Recombinant Human sFRP-1 (Histidine-tagged) Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Secreted Frizzled Related Protein-1 (sFRP-1), also known as SARP-2, FRP, and FrzA, belongs to a family of Wnt-binding proteins with homology to the ligand-binding domain of the Frizzled transmembrane Wnt receptors. The sFRP proteins are approximately 30-35 kDa in size and contain an N-terminal Frizzled-like domain with 10 conserved cysteines and a Netrin-like C-terminal domain (1-3). Mature human sFRP-1 shares 97% and 96% amino acid sequence identity with mouse and rat sFRP-1, respectively. It binds to Wnt-1, -2, -3a, and -4 and prevents their activation of canonical beta-catenin signaling (4-7). sFRP-1 is upregulated in the ischemic heart where it limits inflammation and the severity of tissue damage following myocardial infarction (8-10). During angiogenesis it induces endothelial cell migration, tube formation, and vessel formation (11). sFRP-1 is expressed by bone marrow stromal cells and osteoclasts (12). It binds to TRANCE/RANK Ligand, inhibits osteoclast and osteoblast formation and survival, and inhibits the formation of trabecular bone (13, 14). sFRP-1 additionally restricts kidney tubule formation (7), the inflammatory activation of leukocytes (10), early B lymphoid progression (12), and vitreous fluid outflow in the eye (15).

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), In Vivo, Surface Plasmon Resonance.

Showing Publications 1 - 8 of 8.

Publications using 1384-SF	Applications	Species
T Skaria, E Bachli, G Schoedon WIF1 prevents Wnt5A mediated LIMK/CFL phosphorylation and adherens junction disruption in human vascular endothelial cells J Inflamm (Lond), 2017-05-19;14(0):10. 2017-05-19 [PMID: 28529460] (Bioassay, Human)	Bioassay	Human
T Skaria, E Bachli, G Schoedon Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells Cell Adh Migr, 2016-05-09;11(1):24-38. 2016-05-09 [PMID: 27159116] (Bioassay, Human)	Bioassay	Human
Shen X, Ying H, Yue B Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells. PLoS ONE, 2012-09-13;7(9):e44902. 2012-09-13 [PMID: 23028669] (Bioassay, Human)	Bioassay	Human
Gogolla N, Galimberti I, Deguchi Y, Caroni P Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus. Neuron, 2009-05-28;62(4):510-25. 2009-05-28 [PMID: 19477153] (In Vivo, Mouse)	In Vivo	Mouse
Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, Sato T, Takimoto R, Niitsu Y, Kato J Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp. Hematol., 2008-06-17;36(9):1121-31. 2008-06-17 [PMID: 18562079] (Bioassay, Human)	Bioassay	Human
Lane NE, Nevitt MC, Lui LY, de Leon P, Corr M Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum., 2007-10-01;56(10):3319-25. 2007-10-01 [PMID: 17907185] (ELISA (Standard))	ELISA (Standard)
Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L Wnt3a binds to several sFRPs in the nanomolar range. Biochem. Biophys. Res. Commun., 2007-04-19;357(4):1119-23. 2007-04-19 [PMID: 17462603] (Bioassay, Surface Plasmon Resonance, Mouse)	Bioassay, Surface Plasmon Resonance	Mouse
Lindsley RC, Gill JG, Kyba M, Murphy TL, Murphy KM Canonical Wnt signaling is required for development of embryonic stem cell-derived mesoderm. Development, 2006-08-30;133(19):3787-96. 2006-08-30 [PMID: 16943279] (Bioassay, Mouse)	Bioassay	Mouse

Array 1384-SF

• sFRP-1 Antibodies
• sFRP-1 Lysate
• sFRP-1 Proteins and Enzymes