	Mouse
LM Hillyer, B Woodward Acutely malnourished weanling mice administered Flt3 ligand can support a cell-mediated inflammatory response Cytokine, 2018-07-07;113(0):39-49. 2018-07-07 [PMID: 30539781] (ELISA (Standard), Western Blot, Human)	ELISA (Standard), Western Blot	Human
M Inoue, K Okamoto, A Terashima, T Nitta, R Muro, T Negishi-Ko, T Kitamura, T Nakashima, H Takayanagi Arginine methylation controls the strength of ?c-family cytokine signaling in T cell maintenance Nat. Immunol., 2018-10-15;19(11):1265-1276. 2018-10-15 [PMID: 30323341] (Bioassay, Mouse)	Bioassay	Mouse
SK Martin, S Fitter, N El Khawank, RH Grose, CR Walkley, LE Purton, MA Ruegg, MN Hall, S Gronthos, ACW Zannettino mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis Sci Rep, 2018-09-28;8(1):14501. 2018-09-28 [PMID: 30266921] (Bioassay, Mouse)	Bioassay	Mouse
R Gonzalez-Q, A Nguyen, DH Kono, MBA Oldstone, AN Theofilopo, R Baccala Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition PLoS ONE, 2018-09-10;13(9):e0203118. 2018-09-10 [PMID: 30199535] (Bioassay, Mouse)	Bioassay	Mouse
YW Lin, LC Wang, CK Lee, SH Chen Flt3 ligand treatment reduces enterovirus A71 lethality in mice with enhanced B cell responses Sci Rep, 2018-08-15;8(1):12184. 2018-08-15 [PMID: 30111869] (In Vivo, Mouse)	In Vivo	Mouse
SH Kim, SW Lee, HJ Park, SH Lee, WK Im, YD Kim, KH Kim, SJ Park, S Hong, SH Jeon Anti-cancer activity of Angelica gigas by increasing immune response and stimulating natural killer and natural killer T cells BMC Complement Altern Med, 2018-07-18;18(1):218. 2018-07-18 [PMID: 30021579] (Bioassay, Mouse)	Bioassay	Mouse
P Wünsche, ESP Eckert, T Holland-Le, A Paruzynski, A Hotz-Wagen, R Fronza, T Rath, I Gil-Farina, M Schmidt, C von Kalle, C Klein, CR Ball, F Herbst, H Glimm Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs Cell Stem Cell, 2018-07-05;23(1):132-146.e9. 2018-07-05 [PMID: 29979988] (Bioassay, Mouse)	Bioassay	Mouse
SK Tasian, JA Casas, D Posocco, S Gandre-Bab, AL Gagne, G Liang, ML Loh, MJ Weiss, DL French, ST Chou Mutation-specific signaling profiles and kinase inhibitor sensitivities of juvenile myelomonocytic leukemia revealed by induced pluripotent stem cells Leukemia, 2018-06-08;0(0):. 2018-06-08 [PMID: 29884903] (Bioassay, Mouse)	Bioassay	Mouse
JP Sasine, HA Himburg, CM Termini, M Roos, E Tran, L Zhao, J Kan, M Li, Y Zhang, SC de Barros, DS Rao, CM Counter, JP Chute Wild-type Kras expands and exhausts hematopoietic stem cells JCI Insight, 2018-06-07;3(11):. 2018-06-07 [PMID: 29875320] (Bioassay, Mouse)	Bioassay	Mouse
GH Nam, EJ Lee, YK Kim, Y Hong, Y Choi, MJ Ryu, J Woo, Y Cho, DJ Ahn, Y Yang, IC Kwon, SY Park, IS Kim Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer Nat Commun, 2018-06-04;9(1):2165. 2018-06-04 [PMID: 29867097] (Bioassay, Mouse)	Bioassay	Mouse
LC Cheung, J Tickner, AM Hughes, P Skut, M Howlett, B Foley, J Oommen, JE Wells, B He, S Singh, GA Chua, J Ford, CG Mullighan, RS Kotecha, UR Kees New therapeutic opportunities from dissecting the pre-B leukemia bone marrow microenvironment Leukemia, 2018-05-08;0(0):. 2018-05-08 [PMID: 29740160] (Bioassay, Mouse)	Bioassay	Mouse
