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Recombinant Human IL-1 beta/IL-1F2 Protein, CF

Name: Recombinant Human IL-1 beta/IL-1F2 Protein, CF
Brand: Novus Biologicals
SKU: 201-LB/CF
Price: 294 USD

(544 Publications)

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Recombinant Human IL-1 beta /IL-1F2 (Catalog # 201-LB/CF) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is <12 pg/mL.

1 μg/lane of Recombinant Human IL-1 beta /IL-1F2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 17 kDa.

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	Bioactivity
Format	Carrier-Free

Order Details

View Available Formulations

Catalog# & Formulation	Size	Price
Standard Formulation 201-LB-005

Carrier Free 201-LB-025/CF

Carrier Free 201-LB-500/CF

Carrier Free 201-LB-100/CF

Carrier Free 201-LB-010/CF

Carrier Free 201-LB-01M/CF

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Recombinant Human IL-1 beta/IL-1F2 Protein, CF Summary

Details of Functionality	Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED₅₀ for this effect is <12 pg/mL.
Source	E. coli-derived human IL-1 beta/IL-1F2 protein Ala117-Ser269
Accession #	NP_000567
N-terminal Sequence	Ala117 & Pro118
Protein/Peptide Type	Recombinant Proteins
Gene	IL1B
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

17 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Publications

Read Publications using
201-LB/CF in the following applications:

Binding Assay
2 publications
Bioassay
460 publications
Cell Culture
49 publications
ELISA (Standard)
13 publications
ELISA Capture
3 publications
In Vivo
9 publications
Inhibition
1 publication
Stimulation
2 publications
Surface Plasmon Resonance
1 publication
Western Blot
1 publication
Western Blot Control
1 publication

Packaging, Storage & Formulations

Storage
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Purity	>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 50-200 μg/mL in sterile PBS.

Notes

This product is covered by U.S. patent: 5,681,933.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-1 beta/IL-1F2 Protein, CF

catabolin
IL1 beta
IL-1 beta
IL-1
IL1B
IL-1b
IL1-BETA
IL-1F2
IL1F2IL-1 beta
interleukin 1, beta
interleukin-1 beta
preinterleukin 1 beta
pro-interleukin-1-beta

Background

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI (1-4). The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine (5-7). The 17 kDa mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67%-78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta .

Allan, S.M. et al. (2005) Nat. Rev. Immunol. 5:629.
Boraschi, D. and A. Tagliabue (2006) Vitam. Horm. 74:229.
Kornman, K.S. (2006) Am. J. Clin. Nutr. 83:475S.
Isoda, K. and F. Ohsuzu (2006) J. Atheroscler. Thromb. 13:21.
March, C.J. et al. (1985) Nature 315:641.
Auron, P.E. et al. (1984) Proc. Natl. Acad. Sci. 81:7907.
Martinon, F. and J. Tschopp (2007) Cell Death Differ. 14:10.

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Recombinant Human
IL-1 beta/IL-1F2 Prot ...

201-LB/CF

Species: Hu

Applications: Bioactivity

Publications for IL-1 beta/IL-1F2 (201-LB/CF)(544)

We have publications tested in 13 confirmed species: Human, Mouse, Rat, Bovine, Canine, Guinea Pig, Hamster, N/A, Porcine, Primate - Chlorocebus pygerythrus (Vervet Monkey), Primate - Macaca mulatta (Rhesus Macaque), Primate - Pan troglodytes (Chimpanzee), Rabbit.

We have publications tested in 11 applications: Binding Assay, Bioassay, Cell Culture, ELISA (Standard), ELISA Capture, In Vivo, Inhibition, Stimulation, Surface Plasmon Resonance, Western Blot, Western Blot Control.

Showing Publications 1 - 10 of 544. Show All 544 Publications.

