Recombinant Human M-CSF Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

M-CSF, also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation (1-3). M-CSF is also essential for the survival and proliferation of osteoclast progenitors (1, 4). M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis (2, 3). M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta (5). Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells (1-5). The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. M-CSF mRNAs of various sizes occur (3-9). Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail that forms a 140 kDa covalent dimer. Differential processing produces two proteolytically cleaved, secreted dimers. One is an N- and O- glycosylated 86 kDa dimer, while the other is modified by both glycosylation and chondroitin-sulfate proteoglycan (PG) to generate a 200 kDa subunit. Although PG-modified M-CSF can circulate, it may be immobilized by attachment to type V collagen (8). Shorter transcripts encode
M‑CSF that lacks cleavage and PG sites and produces an N-glycosylated 68 kDa TM dimer and a slowly produced 44 kDa secreted dimer (7). Although forms may vary in activity and half-life, all contain the N‑terminal 150 aa portion that is necessary and sufficient for interaction with the M-CSF receptor (10, 11). The first 223 aa of mature human M-CSF shares 88%, 86%, 81% and 74% aa identity with corresponding regions of dog, cow, mouse and rat M‑CSF, respectively (12, 13). Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

We have publications tested in 11 confirmed species: Human, Mouse, Rat, Canine, Equine, Hamster, Porcine, Primate, Primate - Chlorocebus pygerythrus (Vervet Monkey), Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio anubis (Olive Baboon).

We have publications tested in 5 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), cell differentiation.

Showing Publications 1 - 10 of 233. Show All 233 Publications. Collapse Publications.

Publications using 216-MC/CF	Applications	Species
Patel, R;Cardona, CL;Angeles, E;Singh, G;Ashok, A;Teich, AF;Sproul, AA; Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling bioRxiv : the preprint server for biology 2024-06-28 [PMID: 38979369] (Bioassay, Human)	Bioassay	Human
G Yi, F Yang, A Labani-Mot, JD Moreira, D Ansari, JA Bohorquez, S Patel, F Spagnolo, J Florence, A Vankayalap, R Vankayalap, JJDJ Dennehy, B Samten Bacteriophage therapy for the treatment of Mycobacterium tuberculosis infections in humanized mice bioRxiv : the preprint server for biology, 2023-02-21;0(0):. 2023-02-21 [PMID: 36747734] (Bioassay, Human)	Bioassay	Human
L Feige, T Kozaki, G Dias de Me, V Guillemot, F Larrous, F Ginhoux, H Bourhy Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses Viruses, 2022-12-29;15(1):. 2022-12-29 [PMID: 36680128] (Bioassay, Human)	Bioassay	Human
Y Kitamura, YI Koma, K Tanigawa, S Tsukamoto, Y Azumi, S Miyako, S Urakami, T Kodama, M Nishio, M Shigeoka, Y Kakeji, H Yokozaki Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma Cancers, 2023-01-06;15(2):. 2023-01-06 [PMID: 36672342] (Bioassay, Human)	Bioassay	Human
J Pape, D Bakkalci, RA Hosni, BS Simpson, K Heikinheim, S Fedele, U Cheema RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone model Journal of tissue engineering, 2022-12-24;13(0):2041731422114. 2022-12-24 [PMID: 36582941] (Cell Culture, Human)	Cell Culture	Human
C Bratengeie, AD Bakker, A Liszka, J Schilcher, A Fahlgren The release of osteoclast-stimulating factors on supraphysiological loading by osteoprogenitors coincides with expression of genes associated with inflammation and cytoskeletal arrangement Scientific Reports, 2022-12-14;12(1):21578. 2022-12-14 [PMID: 36517534] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
R Boland, MT Heemskerk, G Forn-Cuní, CJ Korbee, KV Walburg, JJ Esselink, C Carvalho D, AM de Waal, DCM van der Ho, E van der Sa, AS de Ries, J Xie, HP Spaink, M van der Va, MC Haks, AH Meijer, THM Ottenhoff Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis MBio, 2022-12-07;0(0):e0302422. 2022-12-07 [PMID: 36475748] (Cell Culture, Human)	Cell Culture	Human
Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang, L Zhang, Y Zhao FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism Cell Reports, 2022-11-15;41(7):111668. 2022-11-15 [PMID: 36384126] (Bioassay, Human)	Bioassay	Human
D Ding, L Wang, J Yan, Y Zhou, G Feng, L Ma, Y Yang, X Pei, Q Jin Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption PLoS ONE, 2022-07-28;17(7):e0271485. 2022-07-28 [PMID: 35900969] (Bioassay, Rat)	Bioassay	Rat
KE Nilsen, A Skjesol, J Frengen Ko, T Espevik, J Stenvik, M Yurchenko TIRAP/Mal Positively Regulates TLR8-Mediated Signaling via IRF5 in Human Cells Oncogene, 2022-06-22;10(7):. 2022-06-22 [PMID: 35884781] (Bioassay, Human)	Bioassay	Human
AM Soileau, CN Quick, CE Moeller, JC Schaumburg, SS Withers The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages Oncogene, 2022-07-21;9(7):. 2022-07-21 [PMID: 35878391] (Bioassay, Canine)	Bioassay	Canine
S Lin, A Zhang, L Yuan, Y Wang, C Zhang, J Jiang, H Xu, H Yuan, H Yao, Q Zhang, Y Zhang, M Lou, P Wang, ZN Zhang, B Luan Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice Nature Communications, 2022-06-08;13(1):3301. 2022-06-08 [PMID: 35676256] (Bioassay, Human)	Bioassay	Human
