Recombinant Human sFRP-1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein-1 (sFRP-1), also known as SARP-2, FRP, and FrzA, belongs to a family of Wnt-binding proteins with homology to the ligand-binding domain of the Frizzled transmembrane Wnt receptors. The sFRP proteins are approximately 30-35 kDa in size and contain an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain (1-3). Mature human sFRP-1 shares 97% and 96% amino acid sequence identity with mouse and rat sFRP-1, respectively. It binds to Wnt-1, -2, -3a, and -4 and prevents their activation of canonical beta-catenin signaling (4-7). sFRP-1 is up-regulated in the ischemic heart where it limits inflammation and the severity of tissue damage following myocardial infarction (8-10). During angiogenesis it induces endothelial cell migration, tube formation, and vessel formation (11). sFRP-1 is expressed by bone marrow stromal cells and osteoclasts (12). It binds to TRANCE/RANK Ligand, inhibits osteoclast and osteoblast formation and survival, and inhibits the formation of trabecular bone (13, 14). sFRP-1 additionally restricts kidney tubule formation (7), the inflammatory activation of leukocytes (10), early B lymphoid progression (12), and vitreous fluid outflow in the eye (15).

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Chicken.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using 5396-SF	Applications	Species
DA Jeffrey, J Pires Da S, AM Garcia, X Jiang, A Karimpour-, LS Toni, T Lanzicher, B Peña, CA Miyano, K Nunley, A Korst, O Sbaizero, MR Taylor, SD Miyamoto, BL Stauffer, CC Sucharov Serum circulating proteins from pediatric dilated cardiomyopathy patients cause pathologic remodeling and cardiomyocyte stiffness JCI Insight, 2021-10-08;0(0):. 2021-10-08 [PMID: 34383712] (Bioassay, Rat)	Bioassay	Rat
Y Park, M Lofton, D Li, MR Rasin Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs Cells, 2021-01-28;10(2):. 2021-01-28 [PMID: 33525513] (Bioassay, Mouse)	Bioassay	Mouse
SH Cho, IY Kuo, PF Lu, HT Tzeng, WW Lai, WC Su, YC Wang Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness Cell Death Dis, 2018-08-29;9(9):868. 2018-08-29 [PMID: 30158579] (Bioassay, Human)	Bioassay	Human
NJ Hawkshaw, JA Hardman, IS Haslam, A Shahmalak, A Gilhar, X Lim, R Paus Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles PLoS Biol., 2018-05-08;16(5):e2003705. 2018-05-08 [PMID: 29738529] (Bioassay, Human)	Bioassay	Human
F McLeod, A Bossio, A Marzo, L Ciani, S Sibilla, S Hannan, GA Wilson, E Palomer, TG Smart, A Gibb, PC Salinas Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors Cell Rep, 2018-04-24;23(4):1060-1071. 2018-04-24 [PMID: 29694885] (Bioassay, Rat)	Bioassay	Rat
J Steinfeld, I Steinfeld, A Bausch, N Coronato, ML Hampel, H Depner, PG Layer, A Vogel-Höpk BMP-induced reprograming of the retina into RPE requires WNT signalling in the developing chick optic cup Biol Open, 2017-07-15;0(0):. 2017-07-15 [PMID: 28546339] (In Vivo, Chicken)	In Vivo	Chicken
T Nakamura, T Hosoyama, J Murakami, M Samura, K Ueno, H Kurazumi, R Suzuki, A Mikamo, K Hamano Age-related increase in Wnt inhibitor causes a senescence-like phenotype in human cardiac stem cells Biochem. Biophys. Res. Commun., 2017-04-21;0(0):. 2017-04-21 [PMID: 28435069] (Bioassay, Human)	Bioassay	Human
K Minegishi, M Hashimoto, R Ajima, K Takaoka, K Shinohara, Y Ikawa, H Nishimura, AP McMahon, K Willert, Y Okada, H Sasaki, D Shi, T Fujimori, T Ohtsuka, Y Igarashi, TP Yamaguchi, A Shimono, H Shiratori, H Hamada A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking Dev. Cell, 2017-03-13;40(5):439-452.e4. 2017-03-13 [PMID: 28292423] (Bioassay, Mouse)	Bioassay	Mouse
Holger S Willenberg Endothelial cells regulate ?-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor Mol. Cell. Endocrinol., 2016-11-23;0(0):. 2016-11-23 [PMID: 27889473] (Bioassay, Human)	Bioassay	Human
Adipose- and muscle-derived Wnts trigger pancreatic ?-cell adaptation to systemic insulin resistance Sci Rep, 2016-08-16;6(0):31553. 2016-08-16 [PMID: 27527335] (Bioassay, Rat)	Bioassay	Rat
Arensman M, Kovochich A, Kulikauskas R, Lay A, Yang P, Li X, Donahue T, Major M, Moon R, Chien A, Dawson D WNT7B mediates autocrine Wnt/beta-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene, 2013-02-18;33(7):899-908. 2013-02-18 [PMID: 23416978] (Bioassay, Human)	Bioassay	Human
Dawes L, Sugiyama Y, Tanedo A, Lovicu F, McAvoy J Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci, 2013-03-01;54(3):1582-90. 2013-03-01 [PMID: 23385791] (Bioassay, Rat)	Bioassay	Rat
Patel N, Sharpe PT, Miletich I Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals. Dev. Biol., 2011-07-23;358(1):156-67. 2011-07-23 [PMID: 21806977] (Bioassay, Mouse)	Bioassay	Mouse
Scheel C, Eaton E, Li S, Chaffer C, Reinhardt F, Kah K, Bell G, Guo W, Rubin J, Richardson A, Weinberg R Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell, 2011-06-10;145(6):926-40. 2011-06-10 [PMID: 21663795] (Bioassay, Human)	Bioassay	Human
Blakely BD, Bye CR, Fernando CV Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE, 2011-03-31;6(3):e18373. 2011-03-31 [PMID: 21483795] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
Show All 15 Publications. Collapse Publications.

Array 5396-SF

• sFRP-1 Antibodies
• sFRP-1 Lysate
• sFRP-1 Proteins and Enzymes