Publications using 201-LB/CF	Applications	Species
Ma, HY;Li, Q;Wong, WR;N'Diaye, EN;Caplazi, P;Bender, H;Huang, Z;Arlantico, A;Jeet, S;Wong, A;Emson, C;Brightbill, H;Tam, L;Newman, R;Roose-Girma, M;Sandoval, W;Ding, N; LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Science advances 2023-05-26 [PMID: 37235663] (Bioassay, Human)	Bioassay	Human
Cheng, RYS;Ridnour, LA;Wink, AL;Gonzalez, AL;Femino, EL;Rittscher, H;Somasundaram, V;Heinz, WF;Coutinho, L;Rangel, MC;Edmondson, EF;Butcher, D;Kinders, RJ;Li, X;Wong, STC;McVicar, DW;Anderson, SK;Pore, M;Hewitt, SM;Billiar, TR;Glynn, SA;Chang, JC;Lockett, SJ;Ambs, S;Wink, DA; Interferon-gamma is quintessential for NOS2 and COX2 expression in ER- breast tumors that lead to poor outcome Cell death & disease 2023-05-11 [PMID: 37169743] (Bioassay, Human)	Bioassay	Human
HR Lee, YJ Jeong, JW Lee, J Jhun, HS Na, KH Cho, SJ Kim, ML Cho, TH Heo Tannic acid, an IL-1beta-direct binding compound, ameliorates IL-1beta-induced inflammation and cartilage degradation by hindering IL-1beta-IL-1R1 interaction PLoS ONE, 2023;18(4):e0281834. 2023 [PMID: 37079558] (ELISA Capture, Human)	ELISA Capture	Human
HR Lee, YJ Jeong, JW Lee, J Jhun, HS Na, KH Cho, SJ Kim, ML Cho, TH Heo Tannic acid, an IL-1beta-direct binding compound, ameliorates IL-1beta-induced inflammation and cartilage degradation by hindering IL-1beta-IL-1R1 interaction PLoS ONE, 2023-04-20;18(4):e0281834. 2023-04-20 [PMID: 37079558] (ELISA Capture, Human)	ELISA Capture	Human
SY Chang, Y Ko, MJ Kim Regulatory mechanisms of kaempferol on iNOS expression in RINm5F beta-cells under exposure to interleukin-1beta Heliyon, 2023-03-23;9(4):e14818. 2023-03-23 [PMID: 37025778] (Cell Culture, Rat)	Cell Culture	Rat
SY Chang, Y Ko, MJ Kim Regulatory mechanisms of kaempferol on iNOS expression in RINm5F beta-cells under exposure to interleukin-1beta Heliyon, 2023;9(4):e14818. 2023 [PMID: 37025778] (Cell Culture, Rat)	Cell Culture	Rat
AA Perez-Sern, RS Dos Santos, C Ripoll, A Nadal, DL Eizirik, L Marroqui BCL-XL Overexpression Protects Pancreatic beta-Cells against Cytokine- and Palmitate-Induced Apoptosis International Journal of Molecular Sciences, 2023-03-16;24(6):. 2023-03-16 [PMID: 36982731] (Bioassay, Human, Rat)	Bioassay	Human, Rat
F Liu, S Zhan, P Zhang, C Jia, Q Zhu, Q Dai, M Yu, L Cheng, L Xiong, F Sun, P Xia, X Zhang, J Hu Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula Frontiers in Physiology, 2023-03-08;14(0):1138947. 2023-03-08 [PMID: 36969583] (Cell Culture, Human)	Cell Culture	Human
Y Ma, LM Ashander, B Appukuttan, FJ Ryan, ACR Tan, JM Matthews, MZ Michael, DJ Lynn, JR Smith Selective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte Binding International Journal of Molecular Sciences, 2023-02-07;24(4):. 2023-02-07 [PMID: 36834715] (Bioassay, Human)	Bioassay	Human
C Zhu, DM Potenza, Y Yang, G Ajalbert, KD Mertz, S von Gunten, XF Ming, Z Yang Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging Aging Cell, 2023-02-15;0(0):e13790. 2023-02-15 [PMID: 36794355] (Bioassay, Human)	Bioassay	Human
F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells bioRxiv : the preprint server for biology, 2023-02-13;0(0):. 2023-02-13 [PMID: 36789428] (Bioassay, Human)	Bioassay	Human
T Teafatille, SB Subramanya, N Lambrecht, VS Subramania Salmonella Typhimurium Infection Reduces the Ascorbic Acid Uptake in the Intestine Mediators of Inflammation, 2023-01-17;2023(0):2629262. 2023-01-17 [PMID: 36704315] (Bioassay, Human)	Bioassay	Human
H Qin, C Wang, Y He, A Lu, T Li, B Zhang, J Shen Silencing miR-146a-5p Protects against Injury-Induced Osteoarthritis in Mice Biomolecules, 2023-01-07;13(1):. 2023-01-07 [PMID: 36671508] (Cell Culture, Mouse)	Cell Culture	Mouse
L Cao, X Ma, J Zhang, M Yang, Z He, C Yang, S Li, P Rong, W Wang CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response Cell Transplantation, 2023-01-01;32(0):9636897221149. 2023-01-01 [PMID: 36644879] (Bioassay, Human)	Bioassay	Human
S Sim, DH Lee, KS Kim, HJ Park, YK Kim, Y Choi, HS Park Micrococcus luteus-derived extracellular vesicles attenuate neutrophilic asthma by regulating miRNAs in airway epithelial cells Experimental & Molecular Medicine, 2023-01-13;0(0):. 2023-01-13 [PMID: 36639716] (Bioassay, Human)	Bioassay	Human
DS Yoon, EJ Kim, S Cho, S Jung, KM Lee, KH Park, JW Lee, SH Kim RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes International journal of biological sciences, 2023-01-01;19(1):13-33. 2023-01-01 [PMID: 36594090] (Bioassay, Human)	Bioassay	Human
MS Ågren, T Litman, JO Eriksen, P Schjerling, M Bzorek, LMR Gjerdrum Gene Expression Linked to Reepithelialization of Human Skin Wounds International Journal of Molecular Sciences, 2022-12-12;23(24):. 2022-12-12 [PMID: 36555389] (Bioassay, Human)	Bioassay	Human
N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott, Y Zhang, K Johnson, J Shi, S Walter, Y Li, C Jacobi, N Laplanche, M Belaud, J Paul, G Glowacki, T Peters, KA Wharton, I Vostiar, F Polus, I Kramer, S Guth, A Seroutou, S Choudhury, D Laurent, J Gimbel, J Goldhahn, M Schieker, S Brachat, R Roubenoff, M Kneissel Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial Nature Medicine, 2022;0(0):. 2022 [PMID: 36456835] (Bioassay, Human)	Bioassay	Human
N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott, Y Zhang, K Johnson, J Shi, S Walter, Y Li, C Jacobi, N Laplanche, M Belaud, J Paul, G Glowacki, T Peters, KA Wharton, I Vostiar, F Polus, I Kramer, S Guth, A Seroutou, S Choudhury, D Laurent, J Gimbel, J Goldhahn, M Schieker, S Brachat, R Roubenoff, M Kneissel Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial Nature Medicine, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456835] (Bioassay, Human)	Bioassay	Human
HJ Kim, SH Kim, YS Oh, SR Lee, HD Chae Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study Biomedicines, 2022-11-21;10(11):. 2022-11-21 [PMID: 36428561] (Cell Culture, Human)	Cell Culture	Human
L Xu, X Niu, Y Liu, L Liu ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway Mediators of Inflammation, 2022-11-10;2022(0):4258742. 2022-11-10 [PMID: 36405992] (Bioassay, Human)	Bioassay	Human
S Kaur, C Frørup, AH Mirza, T Fløyel, R Yarani, ML Colli, J Johannesen, J Størling, DL Eizirik, F Pociot Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic beta Cells Non-coding RNA, 2022-10-12;8(5):. 2022-10-12 [PMID: 36287121] (Bioassay, Human)	Bioassay	Human
C Bouchet, G Cardouat, M Douard, F Coste, P Robillard, F Delcambre, T Ducret, JF Quignard, P Vacher, I Baudrimont, R Marthan, P Berger, C Guibert, V Freund-Mic Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-beta1-Dependent Mechanism Cells, 2022-09-07;11(18):. 2022-09-07 [PMID: 36139373] (Bioassay, Human)	Bioassay	Human
Y Mu, L Wang, L Fu, Q Li Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1beta-Induced Human Osteoarthritis Chondrocytes through NF-kappaB and NLRP3 Signal Pathway Mediators of Inflammation, 2022-09-12;2022(0):1870579. 2022-09-12 [PMID: 36133743] (Bioassay, Human)	Bioassay	Human
R Chandrasek, C Mathieu, R Sheth, AP Cheng, D Fong, R McCormack, H El-Gabalaw, S Alishetty, M Paige, CD Hoemann UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism PLoS ONE, 2022-09-15;17(9):e0274420. 2022-09-15 [PMID: 36107941] (Bioassay, Human)	Bioassay	Human
F Lemaître, N Farzam-Kia, A Carmena Mo, Y Carpentier, ML Clenet, O Tastet, A Cleret-Buh, JV Guimond, E Haddad, P Duquette, JM Girard, A Prat, C Larochelle, N Arbour IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes Journal of Neuroinflammation, 2022-09-01;19(1):212. 2022-09-01 [PMID: 36050707] (Bioassay, Human)	Bioassay	Human
C Cavallo, G Merli, N Zini, S D'Adamo, L Cattini, M Guescini, B Grigolo, A Di Martino, S Santi, RM Borzì, G Filardo Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-kappaB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis Stem Cells International, 2022-07-18;2022(0):9376338. 2022-07-18 [PMID: 35898656] (Bioassay, Human)	Bioassay	Human
J Xu, P Chen, X Luan, X Yuan, S Wei, Y Li, C Guo, X Wu, G Di The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-beta1 Expression in the Corneal Epithelium Investigative Ophthalmology & Visual Science, 2022-07-08;63(8):15. 2022-07-08 [PMID: 35838447] (Bioassay, Human)	Bioassay	Human
S Otani, T Kanamoto, S Oyama, S Yamakawa, W Shi, R Miyazaki, M Aihara, S Oka, S Kuroda, T Nakai, K Takenaka, Y Sato, M Tsukamoto, A Tsujii, K Ebina, S Okada, K Nakata Meniscus surface texture is associated with degenerative changes in biological and biomechanical properties Scientific Reports, 2022-07-13;12(1):11977. 2022-07-13 [PMID: 35831482] (Bioassay, Human)	Bioassay	Human
W Shi, T Kanamoto, M Aihara, S Oka, S Kuroda, T Nakai, T Mazuka, K Takenaka, Y Sato, M Tsukamoto, K Ebina, K Nakata Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration Scientific Reports, 2022-07-13;12(1):11970. 2022-07-13 [PMID: 35831407] (Bioassay, Human)	Bioassay	Human
Y Yao, R Li, D Liu, L Long, N He Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway Ecotoxicology and environmental safety, 2022-06-24;241(0):113773. 2022-06-24 [PMID: 35753269] (Bioassay, Human)	Bioassay	Human
MY Wang, CM Zhang, HH Zhou, ZB Ge, CC Su, ZH Lou, XY Zhang, TT Xu, SY Li, L Zhu, YL Zhou, Y Wu, SR Ji Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein Oncogene, 2022-06-17;0(0):102160. 2022-06-17 [PMID: 35724961] (Bioassay, Human)	Bioassay	Human
T Ungsudecha, S Honsawek, J Jittikoon, W Udomsinpra Clusterin exacerbates interleukin-1beta-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis Oncogene, 2022-06-15;12(1):9963. 2022-06-15 [PMID: 35705674] (Bioassay, Human)	Bioassay	Human
W Hsu, YT Shih, MS Lee, HY Huang, WN Wu Bead Number Effect in a Magnetic-Beads-Based Digital Microfluidic Immunoassay Biosensors, 2022-05-16;12(5):. 2022-05-16 [PMID: 35624641] (ELISA Capture, Human)	ELISA Capture	Human
M Yu, X Wu, J Wang, M He, H Han, S Hu, J Xu, M Yang, Q Tan, Y Wang, H Wang, W Xie, H Kong Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-kappaB pathways International Journal of Medical Sciences, 2022-03-28;19(4):681-694. 2022-03-28 [PMID: 35582418] (Bioassay, Human)	Bioassay	Human
R Boi, K Ebefors, M Henricsson, J Borén, J Nyström Modified lipid metabolism and cytosolic phospholipase A2 activation in mesangial cells under pro-inflammatory conditions Scientific Reports, 2022-05-05;12(1):7322. 2022-05-05 [PMID: 35513427] (Cell Culture, Human)	Cell Culture	Human
A Shetty, SK Tripathi, S Junttila, T Buchacher, R Biradar, SD Bhosale, T Envall, A Laiho, R Moulder, O Rasool, S Galande, LL Elo, R Lahesmaa A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation Nucleic Acids Research, 2022-05-20;50(9):4938-4958. 2022-05-20 [PMID: 35511484] (Bioassay, Human)	Bioassay	Human
Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model Cell Reports, 2022-04-12;39(2):110670. 2022-04-12 [PMID: 35417708] (Bioassay, Human)	Bioassay	Human
R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation Cell Reports, 2022-04-12;39(2):110646. 2022-04-12 [PMID: 35417687] (Bioassay, Human)	Bioassay	Human
T Lehtola, E Nummenmaa, L Tuure, M Hämäläinen, RM Nieminen, T Moilanen, A Pemmari, E Moilanen Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1 International Journal of Molecular Sciences, 2022-03-31;23(7):. 2022-03-31 [PMID: 35409238] (Bioassay, Human)	Bioassay	Human
ML Yang, S Horstman, R Gee, P Guyer, TT Lam, J Kanyo, AL Perdigoto, C Speake, CJ Greenbaum, A Callebaut, L Overbergh, RG Kibbey, KC Herold, EA James, MJ Mamula Citrullination of glucokinase is linked to autoimmune diabetes Nature Communications, 2022-04-06;13(1):1870. 2022-04-06 [PMID: 35388005] (Bioassay, Rat)	Bioassay	Rat
PM Varghese, U Kishore, R Rajkumari Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain International Journal of Molecular Sciences, 2022-03-11;23(6):. 2022-03-11 [PMID: 35328462] (Bioassay, Human)	Bioassay	Human
P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-03-11;14(6):. 2022-03-11 [PMID: 35326601] (Cell Culture, Human)	Cell Culture	Human
JFS Pereira, C Bessa, P Matos, P Jordan Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells Cancers, 2022-03-09;14(6):. 2022-03-09 [PMID: 35326545] (Cell Culture, Human)	Cell Culture	Human
S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against Tï¿½cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Human)	Cell Culture	Human
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)	Bioassay	Human
N Rana, S Suliman, N Al-Sharabi, K Mustafa Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization Cells, 2022-01-29;11(3):. 2022-01-29 [PMID: 35159282] (Bioassay, Human)	Bioassay	Human
X Wang, J Zhang, J Ji IL?1beta?induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL?1beta antagonists Molecular Medicine Reports, 2022-02-09;25(4):. 2022-02-09 [PMID: 35137920] (Bioassay, Human)	Bioassay	Human
M Horita, SN Hsu, A Raper, C Farquharso, LA Stephen miR-29b inhibits TGF-beta1-induced cell proliferation in articular chondrocytes Biochemistry and Biophysics Reports, 2022-01-24;29(0):101216. 2022-01-24 [PMID: 35128082] (Bioassay, Human)	Bioassay	Human
F D'Addio, A Maestroni, E Assi, M Ben Nasr, G Amabile, V Usuelli, C Loretelli, F Bertuzzi, B Antonioli, F Cardarelli, B El Essawy, A Solini, IC Gerling, C Bianchi, G Becchi, S Mazzucchel, D Corradi, GP Fadini, D Foschi, JF Markmann, E Orsi, J Škrha, MG Camboni, R Abdi, AM James Shap, F Folli, J Ludvigsson, S Del Prato, G Zuccotti, P Fiorina The IGFBP3/TMEM219 pathway regulates beta cell homeostasis Nature Communications, 2022-02-03;13(1):684. 2022-02-03 [PMID: 35115561] (Bioassay, Human)	Bioassay	Human
JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication Oncogene, 2021-12-31;0(0):101430. 2021-12-31 [PMID: 34979329] (Bioassay, Human)	Bioassay	Human
A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma Biomedicines, 2021-12-16;9(12):. 2021-12-16 [PMID: 34944746] (Bioassay, Human)	Bioassay	Human
PM Panipinto, AK Singh, FS Shaikh, RJ Siegel, M Chourasia, S Ahmed Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway International Journal of Molecular Sciences, 2021-11-22;22(22):. 2021-11-22 [PMID: 34830460] (Bioassay, Human)	Bioassay	Human
A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets Cell Reports, 2021-11-23;37(8):110037. 2021-11-23 [PMID: 34818536] (Bioassay, Human)	Bioassay	Human
SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)	Bioassay	Human
C Xu, J Tang, Q Yang, H Zhao, Y Liu, J Cao, Y Zhou, X Chen, J Chen Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling The Journal of Biological Chemistry, 2021-11-03;0(0):101380. 2021-11-03 [PMID: 34740611] (Bioassay, Human)	Bioassay	Human
C Gao, J Deng, H Zhang, X Li, S Gu, M Zheng, M Tang, Y Zhu, X Lin, J Jin, L Zhang, J Huang, J Zou, ZP Xia, PL Xu, L Shen, B Zhao, XH Feng HSPA13 facilitates NF-kappaB-mediated transcription and attenuates cell death responses in TNFalpha signaling Science Advances, 2021-10-06;7(41):eabh1756. 2021-10-06 [PMID: 34613781] (Bioassay, Human)	Bioassay	Human
P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Nature methods, 2021-09-30;18(10):1181-1191. 2021-09-30 [PMID: 34594031] (Bioassay, Human)	Bioassay	Human
X He, S Li, J Zhang, L Cao, C Yang, P Rong, S Yi, K Ghimire, X Ma, W Wang Benefit of Belatacept in Cord Blood-Derived Regulatory T Cell-Mediated Suppression of Alloimmune Response Cell Transplantation, 2021-01-01;30(0):9636897211046. 2021-01-01 [PMID: 34570631] (Bioassay, Human)	Bioassay	Human
JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation Frontiers in Cellular Neuroscience, 2021-09-07;15(0):683687. 2021-09-07 [PMID: 34557075] (Bioassay, Human)	Bioassay	Human
H Yu, M Xie, Z Meng, CY Lo, FL Chan, L Jiang, X Meng, X Yao Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway British Journal of Cancer, 2021-09-21;0(0):. 2021-09-21 [PMID: 34548638] (Bioassay, Human)	Bioassay	Human
HK Min, S Kim, JY Lee, KW Kim, SH Lee, HR Kim IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis Journal of Translational Medicine, 2021-09-16;19(1):392. 2021-09-16 [PMID: 34530864] (Bioassay, Human)	Bioassay	Human
H Gassmann, K Schneider, V Evdokimova, P Ruzanov, SJ Schober, B Xue, K von Heykin, M Thiede, GHS Richter, MW Pfaffl, E Noessner, LD Stein, PH Sorensen, SEG Burdach, U Thiel Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function Cells, 2021-08-13;10(8):. 2021-08-13 [PMID: 34440851] (Bioassay, Human)	Bioassay	Human
N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes Cell Reports, 2021-08-24;36(8):109613. 2021-08-24 [PMID: 34433033] (Stimulation, Mouse)	Stimulation	Mouse
T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model Scientific Reports, 2021-08-23;11(1):17028. 2021-08-23 [PMID: 34426605] (Bioassay, Human)	Bioassay	Human
EL Woods, IV Grigorieva, AC Midgley, CVM Brown, YA Lu, AO Phillips, T Bowen, S Meran, R Steadman CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-beta1 The Journal of Biological Chemistry, 2021-08-06;0(0):100987. 2021-08-06 [PMID: 34364871] (Bioassay, Human)	Bioassay	Human
B Lupse, K Annamalai, H Ibrahim, S Kaur, S Geravandi, B Sarma, A Pal, S Awal, A Joshi, S Rafizadeh, MK Madduri, M Khazaei, H Liu, T Yuan, W He, KDD Gorrepati, Z Azizi, Q Qi, K Ye, J Oberholzer, K Maedler, A Ardestani Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes Cell Reports, 2021-08-03;36(5):109490. 2021-08-03 [PMID: 34348155] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis Nature Communications, 2021-07-27;12(1):4559. 2021-07-27 [PMID: 34315896] (Bioassay, Human)	Bioassay	Human
S Luostarine, M Hämäläinen, N Hatano, K Muraki, E Moilanen The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells Pulmonary pharmacology & therapeutics, 2021-07-21;70(0):102059. 2021-07-21 [PMID: 34302984] (Bioassay, Human)	Bioassay	Human
JK Park, S Shon, HJ Yoo, DH Suh, D Bae, J Shin, JH Jun, N Ha, H Song, YI Choi, T Pap, YW Song Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis Arthritis Research & Therapy, 2021-07-05;23(1):177. 2021-07-05 [PMID: 34225810] (Bioassay, Human)	Bioassay	Human
L Liu, B Zheng, Z Wang Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells Molecular Medicine Reports, 2021-07-02;24(3):. 2021-07-02 [PMID: 34212979] (Rat)		Rat
M Guibourden, J Haug, N Chevalier, M Spatz, N Barbezier, J Gay-Quéhei, PM Anton Food Contaminants Effects on an In Vitro Model of Human Intestinal Epithelium Toxics, 2021-06-09;9(6):. 2021-06-09 [PMID: 34207749] (Cell Culture, Human)	Cell Culture	Human
J Hoffmann, G Luxán, WT Abplanalp, SF Glaser, T Rasper, A Fischer, M Muhly-Rein, M Potente, B Assmus, D John, AM Zeiher, S Dimmeler Post-myocardial infarction heart failure dysregulates the bone vascular niche Nature Communications, 2021-06-25;12(1):3964. 2021-06-25 [PMID: 34172720] (Bioassay, Human)	Bioassay	Human
Y Takashima, S Hayashi, K Fukuda, T Maeda, M Tsubosaka, T Kamenaga, K Kikuchi, M Fujita, Y Kuroda, S Hashimoto, N Nakano, T Matsumoto, R Kuroda Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1beta-induced inflammation Scientific Reports, 2021-06-15;11(1):12516. 2021-06-15 [PMID: 34131243] (Bioassay, Human)	Bioassay	Human
H Zahir, B Dehghani, X Yuan, Y Chinenov, C Kim, A Burge, R Bandhari, D Nemirov, P Fava, P Moley, H Potter, J Nguyen, B Halpern, L Donlin, L Ivashkiv, S Rodeo, M Otero In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis Scientific Reports, 2021-06-01;11(1):11493. 2021-06-01 [PMID: 34075069] (Bioassay, Human)	Bioassay	Human