N Rigamonti, N Veitonmäki, C Domke, S Barsin, S Jetzer, O Abdelmotal, R Bessey, T Lekishvili, F Malvezzi, M Gachechila, M Béhé, V Levitsky, PA Trail A multispecific anti-CD40 DARPin� construct induces tumor-selective CD40 activation and tumor regression Cancer Immunology Research, 2022-05-03;0(0):. 2022-05-03 [PMID: 35319751] (Bioassay, Mouse)	Bioassay	Mouse
X Wang, Y Chen, B Lan, Y Wang, W Lin, X Jiang, J Ye, B Shang, C Feng, J Liu, J Zhai, M Xu, Q Li, L Lin, M Hu, F Zheng, L Chen, C Shao, Y Wang, Y Shi Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells Theranostics, 2022-01-31;12(5):2063-2079. 2022-01-31 [PMID: 35265199] (Bioassay, Human)	Bioassay	Human
P Gao, H Liu, H Huang, Y Sun, B Jia, B Hou, X Zhou, W Strober, F Zhang The Crohn Disease-associated ATG16L1T300A polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling Autophagy, 2022-02-27;0(0):1-15. 2022-02-27 [PMID: 35220902] (Bioassay, Human)	Bioassay	Human
R Liu, Y Zhong, R Chen, S Chen, Y Huang, H Liu Bacterial infections exacerbate myeloma bone disease Journal of Translational Medicine, 2022-01-06;20(1):16. 2022-01-06 [PMID: 34991592] (Bioassay, Human)	Bioassay	Human
PL Chi, CC Cheng, CC Hung, MT Wang, HY Liu, MW Ke, MC Shen, KC Lin, SH Kuo, PP Hsieh, SR Wann, WC Huang MMP-10 from M1 macrophages promotes pulmonary vascular remodeling and pulmonary arterial hypertension International journal of biological sciences, 2022-01-01;18(1):331-348. 2022-01-01 [PMID: 34975336] (Bioassay, Human)	Bioassay	Human
H Guo, D Ding, L Wang, J Yan, L Ma, Q Jin Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-kappaB/ERK signaling pathway PLoS ONE, 2021-12-16;16(12):e0261127. 2021-12-16 [PMID: 34914744] (Bioassay, Mouse)	Bioassay	Mouse
Q Xu, P Zhan, X Li, F Mo, H Xu, Y Liu, Q Lai, B Zhang, M Dai, X Liu Bisphosphonate-enoxacin inhibit osteoclast formation and function by abrogating RANKL-induced JNK signalling pathways during osteoporosis treatment Journal of Cellular and Molecular Medicine, 2021-10-15;0(0):. 2021-10-15 [PMID: 34651433] (Cell Culture, Mouse)	Cell Culture	Mouse
M Zhao, Y Zhang, X Yang, J Jin, Z Shen, X Feng, T Zou, L Deng, D Cheng, X Zhang, C Qin, C Niu, Z Ye, X Zhang, J He, C Hou, G Li, G Han, Q Cheng, Q Wang, L Wei, J Dong, J Zhang Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses PloS Pathogens, 2021-09-10;17(9):e1009901. 2021-09-10 [PMID: 34506605] (Bioassay, Mouse)	Bioassay	Mouse
D Zhang, J Huang, F Wang, H Ding, Y Cui, Y Yang, J Xu, H Luo, Y Gao, L Pan, Y Wu, Y Gong, L Xie, Z Liu, Y Qu, L Zhang, W Liu, W Zhang, S Zhao, Q Yi, T Niu, Y Zheng BMI1 regulates multiple myeloma-associated macrophage's pro-myeloma functions Cell Death & Disease, 2021-05-15;12(5):495. 2021-05-15 [PMID: 33993198] (Bioassay, Human)	Bioassay	Human
M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, R Gruber, A Keane, P Loring, L Guo, TH Xia, B Zhang, P Orning, E Lien, A Degterev, T Hammond, D Ofengeim RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis Cell Reports, 2021-05-11;35(6):109112. 2021-05-11 [PMID: 33979622] (Bioassay, Human)	Bioassay	Human
R Song, Y Gao, I Dozmorov, V Malladi, I Saha, MM McDaniel, S Parameswar, C Liang, C Arana, B Zhang, B Wakeland, J Zhou, MT Weirauch, LC Kottyan, EK Wakeland, C Pasare IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility Cell Reports, 2021-03-23;34(12):108891. 2021-03-23 [PMID: 33761354] (Bioassay, Human)	Bioassay	Human
MS Phuong, RE Hernandez, DJ Wolter, LR Hoffman, S Sad Impairment in inflammasome signaling by the chronic Pseudomonas aeruginosa isolates from cystic fibrosis patients results in an increase in inflammatory response Cell Death & Disease, 2021-03-04;12(3):241. 2021-03-04 [PMID: 33664232] (Bioassay, Human)	Bioassay	Human
Z Zhou, A Xu, J Teng, F Wang, Y Tan, H Liu, X Cheng, Y Su, H Shi, Q Hu, H Chi, J Li, J Hou, Y Sun, C Yang, J Ye Anti-Tyro3 IgG Associates with Disease Activity and Reduces Efferocytosis of Macrophages in New-Onset Systemic Lupus Erythematosus J Immunol Res, 2020-11-10;2020(0):2180708. 2020-11-10 [PMID: 33224991] (Cell Culture, Human)	Cell Culture	Human
Obst J, Simon E, Martin-Estebane M, Pipi E, Barkwill L, Gonzalez-Rivera I, Buchanan F, Prescott A, Faust D, Fox S, Brownlees J, Taylor D, Perry V, Nuthall H, Atkinson P, Karran E, Routledge C, Gomez-Nicola D Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration. Front Immunol, 2020-10-08;11(0):579000. 2020-10-08 [PMID: 33162994] (Cell Culture, Mouse)	Cell Culture	Mouse
S Saha, E Profumo, AR Togna, R Riganò, L Saso, B Buttari Lupeol Counteracts the Proinflammatory Signalling Triggered in Macrophages by 7-Keto-Cholesterol: New Perspectives in the Therapy of Atherosclerosis Oxid Med Cell Longev, 2020-09-27;2020(0):1232816. 2020-09-27 [PMID: 33062133] (Bioassay, Human)	Bioassay	Human
D Olagnier, E Farahani, J Thyrsted, J Blay-Cadan, A Herengt, M Idorn, A Hait, B Hernaez, A Knudsen, MB Iversen, M Schilling, SE Jørgensen, M Thomsen, LS Reinert, M Lappe, HD Hoang, VH Gilchrist, AL Hansen, R Ottosen, CG Nielsen, C Møller, D van der Ho, S Peri, S Balachandr, J Huang, M Jakobsen, EB Svenningse, TB Poulsen, L Bartsch, AL Thielke, Y Luo, T Alain, J Rehwinkel, A Alcamí, J Hiscott, TH Mogensen, SR Paludan, CK Holm SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate Nat Commun, 2020-10-02;11(1):4938. 2020-10-02 [PMID: 33009401] (Cell Culture, Human)	Cell Culture	Human
