Recombinant Human sFRP-5 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein-5 (sFRP-5), also known as SARP-3, belongs to a family of Wnt‑binding proteins with homology to the ligand‑binding domain of the Frizzled receptors. sFRPs are approximately 30-35 kDa in size and contain an N‑terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain (1-3). Mature human sFRP-5 shares 96% aa sequence identity with mouse and rat sFRP‑2 (4). During embryonic development, sFRP-5 is expressed in the anterior visceral endoderm, neural tube, foregut epithelium, and proliferating and prehypertrophic chondrocytes (5-8). sFRP-5 activity is required for the development of foregut, liver, ventral pancreas, and somites (6, 7). In the adult, sFRP-5 is expressed in the retinal pigment epithelium and pancreas (4, 9). sFRP-5 binds and antagonizes the function of mammalian Wnt-5a and Wnt-11 as well as Xenopus Xwnt-8, resulting in an inhibition of both canonical and non-canonical Wnt signaling (7, 9, 10). sFRP-5 down‑regulation is common in breast and gastric cancer cells and is correlated with poor prognosis (11-13). It functions as a tumor suppressor by inhibiting epithelial‑mesenchymal transition, invasiveness, and tumorigenicity of ovarian cancer cells (14). sFRP-5 plays an important role in maintaining glucose handling and insulin sensitivity (10). It is secreted by adipocytes and is down‑regulated in mouse models of obesity and type 2 diabetes (10).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Bioassay, Cell Culture, Surface Plasmon Resonance.

Showing Publications 1 - 5 of 5.

Publications using 6266-SF	Applications	Species
A Sahabian, M Sgodda, O Naujok, R Dettmer, J Dahlmann, F Manstein, T Cantz, R Zweigerdt, U Martin, R Olmer Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential Cells, 2019-12-04;8(12):. 2019-12-04 [PMID: 31817235] (Bioassay, Human)	Bioassay	Human
DT Au, M Migliorini, DK Strickland, SC Muratoglu Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling Mediators Inflamm., 2018-11-04;2018(0):7902841. 2018-11-04 [PMID: 30524198] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
YK Cho, YM Kang, SE Lee, Y Lee, SM Seol, WJ Lee, JY Park, CH Jung Effect of SFRP5 (Secreted Frizzled-Related Protein 5) on the WNT5A (Wingless-Type Family Member 5A)-Induced Endothelial Dysfunction and Its Relevance With Arterial Stiffness in Human Subjects Arterioscler. Thromb. Vasc. Biol., 2018-04-19;0(0):. 2018-04-19 [PMID: 29674475] (Cell Culture, Human)	Cell Culture	Human
Carstensen M, Wiza C, Rohrig K, Fahlbusch P, Roden M, Herder C, Ouwens D Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells. PLoS ONE, 2014-01-21;9(1):e85906. 2014-01-21 [PMID: 24465779] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human

Array 6266-SF

• sFRP-5 Antibodies
• sFRP-5 Lysate
• sFRP-5 Proteins and Enzymes
• sFRP-5 ELISA