HT Fang, CA El Farran, QR Xing, LF Zhang, H Li, B Lim, YH Loh Global H3.3 dynamic deposition defines its bimodal role in cell fate transition Nat Commun, 2018-04-18;9(1):1537. 2018-04-18 [PMID: 29670118] (Bioassay, Mouse)	Bioassay	Mouse
M Kanayama, Y Kato, T Tsuji, Y Konoeda, A Hashimoto, O Kanauchi, T Fujii, D Fujiwara Enhancement of immunomodulative effect of lactic acid bacteria on plasmacytoid dendritic cells with sucrose palmitate Sci Rep, 2018-02-16;8(1):3147. 2018-02-16 [PMID: 29453437] (Bioassay, Mouse)	Bioassay	Mouse
Y Xiao, J Palomero, J Grabowska, L Wang, I de Rink, L van Helver, J Borst Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitor Blood Adv, 2017-10-13;1(23):1993-2006. 2017-10-13 [PMID: 29296846] (Differentiation, Differentiation, Mouse)	Differentiation, Differentiation	Mouse
J Huang, A Khan, BC Au, DL Barber, L López-Vásq, NL Prokopishy, M Boutin, M Rothe, JW Rip, M Abaoui, MS Nagree, S Dworski, A Schambach, A Keating, ML West, J Klassen, PV Turner, S Sirrs, CA Rupar, C Auray-Blai, R Foley, JA Medin Lentivector Iterations and Pre-Clinical Scale-Up/Toxicity Testing: Targeting Mobilized CD34(+) Cells for Correction of Fabry Disease Mol Ther Methods Clin Dev, 2017-05-12;5(0):241-258. 2017-05-12 [PMID: 28603745] (Bioassay, Mouse)	Bioassay	Mouse
MJ Smith, DK Reichenbac, SL Parker, MJ Riddle, J Mitchell, KC Osum, M Mohtashami, HE Stefanski, BT Fife, A Bhandoola, KA Hogquist, GA Holländer, JC Zúñiga-Pfl, J Tolar, BR Blazar T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction JCI Insight, 2017-05-18;2(10):. 2017-05-18 [PMID: 28515359] (Bioassay, Mouse)	Bioassay	Mouse
S Ma, X Wan, Z Deng, L Shi, C Hao, Z Zhou, C Zhou, Y Fang, J Liu, J Yang, X Chen, T Li, A Zang, S Yin, B Li, J Plumas, L Chaperot, X Zhang, G Xu, L Jiang, N Shen, S Xiong, X Gao, Y Zhang, H Xiao Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs J. Exp. Med., 2017-04-17;0(0):. 2017-04-17 [PMID: 28416650] (Bioassay, Mouse)	Bioassay	Mouse
S Shukla, MA Langley, J Singh, JM Edgar, M Mohtashami, JC Zúñiga-Pfl, PW Zandstra Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 Nat. Methods, 2017-04-10;14(5):531-538. 2017-04-10 [PMID: 28394335] (Bioassay, Mouse)	Bioassay	Mouse
S Kumar, R Sunagar, G Pham, BJ Franz, SJ Rosa, KR Hazlett, EJ Gosselin Differential Cultivation of Francisella tularensis Induces Changes in the Immune Response to and Protective Efficacy of Whole Cell-Based Inactivated Vaccines Front Immunol, 2017-01-10;7(0):677. 2017-01-10 [PMID: 28119692] (Bioassay, Mouse)	Bioassay	Mouse
Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms Nat. Med, 2016-12-05;0(0):. 2016-12-05 [PMID: 27918563] (Bioassay, Mouse)	Bioassay	Mouse
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis Cell Death Dis, 2016-11-24;7(11):e2479. 2016-11-24 [PMID: 27882948] (Bioassay, Mouse)	Bioassay	Mouse
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors Nat Commun, 2016-11-21;7(0):13396. 2016-11-21 [PMID: 27869129] (Bioassay, Mouse)	Bioassay	Mouse