FM Davis, LC Tsoi, R Wasikowski, A denDekker, A Joshi, C Wilke, H Deng, S Wolf, A Obi, S Huang, AC Billi, S Robinson, J Lipinski, WJ Melvin, CO Audu, S Weidinger, SL Kunkel, A Smith, JE Gudjonsson, BB Moore, KA Gallagher Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair JCI Insight, 2020-09-03;5(17):. 2020-09-03 [PMID: 32879137] (Cell Culture, Human)	Cell Culture	Human
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)	Bioassay	Human
G Camilli, M Bohm, AC Piffer, R Lavenir, DL Williams, B Neven, G Grateau, S Georgin-La, J Quintin &beta-Glucan-induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies J. Clin. Invest., 2020-09-01;0(0):. 2020-09-01 [PMID: 32716363] (Cell Culture, Human)	Cell Culture	Human
KJ Gregory, SM Morin, A Kubosiak, J Ser-Dolans, B Schalet, DJ Jerry, SS Schneider The use of patient-derived breast tissue explants to study macrophage polarization and the effects of environmental chemical exposure Immunol. Cell Biol., 2020-09-09;0(0):. 2020-09-09 [PMID: 32713010] (Cell Culture, Human)	Cell Culture	Human
S Vakili, TM Ahooyi, SS Yarandi, M Donadoni, J Rappaport, IK Sariyer Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials Brain Sci, 2020-07-03;10(7):. 2020-07-03 [PMID: 32635207] (Human)		Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020-06-19;27(1):125-136.e7. 2020-06-19 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids Cell Stem Cell, 2020;27(1):125-136.e7. 2020 [PMID: 32579880] (Bioassay, Human)	Bioassay	Human
J Xue, Y Cheng, H Hao, J Gao, Y Yin, S Yu, J Zou, J Liu, Q Zhang, Y Mu Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting &beta Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice Stem Cells Int, 2020-04-03;2020(0):4689798. 2020-04-03 [PMID: 32322278] (Bioassay, Human)	Bioassay	Human
M Yin, Y Guo, R Hu, WL Cai, Y Li, S Pei, H Sun, C Peng, J Li, R Ye, Q Yang, N Wang, Y Tao, X Chen, Q Yan Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction Nat Commun, 2020-04-14;11(1):1833. 2020-04-14 [PMID: 32286255] (Bioassay, Mouse)	Bioassay	Mouse
B Moukengue, HK Brown, C Charrier, S Battaglia, M Baud'huin, T Quillard, TM Pham, IS Pateras, VG Gorgoulis, T Helleday, D Heymann, UW Berglund, B Ory, F Lamoureux TH1579, MTH1 inhibitor, delays tumour growth and inhibits metastases development in osteosarcoma model EBioMedicine, 2020-03-07;53(0):102704. 2020-03-07 [PMID: 32151797] (Bioassay, Human)	Bioassay	Human
J Lubow, MC Virgilio, M Merlino, DR Collins, M Mashiba, BG Peterson, Z Lukic, MM Painter, F Gomez-Rive, V Terry, G Zimmerman, KL Collins Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages Elife, 2020-03-02;9(0):. 2020-03-02 [PMID: 32119644] (Bioassay, Human)	Bioassay	Human
V Sharma, M Makhdoomi, L Singh, P Kumar, N Khan, S Singh, HN Verma, K Luthra, S Sarkar, D Kumar Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block Autophagy, 2020-02-20;0(0):1-20. 2020-02-20 [PMID: 32079455] (Bioassay, Human)	Bioassay	Human
X Hu, S Goswami, J Qiu, Q Chen, S Laverdure, BT Sherman, T Imamichi Profiles of Long Non-Coding RNAs and mRNA Expression in Human Macrophages Regulated by Interleukin-27 Int J Mol Sci, 2019-12-09;20(24):. 2019-12-09 [PMID: 31835347] (Bioassay, Human)	Bioassay	Human
KA Lee, KW Kim, BM Kim, JY Won, HK Min, DW Lee, HR Kim, SH Lee Promotion of osteoclastogenesis by IL-26 in rheumatoid arthritis Arthritis Res. Ther., 2019-12-12;21(1):283. 2019-12-12 [PMID: 31831038] (Bioassay, Human)	Bioassay	Human
S Nagel, M Scherr, RAF MacLeod, C Pommerenke, M Koeppel, C Meyer, M Kaufmann, I Dallmann, HG Drexler NKL homeobox gene activities in normal and malignant myeloid cells PLoS ONE, 2019-12-11;14(12):e0226212. 2019-12-11 [PMID: 31825998] (Bioassay, Human)	Bioassay	Human
MR Lee, LY Chang, CH Chang, BS Yan, JY Wang, WH Lin Differed IL-1 Beta Response between Active TB and LTBI Cases by Ex Vivo Stimulation of Human Monocyte-Derived Macrophage with TB-Specific Antigen Dis. Markers, 2019-10-29;2019(0):7869576. 2019-10-29 [PMID: 31781307] (Cell Culture, Human)	Cell Culture	Human
K Li, S Chen, P Cai, K Chen, L Li, X Yang, J Yi, X Luo, Y Du, H Zheng MiRNA-483-5p is involved in the pathogenesis of osteoporosis by promoting osteoclast differentiation Mol. Cell. Probes, 2019-11-06;0(0):101479. 2019-11-06 [PMID: 31706013] (Cell Culture, Human)	Cell Culture	Human
N Berges, MS Nawaz, T Børresdatt, L Hagen, M Bjørås, JK Laerdahl, I Alseth Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform PLoS ONE, 2019-11-08;14(11):e0225081. 2019-11-08 [PMID: 31703097] (Cell Culture, Human)	Cell Culture	Human
N Chiang, S Libreros, PC Norris, X de la Rosa, CN Serhan Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions J. Clin. Invest., 2019-12-02;0(0):. 2019-12-02 [PMID: 31657786] (Cell Culture, Human)	Cell Culture	Human
R Xu, Y Li, H Yan, E Zhang, X Huang, Q Chen, J Chen, J Qu, Y Liu, J He, Q Yi, Z Cai CCL2 promotes macrophages-associated chemoresistance via MCPIP1 dual catalytic activities in multiple myeloma Cell Death Dis, 2019-10-14;10(10):781. 2019-10-14 [PMID: 31611552] (Bioassay, Human)	Bioassay	Human