H Sakagami, S Nakatani, A Enomoto, S Ota, M Kaneko, M Sugimoto, M Horiuchi, K Toeda, T Oizumi Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp Journal of Clinical Medicine, 2021-05-13;10(10):. 2021-05-13 [PMID: 34068182] (Bioassay, Human)	Bioassay	Human
M Pirklbauer, S Sallaberge, P Staudinger, U Corazza, J Leierer, G Mayer, H Schramek Empagliflozin Inhibits IL-1&beta-Mediated Inflammatory Response in Human Proximal Tubular Cells International Journal of Molecular Sciences, 2021-05-11;22(10):. 2021-05-11 [PMID: 34064989] (Bioassay, Human)	Bioassay	Human
J Pettmann, A Huhn, E Abu Shah, MA Kutuzov, DB Wilson, ML Dustin, SJ Davis, PA van der Me, O Dushek The discriminatory power of the T cell receptor Elife, 2021-05-25;10(0):. 2021-05-25 [PMID: 34030769] (Bioassay, Human)	Bioassay	Human
P Cheung, S Schaffert, SE Chang, M Dvorak, M Donato, C Macaubas, MH Foecke, TM Li, L Zhang, JP Coan, GS Schulert, AA Grom, LA Henderson, PA Nigrovic, JE Elias, O Gozani, ED Mellins, P Khatri, PJ Utz, AJ Kuo Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation Nature Immunology, 2021-05-20;22(6):711-722. 2021-05-20 [PMID: 34017121] (Bioassay, Human)	Bioassay	Human
J Jhun, KH Cho, DH Lee, JY Kwon, JS Woo, J Kim, HS Na, SH Park, SJ Kim, ML Cho Oral Administration of Lactobacillus rhamnosus Ameliorates the Progression of Osteoarthritis by Inhibiting Joint Pain and Inflammation Cells, 2021-04-29;10(5):. 2021-04-29 [PMID: 33946919] (Bioassay, Human)	Bioassay	Human
S Genah, F Cialdai, V Ciccone, E Sereni, L Morbidelli, M Monici Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing Biomedicines, 2021-03-16;9(3):. 2021-03-16 [PMID: 33809724] (Bioassay, Human)	Bioassay	Human
K Bernau, JP Leet, H Floerke, EM Bruhn, AL Noll, IS McDermott, S Esnault, NN Jarjour, N Sandbo Interleukin-1&alpha Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation Cells, 2021-03-02;10(3):. 2021-03-02 [PMID: 33801398] (Bioassay, Human)	Bioassay	Human
K Mörs, R Sturm, JA Hörauf, S Kany, P Cavalli, J Omari, M Powerski, A Surov, I Marzi, AJ Nowak, B Relja Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an In Vitro Inflammation Model in HepG2 Cells Disease Markers, 2021-03-18;2021(0):6622701. 2021-03-18 [PMID: 33791043] (Bioassay, Human)	Bioassay	Human
P Rueda, J Merlin, S Chimenti, M Feletou, J Paysant, PJ White, A Christopou, PM Sexton, RJ Summers, WN Charman, LT May, CJ Langmead Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure Frontiers in Pharmacology, 2021-03-11;12(0):628060. 2021-03-11 [PMID: 33776771] (Bioassay, Rat)	Bioassay	Rat
P Gao, P Gao, J Zhao, S Shan, W Luo, OJ Slivano, W Zhang, A Tabuchi, SA LeMaire, L Maegdefess, YH Shen, JM Miano, HA Singer, X Long MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm Redox Biology, 2021-02-20;41(0):101903. 2021-02-20 [PMID: 33667992] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler N4BP1 negatively regulates NF-&kappaB by binding and inhibiting NEMO oligomerization Nature Communications, 2021-03-02;12(1):1379. 2021-03-02 [PMID: 33654074] (Bioassay, Human)	Bioassay	Human
P Kvacskay, N Yao, JH Schnotz, R Scarpone, RA Carvalho, KD Klika, W Merkt, T Tretter, HM Lorenz, LO Tykocinski Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy? Arthritis Research & Therapy, 2021-02-15;23(1):56. 2021-02-15 [PMID: 33588937] (Bioassay, Human)	Bioassay	Human
Q Li, M Wu, G Fang, K Li, W Cui, L Li, X Li, J Wang, Y Cang MicroRNA?186?5p downregulation inhibits osteoarthritis development by targeting MAPK1 Molecular Medicine Reports, 2021-02-04;23(4):. 2021-02-04 [PMID: 33537828] (Bioassay, Human)	Bioassay	Human
TM Garcia-Bat, ML Palma, RR Anderko, DC Hsu, J Ananworani, BT Korber, GD Gaiha, N Phanuphak, R Thomas, S Tovanabutr, BD Walker, JW Mellors, PA Piazza, E Kroon, SA Riddler, NL Michael, CR Rinaldo, RB Mailliard, I4C and RV Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes EBioMedicine, 2021-01-12;63(0):103175. 2021-01-12 [PMID: 33450518] (Bioassay, Human)	Bioassay	Human
C Cavallo, G Merli, RM Borzì, N Zini, S D'Adamo, M Guescini, B Grigolo, A Di Martino, S Santi, G Filardo Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-&kappaB dependent inflammatory/catabolic environment of osteoarthritis Scientific Reports, 2021-01-13;11(1):1053. 2021-01-13 [PMID: 33441764] (Bioassay, Human)	Bioassay	Human
MM Mostafa, A Bansal, AN Michi, SK Sasse, D Proud, AN Gerber, R Newton Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells The Journal of Biological Chemistry, 2020-01-01;296(0):100065. 2020-01-01 [PMID: 33410411] (Bioassay, Human)	Bioassay	Human
Y Yang, P Shen, T Yao, J Ma, Z Chen, J Zhu, Z Gong, S Shen, X Fang Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress Theranostics, 2021-01-01;11(4):1877-1900. 2021-01-01 [PMID: 33408787] (Bioassay, Human)	Bioassay	Human
E Nummenmaa, M Hämäläinen, A Pemmari, LJ Moilanen, L Tuure, RM Nieminen, T Moilanen, K Vuolteenah, E Moilanen Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models International Journal of Molecular Sciences, 2020-12-23;22(1):. 2020-12-23 [PMID: 33374841] (Cell Culture, Human)	Cell Culture	Human
J Martinez-F, L Wang, E Pohler, A Cozzani, S Wilmes, M Kazemian, S Mitra, I Moraga CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci Cell Reports, 2020-12-22;33(12):108545. 2020-12-22 [PMID: 33357429] (Bioassay, Human)	Bioassay	Human
YC Fan, KD Lee, YC Tsai Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression Biomedicines, 2020-12-13;8(12):. 2020-12-13 [PMID: 33322099] (Cell Culture, Human)	Cell Culture	Human
N Gatto, C Dos Santos, AC Shaw, SM Bell, MA Myszczynsk, S Powers, K Meyer, LM Castelli, E Karyka, H Mortiboys, M Azzouz, GM Hautbergue, NM Márkus, PJ Shaw, L Ferraiuolo Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease Aging Cell, 2020-12-13;0(0):e13281. 2020-12-13 [PMID: 33314575] (Bioassay, Human)	Bioassay	Human
Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors. Cell, 2020-11-30;183(6):1634-1649.e17. 2020-11-30 [PMID: 33259803] (Bioassay, Human)	Bioassay	Human
MH Hwang, HG Son, J Kim, H Choi In vitro model of distinct catabolic and inflammatory response patterns of endothelial cells to intervertebral disc cell degeneration Sci Rep, 2020-11-26;10(1):20596. 2020-11-26 [PMID: 33244116] (Cell Culture, Human)	Cell Culture	Human
D Hortobagyi, T Grossmann, M Tschernitz, M Grill, A Kirsch, C Gerstenber, M Gugatschka In vitro mechanical vibration down-regulates pro-inflammatory and pro-fibrotic signaling in human vocal fold fibroblasts PLoS ONE, 2020-11-19;15(11):e0241901. 2020-11-19 [PMID: 33211714] (Cell Culture, Human)	Cell Culture	Human
RP Harshe, A Xie, M Vuerich, LA Frank, B Gromova, H Zhang, RJ Robles, S Mukherjee, E Csizmadia, E Kokkotou, AS Cheifetz, AC Moss, SK Kota, SC Robson, MS Longhi Endogenous antisense RNA curbs CD39 expression in Crohn's disease Nat Commun, 2020-11-18;11(1):5894. 2020-11-18 [PMID: 33208731] (Bioassay, Human)	Bioassay	Human
MM Mostafa, A Bansal, AN Michi, SK Sasse, D Proud, AN Gerber, R Newton Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells J Biol Chem, 2020-11-23;0(0):. 2020-11-23 [PMID: 33184061] (Cell Culture, Human)	Cell Culture	Human
C Salgado, H Morin, N Coriolano, L Neff, C Quintino d, W Vilegas, L Marcourt, JL Wolfender, O Jordan, E Ferreira Q, E Allémann In Vitro Anti-Inflammatory Activity in Arthritic Synoviocytes of A. brachypoda Root Extracts and Its Unusual Dimeric Flavonoids Molecules, 2020-11-09;25(21):. 2020-11-09 [PMID: 33182470] (Cell Culture, Human)	Cell Culture	Human
VV Edara, S Nooka, J Proulx, S Stacy, A Ghorpade, K Borgmann &beta-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes Biomedicines, 2020-11-06;8(11):. 2020-11-06 [PMID: 33171974] (Cell Culture, Human)	Cell Culture	Human
Q Cai, P Shi, Y Yuan, J Peng, X Ou, W Zhou, J Li, T Su, L Lin, S Cai, Y He, J Xu Inflammation-associated senescence promotes Helicobacter pylori-induced atrophic gastritis Cell Mol Gastroenterol Hepatol, 2020-11-05;0(0):. 2020-11-05 [PMID: 33161156] (Bioassay, Human)	Bioassay	Human
D He, D Wang, P Lu, N Yang, Z Xue, X Zhu, P Zhang, G Fan Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations Oncogene, 2020-11-03;0(0):. 2020-11-03 [PMID: 33144684] (Cell Culture, Human)	Cell Culture	Human
WC Huang, CJ Liou, SC Shen, S Hu, CY Hsiao, SJ Wu Luteolin Attenuates IL-1&beta-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-&kappaB and MAPK Pathways Mediators Inflamm, 2020-10-16;2020(0):9421340. 2020-10-16 [PMID: 33122970] (Bioassay, Human)	Bioassay	Human
M Gemei, C Talarico, L Brandolini, C Manelfi, L Za, S Bovolenta, C Liberati, LD Vecchio, R Russo, C Cerchia, M Allegretti, AR Beccari Binding Mode Exploration of B1 Receptor Antagonists' by the Use of Molecular Dynamics and Docking Simulation-How Different Target Engagement Can Determine Different Biological Effects Int J Mol Sci, 2020-10-16;21(20):. 2020-10-16 [PMID: 33081372] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
J Bao, W Yan, K Xu, M Chen, Z Chen, J Ran, Y Xiong, L Wu Oleanolic Acid Decreases IL-1&beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-&kappaB Axis in Osteoarthritis Oxid Med Cell Longev, 2020-09-28;2020(0):7517219. 2020-09-28 [PMID: 33062145] (Bioassay, Human)	Bioassay	Human
EM Wilfong, R Croze, X Fang, M Schwede, E Niemi, GY López, JW Lee, MC Nakamura, MA Matthay Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation PLoS ONE, 2020-10-06;15(10):e0240319. 2020-10-06 [PMID: 33021986] (Cell Culture, Human)	Cell Culture	Human
CM Schafer, JM Gurley, K Kurylowicz, PK Lin, W Chen, MH Elliott, GE Davis, F Bhatti, CT Griffin An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression Proc Natl Acad Sci U S A, 2020-10-05;0(0):. 2020-10-05 [PMID: 33020273] (Bioassay, Mouse)	Bioassay	Mouse
J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta EBioMedicine, 2020-09-23;60(0):102984. 2020-09-23 [PMID: 32979835] (Inhibition, Mouse)	Inhibition	Mouse
HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway Arthritis Research & Therapy, 2020-09-23;22(1):222. 2020-09-23 [PMID: 32972460] (Human)		Human
C Wang, Y Xiao, M Lao, J Wang, S Xu, R Li, X Xu, Y Kuang, M Shi, Y Zou, Q Wang, L Liang, SG Zheng, H Xu Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes JCI Insight, 2020-09-17;5(18):. 2020-09-17 [PMID: 32938830] (Bioassay, Human)	Bioassay	Human
M Fellermann, C Huchler, L Fechter, T Kolb, F Wondany, D Mayer, J Michaelis, S Stenger, K Mellert, P Möller, TFE Barth, S Fischer, H Barth Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells Toxins (Basel), 2020-09-01;12(9):. 2020-09-01 [PMID: 32883045] (Bioassay, Human)	Bioassay	Human
JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease Nature, 2020-09-02;0(0):. 2020-09-02 [PMID: 32879487] (Bioassay, Human)	Bioassay	Human
S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia Cells, 2020-08-31;9(9):. 2020-08-31 [PMID: 32878300] (Bioassay, Human)	Bioassay	Human
C Salgado, L Guénée, R ?erný, E Allémann, O Jordan Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation Int J Pharm, 2020-08-19;589(0):119783. 2020-08-19 [PMID: 32827674] (Bioassay, Human)	Bioassay	Human
C Lammel, J Zwirchmayr, J Seigner, JM Rollinger, R de Martin Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-&kappaB Signaling Biomolecules, 2020-08-21;10(9):. 2020-08-21 [PMID: 32825714] (Bioassay, Human)	Bioassay	Human
E Abu-Shah, N Trendel, P Kruger, J Nguyen, J Pettmann, M Kutuzov, O Dushek Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses J. Immunol., 2020-08-17;0(0):. 2020-08-17 [PMID: 32817332] (Bioassay, Human)	Bioassay	Human
B Zhou, DD Wang, Y Qiu, S Airhart, Y Liu, A Stempien-O, KD O'Brien, R Tian Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure J. Clin. Invest., 2020-11-02;0(0):. 2020-11-02 [PMID: 32790648] (Bioassay, Human)	Bioassay	Human
HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model PLoS ONE, 2020-08-06;15(8):e0237015. 2020-08-06 [PMID: 32760098] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
JF Marchini, A Manica, P Crestani, J Dutzmann, EJ Folco, H Weber, P Libby, K Croce Oxidized Low-Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles J Am Heart Assoc, 2020-07-31;9(15):e015878. 2020-07-31 [PMID: 32750308] (Bioassay, Human)	Bioassay	Human
YT Hsu, CH Wu, CY Chao, YS Wei, YC Chang, YT Chen, SL Lin, SY Tsai, YJ Lee, PS Tsai Hypochlorite-induced porcine model of peritoneal fibrosis through the activation of IL1&beta-CX3CL1-TGF&beta1 signal axis Sci Rep, 2020-07-13;10(1):11496. 2020-07-13 [PMID: 32661265] (Porcine)		Porcine
H El-Kehdy, M Najar, J De Kock, DM Agha, V Rogiers, M Merimi, L Lagneaux, EM Sokal, M Najimi Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells Cells, 2020-07-08;9(7):. 2020-07-08 [PMID: 32650454] (Cell Culture, Human)	Cell Culture	Human
G D'Urso, M Masullo, J Seigner, YM Holper-Sch, R de Martin, A Plaza, S Piacente LC-ESI-FT-MSn Metabolite Profiling of Symphytum officinale L. Roots Leads to Isolation of Comfreyn A, an Unusual Arylnaphthalene Lignan Int J Mol Sci, 2020-06-30;21(13):. 2020-06-30 [PMID: 32630037] (Cell Culture, Human)	Cell Culture	Human
Q Wang, K Notay, GP Downey, CA McCulloch The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation Cell Rep, 2020-06-30;31(13):107781. 2020-06-30 [PMID: 32610117] (Bioassay, Human)	Bioassay	Human
Z Xu, T Ke, Y Zhang, C Fu, W He Agonism of GPR120 prevented IL-1&beta-induced reduction of extracellular matrix through SOX-9 Aging (Albany NY), 2020-06-24;12(12):12074-12085. 2020-06-24 [PMID: 32580167] (Cell Culture, Human)	Cell Culture	Human
MP Wandel, BH Kim, ES Park, KB Boyle, K Nayak, B Lagrange, A Herod, T Henry, M Zilbauer, J Rohde, JD MacMicking, F Randow Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms Nat. Immunol., 2020-06-15;0(0):. 2020-06-15 [PMID: 32541830] (Bioassay, Human)	Bioassay	Human
F Nishimura, H Mogami, K Moriuchi, Y Chigusa, M Mandai, E Kondoh Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone PLoS ONE, 2020-05-04;15(5):e0231944. 2020-05-04 [PMID: 32365105] (Bioassay, Human)	Bioassay	Human
A Rao, O Strauss, E Kokkinou, M Bruchard, KP Tripathi, H Schlums, A Carrasco, L Mazzurana, V Konya, EJ Villablanc, NK Björkström, U Lindforss, H Spits, J Mjösberg Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs Nat Commun, 2020-04-27;11(1):2049. 2020-04-27 [PMID: 32341343] (Bioassay, Human)	Bioassay	Human
M Simental-M, SA Lozano-Sep, V Pérez-Silo, L Fuentes-Me, HG Martínez-R, CA Acosta-Oli, VM Peña-Martí, F Vilchez-Ca Anti?inflammatory and anti?catabolic effect of non?animal stabilized hyaluronic acid and mesenchymal stem cell?conditioned medium in an osteoarthritis coculture model Mol Med Rep, 2020-02-26;21(5):2243-2250. 2020-02-26 [PMID: 32323772] (Bioassay, Human)	Bioassay	Human
W Cho, J Choe Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells BMC Immunol., 2020-04-17;21(1):20. 2020-04-17 [PMID: 32303181] (Cell Culture, Human)	Cell Culture	Human
VT Nguyen, B Canciani, F Cirillo, L Anastasia, GM Peretti, L Mangiavini Effect of Chemically Induced Hypoxia on Osteogenic and Angiogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells in Direct Coculture Cells, 2020-03-19;9(3):. 2020-03-19 [PMID: 32204578] (Cell Culture, Human)	Cell Culture	Human
BR Kim, J Kim, JE Lee, EJ Lee, JS Yoon Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2020-03-09;61(3):39. 2020-03-09 [PMID: 32196098] (Cell Culture, Human)	Cell Culture	Human
N Hafsia, M Forien, F Renaudin, D Delacour, P Reboul, P Van Lent, M Cohen-Sola, F Lioté, F Poirier, HK Ea Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis Int J Mol Sci, 2020-02-22;21(4):. 2020-02-22 [PMID: 32098291] (Cell Culture, Mouse)	Cell Culture	Mouse
N Jiang, Q Zhang, MK Chau, MS Yip, SL Lui, S Liu, KM Chu, HY Ngan, TM Chan, S Yung Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis EBioMedicine, 2020-02-12;52(0):102661. 2020-02-12 [PMID: 32062358] (Bioassay, Human)	Bioassay	Human
Y Chen, Z Yang, B Deng, D Wu, Y Quan, Z Min Interleukin 1&beta/1RA axis in colorectal cancer regulates tumor invasion, proliferation and apoptosis via autophagy Oncol. Rep., 2020-01-22;43(3):908-918. 2020-01-22 [PMID: 32020215] (Cell Culture, Human)	Cell Culture	Human
D Parate, ND Kadir, C Celik, EH Lee, JHP Hui, A Franco-Obr, Z Yang Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration Stem Cell Res Ther, 2020-02-03;11(1):46. 2020-02-03 [PMID: 32014064] (Cell Culture, Human)	Cell Culture	Human
JH Jang, DH Kim, JM Lim, JW Lee, SJ Jeong, KP Kim, YJ Surh Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1&beta Production Cancer Res, 2020-01-22;80(6):1342-1356. 2020-01-22 [PMID: 31969374] (Bioassay, Human)	Bioassay	Human
J Ko, JY Kim, JW Kim, JS Yoon Anti-oxidative and anti-adipogenic effects of caffeine in an in vitro model of Graves' orbitopathy Endocr. J., 2020-01-16;0(0):. 2020-01-16 [PMID: 31941844] (Cell Culture, Human)	Cell Culture	Human
S Demine, AA Schiavo, S Marín-Caña, P Marchetti, M Cnop, DL Eizirik Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells Stem Cell Res Ther, 2020-01-03;11(1):7. 2020-01-03 [PMID: 31900242] (Bioassay, Human)	Bioassay	Human
R Xu, RK Shears, R Sharma, M Krishna, C Webb, R Ali, X Wei, A Kadioglu, Q Zhang IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue Mucosal Immunol, 2020-01-02;13(3):460-470. 2020-01-02 [PMID: 31896761] (Cell Culture, Human)	Cell Culture	Human
X Gao, S Jiang, Z Du, A Ke, Q Liang, X Li KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo Oxid Med Cell Longev, 2019-11-19;2019(0):8564681. 2019-11-19 [PMID: 31827706] (Bioassay, Human)	Bioassay	Human
JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness Int J Mol Sci, 2019-11-15;20(22):. 2019-11-15 [PMID: 31731750] (Cell Culture, Human)	Cell Culture	Human
R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Nat Commun, 2019-11-01;10(1):5016. 2019-11-01 [PMID: 31676788] (Cell Culture, Human)	Cell Culture	Human
A Ardestani, S Li, K Annamalai, B Lupse, S Geravandi, A Dobrowolsk, S Yu, S Zhu, TD Baguley, M Surakattul, J Oetjen, L Hauberg-Lo, R Herranz, S Awal, D Altenhofen, V Nguyen-Tra, S Joseph, PG Schultz, AK Chatterjee, N Rogers, MS Tremblay, W Shen, K Maedler Neratinib protects pancreatic beta cells in diabetes Nat Commun, 2019-11-01;10(1):5015. 2019-11-01 [PMID: 31676778] (Bioassay, Mouse)	Bioassay	Mouse
K Terabe, Y Ohashi, S Tsuchiya, S Ishizuka, CB Knudson, W Knudson Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism J. Biol. Chem., 2019-10-16;0(0):. 2019-10-16 [PMID: 31619518] (Bioassay, Bovine, Human)	Bioassay	Bovine, Human
X Zhang, YS Hwang Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner Oncol Lett, 2019-08-27;18(5):4645-4650. 2019-08-27 [PMID: 31611973] (Cell Culture, Human)	Cell Culture	Human
JS Lee, J Kim, EJ Lee, JS Yoon Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae, in Fibroblasts From Patients With Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2019-10-01;60(13):4129-4140. 2019-10-01 [PMID: 31593984] (Bioassay, Human)	Bioassay	Human
C Merriman, D Fu Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress J. Biol. Chem., 2019-10-07;0(0):. 2019-10-07 [PMID: 31591269] (Bioassay, Human)	Bioassay	Human
P Dolzani, E Assirelli, L Pulsatelli, R Meliconi, E Mariani, S Neri Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components PLoS ONE, 2019-09-24;14(9):e0222947. 2019-09-24 [PMID: 31550275] (Bioassay, Human)	Bioassay	Human
J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression Breast Cancer Res., 2019-09-18;21(1):109. 2019-09-18 [PMID: 31533776] (Bioassay, Human)	Bioassay	Human