L Zhao, RL Frock, Z Du, J Hu, L Chen, MS Krangel, FW Alt Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development J. Exp. Med, 2016-08-15;213(9):1921-36. 2016-08-15 [PMID: 27526713] (Bioassay, Mouse)	Bioassay	Mouse
Hepatitis C Virus Stimulates Murine CD8?-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner PLoS Pathog, 2016-07-06;12(7):e1005736. 2016-07-06 [PMID: 27385030] (Bioassay, Mouse)	Bioassay	Mouse
Ahmed S Elshikha Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus PLoS ONE, 2016-05-27;11(5):e0156583. 2016-05-27 [PMID: 27232337] (Bioassay, Mouse)	Bioassay	Mouse
Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis PLoS ONE, 2016-05-09;11(5):e0154630. 2016-05-09 [PMID: 27159398] (Bioassay, Mouse)	Bioassay	Mouse
Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins Nat. Med., 2016-05-02;22(6):672-8. 2016-05-02 [PMID: 27135740] (Bioassay, Mouse)	Bioassay	Mouse
Niedzielska M, Raffi F, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt U, Wirtz S, Sparwasser T, Hochrein H, Figdor C, Keyse S, Lang R Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol, 2015-07-13;195(4):1753-62. 2015-07-13 [PMID: 26170386] (In Vivo, Mouse)	In Vivo	Mouse
Lee S, Park H, Jeon S, Lee C, Seong R, Park S, Hong S Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages. PLoS ONE, 2015-07-06;10(7):e0132329. 2015-07-06 [PMID: 26147219] (Bioassay, Mouse)	Bioassay	Mouse
Flores M, Chew C, Tyan K, Huang W, Salem A, Clynes R FcgammaRIIB prevents inflammatory type I IFN production from plasmacytoid dendritic cells during a viral memory response. J Immunol, 2015-03-27;194(9):4240-50. 2015-03-27 [PMID: 25821224] (Bioassay, Mouse)	Bioassay	Mouse
Rommler F, Hammel M, Waldhuber A, Muller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells. PLoS ONE, 2015-02-19;10(2):e0116703. 2015-02-19 [PMID: 25695778] (Bioassay, Mouse)	Bioassay	Mouse
Scheuplein V, Seifried J, Malczyk A, Miller L, Hocker L, Vergara-Alert J, Dolnik O, Zielecki F, Becker B, Spreitzer I, Konig R, Becker S, Waibler Z, Muhlebach M High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus. J Virol, 2015-01-21;89(7):3859-69. 2015-01-21 [PMID: 25609809] (Bioassay, Mouse)	Bioassay	Mouse
Lignin-rich enzyme lignin (LREL), a cellulase-treated lignin-carbohydrate derived from plants, activates myeloid dendritic cells via Toll-like receptor 4 (TLR4). J Biol Chem, 2014-12-29;290(0):4410-21. 2014-12-29 [PMID: 25548274] (Bioassay, Mouse)	Bioassay	Mouse
Martinez-Lopez M, Iborra S, Conde-Garrosa R, Sancho D Batf3-dependent CD103+ dendritic cells are major producers of IL-12 that drive local Th1 immunity against Leishmania major infection in mice. Eur J Immunol, 2014-11-28;45(1):119-29. 2014-11-28 [PMID: 25312824] (Bioassay, Mouse)	Bioassay	Mouse
Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014-07-02;124(9):1393-403. 2014-07-02 [PMID: 24990886] (Bioassay, Mouse)	Bioassay	Mouse
Patnode M, Bando J, Krummel M, Locksley R, Rosen S Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. J Exp Med, 2014-06-02;211(7):1281-8. 2014-06-02 [PMID: 24889202] (Bioassay, Mouse)	Bioassay	Mouse
