IL-1 beta/IL-1F2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 17% amino acid (aa) identity in mouse. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature mouse IL-1 beta shares 90% aa sequence identity with cotton rat and rat and 67%-78% with canine, equine, feline, human, porcine, and rhesus macaque IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Rabbit, Transgenic Mouse.

We have publications tested in 20 applications: Bead-based Immunoassay, Bioassay, ChIP, ELISA, Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, IP, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, In Vivo, In vivo assay, MUSTag PCR Assay, Neutralization, Proximity Ligation Assay, Simple Western, Western Blot.

Showing Publications 1 - 10 of 539. Show All 539 Publications. Collapse Publications.

Publications using AF-401-NA	Applications	Species
Zhang, ZH;Zhan, ZY;Jiang, M;Wang, XY;Quan, SL;Wu, YL;Nan, JX;Lian, LH; Casting NETs on Psoriasis: The modulation of inflammatory feedback targeting IL-36/IL-36R axis International immunopharmacology 2024-09-21 [PMID: 39306890] (Western Blot, Immunocytochemistry, Mouse)	Western Blot, Immunocytochemistry	Mouse
Nabukhotna, K;Kordus, SL;Shupe, JA;Cano Rodríguez, R;Smith, A;Bohannon, JK;Washington, MK;Lacy, DB; Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection PLoS pathogens 2024-09-19 [PMID: 39298531] (Western Blot, Mouse)	Western Blot	Mouse
Liu, W;Yang, H;Xu, Q;Lee, J;Sun, J;Xue, S;Yang, X;Sun, X;Che, C; Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis International immunopharmacology 2024-09-13 [PMID: 39276460] (Western Blot, Mouse)	Western Blot	Mouse
Song, M;Deng, M;Peng, Z;Dai, F;Wang, Y;Shu, W;Zhou, X;Zhang, J;Hou, Y;Yu, B; Granulocyte colony-stimulating factor mediates bone loss via the activation of IL-1?/JNK signaling pathway in murine Staphylococcus aureus-induced osteomyelitis International immunopharmacology 2024-08-19 [PMID: 39163688] (In vivo assay, Mouse)	In vivo assay	Mouse
Yao, Q;Wen, J;Chen, S;Wang, Y;Wen, X;Wang, X;Li, C;Zheng, C;Li, J;Ma, Z;Zhan, X;Xiao, X;Bai, Z; Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome Journal of ethnopharmacology 2024-08-17 [PMID: 39159837] (Western Blot, Mouse)	Western Blot	Mouse
Wang, M;Flaswinkel, H;Joshi, A;Napoli, M;Masgrau-Alsina, S;Kamper, JM;Henne, A;Heinz, A;Berouti, M;Schmacke, NA;Hiller, K;Kremmer, E;Wefers, B;Wurst, W;Sperandio, M;Ruland, J;Fröhlich, T;Hornung, V; Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation Nature communications 2024-07-31 [PMID: 39085210] (Western Blot, Human)	Western Blot	Human
Sun, Y;Lu, Y;Liu, L;Saaoud, F;Shao, Y;Xu, K;Drummer Iv, C;Cueto, R;Shan, H;Jiang, X;Zhao, H;Wang, H;Yang, X; Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity JCI insight 2024-07-18 [PMID: 39024553] (Western Blot, Human, Transgenic Mouse)	Western Blot	Human, Transgenic Mouse
Yow, SJ;Rosli, SN;Hutchinson, PE;Chen, KW; Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages Cell death & disease 2024-07-04 [PMID: 38965211] (Western Blot, Mouse, Transgenic Mouse)	Western Blot	Mouse, Transgenic Mouse
Kang, H;Choi, SW;Kim, JY;Oh, SJ;Kim, SJ;Lee, MS; ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation eLife 2024-07-02 [PMID: 38953285] (Western Blot, Mouse)	Western Blot	Mouse
Redmer, T;Raigel, M;Sternberg, C;Ziegler, R;Probst, C;Lindner, D;Aufinger, A;Limberger, T;Trachtova, K;Kodajova, P;Högler, S;Schlederer, M;Stoiber, S;Oberhuber, M;Bolis, M;Neubauer, HA;Miranda, S;Tomberger, M;Harbusch, NS;Garces de Los Fayos Alonso, I;Sternberg, F;Moriggl, R;Theurillat, JP;Tichy, B;Bystry, V;Persson, JL;Mathas, S;Aberger, F;Strobl, B;Pospisilova, S;Merkel, O;Egger, G;Lagger, S;Kenner, L; JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression Molecular cancer 2024-05-29 [PMID: 38811984] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Ge, X;Han, H;Desert, R;Das, S;Song, Z;Komakula, SSB;Chen, W;Athavale, D;Lantvit, D;Nieto, N; A PROTEIN COMPLEX OF LIVER ORIGIN ACTIVATES A PRO-INFLAMMATORY PROGRAM THAT DRIVES HEPATIC AND INTESTINAL INJURY IN ALCOHOL-ASSOCIATED LIVER DISEASE Cellular and molecular gastroenterology and hepatology 2024-05-22 [PMID: 38788899] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
Tran, HT;Kratina, T;Coutansais, A;Michalek, D;Hogan, BM;Lawlor, KE;Vince, JE;Silke, J;Lalaoui, N; RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation Cell death and differentiation 2024-03-21 [PMID: 38514849] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