JC Dos Santos, AM Barroso de, MV Teodoro Si, B Cirovic, LCJ de Bree, MSMA Damen, SJCFM Moorlag, RS Gomes, MM Helsen, M Oosting, ST Keating, A Schlitzer, MG Netea, F Ribeiro-Di, LAB Joosten Î²-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32 Cell Rep, 2019-09-03;28(10):2659-2672.e6. 2019-09-03 [PMID: 31484076] (Bioassay, Human)	Bioassay	Human
L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)	Bioassay	Human
I Hirose, A Kanda, K Noda, S Ishida Glucocorticoid receptor inhibits Mï¿½ller glial galectin-1 expression via DUSP1-dependent and -independent deactivation of AP-1 signalling J. Cell. Mol. Med., 2019-07-21;0(0):. 2019-07-21 [PMID: 31328390] (Cell Culture, Human)	Cell Culture	Human
JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263279] (Cell Culture, Human)	Cell Culture	Human
AE Patrick, W Wang, E Brokamp, TB Graham, TM Aune, JB Duis Juvenile idiopathic arthritis associated with a mutation in GATA3 Arthritis Res. Ther., 2019-06-25;21(1):156. 2019-06-25 [PMID: 31238969] (Bioassay, Human)	Bioassay	Human
MJ Park, SJ Moon, JA Baek, EJ Lee, KA Jung, EK Kim, DS Kim, JH Lee, SK Kwok, JK Min, SJ Kim, SH Park, ML Cho Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis J. Immunol., 2019-05-29;0(0):. 2019-05-29 [PMID: 31142603] (Bioassay, Human)	Bioassay	Human
K Hacker, S Benke, B Agerer, S Scinicarie, V Budroni, GA Versteeg A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52 Sci Rep, 2019-05-27;9(1):7901. 2019-05-27 [PMID: 31133683] (Bioassay, Human)	Bioassay	Human
C De Witte, K Demeyere, S De Bruycke, B Taminiau, G Daube, R Ducatelle, E Meyer, F Haesebrouc Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration Vet. Res., 2019-05-24;50(1):39. 2019-05-24 [PMID: 31126330] (Western Blot Control, Human)	Western Blot Control	Human
J Seigner, M Junker-Sam, A Plaza, G D'Urso, M Masullo, S Piacente, YM Holper-Sch, R de Martin A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-?B Signaling Front Pharmacol, 2019-04-26;10(0):289. 2019-04-26 [PMID: 31105555] (Bioassay, Human)	Bioassay	Human
C Rosette, FJ Agan, N Rosette, L Moro, A Mazzetti, C Hassan, M Gerloni Rifamycin SV exhibits strong anti-inflammatory inï¿½vitro activity through pregnane X receptor stimulation and NF?B inhibition Drug Metab. Pharmacokinet., 2019-01-17;34(3):172-180. 2019-01-17 [PMID: 31101589] (Bioassay, Human)	Bioassay	Human
T Sano, K Akeda, J Yamada, N Takegami, T Sudo, A Sudo Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration BMC Musculoskelet Disord, 2019-05-17;20(1):225. 2019-05-17 [PMID: 31101043] (Cell Culture, Human)	Cell Culture	Human
T Kisukeda, J Onaya, K Yoshioka Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes BMC Musculoskelet Disord, 2019-05-10;20(1):201. 2019-05-10 [PMID: 31077160] (Cell Culture, Human)	Cell Culture	Human
S Vig, M Buitinga, D Rondas, I Crèvecoeur, M van Zandvo, E Waelkens, DL Eizirik, C Gysemans, P Baatsen, C Mathieu, L Overbergh Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells Cell Death Dis, 2019-04-05;10(4):309. 2019-04-05 [PMID: 30952835] (Bioassay, Rat)	Bioassay	Rat
T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)	Bioassay	Human
P Siengdee, W Pradit, S Chomdej, K Nganvongpa Determination of two fluoroquinolones and their combinations with hyaluronan effect in in vitro canine cartilage explants PeerJ, 2019-03-12;7(0):e6553. 2019-03-12 [PMID: 30881764] (Bioassay, Canine)	Bioassay	Canine
A Castellano, I Santin, A Olazagoiti, I Romero-Gar, A Jauregi-Mi, M Legarda, JR Bilbao A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation Sci Rep, 2019-03-12;9(1):4220. 2019-03-12 [PMID: 30862814] (Bioassay, Human)	Bioassay	Human
KC Doh, BM Kim, KW Kim, BH Chung, CW Yang Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression BMC Complement Altern Med, 2019-03-04;19(1):54. 2019-03-04 [PMID: 30832648] (Bioassay, Human)	Bioassay	Human
X Qin, M Liu, S Zhang, C Wang, T Zhang The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis Cytokine, 2019-03-01;117(0):84-90. 2019-03-01 [PMID: 30831444] (Bioassay, Human)	Bioassay	Human
A Kizilyer, MV Singh, VB Singh, S Suwunnakor, J Palis, SB Maggirwar Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis Sci Rep, 2019-02-26;9(1):2781. 2019-02-26 [PMID: 30808933] (Bioassay, Human)	Bioassay	Human
K Spekker-Bo, CM Ufermann, M Maywald, A Zimmermann, A Domröse, C Woite, W Däubener, SK Eller hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye Int J Mol Sci, 2019-02-16;20(4):. 2019-02-16 [PMID: 30781494] (Bioassay, Human)	Bioassay	Human
HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis Nat Commun, 2019-02-12;10(1):709. 2019-02-12 [PMID: 30755603] (Bioassay, Human)	Bioassay	Human
S Botto, J Abraham, N Mizuno, K Pryke, B Gall, I Landais, DN Streblow, KJ Fruh, VR DeFilippis Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1? Protein during Virion-Mediated Activation of the AIM2 Inflammasome MBio, 2019-02-12;10(1):. 2019-02-12 [PMID: 30755509] (Bioassay, Human)	Bioassay	Human
K Kuranda, S Caillat-Zu, S You, R Mallone Inï¿½Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells Mol Ther Methods Clin Dev, 2018-12-31;13(0):112-120. 2018-12-31 [PMID: 30740473] (Bioassay, Human)	Bioassay	Human
BA Kane, H An, P Rajasekari, HP McNeil, K Bryant, N Tedla Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis Sci Rep, 2019-02-04;9(1):1149. 2019-02-04 [PMID: 30718719] (Bioassay, Human)	Bioassay	Human
T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS Cancer Res., 2019-02-01;0(0):. 2019-02-01 [PMID: 30709930] (Bioassay, Human)	Bioassay	Human
B Crifo, B Schaible, E Brown, DN Halligan, CC Scholz, SF Fitzpatric, A Kirwan, HM Roche, M Criscuoli, A Naldini, H Giffney, D Crean, A Blanco, MA Cavadas, EP Cummins, Z Fabian, CT Taylor Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes J. Immunol., 2019-01-30;0(0):. 2019-01-30 [PMID: 30700584] (Bioassay, Human)	Bioassay	Human
K Ni, A Gill, D Cao, K Koike, KS Schweitzer, S Garantziot, I Petrache Intravascular heavy chain-modification of hyaluronan during endotoxic shock Biochem Biophys Rep, 2018-12-26;17(0):114-121. 2018-12-26 [PMID: 30623115] (Bioassay, Human)	Bioassay	Human
MR Tanner, MW Pennington, SS Chauhan, T Laragione, PS Gulko, C Beeton KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis Arthritis Res. Ther., 2019-01-07;21(1):6. 2019-01-07 [PMID: 30612588] (Bioassay, Human)	Bioassay	Human
SJ Lee, J Kim, J Ko, EJ Lee, HJ Koh, JS Yoon Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts PLoS ONE, 2018-12-21;13(12):e0209583. 2018-12-21 [PMID: 30576385] (Bioassay, Human)	Bioassay	Human
R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4 Oncogene, 2018-12-05;0(0):. 2018-12-05 [PMID: 30518876] (Bioassay, Human)	Bioassay	Human
H Takahashi, H Ashikawa, H Nakamura, T Murayama Phosphorylation and inhibition of ceramide kinase by protein kinase C-?: Their changes by serine residue mutations Cell. Signal., 2018-11-15;0(0):. 2018-11-15 [PMID: 30448345] (Cell Culture, Human)	Cell Culture	Human
AN Bubak, CN Como, AM Blackmon, D Jones, MA Nagel Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes J Neuroinflammation, 2018-11-15;15(1):318. 2018-11-15 [PMID: 30442152] (Bioassay, Human)	Bioassay	Human
W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells Sci Rep, 2018-11-09;8(1):16636. 2018-11-09 [PMID: 30413785] (Bioassay, Human)	Bioassay	Human
K Sugioka, A Kodama-Tak, T Sato, K Okada, J Murakami, AM Park, H Mishima, Y Shimomura, S Kusaka, T Nishida Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts Invest. Ophthalmol. Vis. Sci., 2018-10-01;59(12):5098-5107. 2018-10-01 [PMID: 30372736] (Human)		Human
U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma Oncotarget, 2018-10-02;9(77):34582-34594. 2018-10-02 [PMID: 30349651] (Bioassay, Human)	Bioassay	Human
L Kasper, A König, PA Koenig, MS Gresnigt, J Westman, RA Drummond, MS Lionakis, O Gro beta , J Ruland, JR Naglik, B Hube The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes Nat Commun, 2018-10-15;9(1):4260. 2018-10-15 [PMID: 30323213]
A Baek, Y Kim, JW Lee, SC Lee, SR Cho Effect of Polydeoxyribonucleotide on Angiogenesis and Wound Healing in an In Vitro Model of Osteoarthritis Cell Transplant, 2018-10-12;0(0):9636897188041. 2018-10-12 [PMID: 30311500] (Bioassay, Human)	Bioassay	Human
GH Yang, C Zhang, N Wang, Y Meng, YS Wang Anacardic acid suppresses fibroblast-like synoviocyte proliferation and invasion and ameliorates collagen-induced arthritis in a mouse model Cytokine, 2018-09-28;111(0):350-356. 2018-09-28 [PMID: 30273785] (Bioassay, Human)	Bioassay	Human
B Zhang, Z Li, W Wang, J Guo, S Kang, S Liu, H Li, D Wang, X Qi NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression Cell. Physiol. Biochem., 2018-09-27;49(6):2396-2413. 2018-09-27 [PMID: 30261507] (Bioassay, Human)	Bioassay	Human
M Schwede, EM Wilfong, RL Zemans, PJ Lee, C Dos Santos, X Fang, MA Matthay Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-?, IL-1?, and IFN-? Physiol Rep, 2018-08-01;6(16):e13831. 2018-08-01 [PMID: 30136410] (Bioassay, Human)	Bioassay	Human
KA Cavassani, RJ Meza, DM Habiel, JF Chen, A Montes, M Tripathi, GA Martins, TR Crother, S You, CM Hogaboam, N Bhowmick, EM Posadas Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells Cancer Med, 2018-08-09;0(0):. 2018-08-09 [PMID: 30094958] (Human)		Human
SL Figenschau, E Knutsen, I Urbarova, C Fenton, B Elston, M Perander, ES Mortensen, KA Fenton ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes Sci Rep, 2018-08-06;8(1):11720. 2018-08-06 [PMID: 30082828] (Bioassay, Human)	Bioassay	Human
C Angiolilli, PA Kabala, AM Grabiec, M Rossato, WS Lai, G Fossati, P Mascagni, C Steinkühle, PJ Blackshear, KA Reedquist, DL Baeten, TRDJ Radstake Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation Arthritis Res. Ther., 2018-07-20;20(1):148. 2018-07-20 [PMID: 30029685] (Bioassay, Human)	Bioassay	Human
JK Brenke, GM Popowicz, K Schorpp, I Rothenaign, M Roesner, I Meininger, C Kalinski, L Ringelstet, O R'kyek, G Jürjens, M Vincendeau, O Plettenbur, M Sattler, D Krappmann, K Hadian Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity J. Biol. Chem., 2018-06-27;0(0):. 2018-06-27 [PMID: 29950522] (Bioassay, Human)	Bioassay	Human
JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation Cell Death Dis, 2018-06-04;9(6):665. 2018-06-04 [PMID: 29867198] (Bioassay, Human)	Bioassay	Human
A Kock, K Larsson, F Bergqvist, N Eissler, LHM Elfman, J Raouf, M Korotkova, JI Johnsen, PJ Jakobsson, P Kogner Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth EBioMedicine, 2018-05-24;32(0):84-92. 2018-05-24 [PMID: 29804818] (Bioassay, Human)	Bioassay	Human
E Vorkapic, A Kunath, D Wågsäter Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms Mol Med Rep, 2018-04-27;0(0):. 2018-04-27 [PMID: 29749489] (Bioassay, Human)	Bioassay	Human
N Saito, M Honma, T Shibuya, S Iinuma, S Igawa, M Kishibe, A Ishida-Yam RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis J. Dermatol. Sci., 2018-04-10;0(0):. 2018-04-10 [PMID: 29661487] (Bioassay, Human)	Bioassay	Human
TR Nardelli, EC Vanzela, KC Benedicto, F Brozzi, A Fujita, AK Cardozo, D Eizirik, AC Boschero, F Ortis Prolactin protects against cytokine-induced beta cell death by NFkB and JNK inhibition J. Mol. Endocrinol., 2018-04-09;0(0):. 2018-04-09 [PMID: 29632026] (Bioassay, Rat)	Bioassay	Rat
SJ Mancini, D Boyd, OJ Katwan, A Strembitsk, TA Almabrouk, S Kennedy, TM Palmer, IP Salt Canagliflozin inhibits interleukin-1?-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms Sci Rep, 2018-03-27;8(1):5276. 2018-03-27 [PMID: 29588466] (Bioassay, Human)	Bioassay	Human
O Sokolova, T Kähne, K Bryan, M Naumann Interactome analysis of transforming growth factor-?-activated kinase 1 inHelicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37 Oncotarget, 2018-02-21;9(18):14366-14381. 2018-02-21 [PMID: 29581850] (Bioassay, Human)	Bioassay	Human
D Sireesh, U Dhamodhara, K Ezhilarasi, V Vijay, KM Ramkumar Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus Sci Rep, 2018-03-23;8(1):5126. 2018-03-23 [PMID: 29572460] (Bioassay, Human)	Bioassay	Human
C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti Anisakis pegreffii impacts differentiation and function of human dendritic cells Parasite Immunol., 2018-05-01;0(0):e12527. 2018-05-01 [PMID: 29569735] (Bioassay, Human)	Bioassay	Human
B Bergström, H Carlsten, AH Ekwall Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1? on rheumatoid arthritis fibroblast-like synoviocytes Arthritis Res. Ther., 2018-03-20;20(1):49. 2018-03-20 [PMID: 29554943] (Bioassay, Human)	Bioassay	Human
H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209. 2018-01-31 [PMID: 29552576] (Bioassay, Human)	Bioassay	Human
ZM Bian, MG Field, SG Elner, VM Elner Expression and regulation of alarmin cytokine IL-1? in human retinal pigment epithelial cells Exp. Eye Res., 2018-03-15;0(0):. 2018-03-15 [PMID: 29551335] (Bioassay, Human)	Bioassay	Human
KA Jhang, JS Park, HS Kim, YH Chong Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages J Neuroinflammation, 2018-03-12;15(1):75. 2018-03-12 [PMID: 29530050] (Bioassay, Human)	Bioassay	Human
SEJ Chambers, CL O'Neill, J Guduric-Fu, KJ McLoughlin, A Liew, AM Egan, T O'Brien, AW Stitt, RJ Medina The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1? Stem Cells, 2018-03-09;36(6):834-843. 2018-03-09 [PMID: 29484768] (Bioassay, Human)	Bioassay	Human
MW Tang, B Malvar Fer, SP Newsom, JD van Buul, TRDJ Radstake, DL Baeten, PP Tak, KA Reedquist, S García Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes Rheumatology (Oxford), 2018-05-01;0(0):. 2018-05-01 [PMID: 29471421] (Stimulation, Human)	Stimulation	Human
A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, M Ding, J Synnergren, H Zetterberg, G Brolén, R Hicks, A Herland, A Falk Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models Stem Cell Reports, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456185] (Bioassay, Human)	Bioassay	Human
ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells Exp. Eye Res., 2018-02-16;170(0):29-39. 2018-02-16 [PMID: 29454857] (Cell Culture, Human)	Cell Culture	Human
AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes Diabetologia, 2018-02-14;0(0):. 2018-02-14 [PMID: 29445851] (Cell Culture, Human, Mouse)	Cell Culture	Human, Mouse
WR Swindell, MA Beamer, MK Sarkar, S Loftus, J Fullmer, X Xing, NL Ward, LC Tsoi, MJ Kahlenberg, Y Liang, JE Gudjonsson RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature Front Immunol, 2018-01-29;9(0):80. 2018-01-29 [PMID: 29434599] (Cell Culture, Human)	Cell Culture	Human
W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature Neurobiol. Dis., 2018-02-09;0(0):. 2018-02-09 [PMID: 29432809] (Cell Culture, Human)	Cell Culture	Human
M Oshima, KP Knoch, M Diedisheim, A Petzold, P Cattan, M Bugliani, P Marchetti, P Choudhary, GC Huang, SR Bornstein, M Solimena, O Albagli-Cu, R Scharfmann Virus-like infection induces human ? cell dedifferentiation JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415896] (Bioassay, Human)	Bioassay	Human
Q Wang, J Delcorde, T Tang, GP Downey, CA McCulloch Regulation of IL-1 signaling through control of focal adhesion assembly FASEB J., 2018-01-22;0(0):fj201700966R. 2018-01-22 [PMID: 29401618] (Bioassay, Human)	Bioassay	Human
M Haneda, S Hayashi, T Matsumoto, S Hashimoto, K Takayama, N Chinzei, S Kihara, K Takeuchi, K Nishida, R Kuroda Depletion of aquaporin 1 decreased ADAMTS?4 expression in human chondrocytes Mol Med Rep, 2018-02-02;17(4):4874-4882. 2018-02-02 [PMID: 29393494] (Bioassay, Human)	Bioassay	Human
F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Bioassay, Human)	Bioassay	Human
Y Uchino, AM Woodward, J Mauris, K Peterson, P Verma, UJ Nilsson, J Rajaiya, P Argüeso Galectin-3 is an amplifier of the interleukin-1?-mediated inflammatory response in corneal keratinocytes Immunology, 2018-02-15;0(0):. 2018-02-15 [PMID: 29359328] (Bioassay, Human)	Bioassay	Human
X Zhang, Y Zhang, J Xu, H Wang, X Zheng, Y Lou, B Han Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells J Cancer, 2018-01-01;9(2):367-374. 2018-01-01 [PMID: 29344283] (Bioassay, Human)	Bioassay	Human
M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro Mol Brain, 2018-01-15;11(1):3. 2018-01-15 [PMID: 29334986] (Bioassay, Mouse)	Bioassay	Mouse
TA Nakada, P Wacharasin, JA Russell, JH Boyd, E Nakada, SA Thair, T Shimada, KR Walley The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock J Innate Immun, 2018-01-16;0(0):. 2018-01-16 [PMID: 29334679] (Bioassay, Human)	Bioassay	Human
RJW Arts, SJCFM Moorlag, B Novakovic, Y Li, SY Wang, M Oosting, V Kumar, RJ Xavier, C Wijmenga, LAB Joosten, CBEM Reusken, CS Benn, P Aaby, MP Koopmans, HG Stunnenber, R van Crevel, MG Netea BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity Cell Host Microbe, 2018-01-10;23(1):89-100.e5. 2018-01-10 [PMID: 29324233] (Cell Culture, Human)	Cell Culture	Human
YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells PLoS ONE, 2018-01-03;13(1):e0190638. 2018-01-03 [PMID: 29298343] (Bioassay, Human)	Bioassay	Human
S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo A functional DC cross talk promotes human ILC homeostasis in humanized mice Blood Adv, 2017-04-06;1(10):601-614. 2017-04-06 [PMID: 29296702] (Human)		Human
A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 2017-03-30;1(10):577-589. 2017-03-30 [PMID: 29296700] (Human)		Human
L Zhong, S Schivo, X Huang, J Leijten, M Karperien, JN Post Nitric Oxide Mediates Crosstalk between Interleukin 1? and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression Int J Mol Sci, 2017-11-22;18(11):. 2017-11-22 [PMID: 29165387] (Bioassay, Human)	Bioassay	Human
RK Kutty, W Samuel, T Duncan, O Postnikova, C Jaworski, CN Nagineni, TM Redmond Proinflammatory cytokine interferon-? increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cells Cytokine, 2017-10-18;0(0):. 2017-10-18 [PMID: 29054724] (Bioassay, Human)	Bioassay	Human
H Mogami, A Hari Kisho, Y Akgul, RA Word Healing of Preterm Ruptured Fetal Membranes Sci Rep, 2017-10-13;7(1):13139. 2017-10-13 [PMID: 29030612] (Bioassay, Human)	Bioassay	Human
L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis Autophagy, 2017-01-01;0(0):0. 2017-01-01 [PMID: 28933598] (Bioassay, Human)	Bioassay	Human
N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction JCI Insight, 2017-09-07;2(17):. 2017-09-07 [PMID: 28878126] (Bioassay, Human)	Bioassay	Human
A Steinert, I Linas, B Kaya, M Ibrahim, A Schlitzer, P Hruz, K Radulovic, L Terraccian, AJ Macpherson, JH Niess The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models J. Immunol., 2017-09-01;0(0):. 2017-09-01 [PMID: 28864472] (Bioassay, Mouse)	Bioassay	Mouse
L Ding, JA Buckwalter, JA Martin DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone Mediators Inflamm., 2017-07-18;2017(0):2642549. 2017-07-18 [PMID: 28804219] (Bioassay, Bovine)	Bioassay	Bovine
TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath The Role of Inflammation in ?-cell Dedifferentiation Sci Rep, 2017-07-24;7(1):6285. 2017-07-24 [PMID: 28740254] (Bioassay, Human)	Bioassay	Human
AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505. 2017-07-01 [PMID: 28715583] (Bioassay, Human)	Bioassay	Human
R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection J. Leukoc. Biol., 2017-06-29;0(0):. 2017-06-29 [PMID: 28663244] (Bioassay, Human)	Bioassay	Human
