Recombinant Human SOST/Sclerostin His-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Sclerostin (SOST) is a member of the Cerberus/differential screening-selected gene in neuroblastoma (DAN) family, a group of secreted glycoproteins characterized by a cysteine-knot motif. The Cerberus/DAN family consists of multiple members originally identified as putative BMP antagonists including Dan, SOST, Cerberus, Gremlin, USAG-1, PRDC, and Coco (1, 2). While the overall sequence identity between family members is low, they have conserved spacing of six cysteine residues in the C-terminus which form the structurally conserved cysteine-knot motif. Cerberus and Dan have an additional cysteine residue used for dimerization; however, SOST does not and is secreted as a monomer (1). Mature human SOST shares 90% amino acid sequence identity with mouse and rat SOST. SOST appears to be the first example of a BMP antagonist predominately localized to osteoclasts and functions as an important regulator of bone homeostasis by inhibiting bone mineralization (3). SOST has been shown to have unique ligand specificity by binding directly to BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity thereby repressing BMP-induced osteogenesis (4). Mutations in the SOST gene can cause several bone dysplasia disorders characterized by progressive skeletal overgrowth including sclerosteosis and van Buchem disease (5). Additionally, SOST has been shown to be a strong Wnt antagonist by directly binding the Wnt co‑receptors LRP5 and LRP6 (6).

Array 10962-ST

• SOST/Sclerostin Antibodies
• SOST/Sclerostin Lysate
• SOST/Sclerostin Proteins and Enzymes
• SOST/Sclerostin ELISAs