Li, Y;Wu, C;Lee, J;Ning, Q;Lim, J;Eoh, H;Wang, S;Hurrell, BP;Akbari, O;Ou, JJ; Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages PLoS pathogens 2024-03-11 [PMID: 38466743] (Human)		Human
Zhan, ZY;Zhang, ZH;Sun, RH;Wu, YL;Nan, JX;Lian, LH; A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system International immunopharmacology 2024-03-09 [PMID: 38461633] (Western Blot, Mouse)	Western Blot	Mouse
Cao, F;Chen, G;Xu, Y;Wang, X;Tang, X;Zhang, W;Song, X;Yang, X;Zeng, W;Xie, J; METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner Cell death & disease 2024-01-13 [PMID: 38218935] (Western Blot, Mouse)	Western Blot	Mouse
Lee, S;Yun, S;Yang, H;Lee, N;Kim, Y;Lee, S;Zamora, NA;Montero, SS;Yi, DK;Kim, SY;Choi, S;Choi, T;Kim, MS;Lee, Y;Park, YH; Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity Journal of ethnopharmacology 2024-01-03 [PMID: 38176663] (Western Blot, Mouse)	Western Blot	Mouse
Exconde, PM;Hernandez-Chavez, C;Bourne, CM;Richards, RM;Bray, MB;Lopez, JL;Srivastava, T;Egan, MS;Zhang, J;Yoo, W;Shin, S;Discher, BM;Taabazuing, CY; The tetrapeptide sequence of IL-18 and IL-1? regulates their recruitment and activation by inflammatory caspases Cell reports 2023-12-15 [PMID: 38103201] (Western Blot, Bioassay, Human)	Western Blot, Bioassay	Human
Cho, E;Mun, SJ;Kim, HK;Ham, YS;Gil, WJ;Yang, CS; Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models Acta pharmacologica Sinica 2023-12-01 [PMID: 38040838] (Western Blot, Mouse)	Western Blot	Mouse
McCrory, C;Verma, J;Tucey, TM;Turner, R;Weerasinghe, H;Beilharz, TH;Traven, A; The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression mBio 2023-11-06 [PMID: 37929941] (Western Blot, Mouse)	Western Blot	Mouse
Caronni, N;La Terza, F;Vittoria, FM;Barbiera, G;Mezzanzanica, L;Cuzzola, V;Barresi, S;Pellegatta, M;Canevazzi, P;Dunsmore, G;Leonardi, C;Montaldo, E;Lusito, E;Dugnani, E;Citro, A;Ng, MSF;Schiavo Lena, M;Drago, D;Andolfo, A;Brugiapaglia, S;Scagliotti, A;Mortellaro, A;Corbo, V;Liu, Z;Mondino, A;Dellabona, P;Piemonti, L;Taveggia, C;Doglioni, C;Cappello, P;Novelli, F;Iannacone, M;Ng, LG;Ginhoux, F;Crippa, S;Falconi, M;Bonini, C;Naldini, L;Genua, M;Ostuni, R; IL-1?+ macrophages fuel pathogenic inflammation in pancreatic cancer Nature 2023-11-01 [PMID: 37914939] (IHC, Mouse)	IHC	Mouse
Meibers, HE;Warrick, KA;VonHandorf, A;Vallez, CN;Kawarizadeh, K;Saha, I;Donmez, O;Jain, VG;Kottyan, LC;Weirauch, MT;Pasare, C; Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells Cell reports 2023-09-27 [PMID: 37794597] (Flow Cytometry, Western Blot, Mouse)	Flow Cytometry, Western Blot	Mouse
Wong, MP;Juan, EYW;Chelluri, SS;Wang, P;Pahmeier, F;Castillo-Rojas, B;Blanc, SF;Biering, SB;Vance, RE;Harris, E; The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection bioRxiv : the preprint server for biology 2023-09-21 [PMID: 37790301] (Western Blot, Mouse)	Western Blot	Mouse
Shosha, E;Shahror, RA;Morris, CA;Xu, Z;Lucas, R;McGee-Lawrence, ME;Rusch, NJ;Caldwell, RB;Fouda, AY; The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury Cell death & disease 2023-09-21 [PMID: 37735154] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Didi Liu, Yi Huang Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate STAR Protoc 9/7/2023 [PMID: 37682717]
Liu H, Zhang L, Liu Z et al. Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization iScience 9/15/2023 [PMID: 37636061]
Liu H, Zhang L, Liu Z et al. Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization iScience 2023-09-15 [PMID: 37636061]
Sin, R;Sotogaku, N;Ohnishi, YN;Shuto, T;Kuroiwa, M;Kawahara, Y;Sugiyama, K;Murakami, Y;Kanai, M;Funakoshi, H;Chakraborti, A;Bibb, JA;Nishi, A; Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments Brain, behavior, and immunity 2023-08-23 [PMID: 37625556] (Western Blot, Mouse)	Western Blot	Mouse
Ciana Diskin, Emily A. Day, Órlaith C. Henry, Juliana E. Toller-Kawahisa, Luke A. J. O’Neill 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2 The Journal of Immunology 9/15/2023 [PMID: 37578391]
Rondeaux, J;Groussard, D;Renet, S;Tardif, V;Dumesnil, A;Chu, A;Di Maria, L;Lemarcis, T;Valet, M;Henry, JP;Badji, Z;Vézier, C;Béziau-Gasnier, D;Neele, AE;de Winther, MPJ;Guerrot, D;Brand, M;Richard, V;Durand, E;Brakenhielm, E;Fraineau, S; Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI Nature communications 2023-07-25 [PMID: 37491334] (IHC, Mouse)	IHC	Mouse
