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Recombinant Human TRAILR4/TNFRSF10D Fc Chimera Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human TRAILR4/TNFRSF10D Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L‑929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 6.00-60.0 ng/mL in the presence of 20 ng/mL of rhTRAIL.
Source
Mouse myeloma cell line, NS0-derived human TRAILR4/TNFRSF10D protein
Human TRAIL R4
(Ala56 - His211)
Accession # Q9UBN6		 IEGRID Human IgG1
(Pro100 - Lys330)		 6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Ala56
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
TNFRSF10D
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
44.2 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
70-80 kDa, reducing conditions
Publications
Read Publications using
633-TR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TRAILR4/TNFRSF10D Fc Chimera Protein, CF

  • CD264 antigen
  • CD264
  • DcR2
  • DCR2decoy with truncated death domain
  • Decoy receptor 2
  • TNF receptor-related receptor for TRAIL
  • TNF-related apoptosis-inducing ligand receptor 4
  • TNFRSF10D
  • TRAIL R4
  • TRAILR4
  • TRAIL-R4
  • TRAILR4TRAIL receptor 4
  • TRUNDDTRAIL receptor with a truncated death domain
  • tumor necrosis factor receptor superfamily member 10D
  • tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain

Background

Human TRAIL R4, also called decoy receptor 2 (DcR2) and TRUNND (TRAIL receptor with a truncated death domain), is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.

  1. Griffith, T.S. et al. (1998) Curr. Opin. Immunol. 10:559.
  2. Pan, G. et al. (1998) FEBS lett 424:41.
  3. Marsters, S.A. et al. (1997) Cur. Biol. 7:1003.
  4. Degli-Esposti, M.A. et al. (1997) Immunity 7:813.

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Publications for TRAILR4/TNFRSF10D/DcR2 (633-TR)(3)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: Bioassay, ELISA (Capture), ELISA Capture.


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Bioassay
(1)
ELISA (Capture)
(1)
ELISA Capture
(1)
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(3)
Rat
(1)
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Bioinformatics

Gene Symbol TNFRSF10D
Uniprot