Recombinant Human N-Cadherin Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Neuronal Cadherin (N-Cadherin or NCAD), also known as Cadherin-2 (CDH2), is a 130 kDa type I membrane protein belonging to the Cadherin superfamily of calcium-dependent adhesion molecules. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity (1, 2). Human N‑Cadherin is synthesized with a 25 amino acid (aa) signal peptide and a 134 aa N‑terminal propeptide. The mature cell surface‑expressed protein consists of a 565 amino acid (aa) extracellular domain (ECD) that contains five Cadherin repeats, a 21 aa transmembrane segment, and a 161 aa cytoplasmic domain (3). Within the ECD, human N-Cadherin shares 98% aa sequence identity with mouse and rat N-Cadherin. In the nervous system, N-Cadherin mediates adhesion between the opposing faces of developing neuronal synapses and between Schwann cells and neuronal axons (4, 5). It interacts in cis or in trans homophilically and with the GluR2 subunit of neuronal AMPA receptors (1, 6). During synaptic maturation, its expression is lost from inhibitory terminals but maintained at excitatory terminals (5). ADAM10-mediated shedding of the N-Cadherin ECD alters cell-cell adhesion, synaptic development, and AMPA receptor activity (7, 8). N-Cadherin can also be cleaved at multiple additional sites within the intracellular or extracellular domains by Calpain, gamma ‑Secretase, and several MMPs (9-13). Cleavage of N‑Cadherin in atherosclerotic plaques contributes alternatively to vascular smooth muscle cell proliferation (MMP-9 and -12) or apoptosis
(MMP‑7) (12, 13). Aberrant cell surface expression of the pro and mature forms of N-Cadherin in cancer results in increased tumor progression and invasiveness (14, 15). N-Cadherin also mediates the adhesion between hematopoeitic progenitor cells and mesenchymal stromal cells of the bone marrow (16).

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Chicken, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 4 applications: Adhesion Assay, Binding Assay, Bioassay, Western Blot Control.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 1388-NC	Applications	Species
Kim, D;Olson, JM;Cooper, JA; N-cadherin dynamically regulates pediatric glioma cell migration in complex environments bioRxiv : the preprint server for biology 2024-01-11 [PMID: 38260559] (Bioassay, Human)	Bioassay	Human
DS Micalizzi, D Che, BT Nicholson, JF Edd, N Desai, ER Lang, M Toner, S Maheswaran, DT Ting, DA Haber Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody Proceedings of the National Academy of Sciences of the United States of America, 2022-10-18;119(43):e2209563119. 2022-10-18 [PMID: 36256815] (Western Blot Control, Human)	Western Blot Control	Human
M Khorsand, S Khajeh, M Eslami, N Nezafat, Y Ghasemi, V Razban, Z Mostafavi- Telmisartan anti-cancer activities mechanism through targeting N-cadherin by mimicking ADH-1 function Journal of Cellular and Molecular Medicine, 2022-02-27;0(0):. 2022-02-27 [PMID: 35224849] (Bioassay, Human)	Bioassay	Human
C Schinner, BM Erber, S Yeruva, A Schlipp, V Rötzer, E Kempf, S Kant, RE Leube, TD Mueller, J Waschke Stabilization of desmoglein-2 binding rescues arrhythmia in arrhythmogenic cardiomyopathy JCI Insight, 2020-05-07;5(9):. 2020-05-07 [PMID: 32376797] (Bioassay, Mouse)	Bioassay	Mouse
C Monzel, AS Becker, R Saffrich, P Wuchter, V Eckstein, AD Ho, M Tanaka Dynamic cellular phynotyping defines specific mobilization mechanisms of human hematopoietic stem and progenitor cells induced by SDF1? versus synthetic agents Sci Rep, 2018-01-30;8(1):1841. 2018-01-30 [PMID: 29382856] (Bioassay, Human)	Bioassay	Human
Zhe Sun N-Cadherin, a novel and rapidly remodelling site involved in vasoregulation of small cerebral arteries J. Physiol. (Lond.), 2017-02-07;0(0):. 2017-02-07 [PMID: 28008617] (Bioassay, Human)	Bioassay	Human
Parnaud G, Lavallard V, Bedat B, Matthey-Doret D, Morel P, Berney T, Bosco D Cadherin engagement improves insulin secretion of single human beta-cells. Diabetes, 2014-10-02;64(3):887-96. 2014-10-02 [PMID: 25277393] (Adhesion Assay, Human)	Adhesion Assay	Human
Guan X, Bartlett J MMP20 modulates cadherin expression in ameloblasts as enamel develops. 2013-09-25;92(0):. 2013-09-25 [PMID: 24067343] (Bioassay, Mouse)	Bioassay	Mouse
Oblander SA, Brady-Kalnay SM Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin. Mol. Cell. Neurosci., 2010-03-01;44(1):78-93. 2010-03-01 [PMID: 20197094] (Bioassay, Chicken)	Bioassay	Chicken
Pittet P, Lee K, Kulik AJ, Meister JJ, Hinz B Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J. Cell. Sci., 2008-02-26;121(0):877-86. 2008-02-26 [PMID: 18303045] (Binding Assay, Rat)	Binding Assay	Rat
Isakova IA, Baker K, Dutreil M, Dufour J, Gaupp D, Phinney DG Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells, 2007-10-11;25(12):3261-70. 2007-10-11 [PMID: 17932418] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Oblander SA, Ensslen-Craig SE, Longo FM, Brady-Kalnay SM E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Mol. Cell. Neurosci., 2007-02-02;34(3):481-92. 2007-02-02 [PMID: 17276081] (Bioassay, Chicken)	Bioassay	Chicken
Show All 12 Publications. Collapse Publications.

Array 1388-NC

• N-Cadherin Antibodies
• N-Cadherin ELISA Kits
• N-Cadherin Lysate
• N-Cadherin Proteins
• N-Cadherin Proteins and Enzymes
• N-Cadherin ELISA