L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis Cytokine, 2017-06-26;97(0):187-192. 2017-06-26 [PMID: 28662439] (Bioassay, Human)	Bioassay	Human
J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy J. Immunol., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652396] (Bioassay, Human)	Bioassay	Human
J Shen, C Wang, D Li, T Xu, J Myers, JM Ashton, T Wang, MJ Zuscik, A McAlinden, RJ O'Keefe DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism JCI Insight, 2017-06-15;2(12):. 2017-06-15 [PMID: 28614801] (Bioassay, Human)	Bioassay	Human
E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition JCI Insight, 2017-06-15;2(12):. 2017-06-15 [PMID: 28614794] (Bioassay, Human)	Bioassay	Human
D Moulin, V Salone, M Koufany, T Clément, I Behm-Ansma, C Branlant, B Charpentie, JY Jouzeau MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes Biomed Res Int, 2017-05-22;2017(0):9792512. 2017-05-22 [PMID: 28612031] (Bioassay, Human)	Bioassay	Human
R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells Stem Cell Reports, 2017-06-06;8(6):1757-1769. 2017-06-06 [PMID: 28591655] (Bioassay, Human)	Bioassay	Human
NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells Elife, 2017-06-06;6(0):. 2017-06-06 [PMID: 28585919] (Bioassay, Human)	Bioassay	Human
N Takegami, K Akeda, J Yamada, T Sano, K Murata, J Huang, K Masuda, A Sudo RANK/RANKL/OPG system in the intervertebral disc Arthritis Res. Ther., 2017-06-02;19(1):121. 2017-06-02 [PMID: 28576140] (Bioassay, Rat)	Bioassay	Rat
J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells Nat. Immunol., 2017-05-15;0(0):. 2017-05-15 [PMID: 28504697] (Bioassay, Human)	Bioassay	Human
J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2017-05-01;58(5):2544-2553. 2017-05-01 [PMID: 28492873] (Bioassay, Human)	Bioassay	Human
A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes Arthritis Res. Ther., 2017-05-08;19(1):89. 2017-05-08 [PMID: 28482921] (Bioassay, Human)	Bioassay	Human
R Natoli, N Fernando, M Madigan, JA Chu-Tan, K Valter, J Provis, M Rutar Microglia-derived IL-1? promotes chemokine expression by Mï¿½ller cells and RPE in focal retinal degeneration Mol Neurodegener, 2017-04-24;12(1):31. 2017-04-24 [PMID: 28438165] (Bioassay, Human)	Bioassay	Human
N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific Front Immunol, 2017-04-03;8(0):379. 2017-04-03 [PMID: 28421077] (Bioassay, Human)	Bioassay	Human
E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro Stem Cell Res Ther, 2017-04-17;8(1):79. 2017-04-17 [PMID: 28412968] (Bioassay, Human)	Bioassay	Human
G Dharmadhik, K Stolz, M Hauke, NG Morgan, A Varki, E de Koning, S Kelm, K Maedler Siglec-7 restores ?-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes Sci Rep, 2017-04-05;7(0):45319. 2017-04-05 [PMID: 28378743] (Bioassay, Human)	Bioassay	Human
F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017-06-01;0(0):. 2017-06-01 [PMID: 28376277] (Bioassay, Human)	Bioassay	Human
D Li, N Liu, HH Zhao, X Zhang, H Kawano, L Liu, L Zhao, HP Li Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo J Neuroinflammation, 2017-03-29;14(1):67. 2017-03-29 [PMID: 28356158] (Bioassay, Mouse)	Bioassay	Mouse
Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes Am J Transl Res, 2017-02-15;9(2):454-465. 2017-02-15 [PMID: 28337274] (Bioassay, Human)	Bioassay	Human
Y Kokubu, T Yamaguchi, K Kawabata Inï¿½vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells Biochem. Biophys. Res. Commun, 2017-03-21;0(0):. 2017-03-21 [PMID: 28336435] (Bioassay, Human)	Bioassay	Human
BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas J. Immunol, 2017-03-22;0(0):. 2017-03-22 [PMID: 28330899] (Bioassay, Human)	Bioassay	Human
V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients Sci Rep, 2017-03-22;7(0):44941. 2017-03-22 [PMID: 28327551] (Bioassay, Human)	Bioassay	Human
P Siengdee, W Pradit, T Euppayo, S Chomdej, K Nganvongpa Comparison of the effects of cefazolin and ceftriaxone on canine chondrocyte culture J. Vet. Pharmacol. Ther, 2017-03-19;0(0):. 2017-03-19 [PMID: 28317140] (Bioassay, Canine)	Bioassay	Canine
HJ Lee, SN Kim, MS Jeon, T Yi, SU Song ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells Sci Rep, 2017-03-14;7(0):44486. 2017-03-14 [PMID: 28290526] (Bioassay, Human)	Bioassay	Human
C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations JCI Insight, 2017-03-09;2(5):e91127. 2017-03-09 [PMID: 28289717] (Bioassay, Human)	Bioassay	Human
W Cheng, J Jing, Z Wang, D Wu, Y Huang Chondroprotectiveï¿½Effectsï¿½ofï¿½Ginsenosideï¿½Rg1ï¿½inï¿½ Humanï¿½Osteoarthritisï¿½Chondrocytesï¿½andï¿½aï¿½Ratï¿½Modelï¿½ ofï¿½Anteriorï¿½Cruciateï¿½Ligamentï¿½Transection Nutrients, 2017-03-10;9(3):. 2017-03-10 [PMID: 28287423] (Bioassay, Human)	Bioassay	Human
WC Chu, S Zhang, TJ Sng, YJ Ong, WL Tan, VY Ang, CB Foldager, WS Toh Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation Int J Oral Sci, 2017-03-10;0(0):. 2017-03-10 [PMID: 28282029] (Bioassay, Rat)	Bioassay	Rat
F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4 PLoS ONE, 2017-03-09;12(3):e0172738. 2017-03-09 [PMID: 28278201] (Bioassay, Human)	Bioassay	Human
MH Hancock, LM Hook, J Mitchell, JA Nelson Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK? MBio, 2017-03-07;8(2):. 2017-03-07 [PMID: 28270578] (Bioassay, Human)	Bioassay	Human
A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer J. Pathol, 2017-04-03;0(0):. 2017-04-03 [PMID: 28247413] (Bioassay, Human)	Bioassay	Human
L Israel, Y Wang, K Bulek, E Della Mina, Z Zhang, V Pedergnana, M Chrabieh, NA Lemmens, V Sancho-Shi, M Descatoire, T Lasseau, E Israelsson, L Lorenzo, L Yun, A Belkadi, A Moran, LE Weisman, F Vandenesch, F Batteux, S Weller, M Levin, J Herberg, A Abhyankar, C Prando, Y Itan, WJB van Wamel, C Picard, L Abel, D Chaussabel, X Li, B Beutler, PD Arkwright, JL Casanova, A Puel Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity Cell, 2017-02-23;168(5):789-800.e10. 2017-02-23 [PMID: 28235196] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
CY Chiu, SC Su, WL Fan, SH Lai, MH Tsai, SH Chen, KS Wong, WH Chung Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption Sci Rep, 2017-02-24;7(0):43469. 2017-02-24 [PMID: 28233860] (Bioassay, Human)	Bioassay	Human
SC Liu, CP Chiu, CH Tsai, CY Hung, TM Li, YC Wu, CH Tang Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models Sci Rep, 2017-02-22;7(0):43205. 2017-02-22 [PMID: 28225075] (Bioassay, Human)	Bioassay	Human
A Riba, M Emmenlauer, A Chen, F Sigoillot, F Cong, C Dehio, J Jenkins, M Zavolan Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results Cell Syst, 2017-02-15;4(2):182-193.e4. 2017-02-15 [PMID: 28215525] (Bioassay, Human)	Bioassay	Human
MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates Cell Rep, 2017-02-14;18(7):1761-1773. 2017-02-14 [PMID: 28199847] (Bioassay, Human)	Bioassay	Human
M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells Clin. Cancer Res, 2017-02-09;0(0):. 2017-02-09 [PMID: 28183713] (Bioassay, Human)	Bioassay	Human
A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation Mol. Ther, 2017-01-04;25(1):102-119. 2017-01-04 [PMID: 28129106] (Bioassay, In Vivo, Human, Mouse)	Bioassay, In Vivo	Human, Mouse
Elias S, Schmidt A, Kannan V, Andersson J, Tegner J TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner. Front Immunol, 2016-12-23;7(0):603. 2016-12-23 [PMID: 28066414] (Bioassay, Human)	Bioassay	Human
Analysis of CXCR5(+)Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis Sci Rep, 2016-12-22;6(0):39474. 2016-12-22 [PMID: 28004828] (Bioassay, Human)	Bioassay	Human
Shailesh Dudhgaonka Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity J. Immunol, 2016-12-21;0(0):. 2016-12-21 [PMID: 28003376] (Bioassay, Human)	Bioassay	Human
P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression Stem Cell Res Ther, 2016-12-01;7(1):175. 2016-12-01 [PMID: 27906099] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Sci Rep, 2016-12-01;6(0):37977. 2016-12-01 [PMID: 27905482] (Bioassay, Human)	Bioassay	Human
Nathalie Castex-Riz Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434. 2016-11-10 [PMID: 27877060] (Bioassay, Human)	Bioassay	Human
Andrea Todisco Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2. 2016-11-17 [PMID: 27856416] (Bioassay, Human)	Bioassay	Human
Robert Sabat MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations Mediators Inflamm., 2016-10-23;2016(0):4097574. 2016-10-23 [PMID: 27843200] (Bioassay, Human)	Bioassay	Human
Derek N J Hart The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population J. Immunol., 2016-11-11;0(0):. 2016-11-11 [PMID: 27837105] (Human)		Human
Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration JCI Insight, 2016-08-04;1(12):e86820. 2016-08-04 [PMID: 27699225] (Bioassay, Human)	Bioassay	Human
I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia Haematologica, 2016-08-04;101(11):e461-e464. 2016-08-04 [PMID: 27662009] (Bioassay, Human)	Bioassay	Human
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-? Aging Cell, 2016-09-22;0(0):. 2016-09-22 [PMID: 27660103] (Bioassay, Porcine)	Bioassay	Porcine
Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation J Biol Chem, 2016-09-20;0(0):. 2016-09-20 [PMID: 27650497] (Bioassay, Human)	Bioassay	Human
Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue J Immunol, 2016-09-19;0(0):. 2016-09-19 [PMID: 27647830] (Bioassay, Human)	Bioassay	Human
Jean-Philippe Pradère, Céline Hernandez, Christiane Koppe, Richard A Friedman, Tom Luedde, Robert F Schwabe Negative regulation of NF-?B p65 activity by serine 536 phosphorylation. Science Signaling, 2016-08-23;0(0):1937-9145. 2016-08-23 [PMID: 27555662] (Bioassay, Human)	Bioassay	Human
DUSP1 maintains IRF1 and leads to increased expression of IRF1-dependent genes: A mechanism promoting glucocorticoid-insensitivity J Biol Chem, 2016-08-22;0(0):. 2016-08-22 [PMID: 27551049] (Bioassay, Human)	Bioassay	Human
Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism Stem Cells Transl Med, 2016-07-11;0(0):. 2016-07-11 [PMID: 27400792] (Bioassay, Human)	Bioassay	Human
Jenny Z Kechagia Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop Sci Rep, 2016-06-20;6(0):28261. 2016-06-20 [PMID: 27321784] (Bioassay, Human)	Bioassay	Human
Chan-Mi Lee Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts Cell Biosci, 2016-06-16;6(0):43. 2016-06-16 [PMID: 27313839] (Bioassay, Human)	Bioassay	Human
Guanghui Yi Structural and functional attributes of the Interleukin-36 receptor J Biol Chem, 2016-06-15;0(0):. 2016-06-15 [PMID: 27307043] (Bioassay, Human)	Bioassay	Human
Marcin Ratajewski Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor J Leukoc Biol, 2016-06-02;0(0):. 2016-06-02 [PMID: 27256574] (Bioassay, Human)	Bioassay	Human
IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice J Immunol, 2016-05-13;0(0):. 2016-05-13 [PMID: 27183574] (Bioassay, Mouse)	Bioassay	Mouse
Silk-based blood stabilization for diagnostics Proc Natl Acad Sci USA, 2016-05-09;113(21):5892-7. 2016-05-09 [PMID: 27162330] (Bioassay, Human)	Bioassay	Human
Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation Sci Rep, 2016-05-04;6(0):25171. 2016-05-04 [PMID: 27142573] (Bioassay, Human)	Bioassay	Human
4-methylumbelliferone diminishes catabolically-activated articular chondrocytes and cartilage explants via a mechanism independent of hyaluronan inhibition J Biol Chem, 2016-04-25;0(0):. 2016-04-25 [PMID: 27129266] (Bioassay, Bovine, Human)	Bioassay	Bovine, Human
Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis PLoS ONE, 2016-04-28;11(4):e0154107. 2016-04-28 [PMID: 27123995] (Bioassay, Mouse)	Bioassay	Mouse
SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nat Immunol, 2016-04-25;0(0):. 2016-04-25 [PMID: 27111145] (Bioassay, Human)	Bioassay	Human
M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu, D Ren, B Yu, L Zheng, X Hu, W Shi, J Xu Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis Stem Cell Res Ther, 2016-04-23;7(1):63. 2016-04-23 [PMID: 27107963] (Bioassay, Human)	Bioassay	Human
F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik Ubiquitin D regulates IRE1?/JNK-dependent apoptosis in pancreatic beta cells J Biol Chem, 2016-04-04;0(0):. 2016-04-04 [PMID: 27044747] (Bioassay, Human)	Bioassay	Human
R Flynn, K Paz, J Du, DK Reichenbac, PA Taylor, A Panoskalts, A Vulic, L Luznik, KK MacDonald, GR Hill, MS Nyuydzefe, JM Weiss, W Chen, A Trzeciak, JS Serody, EG Aguilar, WJ Murphy, I Maillard, D Munn, J Koreth, CS Cutler, JH Antin, J Ritz, SD Waksal, A Zanin-Zhor, BR Blazar Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism Blood, 2016-03-16;127(17):2144-54. 2016-03-16 [PMID: 26983850] (Bioassay, Human)	Bioassay	Human
MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7 Stem Cells Dev., 2016-05-02;25(10):774-87. 2016-05-02 [PMID: 26979751] (Bioassay, Human)	Bioassay	Human
Gwendolyn Sowa NF-?B Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors Phys Ther, 2016-02-18;96(5):704-11. 2016-02-18 [PMID: 26893504] (Bioassay, Rabbit)	Bioassay	Rabbit
Guo Z, Zheng L, Liao X, Geller D Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex. PLoS ONE, 2016-01-11;11(1):e0146640. 2016-01-11 [PMID: 26751080] (Bioassay, Human)	Bioassay	Human
BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis J. Biol. Chem, 2015-12-23;291(8):4048-57. 2015-12-23 [PMID: 26702052] (Bioassay, Human)	Bioassay	Human
Dorgham K, Amoura Z, Parizot C, Arnaud L, Frances C, Pionneau C, Devilliers H, Pinto S, Zoorob R, Miyara M, Larsen M, Yssel H, Gorochov G, Mathian A Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand. Eur J Immunol, 2015-10-16;45(11):3174-87. 2015-10-16 [PMID: 26354876] (Bioassay, Human)	Bioassay	Human
Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways. J Immunol, 2015-08-14;195(6):2818-28. 2015-08-14 [PMID: 26276870] (Bioassay, Human)	Bioassay	Human
Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, Woska J, Mennerich D, Brown S, Mbow M, Kao C Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. J Biol Chem, 2015-08-12;290(39):23997-4006. 2015-08-12 [PMID: 26269592] (Bioassay, Human)	Bioassay	Human
Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X, Jiang M, Liao L, Zhou Z, Hu J Pro-Inflammatory Cytokine IL-1beta Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma. PLoS ONE, 2015-07-15;10(7):e0132677. 2015-07-15 [PMID: 26176534] (Bioassay, Human)	Bioassay	Human
Onderdijk A, Baerveldt E, Kurek D, Kant M, Florencia E, Debets R, Prens E IL-4 Downregulates IL-1beta and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine. J Immunol, 2015-07-13;195(4):1744-52. 2015-07-13 [PMID: 26170379] (Bioassay, Human)	Bioassay	Human
Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma. J Transl Med, 2015-06-20;13(0):197. 2015-06-20 [PMID: 26088750] (Bioassay, Human)	Bioassay	Human
Jeong J, Moon S, Jhun J, Yang E, Cho M, Min J Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes. PLoS ONE, 2015-06-17;10(6):e0130882. 2015-06-17 [PMID: 26083352] (Bioassay, Human)	Bioassay	Human
Ahn Y, Weeres M, Neulen M, Choi J, Kang S, Heo D, Bergerson R, Blazar B, Miller J, Verneris M Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation. Eur J Immunol, 2015-06-22;45(8):2335-42. 2015-06-22 [PMID: 26046454] (Bioassay, Human)	Bioassay	Human
Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med, 2015-05-25;212(6):939-51. 2015-05-25 [PMID: 26008899] (Bioassay, Human)	Bioassay	Human
Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G Generation of articular chondrocytes from human pluripotent stem cells. Nat Biotechnol, 2015-05-11;33(6):638-45. 2015-05-11 [PMID: 25961409] (Bioassay, Human)	Bioassay	Human
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med, 2015-04-27;212(5):619-31. 2015-04-27 [PMID: 25918342] (Bioassay, Human)	Bioassay	Human
Brand O, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson A, Hill A, Jablons D, Wolters P, Lou J, Marks J, Baron J, Nishimura S Transforming Growth Factor-beta and Interleukin-1beta Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem, 2015-04-27;290(23):14717-28. 2015-04-27 [PMID: 25918170] (Bioassay, Human)	Bioassay	Human
Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. PLoS ONE, 2015-03-23;10(3):e0121654. 2015-03-23 [PMID: 25799427] (Bioassay, Human)	Bioassay	Human
Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment. Nat Med, 2015-03-16;21(4):363-72. 2015-03-16 [PMID: 25774850] (Bioassay, Human)	Bioassay	Human
Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production. Infect Immun, 2015-03-02;83(5):1973-82. 2015-03-02 [PMID: 25733519] (Bioassay, Human)	Bioassay	Human
Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J The expression and regulation of chemerin in the epidermis. PLoS ONE, 2015-02-06;10(2):e0117830. 2015-02-06 [PMID: 25659101] (Bioassay, Human)	Bioassay	Human
Herova M, Schmid M, Gemperle C, Hersberger M ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 2015-01-30;194(5):2330-7. 2015-01-30 [PMID: 25637017] (Bioassay, Human)	Bioassay	Human
Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands. PLoS ONE, 2015-01-27;10(1):e0116773. 2015-01-27 [PMID: 25625944] (Bioassay, Human)	Bioassay	Human
Arous C, Ferreira P, Dermitzakis E, Halban P Short term exposure of beta cells to low concentrations of interleukin-1beta improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression. J Biol Chem, 2015-01-13;290(10):6653-69. 2015-01-13 [PMID: 25586177] (Bioassay, Human)	Bioassay	Human
Yan X, Jiang E, Weng H Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta. J Neuroinflammation, 2015-01-09;12(0):222. 2015-01-09 [PMID: 25571780] (Bioassay, Mouse)	Bioassay	Mouse
Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Pathog, 2014-12-11;10(12):e1004551. 2014-12-11 [PMID: 25503264] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Bigildeev A, Zezina E, Shipounova I, Drize N Interleukin-1 beta enhances human multipotent mesenchymal stromal cell proliferative potential and their ability to maintain hematopoietic precursor cells. Cytokine, 2014-11-24;71(2):246-54. 2014-11-24 [PMID: 25461405] (Bioassay, Human)	Bioassay	Human
Scarlata C, Celse C, Pignon P, Ayyoub M, Valmori D Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. Eur J Immunol, 2015-01-16;45(2):474-9. 2015-01-16 [PMID: 25446972] (Bioassay, Human)	Bioassay	Human
Muller I, Beissert S, Kulms D Anti-apoptotic NF-kappaB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production. J Invest Dermatol, 2014-11-07;135(3):851-60. 2014-11-07 [PMID: 25380350] (Bioassay, Human)	Bioassay	Human
Lam , Sharon, Sung , Julia, Cruz , Conrad, Castillo-Caro , Paul, Ngo , Minhtran, Garrido , Carolina, Kuruc , Joann, Archin , Nancie, Rooney , Cliona, Margolis , David, Bollard , Catherin Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 2014-11-04;23(2):387-95. 2014-11-04 [PMID: 25366030] (Bioassay, Human)	Bioassay	Human
Van Belle T, Vanherwegen A, Feyaerts D, De Clercq P, Verstuyf A, Korf H, Gysemans C, Mathieu C 1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients. PLoS ONE, 2014-10-03;9(10):e109194. 2014-10-03 [PMID: 25279717] (Bioassay, Human)	Bioassay	Human
Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J Clin Invest, 2014-09-17;124(10):4657-67. 2014-09-17 [PMID: 25244097] (Bioassay, Human)	Bioassay	Human
Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE, 2014-09-03;9(9):e106673. 2014-09-03 [PMID: 25184791] (Bioassay, Human)	Bioassay	Human
Gotoh M, Nagano A, Tsukahara R, Murofushi H, Morohoshi T, Otsuka K, Murakami-Murofushi K Cyclic phosphatidic acid relieves osteoarthritis symptoms. Mol Pain, 2014-08-14;10(0):52. 2014-08-14 [PMID: 25123228] (Bioassay, Human)	Bioassay	Human
Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, Guabiraba R, Chang H, Fukada S, Salmond R, Schmitt E, Bopp T, Ryffel B, Liew F Nitric oxide enhances Th9 cell differentiation and airway inflammation. Nat Commun, 2014-08-07;5(0):4575. 2014-08-07 [PMID: 25099390] (Bioassay, Human)	Bioassay	Human
Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. J Immunol, 2014-07-30;193(5):2297-305. 2014-07-30 [PMID: 25080481] (Bioassay, Human)	Bioassay	Human
Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells. J Biol Chem, 2014-07-28;289(37):25546-55. 2014-07-28 [PMID: 25070893] (Bioassay, Human)	Bioassay	Human
Altara , Raffaele, Manca , Marco, Hessel , Marleen, Janssen , Ben J, Struijker-Boudier , Harry H, Hermans , Rob J J, Blankesteijn , W Matthi Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample. BMC Biotechnol, 2014-07-15;14(0):63. 2014-07-15 [PMID: 25022797] (ELISA (Standard))	ELISA (Standard)
Lewis , Nuruddee, Patnaude , Lori A, Pelletier , Josephin, Souza , Donald J, Lukas , Susan M, King , F James, Hill , Jonathan, Stefanopoulos , Dimitria, Ryan , Kelli, Desai , Sudha, Skow , Donna, Kauschke , Stefan G, Broermann , Andre, Kuzmich , Daniel, Harcken , Christia, Hickey , Eugene R, Modis , Louise K A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo. PLoS ONE, 2014-06-26;9(6):e100883. 2014-06-26 [PMID: 24967665] (Bioassay, Human)	Bioassay	Human
Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol, 2014-06-23;193(3):1047-54. 2014-06-23 [PMID: 24958901] (Bioassay, Human)	Bioassay	Human
Kastrati I, Canestrari E, Frasor J PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres. Oncogene, 2014-06-23;34(18):2309-16. 2014-06-23 [PMID: 24954507] (Bioassay, Human)	Bioassay	Human
Brozzi F, Gerlo S, Grieco F, Nardelli T, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, Eizirik D A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. J Biol Chem, 2014-07-25;289(30):20677-93. 2014-07-25 [PMID: 24936061] (Bioassay, Human, Rat)	Bioassay	Human, Rat
Pomianowska E, Sandnes D, Grzyb K, Schjolberg A, Aasrum M, Tveteraas I, Tjomsland V, Christoffersen T, Gladhaug I Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma. BMC Cancer, 2014-06-09;14(0):413. 2014-06-09 [PMID: 24912820] (Bioassay, Human)	Bioassay	Human
Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol, 2014-06-06;134(2):373-81. 2014-06-06 [PMID: 24910175] (Bioassay, Human)	Bioassay	Human
Zhao Y, Xiao X, Frank S, Lin H, Xia Y Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta. Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98. 2014-06-03 [PMID: 24895283] (Bioassay, Human)	Bioassay	Human
Duhen T, Campbell D IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol, 2014-06-02;193(1):120-9. 2014-06-02 [PMID: 24890729] (Bioassay, Human)	Bioassay	Human
Backman S, Kollara A, Haw R, Stein L, Brown T Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells. PLoS ONE, 2014-05-21;9(5):e97997. 2014-05-21 [PMID: 24848801] (Bioassay, Human)	Bioassay	Human
Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzi R, Meliconi R Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1beta-stimulated production of chemokines and matrix-degrading enzymes in vitro. PLoS ONE, 2014-05-12;9(5):e96925. 2014-05-12 [PMID: 24819779] (Bioassay, Human)	Bioassay	Human
Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-05-08;124(6):2513-22. 2014-05-08 [PMID: 24812667] (Bioassay, Human)	Bioassay	Human
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Bioassay, Human)	Bioassay	Human
Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J, Zheng F, Ouyang X, Lin X, Lin Y, Huang Q, Wang L, Tan J Additive effects of EGF and IL-1beta regulate tumor cell migration and invasion in gastric adenocarcinoma via activation of ERK1/2. Int J Oncol, 2014-04-28;45(1):291-301. 2014-04-28 [PMID: 24789460] (Bioassay, Human)	Bioassay	Human
Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments. PLoS ONE, 2014-04-21;9(4):e95586. 2014-04-21 [PMID: 24751986] (Bioassay, Human)	Bioassay	Human
Liu J, Ren Y, Kang L, Zhang L Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice. PLoS ONE, 2014-04-10;9(4):e94912. 2014-04-10 [PMID: 24722330] (Bioassay, Human)	Bioassay	Human
Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, de Martin R, Groger M, Petzelbauer P, Huk I, Huber K, Wojta J, Demyanets S Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis. J Thromb Haemost, 2014-06-01;12(6):948-57. 2014-06-01 [PMID: 24702774] (Bioassay, Human)	Bioassay	Human
Shah S, King E, Chandrasekhar A, Newton R Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone. J Biol Chem, 2014-04-01;289(19):13667-79. 2014-04-01 [PMID: 24692548] (Bioassay, Human)	Bioassay	Human
Reed , Daniel M, Foldes , Gabor, Gatheral , Timothy, Paschalaki , Koralia, Lendvai , Zsuzsann, Bagyura , Zsolt, Nemeth , Tamas, Skopal , Judit, Merkely , Bela, Telcian , Aurica G, Gogsadze , Leila, Edwards , Michael, Gough , Peter J, Bertin , John, Johnston , Sebastia, Harding , Sian E, Mitchell , Jane A Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors. PLoS ONE, 2014-04-01;9(4):e91119. 2014-04-01 [PMID: 24690886] (Bioassay, Human)	Bioassay	Human
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol, 2014-03-21;134(9):2351-60. 2014-03-21 [PMID: 24658504] (Bioassay, Human)	Bioassay	Human
Coward W, Feghali-Bostwick C, Jenkins G, Knox A, Pang L A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis. FASEB J, 2014-03-20;28(7):3183-96. 2014-03-20 [PMID: 24652950] (Bioassay, Human)	Bioassay	Human
Ardestani , Amin, Paroni , Federico, Azizi , Zahra, Kaur , Supreet, Khobragade , Vrushali, Yuan , Ting, Frogne , Thomas, Tao , Wufan, Oberholzer , Jose, Pattou , Francois, Kerr Conte , Julie, Maedler , Kathrin MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med, 2014-03-16;20(4):385-97. 2014-03-16 [PMID: 24633305] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Marroqui L, Santin I, Dos Santos R, Marselli L, Marchetti P, Eizirik D BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2. Diabetes, 2014-03-07;63(7):2516-27. 2014-03-07 [PMID: 24608439] (Bioassay, Human)	Bioassay	Human
Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog, 2014-03-06;10(3):e1003936. 2014-03-06 [PMID: 24603878] (Bioassay, Human)	Bioassay	Human
Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, Hirschfield M, Casanova J, Picard C, Puel A, Lin L, Rao V Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner. J Biol Chem, 2014-02-24;289(15):10865-75. 2014-02-24 [PMID: 24567333] (Bioassay, Human)	Bioassay	Human
Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure. PLoS ONE, 2014-02-14;9(2):e88714. 2014-02-14 [PMID: 24551140] (Bioassay, Human)	Bioassay	Human
Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Bioassay, Human)	Bioassay	Human
Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis. J Immunol, 2014-02-05;192(5):2449-59. 2014-02-05 [PMID: 24501201] (Bioassay, Human)	Bioassay	Human
Milwid , Jack M, Elman , Jessica, Li , Matthew, Shen , Keyue, Manrai , Arjun, Gabow , Aaron, Yarmush , Joshua, Jiao , Yunxin, Fletcher , Anne, Lee , Jungwoo, Cima , Michael, Yarmush , Martin L, Parekkadan , Biju Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators. Mol Ther, 2014-02-05;22(5):999-1007. 2014-02-05 [PMID: 24496384] (Bioassay, Human)	Bioassay	Human
Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L TNF-alpha blockade induces IL-10 expression in human CD4+ T cells. Nat Commun, 2014-01-01;5(0):3199. 2014-01-01 [PMID: 24492460] (Bioassay, Human)	Bioassay	Human
Chiliveru S, Rahbek S, Jensen S, Jorgensen S, Nissen S, Christiansen S, Mogensen T, Jakobsen M, Iversen L, Johansen C, Paludan S Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA. J Immunol, 2014-01-31;192(5):2395-404. 2014-01-31 [PMID: 24489095] (Bioassay, Human)	Bioassay	Human
Huang Q, Lan F, Wang X, Yu Y, Ouyang X, Zheng F, Han J, Lin Y, Xie Y, Xie F, Liu W, Yang X, Wang H, Dong L, Wang L, Tan J IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9. Mol Cancer, 2014-01-31;13(0):18. 2014-01-31 [PMID: 24479681] (Bioassay, Human)	Bioassay	Human
Haseeb A, Makki M, Haqqi T Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes. J Biol Chem, 2014-01-27;289(10):6877-85. 2014-01-27 [PMID: 24469454] (Bioassay, Human)	Bioassay	Human
Gattu A, Birkenfeld A, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel V, Crawford S, Chung C Pigment epithelium-derived factor (PEDF) suppresses IL-1beta-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology, 2014-01-23;155(4):1373-85. 2014-01-23 [PMID: 24456163] (Bioassay, Human)	Bioassay	Human
Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A, 2014-01-13;111(4):1509-14. 2014-01-13 [PMID: 24434549] (Bioassay, Human)	Bioassay	Human
Fielding C, Jones G, McLoughlin R, McLeod L, Hammond V, Uceda J, Williams A, Lambie M, Foster T, Liao C, Rice C, Greenhill C, Colmont C, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig K, Williams J, Williams G, Davies S, Humphreys I, O'Donnell V, Taylor P, Jenkins B, Topley N, Jones S Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity, 2014-01-09;40(1):40-50. 2014-01-09 [PMID: 24412616] (Bioassay, Human)	Bioassay	Human
Ho L, Hung L, Liu F, Hou T, Lin L, Huang C, Lai J Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis. PLoS ONE, 2013-12-11;8(12):e82033. 2013-12-11 [PMID: 24349175] (Bioassay, Human)	Bioassay	Human
Nold-Petry C, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho S, Zepp J, Azam T, Dinkel H, Palmer B, Boisvert W, Cool C, Taraseviciene-Stewart L, Heinhuis B, Joosten L, Dinarello C, Voelkel N, Nold M IL-32 promotes angiogenesis. J Immunol, 2013-12-11;192(2):589-602. 2013-12-11 [PMID: 24337385] (Bioassay, Human)	Bioassay	Human
Cheng X, He P, Lee T, Yao H, Li R, Shen Y High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014-01-01;184(1):141-7. 2014-01-01 [PMID: 24332014] (Cell Culture, Human)	Cell Culture	Human
Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H p38-Mediated phosphorylation of Eps15 endocytic adaptor protein. FEBS Lett, 2013-11-21;588(1):131-7. 2013-11-21 [PMID: 24269888] (Bioassay, Human)	Bioassay	Human
Kim J, Kim S, Lim S, Kieff E, Song Y Role of Ca2+/calmodulin-dependent kinase II-IRAK1 interaction in LMP1-induced NF-kappaB activation. Mol Cell Biol, 2013-11-18;34(3):325-34. 2013-11-18 [PMID: 24248603] (Bioassay, Mouse)	Bioassay	Mouse
Cucchiarini M, Madry H, Terwilliger E Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis. J Cell Mol Med, 2013-11-17;18(1):115-24. 2013-11-17 [PMID: 24237934] (Bioassay, Human)	Bioassay	Human
Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes. PLoS Pathog, 2013-10-17;9(10):e1003700. 2013-10-17 [PMID: 24204260] (Bioassay, Human)	Bioassay	Human
Issafras H, Corbin J, Goldfine I, Roell M Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1beta antibody with differential receptor-modulating properties. J Pharmacol Exp Ther, 2013-11-05;348(1):202-15. 2013-11-05 [PMID: 24194526] (Binding Assay, Surface Plasmon Resonance)	Binding Assay, Surface Plasmon Resonance
Sidney L, Kirkham G, Buttery L Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma. Stem Cells Dev, 2014-01-23;23(6):605-17. 2014-01-23 [PMID: 24192281] (Bioassay, Mouse)	Bioassay	Mouse
Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2. Eur J Immunol, 2013-12-02;44(2):553-60. 2013-12-02 [PMID: 24165969] (Bioassay, Human)	Bioassay	Human
Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma. Clin Cancer Res, 2013-09-13;19(23):6484-94. 2013-09-13 [PMID: 24036851] (Cell Culture, Human)	Cell Culture	Human
Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife, 2013-07-23;2(0):e00762. 2013-07-23 [PMID: 23898399] (Bioassay, Mouse)	Bioassay	Mouse
Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Muller I Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur J Immunol, 2013-07-23;43(10):2741-9. 2013-07-23 [PMID: 23817958] (Bioassay, Human)	Bioassay	Human
Afzali B, Mitchell P, Edozie F, Povoleri G, Dowson S, Demandt L, Walter G, Canavan J, Scotta C, Menon B, Chana P, Khamri W, Kordasti S, Heck S, Grimbacher B, Tree T, Cope A, Taams L, Lechler R, John S, Lombardi G CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner. Eur J Immunol, 2013-07-03;43(8):2043-54. 2013-07-03 [PMID: 23677517] (Bioassay, Human)	Bioassay	Human
Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol, 2013-05-08;43(7):1727-34. 2013-05-08 [PMID: 23568529] (Bioassay, Mouse)	Bioassay	Mouse
El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS ONE, 2013-03-08;8(3):e58935. 2013-03-08 [PMID: 23520544] (Bioassay, Mouse)	Bioassay	Mouse
Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation. J Immunol, 2013-03-13;190(8):4196-204. 2013-03-13 [PMID: 23487424] (Bioassay, Human)	Bioassay	Human
Fitzgerald D, Fonseca-Kelly Z, Cullimore M, Safabakhsh P, Saris C, Zhang G, Rostami A Independent and interdependent immunoregulatory effects of IL-27, IFN-beta, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis. J Immunol, 2013-03-01;190(7):3225-34. 2013-03-01 [PMID: 23455508] (Bioassay, Human)	Bioassay	Human
Tang , Xin-Zi, Jo , Juandy, Tan , Anthony, Sandalova , Elena, Chia , Adeline, Tan , Kai Chah, Lee , Kang Hoe, Gehring , Adam J, De Libero , Gennaro, Bertoletti , Antonio IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells. J Immunol, 2013-02-27;190(7):3142-52. 2013-02-27 [PMID: 23447689] (Bioassay, Human)	Bioassay	Human
Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients. Clin Cancer Res, 2013-02-26;19(7):1858-72. 2013-02-26 [PMID: 23444227] (Bioassay, Human)	Bioassay	Human
Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target. Proc Natl Acad Sci U S A, 2013-02-19;110(10):E928-37. 2013-02-19 [PMID: 23431165] (Bioassay, Human)	Bioassay	Human
Sankpal N, Fleming T, Gillanders W EpCAM modulates NF-kappaB signaling and interleukin-8 expression in breast cancer. Mol Cancer Res, 2013-02-01;11(4):418-26. 2013-02-01 [PMID: 23378578] (Bioassay, Human)	Bioassay	Human
Shin M, Kang Y, Lee N, Wahl E, Kim S, Kang K, Lazova R, Kang I Self double-stranded (ds)DNA induces IL-1beta production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies. J Immunol, 2013-01-11;190(4):1407-15. 2013-01-11 [PMID: 23315075] (Cell Culture, Human)	Cell Culture	Human
Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice. Arthritis Rheum, 2013-04-01;65(4):949-59. 2013-04-01 [PMID: 23280308] (Bioassay, Human)	Bioassay	Human
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol, 2012-10-28;13(12):1178-86. 2012-10-28 [PMID: 23104095] (Bioassay, Human)	Bioassay	Human
Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J. Exp. Med., 2012-10-15;209(11):2033-47. 2012-10-15 [PMID: 23071254] (Bioassay, Human)	Bioassay	Human
Kothari H, Rao L, Vankayalapati R, Pendurthi U Mycobacterium tuberculosis infection and tissue factor expression in macrophages. PLoS ONE, 2012-09-24;7(9):e45700. 2012-09-24 [PMID: 23029190] (Bioassay, Human)	Bioassay	Human
Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients. J Biol Chem, 2012-08-14;287(42):35484-95. 2012-08-14 [PMID: 22893706] (Bioassay, Human)	Bioassay	Human
Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation. Infect Immun, 2012-08-13;80(11):3795-803. 2012-08-13 [PMID: 22890997] (Bioassay, Human)	Bioassay	Human
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J. Exp. Med., 2012-07-16;209(8):1505-17. 2012-07-16 [PMID: 22802353] (Bioassay, Human)	Bioassay	Human
Flanagan K, Fitzgerald K, Baker J Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07-06;7(7):e40443. 2012-07-06 [PMID: 22792325] (Bioassay, Human)	Bioassay	Human
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human)	Bioassay	Human
Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC The SDF-1ÃŽÂ±/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells. PLoS ONE, 2012-06-22;7(6):e38721. 2012-06-22 [PMID: 22761699] (Bioassay, Human)	Bioassay	Human
Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure. Oncoimmunology, 2012-03-01;1(2):129-140. 2012-03-01 [PMID: 22720234] (Bioassay, Human)	Bioassay	Human
Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, ÃƒËœIe E Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure. PLoS ONE, 2012-05-15;7(5):e36815. 2012-05-15 [PMID: 22615818] (Bioassay, Human)	Bioassay	Human
Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur. J. Immunol., 2012-04-01;42(4):936-45. 2012-04-01 [PMID: 22531918] (Bioassay, Human)	Bioassay	Human
Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production. PLoS ONE, 2012-04-18;7(4):e34965. 2012-04-18 [PMID: 22529962] (Bioassay, Human)	Bioassay	Human
Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency. J. Clin. Invest., 2011-11-21;121(12):4889-902. 2011-11-21 [PMID: 22105173] (Bioassay, Human)	Bioassay	Human
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells. Gene Ther, 2011-11-10;19(10):1035-40. 2011-11-10 [PMID: 22071967] (Bioassay, Human)	Bioassay	Human
Ramirez-Carrozzi V, Sambandam A, Luis E IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol., 2011-10-12;12(12):1159-66. 2011-10-12 [PMID: 21993848] (Bioassay, Human)	Bioassay	Human
Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis. J Korean Med Sci, 2011-09-01;26(9):1132-9. 2011-09-01 [PMID: 21935266] (ELISA (Standard))	ELISA (Standard)
Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission. J Transl Med, 2011-09-13;9(0):151. 2011-09-13 [PMID: 21910911] (Bioassay, Human)	Bioassay	Human
Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli. J. Immunol., 2011-05-04;186(12):6701-9. 2011-05-04 [PMID: 21543643] (Bioassay, Human)	Bioassay	Human
Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB Cadherin-11 regulates fibroblast inflammation. Proc. Natl. Acad. Sci. U.S.A., 2011-05-02;108(20):8402-7. 2011-05-02 [PMID: 21536877] (Bioassay, Human)	Bioassay	Human
Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, Markovic-Plese S B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis. J. Immunol., 2011-03-02;186(0):4518. 2011-03-02 [PMID: 21368231] (Bioassay, Human)	Bioassay	Human
Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression. J. Immunol., 2011-01-17;186(4):2613-22. 2011-01-17 [PMID: 21242515] (Bioassay, Human)	Bioassay	Human
Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury. J. Biol. Chem., 2011-01-14;286(12):10265-75. 2011-01-14 [PMID: 21239489] (Bioassay, Human)	Bioassay	Human
Shin HS, Xu F, Bagchi A, Herrup E, Wilhelmsen K Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo. J. Immunol., 2010-12-17;186(2):1119-30. 2010-12-17 [PMID: 21169547] (Bioassay, Human)	Bioassay	Human
Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1. Am. J. Reprod. Immunol., 2010-11-19;65(5):470-9. 2010-11-19 [PMID: 21087336] (Bioassay, Human)	Bioassay	Human
Xu H, Wang X, Pahar B Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression. J. Immunol., 2010-11-08;185(12):7340-8. 2010-11-08 [PMID: 21059890] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases. MAbs, 2011-01-01;3(1):49-60. 2011-01-01 [PMID: 21048425] (Binding Assay, Human)	Binding Assay	Human
Kalliolias GD, Gordon RA, Ivashkiv LB Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J. Immunol., 2010-10-22;185(11):7047-56. 2010-10-22 [PMID: 20971923] (Bioassay, Human)	Bioassay	Human
Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta. J. Immunol., 2010-10-08;185(10):5926-34. 2010-10-08 [PMID: 20935210] (Bioassay, Human)	Bioassay	Human
Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J., 2010-09-08;25(1):409-19. 2010-09-08 [PMID: 20826539] (Bioassay, Human)	Bioassay	Human
Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice. J. Immunol., 2010-07-16;185(0):2516-24. 2010-07-16 [PMID: 20639493] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Mengshol JA, Golden-Mason L, Arikawa T A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS ONE, 2010-03-04;5(3):e9504. 2010-03-04 [PMID: 20209097] (Bioassay, Human)	Bioassay	Human
Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat. Med., 2010-01-10;16(2):191-7. 2010-01-10 [PMID: 20062065] (Bioassay, Human)	Bioassay	Human
Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts. Gut, 2009-12-08;59(4):531-41. 2009-12-08 [PMID: 19996325] (Bioassay, Human)	Bioassay	Human
Lee WW, Kang SW, Choi J Regulating human Th17 cells via differential expression of IL-1 receptor. Blood, 2009-11-12;115(3):530-40. 2009-11-12 [PMID: 19965648] (Bioassay, Human)	Bioassay	Human
Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem, 2009-07-15;284(36):24035-48. 2009-07-15 [PMID: 19605353] (Bioassay, Human)	Bioassay	Human
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol., 2009-07-05;10(8):857-63. 2009-07-05 [PMID: 19578369] (Bioassay, Human)	Bioassay	Human
Brunton PJ, McKay AJ, Ochedalski T, Piastowska A, Rebas E, Lachowicz A, Russell JA Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone. J. Neurosci., 2009-05-20;29(20):6449-60. 2009-05-20 [PMID: 19458216] (In Vivo, Rat)	In Vivo	Rat
Nishida A, Andoh A, Inatomi O, Fujiyama Y Interleukin-32 expression in the pancreas. J. Biol. Chem., 2009-04-21;284(26):17868-76. 2009-04-21 [PMID: 19386602] (Bioassay, Human)	Bioassay	Human
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J., 2009-04-20;23(9):2928-41. 2009-04-20 [PMID: 19380511] (Bioassay, Human)	Bioassay	Human
Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 2009-03-09;206(3):535-48. 2009-03-09 [PMID: 19273625] (Bioassay, Human)	Bioassay	Human
Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone, 2009-03-02;44(6):1143-50. 2009-03-02 [PMID: 19264156] (Bioassay, Human)	Bioassay	Human
Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-03-02;119(10):1424-32. 2009-03-02 [PMID: 19255340] (Bioassay, Human)	Bioassay	Human
Yammani RR, Long D, Loeser RF Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes. Arthritis Rheum., 2009-03-01;60(3):792-800. 2009-03-01 [PMID: 19248116] (Bioassay, Human)	Bioassay	Human
Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9. 2009-01-17 [PMID: 19151401] (Bioassay, Human)	Bioassay	Human
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4. 2008-12-03 [PMID: 19056110] (Bioassay, Human)	Bioassay	Human
Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation. Clin. Exp. Immunol., 2008-12-01;154(3):384-90. 2008-12-01 [PMID: 19037921] (Bioassay, Human)	Bioassay	Human
Chang SY, Su PF, Lee TC Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway. Cytokine, 2008-11-20;45(1):32-8. 2008-11-20 [PMID: 19026558] (Bioassay, Human)	Bioassay	Human
Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc. Natl. Acad. Sci. U.S.A., 2008-09-16;105(38):14692-7. 2008-09-16 [PMID: 18796608] (Bioassay, Human)	Bioassay	Human
Taishi P, Churchill L, De A, Obal F, Krueger JM Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo. Brain Res., 2008-06-05;1226(0):89-98. 2008-06-05 [PMID: 18620339] (Bioassay, In Vivo, Rat)	Bioassay, In Vivo	Rat
Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA Endogenous IL-32 controls cytokine and HIV-1 production. J. Immunol., 2008-07-01;181(1):557-65. 2008-07-01 [PMID: 18566422] (Bioassay, Human)	Bioassay	Human
Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J. Allergy Clin. Immunol., 2008-06-01;121(6):1484-90. 2008-06-01 [PMID: 18539196] (Bioassay, Human)	Bioassay	Human
Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci., 2008-04-20;82(23):1203-9. 2008-04-20 [PMID: 18495175] (Bioassay, Human)	Bioassay	Human
Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation. J. Immunol., 2008-05-15;180(10):6629-39. 2008-05-15 [PMID: 18453582] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Crocker SJ, Frausto RF, Whitton JL, Milner R A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia. Glia, 2008-08-15;56(0):1187-98. 2008-08-15 [PMID: 18449943] (Bioassay, Human)	Bioassay	Human
Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human)	Bioassay	Human
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum., 2008-04-01;58(4):1001-9. 2008-04-01 [PMID: 18383392] (Bioassay, Human)	Bioassay	Human
Das S, Mishra MK, Ghosh J, Basu A Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death. J. Neuroimmunol., 2008-03-28;195(1):60-72. 2008-03-28 [PMID: 18374991] (Bioassay, Human)	Bioassay	Human
Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62. 2008-03-01 [PMID: 18327985] (ELISA (Standard))	ELISA (Standard)
Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol., 2008-02-15;83(5):1181-93. 2008-02-15 [PMID: 18281438] (Bioassay, Human)	Bioassay	Human
Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J. Pathol., 2008-02-01;214(3):328-36. 2008-02-01 [PMID: 18069648] (Bioassay, Human)	Bioassay	Human
Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-12-07;294(2):L334-43. 2007-12-07 [PMID: 18065658] (Bioassay, Human)	Bioassay	Human
Pfleger C, Schloot N, ter Veld F Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-10-22;329(1):214-8. 2007-10-22 [PMID: 17964594] (ELISA (Standard))	ELISA (Standard)
Lee SK, Pi SH, Kim SH, Min KS, Lee HJ, Chang HS, Kang KH, Kim HR, Shin HI, Lee SK, Kim EC Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells. Clin. Exp. Immunol., 2007-10-09;150(3):567-75. 2007-10-09 [PMID: 17924972] (Bioassay, Human)	Bioassay	Human
Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, Barrett SD, Schrier DJ, Flory CM Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms. Arthritis Rheum., 2007-10-01;56(10):3347-57. 2007-10-01 [PMID: 17907188] (In Vivo, Rabbit)	In Vivo	Rabbit
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA (Standard))	ELISA (Standard)
Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques. Transplantation, 2007-07-27;84(2):196-206. 2007-07-27 [PMID: 17667811] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
Luty WH, Rodeberg D, Parness J, Vyas YM Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J. Immunol., 2007-07-15;179(2):819-29. 2007-07-15 [PMID: 17617572] (Bioassay, Human)	Bioassay	Human
Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin. Exp. Immunol., 2007-06-22;149(3):480-6. 2007-06-22 [PMID: 17590175] (Bioassay, Human)	Bioassay	Human
Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest., 2007-07-01;117(7):1951-60. 2007-07-01 [PMID: 17557119] (Bioassay, Human)	Bioassay	Human
Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS, 2007;21(10):1263-72. 2007 [PMID: 17545702] (ELISA (Standard), N/A)	ELISA (Standard)	N/A
Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork. Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43. 2007-06-01 [PMID: 17525194] (Bioassay, Human)	Bioassay	Human
Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-18;293(2):L375-82. 2007-05-18 [PMID: 17513456] (Bioassay, Human)	Bioassay	Human
Gesser B, Johansen C, Rasmussen MK, Funding AT, Otkjaer K, Kjellerup RB, Kragballe K, Iversen L Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect. J. Invest. Dermatol., 2007-05-10;127(9):2129-37. 2007-05-10 [PMID: 17495961] (Bioassay, Human)	Bioassay	Human
Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut, 2007-04-20;56(9):1257-65. 2007-04-20 [PMID: 17449633] (Bioassay, Human)	Bioassay	Human
Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J. Immunol., 2007-05-01;178(9):5973-81. 2007-05-01 [PMID: 17442982] (Bioassay, Human)	Bioassay	Human
Funding AT, Johansen C, Kragballe K, Iversen L Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis. J. Invest. Dermatol., 2007-04-12;127(8):2012-9. 2007-04-12 [PMID: 17429437] (Bioassay, Human)	Bioassay	Human
Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. Biochem. Biophys. Res. Commun., 2007-04-02;357(2):402-7. 2007-04-02 [PMID: 17420005] (Bioassay, Human)	Bioassay	Human
Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig. Dis. Sci., 2007-04-06;52(12):3404-15. 2007-04-06 [PMID: 17415633] (Bioassay, Human)	Bioassay	Human
Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci., 2007-02-03;80(20):1821-31. 2007-02-03 [PMID: 17400256] (Bioassay, Human)	Bioassay	Human
van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig. Dis. Sci., 2007-03-30;52(10):2775-83. 2007-03-30 [PMID: 17394066] (Bioassay, Human)	Bioassay	Human
Kang YM, Kim SY, Kang JH LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes. Arthritis Rheum., 2007-04-01;56(4):1106-17. 2007-04-01 [PMID: 17393389] (Bioassay, Human)	Bioassay	Human
Girard BM, Young BA, Buttolph TR, White SL, Parsons RL Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia. Neuroscience, 2007-03-23;146(2):584-93. 2007-03-23 [PMID: 17367946] (Bioassay, Guinea Pig)	Bioassay	Guinea Pig
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br. J. Pharmacol., 2007-03-12;151(1):115-27. 2007-03-12 [PMID: 17351655] (Bioassay, Western Blot, Human)	Bioassay, Western Blot	Human
Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression. Int. J. Oncol., 2007-04-01;30(4):977-83. 2007-04-01 [PMID: 17332938] (Bioassay, Human)	Bioassay	Human
Emsley HC, Smith CJ, Gavin CM Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol, 2007-02-28;7(0):5. 2007-02-28 [PMID: 17328808] (ELISA (Standard))	ELISA (Standard)
Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Sa SM, Valdez PA, Wu J The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol., 2007-02-15;178(4):2229-40. 2007-02-15 [PMID: 17277128] (Bioassay, Human)	Bioassay	Human
Dame TM, Orenzoff BL, Palmer LE, Furie MB IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation. J. Immunol., 2007-01-15;178(2):1172-9. 2007-01-15 [PMID: 17202382] (Bioassay, Human)	Bioassay	Human
Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells. J. Immunol., 2007-01-01;178(1):253-61. 2007-01-01 [PMID: 17182562] (Bioassay, Human)	Bioassay	Human
Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood, 2007-04-01;109(7):2806-14. 2007-04-01 [PMID: 17179229] (Bioassay, Human)	Bioassay	Human
Sadowsky DW, Adams KM, Gravett MG, Witkin SS, Novy MJ Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model. Am. J. Obstet. Gynecol., 2006-12-01;195(6):1578-89. 2006-12-01 [PMID: 17132473] (In Vivo, Primate - Macaca mulatta (Rhesus Macaque))	In Vivo	Primate - Macaca mulatta (Rhesus Macaque)
Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol., 2006-12-01;177(11):7665-72. 2006-12-01 [PMID: 17114436] (Bioassay, Human)	Bioassay	Human
Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression. J. Endocrinol., 2006-10-01;191(1):65-81. 2006-10-01 [PMID: 17065390] (Bioassay, Hamster)	Bioassay	Hamster
Miranda LA, Braga F, Fischer RG, Sztajnbok FR, Figueredo CM, Gustafsson A Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis. J. Periodontol., 2006-10-01;77(10):1695-700. 2006-10-01 [PMID: 17032112] (ELISA (Standard))	ELISA (Standard)
Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway. J. Cell. Physiol., 2007-01-01;210(1):192-200. 2007-01-01 [PMID: 17013806] (Bioassay, Human)	Bioassay	Human
Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. Arthritis Rheum., 2006-10-01;54(10):3152-62. 2006-10-01 [PMID: 17009243] (Bioassay, Human)	Bioassay	Human
Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes, 2006-10-01;55(10):2713-22. 2006-10-01 [PMID: 17003335] (Bioassay, Human)	Bioassay	Human
Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta. Glia, 2006-11-01;54(6):619-29. 2006-11-01 [PMID: 16944452] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
Bengtson SH, Phagoo SB, Norrby-Teglund A, Pahlman L, Morgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H Kinin receptor expression during Staphylococcus aureus infection. Blood, 2006-05-30;108(6):2055-63. 2006-05-30 [PMID: 16735595] (Bioassay, Human)	Bioassay	Human
Macagno A, Molteni M, Rinaldi A A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression. J. Exp. Med., 2006-05-22;203(6):1481-92. 2006-05-22 [PMID: 16717116] (Bioassay, Human)	Bioassay	Human
Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes. Arthritis Res. Ther., 2006-04-28;8(3):R80. 2006-04-28 [PMID: 16646978] (Bioassay, Human)	Bioassay	Human
Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Bioassay, Human)	Bioassay	Human
Nguyen AN, Stebbins EG, Henson M, O&apos;Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human)	Bioassay	Human
Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74. 2006-03-16 [PMID: 16543607] (Bioassay, Human)	Bioassay	Human
LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J. Immunol., 2006-03-15;176(6):3742-52. 2006-03-15 [PMID: 16517743] (Bioassay, Human)	Bioassay	Human
Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G Th2 cytokine response in Major Depressive Disorder patients before treatment. J. Neuroimmunol., 2006-02-02;172(1):156-65. 2006-02-02 [PMID: 16457895] (ELISA (Standard))	ELISA (Standard)
Edwards MR, Johnson MW, Johnston SL Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am. J. Respir. Cell Mol. Biol., 2006-01-19;34(5):616-24. 2006-01-19 [PMID: 16424382] (Bioassay, Human)	Bioassay	Human
Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone, 2005-12-05;38(4):497-508. 2005-12-05 [PMID: 16337237] (Bioassay, Human)	Bioassay	Human
Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes. J. Immunol. Methods, 2005-11-21;308(1):138-55. 2005-11-21 [PMID: 16325847] (Primate - Chlorocebus pygerythrus (Vervet Monkey))		Primate - Chlorocebus pygerythrus (Vervet Monkey)
Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Bioassay, Human)	Bioassay	Human
Ameredes BT, Calhoun WJ Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle. J. Allergy Clin. Immunol., 2005-07-01;116(1):65-72. 2005-07-01 [PMID: 15990776] (Bioassay, Human)	Bioassay	Human
Tang C, Sula MJ, Bohnet S, Rehman A, Taishi P, Krueger JM Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP. Brain Res. Mol. Brain Res., 2005-04-25;137(1):213-22. 2005-04-25 [PMID: 15950780] (In Vivo, Rat)	In Vivo	Rat
Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine, 2005-07-21;31(2):153-60. 2005-07-21 [PMID: 15923123] (Bioassay, Human)	Bioassay	Human
Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus. Arthritis Rheum., 2005-05-01;52(5):1504-16. 2005-05-01 [PMID: 15880822] (Bioassay, Human)	Bioassay	Human
Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J. Rheumatol., 2005-04-01;32(4):713-20. 2005-04-01 [PMID: 15801030] (Bioassay, Human)	Bioassay	Human
Yamamoto H, Nagata M, Sakamoto Y CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1. Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300. 2005-02-01 [PMID: 15765748] (Bioassay, Human)	Bioassay	Human
Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 2005-03-01;52(3):770-8. 2005-03-01 [PMID: 15751070] (Bioassay, Human)	Bioassay	Human
Miller AM, McPhaden AR, Preston A, Wadsworth RM, Wainwright CL TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation. Atherosclerosis, 2004-12-23;179(1):51-9. 2004-12-23 [PMID: 15721009] (Bioassay, Rabbit)	Bioassay	Rabbit
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC trans fatty acids and systemic inflammation in heart failure. Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5. 2004-12-01 [PMID: 15585763] (ELISA (Standard))	ELISA (Standard)
Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med., 2004-11-22;200(11):1419-26. 2004-11-22 [PMID: 15557347] (Bioassay, Human)	Bioassay	Human
Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11. 2004-11-09 [PMID: 15536127] (Bioassay, Human)	Bioassay	Human
Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J. Immunol., 2004-11-01;173(9):5810-7. 2004-11-01 [PMID: 15494534] (Bioassay, Human)	Bioassay	Human
Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-09-01;173(5):3482-91. 2004-09-01 [PMID: 15322213] (Bioassay, Human)	Bioassay	Human
Bai L, Maedler K, Donath M, Tuch BE Expression of Fas but not Fas ligand on fetal pig beta cells. Xenotransplantation, 2004-09-01;11(5):426-35. 2004-09-01 [PMID: 15303979] (Bioassay, Porcine)	Bioassay	Porcine
Morita K, Miyasako T, Kitayama S, Dohi T Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells. Biochim. Biophys. Acta, 2004-08-04;1673(3):160-9. 2004-08-04 [PMID: 15279887] (Bioassay, Bovine)	Bioassay	Bovine
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254]
Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus. J. Virol., 2004-06-01;78(12):6151-61. 2004-06-01 [PMID: 15163708] (Bioassay, Primate - Pan troglodytes (Chimpanzee))	Bioassay	Primate - Pan troglodytes (Chimpanzee)
Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 2004-03-25;104(2):314-20. 2004-03-25 [PMID: 15044249] (Bioassay, Human)	Bioassay	Human
Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C CD14 is an acute-phase protein. J. Immunol., 2004-04-01;172(7):4470-9. 2004-04-01 [PMID: 15034063] (Bioassay, Human)	Bioassay	Human
Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor. Biochem. J., 2004-06-01;380(0):425-33. 2004-06-01 [PMID: 14992689] (Bioassay, Human)	Bioassay	Human
Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit)	Bioassay	Rabbit
Ruan HH, Scott KR, Bautista E, Ammons WS ING-1(heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model. Neoplasia, 2003-11-01;5(6):489-94. 2003-11-01 [PMID: 14965442] (In Vivo, Mouse)	In Vivo	Mouse
Copeland S, Siddiqui J, Remick D Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-01-01;284(1):99-106. 2004-01-01 [PMID: 14736420] (ELISA (Standard))	ELISA (Standard)
Liu R, Liote F, Rose DM, Merz D, Terkeltaub R Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes. Arthritis Rheum., 2004-01-01;50(1):247-58. 2004-01-01 [PMID: 14730623] (Bioassay, Bovine)	Bioassay	Bovine
Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads. Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22. 2004-01-12 [PMID: 14722222] (Bioassay, Human)	Bioassay	Human
McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest., 2003-08-01;112(4):598-607. 2003-08-01 [PMID: 12925700] (Bioassay, Human)	Bioassay	Human
Park JS, 107290, Kim YS, Jee YK, Myong NH, Lee KY Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta. Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models, 2003-05-01;57(5):463-9. 2003-05-01 [PMID: 12753503] (Bioassay, Human)	Bioassay	Human
Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity, 2003-01-01;18(1):87-96. 2003-01-01 [PMID: 12530978] (Bioassay, Human)	Bioassay	Human
Borsody MK, Weiss JM Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing hormone. Neuroimmunomodulation, 2003-01-01;10(2):101-21. 2003-01-01 [PMID: 12372984] (In Vivo, Rat)	In Vivo	Rat
Yang CM, Luo SF, Wang CC, Chiu CT, Chien CS, Lin CC, Hsiao LD Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells. Br. J. Pharmacol., 2000-06-01;130(4):891-9. 2000-06-01 [PMID: 10864897] (Bioassay, Canine)	Bioassay	Canine
Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity. Eur. J. Oral Sci., 1998-06-01;106(3):778-87. 1998-06-01 [PMID: 9672100] (Bioassay, Mouse)	Bioassay	Mouse
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The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver
By Victoria Osinski, PhDWhat is the NLRP3 Inflammasome?With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ... Read full blog post.

