Recombinant Human Siglec-8 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Siglec-8, also known as SAF, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules (1). Mature human Siglec-8 consists of a 347 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 115 aa cytoplasmic domain with two tyrosine based signaling motifs (2, 3). Alternative splicing generates additional isoforms that either lack most of the second Ig-like domain or have a substituted cytoplasmic domain without the signaling motifs (4, 5). Siglec-8 is expressed on eosinophils, basophils, and mast cells (2, 3), and it shows a binding preference for the carbohydrate 6-O sulfated sLe^x (3, 6, 7). In mouse, Siglec-F is a functional paralog of human Siglec-8, as shown by its similar expression profile and ligand specificity (8). Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation (9). It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF (10-12).

Array 9045-SL

• Siglec-8 Antibodies
• Siglec-8 Lysate
• Siglec-8 Protein
• Siglec-8 Proteins and Enzyme