Bai, Y;Min, R;Chen, P;Mei, S;Deng, F;Zheng, Z;Jiang, C;Miao, R;Wu, Z;Zhang, P;Pan, Y;Lieberman, J;Liu, X; Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2 Proceedings of the National Academy of Sciences of the United States of America 2023-08-01 [PMID: 37487070] (Western Blot, Mouse)	Western Blot	Mouse
Veronica Mutti, Giulia Carini, Alice Filippini, Stefania Castrezzati, Lorena Giugno, Massimo Gennarelli et al. LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer’s and Parkinson’s Disease-Related Neuroinflammation Cells 7/6/2023 [PMID: 37443833]
Bingwei Wang, Yan Ma, Sheng Li, Hang Yao, Mingna Gu, Ying Liu et al. GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease Acta Pharmaceutica Sinica B 6/1/2023 [PMID: 37425058]
Germana Lentini, Agata Famà, Giuseppe Valerio De Gaetano, Francesco Coppolino, Ahlem Khachroub Mahjoub, Liv Ryan et al. Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation Cell Reports Medicine 7/18/2023 [PMID: 37390829]
Yingting Hou, Hongbin He, Ming Ma, Rongbin Zhou Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage Frontiers in Immunology 6/8/2023 [PMID: 37359517]
Leem YH, Kim DY, Park JE, Kim HS Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and ?-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease Scientific reports 5/31/2023 [PMID: 37258791]
Fang L, Ohashi K, Hayakawa S et al. Adipolin protects against renal injury via PPAR?-dependent reduction of inflammasome activation iScience 5/1/2023 [PMID: 37250342]
Fang L, Ohashi K, Hayakawa S et al. Adipolin protects against renal injury via PPAR?-dependent reduction of inflammasome activation iScience 2023-05-01 [PMID: 37250342]
Zhang, Z;Song, J;Kwon, SH;Wang, Z;Park, SG;Piao, X;Ryu, JH;Kim, N;Kim, OS;Kim, SH;Koh, JT; Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-?B Signaling Pathway in Mice International journal of molecular sciences 2023-05-12 [PMID: 37240020] (IHC, Mouse)	IHC	Mouse
Jack P. Green, Lina Y. El-Sharkawy, Stefan Roth, Jie Zhu, Jiayu Cao, Andrew G. Leach et al. Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome iScience 5/19/2023 [PMID: 37216118]
Weerasinghe, H;Simm, C;Djajawi, TM;Tedja, I;Lo, TL;Simpson, DS;Shasha, D;Mizrahi, N;Olivier, FAB;Speir, M;Lawlor, KE;Ben-Ami, R;Traven, A; Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response Cell reports 2023-05-18 [PMID: 37204928] (Western Blot, Mouse)	Western Blot	Mouse
Foster, SL;Dutton, AJ;Yerzhan, A;March, LB;Barry, K;Seehus, CR;Huang, X;Talbot, S;Woolf, CJ; A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages Cells 4/19/2023 [PMID: 37190098]
Ren, M;Chen, J;Xu, H;Li, W;Wang, T;Chi, Z;Lin, Y;Zhang, A;Chen, G;Wang, X;Sun, X;Liang, G;Wang, J;Luo, W; Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis International immunopharmacology 2023-05-12 [PMID: 37182452] (Western Blot, Transgenic Mouse, Mouse)	Western Blot	Transgenic Mouse, Mouse
Liu, L;Feng, L;Gao, J;Hu, J;Li, A;Zhu, Y;Zhang, C;Qiu, B;Shen, Z; Parthenolide targets NLRP3 to treat inflammasome-related diseases International immunopharmacology 2023-06-01 [PMID: 37167640] (Bioassay, Mouse)	Bioassay	Mouse
Huang, LS;Anas, M;Xu, J;Zhou, B;Toth, PT;Krishnan, Y;Di, A;Malik, AB; Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury eLife 2023-05-09 [PMID: 37158595] (Mouse)		Mouse
Siopi, E;Galerne, M;Rivagorda, M;Saha, S;Moigneu, C;Moriceau, S;Bigot, M;Oury, F;Lledo, PM; Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice Molecular psychiatry 2023-05-02 [PMID: 37131071] (Western Blot, Mouse)	Western Blot	Mouse
JH Kang, SB Lee, J Seok, DH Kim, G Ma, J Park, AJ Jeong, SK Ye, TB Kang Novel Activity of ODZ10117, a STAT3 Inhibitor, for Regulation of NLRP3 Inflammasome Activation International Journal of Molecular Sciences, 2023-03-23;24(7):. 2023-03-23 [PMID: 37047051] (Western Blot, Mouse)	Western Blot	Mouse
A Ta, R Ricci-Azev, SO Vasudevan, SS Wright, P Kumari, MS Havira, M Surendran, VA Rathinam, SK Vanaja A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3 Nature Communications, 2023-04-11;14(1):2035. 2023-04-11 [PMID: 37041208] (Western Blot, Mouse)	Western Blot	Mouse
SB Lee, JH Kang, EJ Sim, YR Jung, JH Kim, PF Hillman, SJ Nam, TB Kang Cornus officinalis Seed Extract Inhibits AIM2-Inflammasome Activation and Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation International Journal of Molecular Sciences, 2023-03-15;24(6):. 3/15/2023 [PMID: 36982727]
Jeon Y, Chow SH, Stuart I et al. FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins Life science alliance 6/1/2023 [PMID: 36977592]