C Liang, J Li, C Lu, D Xie, J Liu, C Zhong, X Wu, R Dai, H Zhang, D Guan, B Guo, B He, F Li, X He, W Zhang, BT Zhang, G Zhang, A Lu HIF1alpha inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis Nat Commun, 2019-10-08;10(1):4579. 2019-10-08 [PMID: 31594926] (Bioassay, Human)	Bioassay	Human
S Gooding, SWZ Olechnowic, EV Morris, AE Armitage, J Arezes, J Frost, E Repapi, JR Edwards, N Ashley, C Waugh, N Gray, E Martinez-H, PJ Lim, SR Pasricha, H Knowles, AJ Mead, K Ramasamy, H Drakesmith, CM Edwards Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease Nat Commun, 2019-10-04;10(1):4533. 2019-10-04 [PMID: 31586071] (Bioassay, Human)	Bioassay	Human
Y Zhao, X Ni, P Xu, Q Liu, T Sun, X Liu, X Ji, J Qiu, J Li, S Wang, P Han, J Peng, M Hou, G Li Interleukin-37 reduces inflammation and impairs phagocytosis of platelets in immune thrombocytopenia (ITP) Cytokine, 2019-09-23;125(0):154853. 2019-09-23 [PMID: 31557634] (Bioassay, Human)	Bioassay	Human
VA Salazar, J Arranz-Tru, G Prats-Ejar, M Torrent, D Andreu, D Pulido, E Boix Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides Int J Mol Sci, 2019-09-14;20(18):. 2019-09-14 [PMID: 31540052] (Bioassay, Human)	Bioassay	Human
W Wheat, L Chow, A Kuzmik, S Soontarara, J Kurihara, M Lappin, S Dow Local immune and microbiological responses to mucosal administration of a Liposome-TLR agonist immunotherapeutic in dogs BMC Vet. Res., 2019-09-13;15(1):330. 2019-09-13 [PMID: 31519215] (Bioassay, Canine)	Bioassay	Canine
MF Wu, CC Shu, JY Wang, BS Yan, HC Lai, BL Chiang, LS Wu, CJ Yu NLRP3 inflammasome is attenuated in patients with Mycobacterium avium complex lung disease and correlated with decreased interleukin-1 β response and host susceptibility Sci Rep, 2019-08-29;9(1):12534. 2019-08-29 [PMID: 31467293] (Bioassay, Human)	Bioassay	Human
P R Andrade, M Mehta, J Lu, R M B Teles, D Montoya, P O Scumpia, E Nunes Sarn, MT Ochoa, F Ma, M Pellegrini, RL Modlin The cell fate regulator NUPR1 is induced by Mycobacterium leprae via type I interferon in human leprosy PLoS Negl Trop Dis, 2019-07-25;13(7):e0007589. 2019-07-25 [PMID: 31344041] (Bioassay, Human)	Bioassay	Human
FL Collins, MD Stone, J Turton, LR McCabe, ECY Wang, AS Williams Oestrogen-deficiency induces bone loss by modulating CD14+ monocyte and CD4+ T cell DR3 expression and serum TL1A levels BMC Musculoskelet Disord, 2019-07-12;20(1):326. 2019-07-12 [PMID: 31299941] (Bioassay, Human)	Bioassay	Human
MI Koehler, ES Hartmann, S Schluessel, F Beck, JI Redeker, B Schmitt, M Unger, M van Griens, B Summer, A Fottner, S Mayer-Wagn Impact of Periprosthetic Fibroblast-Like Cells on Osteoclastogenesis in Co-Culture with Peripheral Blood Mononuclear Cells Varies Depending on Culture System Int J Mol Sci, 2019-05-26;20(10):. 2019-05-26 [PMID: 31130703] (Bioassay, Human)	Bioassay	Human
Z Zhang, H Li, Z Zhao, B Gao, L Meng, X Feng miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom Taiwan J Obstet Gynecol, 2019-05-01;58(3):401-408. 2019-05-01 [PMID: 31122533] (Bioassay, Human)	Bioassay	Human
E Braun, D Hotter, L Koepke, F Zech, R Gro beta , KMJ Sparrer, JA Müller, CK Pfaller, E Heusinger, R Wombacher, K Sutter, U Dittmer, M Winkler, G Simmons, MR Jakobsen, KK Conzelmann, S Pöhlmann, J Münch, OT Fackler, F Kirchhoff, D Sauter Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins Cell Rep, 2019-05-14;27(7):2092-2104.e10. 2019-05-14 [PMID: 31091448] (cell differentiation, Human)	cell differentiation	Human
AT Dang, RM Teles, DI Weiss, K Parvatiyar, EN Sarno, MT Ochoa, G Cheng, M Gilliet, BR Bloom, RL Modlin IL-26 contributes to host defense against intracellular bacteria J. Clin. Invest., 2019-04-02;129(5):1926-1939. 2019-04-02 [PMID: 30939123] (Bioassay, Human)	Bioassay	Human
DJ Montoya, P Andrade, BJA Silva, RMB Teles, F Ma, B Bryson, S Sadanand, T Noel, J Lu, E Sarno, KB Arnvig, D Young, R Lahiri, DL Williams, S Fortune, BR Bloom, M Pellegrini, RL Modlin Dual RNA-Seq of Human Leprosy Lesions Identifies Bacterial Determinants Linked to Host Immune Response Cell Rep, 2019-03-26;26(13):3574-3585.e3. 2019-03-26 [PMID: 30917313] (Bioassay, Human)	Bioassay	Human
S Ashraf, M Radhi, P Gowler, JJ Burston, RD Gandhi, GJ Thorn, AM Piccinini, DA Walsh, V Chapman, CH de Moor The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis Sci Rep, 2019-03-18;9(1):4696. 2019-03-18 [PMID: 30886197] (Bioassay, Human)	Bioassay	Human
A Skjesol, M Yurchenko, K Bösl, C Gravastran, KE Nilsen, LM Grøvdal, F Agliano, F Patane, G Lentini, H Kim, G Teti, A Kumar Shar, RK Kandasamy, B Sporsheim, KK Starheim, DT Golenbock, H Stenmark, M McCaffrey, T Espevik, H Husebye The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 PLoS Pathog., 2019-03-18;15(3):e1007684. 2019-03-18 [PMID: 30883606] (Bioassay, Human)	Bioassay	Human
P Martine, A Chevriaux, V Derangère, L Apetoh, C Garrido, F Ghiringhel, C Rébé HSP70 is a negative regulator of NLRP3 inflammasome activation Cell Death Dis, 2019-03-15;10(4):256. 2019-03-15 [PMID: 30874540] (Bioassay, Mouse)	Bioassay	Mouse
F De Santis, N Poerio, A Gismondi, V Nanni, G Di Marco, R Nisini, MC Thaller, A Canini, M Fraziano Hydroalcoholic extract from Origanum vulgare induces a combined anti-mycobacterial and anti-inflammatory response in innate immune cells PLoS ONE, 2019-03-04;14(3):e0213150. 2019-03-04 [PMID: 30830942] (Bioassay, Human)	Bioassay	Human