Immune Cell Metabolic Flux Influences Type I Diabetes
By Hunter MartinezWhat is Immunometabolism?It is well established that abnormal metabolic environments can be a risk factor for disease development. One characteristic example is the role of dyslipidemia (high lev... Read full blog post.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T... Read full blog post.

IL-1 beta (interleukin 1 beta, lymphocyte activating factor (LAF))
IL-1 was originally identified and cloned as a lymphocyte mitogen and much later, was found to be comprised of two closely related but distinct proteins, interleukin 1 alpha (IL-1 alpha) and interleukin 1 beta (IL-1 beta). Both these proteins bind ... Read full blog post.

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Western blot shows lysates of THP-1 human acute monocytic leukemia cell line untreated (-) or treated (+) with 200 nM PMA for 24 hours and 10 µg/mL LPS for 4 hours and RAW 264.7 mouse monocyte/macrophage cell line untreated (-) or treated (+) with 10 µg/mL LPS for 24 hours. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse IL-1 beta /IL-1F2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-401-NA) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (HAF017). A specific band was detected for IL-1 beta /IL-1F2 at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

IL-1 beta/IL-1F2 Antibody [Unconjugated]
AF-401-NA

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.

TNF-alpha [Unconjugated]
210-TA-005

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Gene Symbol	IL1B
Uniprot	NP_000567()

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Recombinant Human IL-1 beta/IL-1F2 Protein, CF

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