S Bollenbeck, K Heitman, B Czaya, M Easter, MJ Hirsch, S Vang, E Harris, ES Helton, JW Barnes, C Faul, S Krick Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium Scientific Reports, 2023-03-25;13(1):4898. 2023-03-25 [PMID: 36966182] (IHC, Mouse)	IHC	Mouse
J Li, Q Lin, X Shao, S Li, X Zhu, J Wu, S Mou, L Gu, Q Wang, M Zhang, K Zhang, J Lu, Z Ni HIF1alpha-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome Cell Death & Disease, 2023-03-17;14(3):200. 2023-03-17 [PMID: 36928344] (ICC, IHC, Western Blot, Mouse)	ICC, IHC, Western Blot	Mouse
TT Lin, CY Jiang, L Sheng, L Wan, W Fan, JC Li, XD Sun, CJ Xu, L Hu, XF Wu, Y Han, WT Liu, YB Pan Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway Neural regeneration research, 2023-09-01;18(9):2067-2074. 2023-09-01 [PMID: 36926733] (Western Blot, Mouse)	Western Blot	Mouse
Y Chen, J Pu, X Li, L Lian, C Ge, Z Liu, W Wang, L Hou, W Chen, J Li Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model Investigative Ophthalmology & Visual Science, 2023-03-01;64(3):26. 2023-03-01 [PMID: 36920364] (Western Blot, Mouse)	Western Blot	Mouse
A Hooftman, CG Peace, DG Ryan, EA Day, M Yang, AF McGettrick, M Yin, EN Montano, L Huo, JE Toller-Kaw, V Zecchini, TAJ Ryan, A Bolado-Car, AM Casey, HA Prag, ASH Costa, G De Los San, M Ishimori, DJ Wallace, S Venuturupa, E Nikitopoul, N Frizzell, C Johansson, A Von Kriegs, MP Murphy, C Jefferies, C Frezza, LAJ O'Neill Macrophage fumarate hydratase restrains mtRNA-mediated interferon production Nature, 2023-03-08;615(7952):490-498. 2023-03-08 [PMID: 36890227] (Western Blot, Mouse)	Western Blot	Mouse
WJ Zhong, J Zhang, JX Duan, CY Zhang, SC Ma, YS Li, NS Yang, HH Yang, JB Xiong, CX Guan, ZX Jiang, ZJ You, Y Zhou TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury Journal of Translational Medicine, 2023-03-06;21(1):179. 2023-03-06 [PMID: 36879273] (Western Blot, Mouse)	Western Blot	Mouse
Haowen Xu, Jiahao Chen, Pan Chen, Weifeng Li, Jingjing Shao, Shanshan Hong et al. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases Acta Pharmaceutica Sinica B 2/1/2023 [PMID: 36873170]
Ah-Ra Jang, Ha-Nul Lee, Jung Joo Hong, Young-Min Kim, Jong-Hwan Park Ethanol extract of Chrysanthemum zawadskii inhibits the NLRP3 inflammasome by suppressing ASC oligomerization in macrophages Experimental and Therapeutic Medicine 2/7/2023 [PMID: 36845948]
Yi Huang, Yun Guo, Yan Zhou, Qian Huang, Yi Ru, Yingli Luo et al. Tivantinib alleviates inflammatory diseases by directly targeting NLRP3 iScience 3/17/2023 [PMID: 36843841]
A Filippini, V Salvi, V Dattilo, C Magri, S Castrezzat, R Veerhuis, D Bosisio, M Gennarelli, I Russo LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid beta1-42 Fibrils Biomolecules, 2023-02-06;13(2):. 2023-02-06 [PMID: 36830676] (Western Blot, Mouse)	Western Blot	Mouse
PM Exconde, C Hernandez-, MB Bray, JL Lopez, T Srivastava, MS Egan, J Zhang, S Shin, BM Discher, CY Taabazuing The tetrapeptide sequence of IL-1beta regulates its recruitment and activation by inflammatory caspases bioRxiv : the preprint server for biology, 2023-02-16;0(0):. 2/16/2023 [PMID: 36824844]
Y Wang, D Sadike, B Huang, P Li, Q Wu, N Jiang, Y Fang, G Song, L Xu, W Wang, M Xie Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-kappaB pathway in LPC-induced demyelination Journal of Neuroinflammation, 2023-02-18;20(1):41. 2023-02-18 [PMID: 36803990] (IHC, Mouse)	IHC	Mouse
X Shu, C Wei, WY Tu, K Zhong, S Qi, A Wang, L Bai, SX Zhang, B Luo, ZZ Xu, K Zhang, C Shen Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome Cell Reports, 2023-02-16;42(2):112133. 2023-02-16 [PMID: 36800288] (Western Blot, Mouse)	Western Blot	Mouse
Fangfang Wang, Meng Zhang, Meng Yuan, Zixuan Xia, Fengge Yang, Sihao Zhang et al. A novel sorbicillinoid compound as a potent anti‐inflammation agent through inducing NLRP3 protein degradation British Journal of Pharmacology 8/1/2023 [PMID: 36788033]
Nevien Hendawy, Tala H. Salaheldin, Sally A. Abuelezz PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1 Journal of Neuroimmune Pharmacology 2/13/2023 [PMID: 36781714]
Wenhua Zhao, Yanan Cao, Yue Chen, Yuyi Chen, Tianxiao Wang, Lu Li et al. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs International Journal of Biological Sciences 1/16/2023 [PMID: 36778113]
A Ramadan, Z Cao, M Gadjeva, TS Zaidi, VA Rathinam, N Panjwani The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis Investigative Ophthalmology & Visual Science, 2023-02-01;64(2):11. 2023-02-01 [PMID: 36749596] (Western Blot, Mouse)	Western Blot	Mouse