H Löfvall, A Katri, A D?browska, MA Karsdal, Y Luo, Y He, T Manon-Jens, MH Dziegiel, AC Bay-Jensen, CS Thudium, K Henriksen GPDPLQ1237-A Type II Collagen Neo-Epitope Biomarker of Osteoclast- and Inflammation-Derived Cartilage Degradation in vitro Sci Rep, 2019-02-28;9(1):3050. 2019-02-28 [PMID: 30816326] (Bioassay, Human)	Bioassay	Human
F Beck, ES Hartmann, MI Koehler, JI Redeker, S Schluessel, B Schmitt, A Fottner, M Unger, M van Griens, J Michael, B Summer, KH Kunzelmann, R Beutner, D Scharnwebe, PJ Kostenuik, S Mayer-Wagn Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes Int J Mol Sci, 2019-02-26;20(5):. 2019-02-26 [PMID: 30813507] (Bioassay, Human)	Bioassay	Human
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T Plitnik, ME Sharkey, B Mahboubi, B Kim, M Stevenson Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection Pathog Immun, 2018-12-06;3(2):197-223. 2018-12-06 [PMID: 30656243] (Bioassay, Human)	Bioassay	Human
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A Hyder, S Ehnert, F Fändrich, H Ungefroren Transfection of Peripheral Blood Monocytes with SOX2 Enhances Multipotency, Proliferation, and Redifferentiation into Neohepatocytes and Insulin-Producing Cells Stem Cells Int, 2018-10-04;2018(0):4271875. 2018-10-04 [PMID: 30402109] (Bioassay, Human)	Bioassay	Human
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AMJ Møller, EM Füchtbauer, A Brüel, TL Andersen, XG Borggaard, NJ Pavlos, JS Thomsen, FS Pedersen, JM Delaisse, K Søe Septins are critical regulators of osteoclastic bone resorption Sci Rep, 2018-08-29;8(1):13016. 2018-08-29 [PMID: 30158637] (Bioassay, Human)	Bioassay	Human
H Nakano, Y Kirino, M Takeno, K Higashitan, H Nagai, R Yoshimi, Y Yamaguchi, I Kato, I Aoki, H Nakajima GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Beh�et's disease Arthritis Res. Ther., 2018-06-12;20(1):124. 2018-06-12 [PMID: 29895319] (Bioassay, Human)	Bioassay	Human
Maria J Forteza, Konstantinos A Polyzos, Roland Baumgartn, Bianca E Suur, Marion Mussbache, Daniel K Johansson, Andreas Hermansso, Göran K Hansson, Daniel F J Ketelhuth Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice. Frontiers in Immunology, 2018-05-07;0(0):1664-3224. 2018-05-07 [PMID: 29867939] (Bioassay, Human)	Bioassay	Human
R Berndt, L Hummitzsch, K He beta , M Albrecht, K Zitta, R Rusch, B Sarras, A Bayer, J Cremer, F Faendrich, J Gro beta Allogeneic transplantation of programmable cells of monocytic origin (PCMO) improves angiogenesis and tissue recovery in critical limb ischemia (CLI): a translational approach Stem Cell Res Ther, 2018-04-27;9(1):117. 2018-04-27 [PMID: 29703251] (Bioassay, Human)	Bioassay	Human
CF Kjelgaard-, A Platt, M Braddock, MA Jenkins, K Musa, E Graham, T Gantzel, G Slynn, ME Weinblatt, MA Karsdal, CS Thudium, AC Bay-Jensen Translational Biomarkers and Ex Vivo Models of Joint Tissues as a Tool for Drug Development in Rheumatoid Arthritis Arthritis & rheumatology (Hoboken, N.J.), 2018-07-24;0(0):. 2018-07-24 [PMID: 29669391] (Cell Culture, Human)	Cell Culture	Human
J Costa-Rodr, MH Fernandes, O Pinho, PRR Monteiro Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene J. Nutr. Biochem., 2018-03-15;57(0):26-34. 2018-03-15 [PMID: 29655028] (Bioassay, Human)	Bioassay	Human
D Kishimoto, Y Kirino, M Tamura, M Takeno, Y Kunishita, K Takase-Min, H Nakano, I Kato, K Nagahama, R Yoshimi, K Igarashi, I Aoki, H Nakajima Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons Arthritis Res. Ther., 2018-04-10;20(1):64. 2018-04-10 [PMID: 29636091] (Bioassay, Human)	Bioassay	Human
K Matsuoka, Y Kohara, Y Naoe, A Watanabe, M Ito, K Ikeda, S Takeshita WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation J. Bone Miner. Res., 2018-05-11;0(0):. 2018-05-11 [PMID: 29624737] (Bioassay, Mouse)	Bioassay	Mouse
N Fournier, E Jacque, A Fontayne, D Derache, G Dupont, L Verhaeghe, L Baptista, A Dehenne, AS Dezetter, A Terrier, A Longue, V Pochet-Beg, C Beghin, S Chtourou, C de Romeuf Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern MAbs, 2018-04-10;0(0):1-37. 2018-04-10 [PMID: 29553870] (Bioassay, Human)	Bioassay	Human
B Meltzer, D Dabbagh, J Guo, F Kashanchi, M Tyagi, Y Wu Tat controls transcriptional persistence of unintegrated HIV genome in primary human macrophages Virology, 2018-03-15;518(0):241-252. 2018-03-15 [PMID: 29549786] (Bioassay, Human)	Bioassay	Human
X Jin, H Xu, MS McGrath Methylglyoxal-bis-guanylhydrazone inhibits osteopontin expression and differentiation in cultured human monocytes PLoS ONE, 2018-03-14;13(3):e0192680. 2018-03-14 [PMID: 29538412] (Bioassay, Human)	Bioassay	Human
M Viaud, S Ivanov, N Vujic, M Duta-Mare, LE Aira, T Barouillet, E Garcia, F Orange, I Dugail, I Hainault, C Stehlik, S Marchetti, L Boyer, R Guinamard, F Foufelle, AE Bochem, KG Hovingh, EB Thorp, EL Gautier, D Kratky, PA Da Silva-J, L Yvan-Charv Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production Circ. Res., 2018-03-09;0(0):. 2018-03-09 [PMID: 29523554] (Bioassay, Human)	Bioassay	Human
H Singleton, SP Graham, JP Frossard, KB Bodman-Smi, F Steinbach Infection of monocytes with European porcine reproductive and respiratory syndrome virus (PRRSV-1) strain Lena is significantly enhanced by dexamethasone and IL-10 Virology, 2018-03-02;0(0):. 2018-03-02 [PMID: 29502802] (Bioassay, Porcine)	Bioassay	Porcine