Dai P, Wang W, Cao H, Avogadri F, Dai L, Drexler I, Joyce J, Li X, Chen Z, Merghoub T, Shuman S, Deng L Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS Pathog, 2014-04-17;10(4):e1003989. 2014-04-17 [PMID: 24743339] (Bioassay, Mouse)	Bioassay	Mouse
Treanor L, Zhou S, Janke L, Churchman M, Ma Z, Lu T, Chen S, Mullighan C, Sorrentino B Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. J Exp Med, 2014-03-31;211(4):701-13. 2014-03-31 [PMID: 24687960] (Bioassay, Mouse)	Bioassay	Mouse
Wallington-Beddoe C, Powell J, Tong D, Pitson S, Bradstock K, Bendall L Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer Res, 2014-03-31;74(10):2803-15. 2014-03-31 [PMID: 24686171] (Bioassay, Mouse)	Bioassay	Mouse
Krutikov K, Zheng Y, Chesney A, Huang X, Vaags A, Evdokimova V, Hough M, Chen E Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK. PLoS ONE, 2014-02-26;9(2):e89649. 2014-02-26 [PMID: 24586935] (Bioassay, Mouse)	Bioassay	Mouse
Coffey F, Lee S, Buus T, Lauritsen J, Wong G, Joachims M, Thompson L, Zuniga-Pflucker J, Kappes D, Wiest D The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification. J Exp Med, 2014-02-03;211(2):329-43. 2014-02-03 [PMID: 24493796] (Bioassay, Mouse)	Bioassay	Mouse
Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 2013-11-27;1(6):545-59. 2013-11-27 [PMID: 24371809] (Bioassay, Mouse)	Bioassay	Mouse
Narendra S, Chalise J, Hook N, Magnusson M Dendritic cells activated by double-stranded RNA induce arthritis via autocrine type I IFN signaling. J Leukoc Biol, 2013-12-04;95(4):661-6. 2013-12-04 [PMID: 24304616] (Bioassay, Mouse)	Bioassay	Mouse
Gao , Xin, Johnson , Kirby D, Chang , Yuan-I, Boyer , Meghan E, Dewey , Colin N, Zhang , Jing, Bresnick , Emery H Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo. J Exp Med, 2013-12-02;210(13):2833-42. 2013-12-02 [PMID: 24297994] (Bioassay, Mouse)	Bioassay	Mouse
Pereira C, Chang B, Qiu J, Niu X, Papatsenko D, Hendry C, Clark N, Nomura-Kitabayashi A, Kovacic J, Ma'ayan A, Schaniel C, Lemischka I, Moore K Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell, 2013-06-13;13(2):205-18. 2013-06-13 [PMID: 23770078] (Bioassay, Mouse)	Bioassay	Mouse
Manley , Nathan C, Caso , Javier R, Works , Melissa, Cutler , Andrew B, Zemlyak , Ilona, Sun , Guohua, Munhoz , Carolina, Chang , Sydney, Sorrells , Shawn F, Ermini , Florian, Decker , Johannes, Bertrand , Anthony, Dinkel , Klaus M, Steinberg , Gary K, Sapolsky , Robert M Derivation of injury-responsive dendritic cells for acute brain targeting and therapeutic protein delivery in the stroke-injured rat. PLoS ONE, 2013-04-16;8(4):e61789. 2013-04-16 [PMID: 23613937] (Bioassay, Rat)	Bioassay	Rat
Kim D, Niewiesk S Synergistic induction of interferon alpha through TLR-3 and TLR-9 agonists identifies CD21 as interferon alpha receptor for the B cell response. PLoS Pathog, 2013-03-14;9(3):e1003233. 2013-03-14 [PMID: 23516365] (Bioassay, Cotton Rat)	Bioassay	Cotton Rat
Gatto D, Wood K, Caminschi I, Murphy-Durland D, Schofield P, Christ D, Karupiah G, Brink R The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat Immunol, 2013-03-17;14(5):446-53. 2013-03-17 [PMID: 23502855] (Bioassay, Mouse)	Bioassay	Mouse