Junedh M. Lavine, Junedh Amrute, Vinay Penna, Andrea Bredemeyer, Andrea Bredemeyer, Steven Yamawaki et al. Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis Research Square 8/25/2023 [PMID: 36747878]
G Lin, N Li, D Li, L Chen, H Deng, S Wang, J Tang, W Ouyang Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps International immunopharmacology, 2023-02-02;116(0):109819. 2023-02-02 [PMID: 36738671] (Western Blot, Mouse)	Western Blot	Mouse
MB Reynolds, HS Hong, BC Michmerhui, AE Lawrence, L Zhang, JS Knight, CA Lyssiotis, BH Abuaita, MX O'Riordan Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation Science Advances, 2023-02-03;9(5):eade8701. 2023-02-03 [PMID: 36735777] (Western Blot, Mouse)	Western Blot	Mouse
Zhouyangfan Peng, Xiqing Tan, Liangpeng Xie, Ze Li, Sufang Zhou, Yapei Li PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation iScience 1/20/2023 [PMID: 36691613]
L González-C, J P Green, I Cuadrado, Á Amesty, S Oramas-Roy, David Brou, A Estévez-Br, S Hortelano, B de Las Her Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors Bioorganic chemistry, 2023-01-14;132(0):106362. 2023-01-14 [PMID: 36657273] (Western Blot, Mouse)	Western Blot	Mouse
Meyers AK, Wang Z, Han W et al. Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation Cell Reports 2023-01-31 [PMID: 36640341]
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HW Xu, WF Li, SS Hong, JJ Shao, JH Chen, N Chattipako, D Wu, W Luo, G Liang Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice Acta pharmacologica Sinica, 2023-01-10;0(0):. 2023-01-10 [PMID: 36627344] (Western Blot, Mouse)	Western Blot	Mouse
G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation Scientific Reports, 2022-12-28;12(1):22484. 2022-12-28 [PMID: 36577816] (Western Blot, Mouse)	Western Blot	Mouse
Jae-Sung Kim, Hyo Keun Kim, Minsoo Kim, Sein Jang, Euni Cho, Seok-Jun Mun et al. Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse Antioxidants (Basel) 11/30/2022 [PMID: 36552583]
SK Juin, S Pushpakuma, SC Tyagi, U Sen Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes Scientific Reports, 2022-12-15;12(1):21707. 2022-12-15 [PMID: 36522378] (Western Blot, Mouse)	Western Blot	Mouse
LM Branco, MP Amaral, H Boekhoff, ABF de Lima, IS Farias, SL Lage, GJS Pereira, BS Franklin, KR Bortoluci Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1beta secretion Cell Death & Disease, 2022-12-08;13(12):1029. 2022-12-08 [PMID: 36481780] (Mouse)		Mouse
C Oh, L Li, A Verma, AD Reuven, EA Miao, JB Bliska, Y Aachoui Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins Cell Reports, 2022-11-22;41(8):111688. 2022-11-22 [PMID: 36417874] (Western Blot, Mouse, Transgenic Mouse)	Western Blot	Mouse, Transgenic Mouse
Ilia D. Vainchtein, Astrid M. Alsema, Marissa L. Dubbelaar, Corien Grit, Jonathan Vinet, Hilmar R. J. van Weering et al. Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis Glia 3/1/2023 [PMID: 36377669]
YH Wu, ST Mo, IT Chen, FY Hsieh, SL Hsieh, J Zhang, MZ Lai Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells Science Advances, 2022-11-11;8(45):eabn9912. 2022-11-11 [PMID: 36367942] (Western Blot, Transgenic Mouse)	Western Blot	Transgenic Mouse
MSJ Mangan, F Gorki, K Krause, A Heinz, A Pankow, T Ebert, D Jahn, K Hiller, V Hornung, M Maurer, FI Schmidt, R Gerhard, E Latz Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever PloS Biology, 2022-11-07;20(11):e3001351. 2022-11-07 [PMID: 36342970] (Western Blot, Human)	Western Blot	Human
Tianyin Sun, Ruiqian Xie, Hongbin He, Qianqian Xie, Xueqin Zhao, Guijie Kang et al. Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35 Frontiers in Immunology 10/13/2022 [PMID: 36311752]
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SL Kim, MW Shin, SW Kim Lipocalin 2 activates the NLRP3 inflammasome via LPS?induced NF?kappaB signaling and plays a role as a pro?inflammatory regulator in murine macrophages Molecular Medicine Reports, 2022-10-20;26(6):. 2022-10-20 [PMID: 36263611] (Western Blot, Mouse)	Western Blot	Mouse
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Touya Toyomoto, Tomohiro Sawa Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection STAR Protocols 12/16/2022 [PMID: 36201318]
Q Lin, D Zhang, J Zhang, W Luo, Z Xu, J Yao, L Wang Identification of lncRNA DLEU2 as a potential diagnostic biomarker and anti-inflammatory target for ulcerative colitis Frontiers in Pharmacology, 2022-09-14;13(0):991448. 2022-09-14 [PMID: 36188540] (Western Blot, Human)	Western Blot	Human