T Prabakaran, C Bodda, C Krapp, BC Zhang, MH Christense, C Sun, L Reinert, Y Cai, SB Jensen, MK Skouboe, JR Nyengaard, CB Thompson, RJ Lebbink, GC Sen, G van Loo, R Nielsen, M Komatsu, LN Nejsum, MR Jakobsen, M Gyrd-Hanse, SR Paludan Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1 EMBO J., 2018-03-01;0(0):. 2018-03-01 [PMID: 29496741] (Bioassay, Human)	Bioassay	Human
C Li, Y Wang, Y Li, Q Yu, X Jin, X Wang, A Jia, Y Hu, L Han, J Wang, H Yang, D Yan, Y Bi, G Liu HIF1?-dependent glycolysis promotes macrophage functional activities in protecting against bacterial and fungal infection Sci Rep, 2018-02-26;8(1):3603. 2018-02-26 [PMID: 29483608] (Bioassay, Human)	Bioassay	Human
M Yurchenko, A Skjesol, L Ryan, GM Richard, RK Kandasamy, N Wang, C Terhorst, H Husebye, T Espevik SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages J. Cell Biol., 2018-02-12;0(0):. 2018-02-12 [PMID: 29440514] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
H Hussein, P Boyaka, J Dulin, D Russell, L Smanik, M Azab, AL Bertone Cathepsin K Localizes to Equine Boneand Inhibits Bone Marrow Stem and Progenitor Cells Differentiation J Stem Cells Regen Med, 2017-12-18;13(2):45-53. 2017-12-18 [PMID: 29391749] (Bioassay, Equine)	Bioassay	Equine
CJ Korbee, MT Heemskerk, D Kocev, E van Strije, O Rabiee, KLMC Franken, L Wilson, NDL Savage, S Džeroski, MC Haks, THM Ottenhoff Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials Nat Commun, 2018-01-24;9(1):358. 2018-01-24 [PMID: 29367740] (Bioassay, Human)	Bioassay	Human
SP Mukherjee, O Bondarenko, P Kohonen, FT Andón, T Brzicová, I Gessner, S Mathur, M Bottini, P Calligari, L Stella, E Kisin, A Shvedova, R Autio, H Salminen-M, R Lahesmaa, B Fadeel Macrophage sensing of single-walled carbon nanotubes via Toll-like receptors Sci Rep, 2018-01-18;8(1):1115. 2018-01-18 [PMID: 29348435] (Bioassay, Human)	Bioassay	Human
T Do, R Tan, M Bennett, M Medvedovic, AA Grom, N Shen, S Thornton, GS Schulert MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms J. Leukoc. Biol., 2017-12-29;103(1):71-85. 2017-12-29 [PMID: 29345059] (Bioassay, Human)	Bioassay	Human
R Yang, M Wu, S Lin, RP Nargund, X Li, T Kelly, L Yan, G Dai, Y Qian, Q Dallas-Yan, PA Fischer, Y Cui, X Shen, P Huo, DD Feng, MD Erion, DE Kelley, J Mu A glucose-responsive insulin therapy protects animals against hypoglycemia JCI Insight, 2018-01-11;3(1):. 2018-01-11 [PMID: 29321379] (Bioassay, Human)	Bioassay	Human
M Kostine, IH Briaire-de, AHG Cleven, C Vervat, WE Corver, MW Schilham, E Van Beelen, H van Boven, RL Haas, A Italiano, AM Cleton-Jan, JVMG Bovée Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies Oncoimmunology, 2017-10-26;7(2):e1386828. 2017-10-26 [PMID: 29308311] (Cell Culture, Human)	Cell Culture	Human
H Di, JC Madden, EK Morantz, HY Tang, RL Graham, RS Baric, MA Brinton Expanded subgenomic mRNA transcriptome and coding capacity of a nidovirus Proc. Natl. Acad. Sci. U.S.A., 2017-10-04;114(42):E8895-E8904. 2017-10-04 [PMID: 29073030] (Bioassay, Primate)	Bioassay	Primate
ST Chen, FJ Li, TY Hsu, SM Liang, YC Yeh, WY Liao, TY Chou, NJ Chen, M Hsiao, WB Yang, SL Hsieh CLEC5A is a critical receptor in innate immunity against Listeria infection Nat Commun, 2017-08-21;8(1):299. 2017-08-21 [PMID: 28824166] (Bioassay, Human)	Bioassay	Human
L Stenberg, M Stö beta el, G Ronchi, S Geuna, Y Yin, S Mommert, L Mårtensson, J Metzen, C Grothe, LB Dahlin, K Haastert-T Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides BMC Neurosci, 2017-07-18;18(1):53. 2017-07-18 [PMID: 28720074] (Bioassay, Human)	Bioassay	Human
N Gajanayaka, S O'Hara, Y Konarski, J Fernandes, K Muthumani, M Kozlowski, JB Angel, A Kumar HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways J. Leukoc. Biol., 2017-07-11;0(0):. 2017-07-11 [PMID: 28698313] (Bioassay, Human)	Bioassay	Human
NR Roan, N Sandi-Monr, N Kohgadai, SM Usmani, KG Hamil, J Neidleman, M Montano, L Ständker, A Röcker, M Cavrois, J Rosen, K Marson, JF Smith, CD Pilcher, F Gagsteiger, O Sakk, M O'Rand, PV Lishko, F Kirchhoff, J Münch, WC Greene Semen amyloids participate in spermatozoa selection and clearance Elife, 2017-06-27;6(0):. 2017-06-27 [PMID: 28653619] (Bioassay, Human)	Bioassay	Human
A Sucur, Z Jajic, M Artukovic, MI Matijasevi, B Anic, D Flegar, A Markotic, T Kelava, S Ivcevic, N Kovacic, V Katavic, D Grcevic Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells Arthritis Res. Ther., 2017-06-15;19(1):142. 2017-06-15 [PMID: 28619088] (Bioassay, Human)	Bioassay	Human
EL Stattin, P Henning, J Klar, E McDermott, C Stecksen-B, PE Sandström, TG Kellgren, P Rydén, G Hallmans, T Lönnerholm, A Ameur, MH Helfrich, FP Coxon, N Dahl, J Wikström, UH Lerner SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts Sci Rep, 2017-06-07;7(1):3012. 2017-06-07 [PMID: 28592808] (Bioassay, Human)	Bioassay	Human
S Vollmer, S Strickson, T Zhang, N Gray, K Lee, V Rao, P Cohen The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-Like receptor agonists Biochem. J., 2017-06-06;0(0):. 2017-06-06 [PMID: 28512203] (Bioassay, Human)	Bioassay	Human
MV Baranov, NH Revelo, DRJ Verboogen, M Ter Beest, G van den Bo SWAP70 is a universal GEF-like adapter for tethering actin to phagosomes Small GTPases, 2018-02-09;0(0):0. 2018-02-09 [PMID: 28489960] (Bioassay, Mouse)	Bioassay	Mouse