Smith , Christop, Berry , Donna M, McGlade , C Jane The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. J Cell Sci, 2013-02-15;126(0):1366-80. 2013-02-15 [PMID: 23418353] (Bioassay, Mouse)	Bioassay	Mouse
Iborra S, Izquierdo HM, Martinez-Lopez M, Blanco-Menendez N, Reis E Sousa C, Sancho D The DC receptor DNGR-1 mediates cross-priming of CTLs during vaccinia virus infection in mice. J. Clin. Invest., 2012-04-16;122(5):1628-43. 2012-04-16 [PMID: 22505455] (Bioassay, Mouse)	Bioassay	Mouse
Shinohara ML, Kim JH, Garcia VA, Cantor H Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 2008-07-18;29(1):68-78. 2008-07-18 [PMID: 18619869] (Bioassay, Mouse)	Bioassay	Mouse
Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur. J. Immunol., 2007-10-01;37(10):2695-706. 2007-10-01 [PMID: 17899546] (Bioassay, Mouse)	Bioassay	Mouse
Rajesh</LastName><ForeNam D</Initial, Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells. Stem Cells, 2007-02-01;25(2):490-9. 2007-02-01 [PMID: 17284653] (Bioassay, Human, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Human, Primate - Macaca mulatta (Rhesus Macaque)
Kared H, Adle-Biassette H, Fois E, Masson A, Bach JF, Chatenoud L, Schneider E, Zavala F Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity, 2006-11-02;25(5):823-34. 2006-11-02 [PMID: 17081781] (In Vivo, Mouse)	In Vivo	Mouse
Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood, 2006-05-23;108(6):2041-4. 2006-05-23 [PMID: 16720837] (Bioassay, Mouse)	Bioassay	Mouse
Azhipa O, Kimizuka K, Nakao A, Toyokawa H, Okuda T, Neto JS, Alber SM, Kaizu T, Thomson AW, Demetris AJ, Murase N Comparative analysis of the fate of donor dendritic cells and B cells and their influence on alloreactive T cell responses under tacrolimus immunosuppression. Clin. Immunol., 2005-02-01;114(2):199-209. 2005-02-01 [PMID: 15639654] (Bioassay, Rat)	Bioassay	Rat
Miller MJ, Hejazi AS, Wei SH, Cahalan MD, Parker I T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. U.S.A., 2004-01-13;101(4):998-1003. 2004-01-13 [PMID: 14722354] (In Vivo, Mouse)	In Vivo	Mouse
Asselin-Paturel C, Brizard G, Pin JJ, Briere F, Trinchieri G Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol., 2003-12-15;171(12):6466-77. 2003-12-15 [PMID: 14662846] (Bioassay, Mouse)	Bioassay	Mouse
Blumenthal RD, Reising A, Leon E Modulation of marrow proliferation and chemosensitivity by tumor-produced cytokines from syngeneic pancreatic tumor lines. Clin. Cancer Res., 2002-05-01;8(5):1301-9. 2002-05-01 [PMID: 12006552] (Bioassay, Mouse)	Bioassay	Mouse
Shih CC, Hu MC, Hu J A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells. Blood, 2000-03-15;95(6):1957-66. 2000-03-15 [PMID: 10706861] (ELISA Developmet, Mouse)	ELISA Developmet	Mouse
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Array 427-FL/CF

• Flt-3 Ligand/FLT3L Antibodies
• Flt-3 Ligand/FLT3L Lysate
• Flt-3 Ligand/FLT3L Proteins
• Flt-3 Ligand/FLT3L Proteins and Enzymes
• Flt-3 Ligand/FLT3L ELISAs