P Sharma, K Karnam, A Mahale, K Sedmaki, V Krishna Ve, OP Kulkarni HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy International immunopharmacology, 2022-09-29;112(0):109264. 2022-09-29 [PMID: 36183679] (Western Blot, Mouse)	Western Blot	Mouse
Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors eLife 9/26/2022 [PMID: 36155655]
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M Duhalde Ve, D Olivera, G Gastão Dav, M Bertullo, V Noya, G Fabiano de, S Primon Mur, I Castro, AP Arévalo, M Crispo, G Galliussi, S Russo, D Charbonnie, F Rammauro, M Jeldres, C Alamón, V Varela, C Batthyany, M Bollati-Fo, P Oppezzo, O Pritsch, JL Proença-Mó, HI Nakaya, E Trias, L Barbeito, I Anegon, MC Cuturi, P Moraes-Vie, M Segovia, M Hill PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical beta-coronavirus disease Science Advances, 2022-09-21;8(38):eabn6545. 2022-09-21 [PMID: 36129987] (Neutralization, Mouse)	Neutralization	Mouse
I de Castro, A Bianchi, NU Deshpande, P Sharma, S Mehra, VT Garrido, SJ Saigh, J England, PJ Hosein, D Kwon, NB Merchant, J Datta Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study Elife, 2022-09-15;11(0):. 2022-09-15 [PMID: 36107485] (Neutralization, Mouse)	Neutralization	Mouse
Y Zhu, H Zhang, H Mao, S Zhong, Y Huang, S Chen, K Yan, Z Zhao, X Hao, Y Zhang, H Yao, X Huang, M Wang, W Zhang, J Li, G Meng, X Qin, Z Ye, J Shen, Y Song, Y Xu, Z Yang, L Wang, Y Zhang, L Wen FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system Cell Death and Differentiation, 2022-09-14;0(0):. 2022-09-14 [PMID: 36104448] (Western Blot, Mouse)	Western Blot	Mouse
SM Ruwanpura, L McLeod, LF Dousha, HJ Seow, AC West, AJ West, T Weng, M Alanazi, M MacDonald, PT King, PG Bardin, C Gabay, DM Klinman, S Bozinovski, R Vlahos, GP Anderson, S Rose-John, MI Saad, BJ Jenkins Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1beta axes bridge innate immunity and epithelial apoptosis to promote emphysema Proceedings of the National Academy of Sciences of the United States of America, 2022-08-29;119(36):e2201494119. 2022-08-29 [PMID: 36037355] (Western Blot, Mouse)	Western Blot	Mouse
Lee J, Kim SJ, Choi GE et al. Sweet taste receptor agonists attenuate macrophage IL-1 beta expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells Clinical and translational medicine 8/1/2022 [PMID: 35988262] Details: Dilution used 1:400
C Yuan, K Ai, M Xiang, C Xie, M Zhao, M Wu, H Li, Y Wu, Y Cao, C Li, Y Zhong, X Pei, HKW Law, L Gao, Q Xiao, X Yang Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling Cell Death & Disease, 2022-08-18;13(8):722. 8/18/2022 [PMID: 35982051]
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H Shi, Y Zhu, C Xing, S Li, Z Bao, L Lei, D Lin, Y Wang, H Chen, X Xu An injectable thermosensitive hydrogel for dual delivery of diclofenac and Avastin� to effectively suppress inflammatory corneal neovascularization International journal of pharmaceutics, 2022-08-05;0(0):122081. 2022-08-05 [PMID: 35934166] (IHC, Rabbit)	IHC	Rabbit
AQ Dong, YP Yang, SM Jiang, XY Yao, D Qi, CJ Mao, XY Cheng, F Wang, LF Hu, CF Liu Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease Acta pharmacologica Sinica, 2022-07-27;0(0):. 2022-07-27 [PMID: 35896696] (Western Blot, Mouse)	Western Blot	Mouse
AB Lopez-Rodr, C Decouty-Pe, V Farré-Alin, A Palomino-A, P Narros-Fer, J Egea Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma Pharmaceutics, 2022-07-26;14(8):. 2022-07-26 [PMID: 35893807] (Western Blot, Mouse)	Western Blot	Mouse
Jae Sang Han, Ye Lin Kim, Hyo Jeong Yu, Jung Mee Park, Yeonji Kim, So Young Park et al. Safety and Efficacy of Intratympanic Alpha-Lipoic Acid Injection in a Mouse Model of Noise-Induced Hearing Loss Antioxidants (Basel) 7/22/2022 [PMID: 35892625]
Xintong Dong, Nathachit Limjunyawong, Elizabeth I. Sypek, Gaofeng Wang, Roger V. Ortines, Christine Youn et al. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection Immunity 9/1/2022 [PMID: 35882236]
JH Ma, E Lee, SH Yoon, H Min, JH Oh, I Hwang, Y Sung, JH Ryu, J Bok, JW Yu Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model EBioMedicine, 2022-07-20;82(0):104184. 2022-07-20 [PMID: 35870427] (Western Blot, Mouse)	Western Blot	Mouse
Hao Zhou, Xun Shen, Chen Yan, Wu Xiong, Zemeng Ma, Zhenggang Tan et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage Stem Cell Research & Therapy 12/1/2022 [PMID: 35842714]