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G Chinetti-G, M Daoudi, M Rosa, M Vinod, L Louvet, C Copin, M Fanchon, J Vanhoutte, B Derudas, L Belloy, S Haulon, C Zawadzki, S Susen, ZA Massy, J Eeckhoute, B Staels Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity Circ. Res., 2017-04-24;0(0):. 2017-04-24 [PMID: 28438779] (Bioassay, Human)	Bioassay	Human
PA Hulley, T Bishop, A Vernet, JE Schneider, JR Edwards, NA Athanasou, HJ Knowles Hypoxia-Inducible Factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2 J. Pathol., 2017-05-29;0(0):. 2017-05-29 [PMID: 28418093] (Bioassay, Human)	Bioassay	Human
KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity Nat. Immunol., 2017-04-17;0(0):. 2017-04-17 [PMID: 28414311] (Bioassay, Human)	Bioassay	Human
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A Kamalakar, CL Washam, NS Akel, BJ Allen, DK Williams, FL Swain, K Leitzel, A Lipton, D Gaddy, LJ Suva PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan J. Bone Miner. Res., 2017-04-19;0(0):. 2017-04-19 [PMID: 28370412] (Bioassay, Human)	Bioassay	Human
AJ Martins, M Narayanan, T Prüstel, B Fixsen, K Park, RA Gottschalk, Y Lu, C Andrews-Pf, WW Lau, KV Wendelsdor, JS Tsang Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network Cell Syst, 2017-03-29;0(0):. 2017-03-29 [PMID: 28365150] (Bioassay, Human)	Bioassay	Human
DC Thomas, S Clare, JM Sowerby, M Pardo, JK Juss, DA Goulding, L van der We, D Storistean, A Prakash, M Espéli, S Flint, JC Lee, K Hoenderdos, L Kane, K Harcourt, S Mukhopadhy, Y Umrania, R Antrobus, JA Nathan, DJ Adams, A Bateman, JS Choudhary, PA Lyons, AM Condliffe, ER Chilvers, G Dougan, KG Smith Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity J. Exp. Med, 2017-03-28;0(0):. 2017-03-28 [PMID: 28351984] (Bioassay, Human)	Bioassay	Human
RD Stultz, JJ Cenker, D McDonald Imaging HIV-1 Genomic DNA from Entry through Productive Infection J. Virol, 2017-04-13;0(0):. 2017-04-13 [PMID: 28250118] (Bioassay, Human)	Bioassay	Human
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JE Hammonds, N Beeman, L Ding, S Takushi, AC Francis, JJ Wang, GB Melikyan, P Spearman Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1 PLoS Pathog, 2017-01-27;13(1):e1006181. 2017-01-27 [PMID: 28129379] (Bioassay, Human)	Bioassay	Human
MJ Bae, S Ryu, HJ Kim, SI Cha, CH Kim, J Lee Mycobacterium tuberculosis ESAT6 and CPF10 Induce Adenosine Deaminase 2 mRNA Expression in Monocyte-Derived Macrophages Tuberc Respir Dis (Seoul), 2016-12-30;80(1):77-82. 2016-12-30 [PMID: 28119750] (Bioassay, Human)	Bioassay	Human
Nkx2-5 Is Expressed in Atherosclerotic Plaques and Attenuates Development of Atherosclerosis in Apolipoprotein E-Deficient Mice J Am Heart Assoc, 2016-12-19;5(12):. 2016-12-19 [PMID: 27993833] (Bioassay, Human)	Bioassay	Human
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oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages PLoS ONE, 2016-11-21;11(11):e0166798. 2016-11-21 [PMID: 27870891] (Bioassay, Human)	Bioassay	Human
Mark L Chiu Fc engineering approaches to enhance the agonism and effector functions of an anti-OX40 antibody J. Biol. Chem., 2016-11-17;0(0):. 2016-11-17 [PMID: 27856634] (Bioassay, Human)	Bioassay	Human
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Imprime PGG-Mediated Anti-Cancer Immune Activation Requires Immune Complex Formation PLoS ONE, 2016-11-03;11(11):e0165909. 2016-11-03 [PMID: 27812183] (Bioassay, Human)	Bioassay	Human
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease Sci Rep, 2016-10-14;6(0):35282. 2016-10-14 [PMID: 27739482] (Bioassay, Human)	Bioassay	Human
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype Nat Immunol, 2016-09-12;0(0):. 2016-09-12 [PMID: 27618552] (Bioassay, Human)	Bioassay	Human
Curcumin inhibits osteoclastogenic potential in PBMCs from rheumatoid arthritis patients via the suppression of MAPK/RANK/c-Fos/NFATc1 signaling pathways Mol Med Rep, 2016-08-25;14(4):3620-6. 2016-08-25 [PMID: 27572279] (Bioassay, Human)	Bioassay	Human
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Yasunori Omata Identification of Nedd9 as a TGF-?-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis PLoS ONE, 2016-06-23;11(6):e0157992. 2016-06-23 [PMID: 27336669] (Bioassay, Mouse)	Bioassay	Mouse
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Rhein B, Powers L, Rogers K, Anantpadma M, Singh B, Sakurai Y, Bair T, Miller-Hunt C, Sinn P, Davey R, Monick M, Maury W Interferon-gamma Inhibits Ebola Virus Infection. PLoS Pathog, 2015-11-12;11(11):e1005263. 2015-11-12 [PMID: 26562011] (Bioassay, Human)	Bioassay	Human
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Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, Cantatore FP, Tamma R, Rizzi R, Liso V, Zallone A, Grano M Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia, 2009-07-09;23(11):2139-46. 2009-07-09 [PMID: 19587706] (Bioassay, Human)	Bioassay	Human
Pytlik R, Stehlik D, Soukup T, Kalbacova M, Rypacek F, Trc T, Mulinkova K, Michnova P, Kideryova L, Zivny J, Klener P, Vesela R, Trneny M, Klener P The cultivation of human multipotent mesenchymal stromal cells in clinical grade medium for bone tissue engineering. Biomaterials, 2009-04-10;30(20):3415-27. 2009-04-10 [PMID: 19362364] (Bioassay, Human)	Bioassay	Human
