Siglec-1/CD169 Antibody (HSn 7D2) - BSA Free

Sialoadhesin, also known as sialic acid-binding Ig-like lectin 1, siglec-1, CD169, SIGLEC1, and SN, is a member of the sialic acid binding Ig-like lectin (SIGLEC) family. The SIGLECs are a family of membrane bound lectins that belong to the immunoglobulin superfamily. SIGLECs bind sialic acid and mediate cell to cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a lectin-like macrophage-specific cell adhesion molecule that mediates sialic acid dependent binding of glycoconjugate ligands on activated macrophages, lymphocytes, granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. The Sialoadhesin protein is found in two locations within the cell, the cell membrane (isoform 1) and secreted in the cytoplasm (isoform 2). Sialoadhesin is expressed in spleen, lymph node, brain, bone marrow, liver, colon and lung tissues and in inflammatory macrophages in rheumatoid arthritis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Porcine, Virus.

We have publications tested in 7 applications: FLOW, ICC/IF, IF/IHC, IHC-Fr, IHC-P, In vitro, WB.

Showing Publications 1 - 10 of 23. Show All 23 Publications. Collapse Publications.

Publications using NB600-534	Applications	Species
Zwart ES, van Ee T, Affandi AJ et al. Spatial immune composition of tumor microenvironment in patients with pancreatic cancer Cancer immunology, immunotherapy : CII 2023-11-08 [PMID: 37938368] (FLOW, Human)	FLOW	Human
Yanqiu Wang, Zhou Jin, Jiajun Sun, Xinxin Chen, Pu Xie, Yulin Zhou, Shu Wang The role of activated monocyte IFN/SIGLEC1 signalling in Graves' disease. The Journal of endocrinology 2022-09-08 [PMID: 35695299]
Dhiraj K. Singh, Ekaterina Aladyeva, Shibali Das, Bindu Singh, Ekaterina Esaulova, Amanda Swain, Mushtaq Ahmed, Journey Cole, Chivonne Moodley, Smriti Mehra, Larry S. Schlesinger, Maxim N. Artyomov, Shabaana A. Khader, Deepak Kaushal Myeloid cell interferon responses correlate with clearance of SARS-CoV-2 Nature Communications 2022-02-03 [PMID: 35115549]
Tanboon J, Uruha A, Arahata Y et al. Inflammatory features in sporadic late-onset nemaline myopathy are independent from monoclonal gammopathy Brain pathology (Zurich, Switzerland) 2021-05-01 [PMID: 34043258]
Ostendorf L, Dittert P, Biesen R et al. SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients Scientific reports 2021-05-13 [PMID: 33986412] (IF/IHC, Human)	IF/IHC	Human
Verollet C, Dupont M, Souriant S et al. Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages Elife 2020-04-01 [PMID: 32223897]
Roos A, Preusse C, Hathazi D et al. Proteomic Profiling Unravels a Key Role of Specific Macrophage Subtypes in Sporadic Inclusion Body Myositis Front Immunol 2019-05-31 [PMID: 31143183] (IHC-Fr, Human)	IHC-Fr	Human
OhAinle M, Helms L, Vermeire J et al. A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV Elife 2018-12-06 [PMID: 30520725] (FLOW, Human)	FLOW	Human
Bihari C, Lal D, Thakur M et al. Suboptimal Level of Bone-Forming Cells in Advanced Cirrhosis are Associated with Hepatic Osteodystrophy. Hepatol Commun 2018-09-01 [PMID: 30202823] (IF/IHC, Human)	IF/IHC	Human
Jadapalli JK, Wright GW, Kain V et al. Doxorubicin triggers splenic contraction and irreversible dysregulation of COX and LOX that alters the inflammation-resolution program in the myocardium Am J Physiol Heart Circ Physiol 2018-08-04 [PMID: 30074834] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Akiyama H, Ramirez NP, Gibson G et al. Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon J Virol 2017-08-11 [PMID: 28794041] (IHC-Fr, Human)	IHC-Fr	Human
de Carvalho LM, Ngoumou G, Park JW et al. Musculoskeletal Disease in MDA5-Related Type I Interferonopathy: A Mendelian Mimic of Jaccoud's Arthropathy Arthritis & rheumatology (Hoboken, N.J.) 2017-10-01 [PMID: 28605144] (IHC-Fr, Human)	IHC-Fr	Human
Novakovic P, Harding JC, Ladinig A et al. Relationships of CD163 and CD169 positive cell numbers in the endometrium and fetal placenta with type 2 PRRSV RNA concentration in fetal thymus. Vet. Res. 2016-08-06 [PMID: 27494990] (IF/IHC, Porcine)	IF/IHC	Porcine
Yayi H, Yeda X, Huaxin W et al. Toll-like receptor 7 involves the injury in acute kidney ischemia/reperfusion of STZ-induced diabetic rats. Acta Cir Bras. 2016-07-01 [PMID: 27487279] (WB, Virus)	WB	Virus
Groenendyk J, Lee D, Jung J et al. Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis PLoS ONE 2016-07-22 [PMID: 27441395] (IF/IHC, Porcine)	IF/IHC	Porcine
Kusumi S, Koga D, Kanda TUshiki T. Three-dimensional reconstruction of serial sections for analysis of the microvasculature of the white pulp and the marginal zone in the human spleen. Biomed Res 2015-06-24 [PMID: 26106049] (IF/IHC, Human) Details: Using the PE conjugated version of NB600-534, catalog number NB600-534PE.	IF/IHC	Human
Verollet C, Dupont M, Souriant S et al. Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages BioRxiv (IHC-P, ICC/IF, Human)	IHC-P, ICC/IF	Human
Akiyama H, Ramirez NG, Gudheti MV, Gummuluru S. CD169-Mediated Trafficking of HIV to Plasma Membrane Invaginations in Dendritic Cells Attenuates Efficacy of Anti-gp120 Broadly Neutralizing Antibodies. PLoS Pathog. 2015-03-01 [PMID: 25760631] (WB, FLOW, Human)	WB, FLOW	Human
Puryear WB, Akiyama H, Geer SD et al. Interferon-Inducible Mechanism of Dendritic Cell-Mediated HIV-1 Dissemination Is Dependent on Siglec-1/CD169. PLoS Pathog 2013-04-01 [PMID: 23593001] (WB, Human)	WB	Human
Rempel H, Calosing C, Sun B Sialoadhesin expressed on IFN-induced monocytes binds HIV-1 and enhances infectivity. PLoS One. 2008-04-16 [PMID: 18414664] (WB, In vitro, FLOW, Human)	WB, In vitro, FLOW	Human
Pack M, Trumpfheller C, Thomas D et al. DEC-205/CD205+ dendritic cells are abundant in the white pulp of the human spleen, including the border region between the red and white pulp. Immunology. 2008-03-01 [PMID: 17944899] (IHC-Fr, Human)	IHC-Fr	Human
Hartnell A, Steel J, Turley H et al. Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood;97(1):288-96. 2001-01-01 [PMID: 11133773] (IF/IHC)	IF/IHC
Steiniger B et al. The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. Immunol 92: 307-316. 1997-01-01 [PMID: 9415041]
Show All 23 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IHC-Fr	Mouse	12/16/2018	View Summary Application Immunohistochemistry-Frozen Sample Tested Adult small intestine Species Mouse Lot A-5

Array NB600-534

• Siglec-1/CD169 Antibodies
• Siglec-1/CD169 ELISA Kits
• Siglec-1/CD169 Protein
• Siglec-1/CD169 Proteins and Enzymes