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W Chen, S Chen, C Yan, Y Zhang, R Zhang, M Chen, S Zhong, W Fan, S Zhu, D Zhang, X Lu, J Zhang, Y Huang, L Zhu, X Li, D Lv, Y Fu, H Iv, Z Ling, L Ma, H Jiang, G Long, J Zhu, D Wu, B Wu, B Sun Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion Nature Immunology, 2022-07-06;23(7):1021-1030. 2022-07-06 [PMID: 35794369] (Western Blot, Mouse)	Western Blot	Mouse
H Dong, B Zhao, J Chen, Z Liu, X Li, L Li, H Wen Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome Proceedings of the National Academy of Sciences of the United States of America, 2022-06-22;119(26):e2123247119. 6/22/2022 [PMID: 35733245]
W Yu, Z Wang, X Yu, Y Zhao, Z Xie, K Zhang, Z Chi, S Chen, T Xu, D Jiang, X Guo, M Li, J Zhang, H Fang, D Yang, Y Guo, X Yang, X Zhang, Y Wu, W Yang, D Wang Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters Nature Communications, 2022-06-21;13(1):3544. 2022-06-21 [PMID: 35729093] (Western Blot, Mouse)	Western Blot	Mouse
Shuhan Liu, Shengxiang Wang, Runze Gu, Na Che, Jing Wang, Jinbo Cheng et al. The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-kappa B/NLRP3 Pathway Frontiers in Pharmacology 6/1/2022 [PMID: 35721113]
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Y Jin, Y Liu, L Xu, J Xu, Y Xiong, Y Peng, K Ding, S Zheng, N Yang, Z Zhang, L Li, L Tan, H Song, J Fu Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis Cell Death & Disease, 2022-05-31;13(5):512. 2022-05-31 [PMID: 35641492] (Western Blot, Mouse)	Western Blot	Mouse
Isak W. Tengesdal, Suzhao Li, Nicholas E. Powers, Makenna May, Charles P. Neff, Leo A. B. Joosten et al. Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers Pharmaceuticals (Basel) 5/4/2022 [PMID: 35631400]
Q Zhang, W Liu, H Wang, H Zhou, K Bulek, X Chen, CJ Zhang, J Zhao, R Zhang, C Liu, Z Kang, RA Bermel, G Dubyak, DW Abbott, TS Xiao, LE Nagy, X Li TH17 cells promote CNS inflammation by sensing danger signals via Mincle Nature Communications, 2022-05-03;13(1):2406. 2022-05-03 [PMID: 35504893] (Western Blot, Mouse)	Western Blot	Mouse
L Zhou, S Yang, X Zou Farrerol Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting Macrophages and NLRP3 Frontiers in Pharmacology, 2022-04-13;13(0):879232. 2022-04-13 [PMID: 35496295] (Western Blot, Mouse)	Western Blot	Mouse
LK Billingham, JS Stoolman, K Vasan, AE Rodriguez, TA Poor, M Szibor, HT Jacobs, CR Reczek, A Rashidi, P Zhang, J Miska, NS Chandel Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation Nature Immunology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484407] (Simple Western, Mouse)	Simple Western	Mouse
ES Jung, K Suh, J Han, H Kim, HS Kang, WS Choi, I Mook-Jung Amyloid-beta activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway Aging Cell, 2022-04-27;0(0):e13623. 2022-04-27 [PMID: 35474599] (Western Blot, Mouse)	Western Blot	Mouse
F Li, L Lin, Y He, G Sun, D Dong, B Wu BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBalpha in mice International journal of biological sciences, 2022-03-21;18(6):2597-2608. 2022-03-21 [PMID: 35414779] (Western Blot, Mouse)	Western Blot	Mouse
Peili Li, Yasutaka Kurata, Fikri Taufiq, Masanari Kuwabara, Haruaki Ninomiya, Katsumi Higaki et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes Molecular Biology Reports 7/1/2022 [PMID: 35368226]
Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Katsuhiko Ono, Yukio Fujiwara, Sunao Iyoda et al. Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection iScience 4/15/2022 [PMID: 35345462]
K Molnár, B Nógrádi, R Kristóf, Á Mészáros, K Pajer, L Siklós, A Nógrádi, I Wilhelm, IA Krizbai Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury Journal of Neuroinflammation, 2022-03-19;19(1):68. 2022-03-19 [PMID: 35305649] (Western Blot, Mouse)	Western Blot	Mouse
CMA Rego, AF Francisco, CN Boeno, MV Paloschi, JA Lopes, MDS Silva, HM Santana, SN Serrath, JE Rodrigues, CTL Lemos, RSS Dutra, JN da Cruz, CBR Dos Santos, S da S Setúb, MRM Fontes, AM Soares, WL Pires, JP Zuliani Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom Scientific Reports, 2022-03-18;12(1):4706. 2022-03-18 [PMID: 35304541] (ELISA, Human)	ELISA	Human
B Czaya, K Heitman, I Campos, C Yanucil, D Kentrup, D Westbrook, O Gutierrez, JL Babitt, G Jung, IB Salusky, M Hanudel, C Faul Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling Elife, 2022-03-18;11(0):. 2022-03-18 [PMID: 35302487] (Neutralization, Mouse)	Neutralization	Mouse