Irie N, Takada Y, Watanabe Y, Matsuzaki Y, Naruse C, Asano M, Iwakura Y, Suda T, Matsuo K Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis. J. Biol. Chem., 2009-03-19;284(21):14637-44. 2009-03-19 [PMID: 19299512] (Bioassay, Mouse)	Bioassay	Mouse
Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone, 2009-03-02;44(6):1143-50. 2009-03-02 [PMID: 19264156] (Cell Culture, Human)	Cell Culture	Human
Mizutani K, Sud S, Pienta KJ Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts. J. Cell. Biochem., 2009-03-01;106(4):563-9. 2009-03-01 [PMID: 19170075] (Bioassay, Human)	Bioassay	Human
Mabilleau G, Sabokbar A Interleukin-32 promotes osteoclast differentiation but not osteoclast activation. PLoS ONE, 2009-01-12;4(1):e4173. 2009-01-12 [PMID: 19137064] (Bioassay, Human)	Bioassay	Human
Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis. Blood, 2008-12-05;113(9):1992-2002. 2008-12-05 [PMID: 19060246] (Bioassay, Human)	Bioassay	Human
Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts. Arthritis Rheum., 2008-12-01;58(12):3820-30. 2008-12-01 [PMID: 19035475] (Bioassay, Human)	Bioassay	Human
Savage ND, De Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J. Immunol., 2008-08-01;181(3):2220-6. 2008-08-01 [PMID: 18641362] (Bioassay, Human)	Bioassay	Human
Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C, Chauhan D, Okawa Y, Munshi NC, Richardson PG, Anderson KC Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia, 2008-07-03;22(10):1925-32. 2008-07-03 [PMID: 18596740] (Bioassay, Human)	Bioassay	Human
Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M Isolation and characterization of CD146+ multipotent mesenchymal stromal cells. Exp. Hematol., 2008-05-27;36(8):1035-46. 2008-05-27 [PMID: 18504067] (Bioassay, Human)	Bioassay	Human
Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications. Br. J. Haematol., 2008-04-07;141(5):598-606. 2008-04-07 [PMID: 18397345] (Bioassay, Human)	Bioassay	Human
Boissy P, Andersen TL, Lund T, Kupisiewicz K, Plesner T, Delaisse JM Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk. Res., 2008-04-18;32(11):1661-8. 2008-04-18 [PMID: 18394701] (Bioassay, Human)	Bioassay	Human
Clerin V, Shih HH, Deng N, Hebert G, Resmini C, Shields KM, Feldman JL, Winkler A, Albert L, Maganti V, Wong A, Paulsen JE, Keith JC, Vlasuk GP, Pittman DD Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis. Atherosclerosis, 2008-02-21;0(0):. 2008-02-21 [PMID: 18377911] (Bioassay, Human)	Bioassay	Human
Chamoux E, Houde N, L'Eriger K, Roux S Osteoprotegerin decreases human osteoclast apoptosis by inhibiting the TRAIL pathway. J. Cell. Physiol., 2008-08-01;216(2):536-42. 2008-08-01 [PMID: 18338379] (Bioassay, Human)	Bioassay	Human
Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 2008-02-15;83(5):1181-93. 2008-02-15 [PMID: 18281438] (Bioassay, Human)	Bioassay	Human
Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. Br. J. Haematol., 2007-10-01;139(1):55-63. 2007-10-01 [PMID: 17854307] (Bioassay, Human)	Bioassay	Human
Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis. J. Pathol., 2007-05-01;212(1):47-55. 2007-05-01 [PMID: 17370327] (Bioassay, Human)	Bioassay	Human
Tang CH, Hsu TL, Lin WW, Lai MZ, Yang RS, Hsieh SL, Fu WM Attenuation of bone mass and increase of osteoclast formation in decoy receptor 3 transgenic mice. J. Biol. Chem., 2006-11-10;282(4):2346-54. 2006-11-10 [PMID: 17099218] (Bioassay, Mouse)	Bioassay	Mouse
Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum., 2006-05-01;54(5):1451-62. 2006-05-01 [PMID: 16649193] (Bioassay, Human)	Bioassay	Human
de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts. J. Cell. Biochem., 2006-05-15;98(2):370-82. 2006-05-15 [PMID: 16440316] (Bioassay, Human)	Bioassay	Human
Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes. J. Immunol. Methods, 2005-11-21;308(1):138-55. 2005-11-21 [PMID: 16325847] (Bioassay, Primate - Chlorocebus pygerythrus (Vervet Monkey))	Bioassay	Primate - Chlorocebus pygerythrus (Vervet Monkey)
Roux S, Lambert-Comeau P, Saint-Pierre C, Lepine M, Sawan B, Parent JL Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis. Biochem. Biophys. Res. Commun., 2005-07-22;333(1):42-50. 2005-07-22 [PMID: 15936719] (Bioassay, Human)	Bioassay	Human
Wei S, Kitaura H, Zhou P, Ross FP, Teitelbaum SL IL-1 mediates TNF-induced osteoclastogenesis. J. Clin. Invest., 2005-02-01;115(2):282-90. 2005-02-01 [PMID: 15668736] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Sharif MN, Tassiulas I, Hu Y, Mecklenbrauker I, Tarakhovsky A, Ivashkiv LB IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis. J. Immunol., 2004-05-15;172(10):6476-81. 2004-05-15 [PMID: 15128840] (Bioassay, Human)	Bioassay	Human
Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J. Immunol., 2004-03-15;172(6):3678-85. 2004-03-15 [PMID: 15004171] (Bioassay, Mouse)	Bioassay	Mouse
Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB Reprogramming of IL-10 activity and signaling by IFN-gamma. J. Immunol., 2003-11-15;171(10):5034-41. 2003-11-15 [PMID: 14607900] (Bioassay, Human)	Bioassay	Human
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Array 216-MC/CF

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