MF Mohamed, K Gupta, JW Goldufsky, R Roy, LT Callaghan, DM Wetzel, TM Kuzel, J Reiser, SH Shafikhani CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT Nature Communications, 2022-03-11;13(1):1295. 2022-03-11 [PMID: 35277504] (Western Blot, Mouse)	Western Blot	Mouse
Cong Li, Hualong Lin, Hongbin He, Ming Ma, Wei Jiang, Rongbin Zhou Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis Frontiers in Cell and Developmental Biology 2/16/2022 [PMID: 35252186]
Hualong Lin, Mingyang Yang, Cong Li, Bolong Lin, Xianming Deng, Hongbin He et al. An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups Frontiers in Pharmacology 2/17/2022 [PMID: 35250572]
K Eislmayr, A Bestehorn, L Morelli, M Borroni, LV Walle, M Lamkanfi, P Kovarik Nonredundancy of IL-1alpha and IL-1beta is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection Science Advances, 2022-03-02;8(9):eabj7293. 2022-03-02 [PMID: 35235356] (Western Blot, Mouse)	Western Blot	Mouse
Tan Zhang, Jingyao Zhao, Tiemin Liu, Wei Cheng, Yibing Wang, Shuzhe Ding et al. A novel mechanism for NLRP3 inflammasome activation Metabolism Open 3/1/2022 [PMID: 35198946]
YT Wang, TY Liu, CH Shen, SY Lin, CC Hung, LC Hsu, GC Chen K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy Cell Reports, 2022-02-22;38(8):110354. 2022-02-22 [PMID: 35196483] (Western Blot, Mouse)	Western Blot	Mouse
Y Jiao, J Nan, B Mu, Y Zhang, N Zhou, S Yang, S Zhang, W Lin, F Wang, A Xia, Z Cao, P Chen, Z Pan, G Lin, S Pan, H Bin, L Li, S Yang Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis European Journal of Medicinal Chemistry, 2022-02-11;232(0):114194. 2022-02-11 [PMID: 35183871] (Western Blot, Mouse)	Western Blot	Mouse
Daniel S. Simpson, Jiyi Pang, Ashley Weir, Isabella Y. Kong, Melanie Fritsch, Maryam Rashidi et al. Interferon-gamma primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway Immunity 3/1/2022 [PMID: 35139355]
Christopher Hoyle, Jack P. Green, Stuart M. Allan, David Brough, Eloise Lemarchand Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages Immunology 4/1/2022 [PMID: 35137954]
Alejandra Romero, Pilar Dongil, Inés Valencia, Susana Vallejo, Álvaro San Hipólito-Luengo, Guillermo Díaz-Araya et al. Pharmacological Blockade of NLRP3 Inflammasome/IL-1 beta -Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction Aging and disease 2/1/2022 [PMID: 35111374]
T Xu, W Yu, H Fang, Z Wang, Z Chi, X Guo, D Jiang, K Zhang, S Chen, M Li, Y Guo, J Zhang, D Yang, Q Yu, D Wang, X Zhang Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation Cell Death and Differentiation, 2022-02-02;0(0):. 2022-02-02 [PMID: 35110683] (Western Blot, Human)	Western Blot	Human
K Tóth, N Lénárt, P Berki, R Fekete, E Szabadits, B Pósfai, C Cserép, A Alatshan, S Benk?, D Kiss, CA Hübner, A Gulyás, K Kaila, Z Környei, Á Dénes The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner PloS Biology, 2022-01-27;20(1):e3001526. 2022-01-27 [PMID: 35085235] (IHC, Mouse)	IHC	Mouse
S Wang, K Jing, H Wu, X Li, C Yang, T Li, H Tang, T Zou, Y She, HF Liu Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy Oxidative Medicine and Cellular Longevity, 2022-01-12;2022(0):2812493. 2022-01-12 [PMID: 35082964] (Western Blot, Mouse)	Western Blot	Mouse
Y Li, Y Zhu, S Feng, Y Ishida, TP Chiu, T Saito, S Wang, DK Ann, JJ Ou Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3 Cell Reports, 2022-01-25;38(4):110284. 1/25/2022 [PMID: 35081341]
S Murthy, S Baruah, JL Bowen, K Keck, BA Wagner, GR Buettner, DB Sykes, J Klesney-Ta TREM-1 is required for enhanced OpZ-induced superoxide generation following priming Journal of leukocyte biology, 2022-01-24;0(0):. 2022-01-24 [PMID: 35075692] (Western Blot, Mouse)	Western Blot	Mouse
D Szabó, P Tod, F Gölöncsér, V Román, B Lendvai, L Otrokocsi, B Sperlágh Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1beta pathway Brain, Behavior, and Immunity, 2022-01-20;0(0):. 2022-01-20 [PMID: 35065198] (In Vivo, Mouse)	In Vivo	Mouse
Jakob A. Østergaard, Jay C. Jha, Arpeeta Sharma, Aozhi Dai, Judy S.Y. Choi, Judy B. de Haan et al. Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease Clinical Science 1/28/2022 [PMID: 35048962]
MA Munoz, EK Fletcher, OP Skinner, J Jurczyluk, E Kristianto, MP Hodson, S Sun, FH Ebetino, DR Croucher, PM Hansbro, JR Center, MJ Rogers Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages Elife, 2021-12-30;10(0):. 2021-12-30 [PMID: 34967731] (Western Blot, Mouse)	Western Blot	Mouse
Yuzi Tian, Patrick Li, Zhenyu Wu, Qiufang Deng, Baihong Pan, Kathleen A. Stringer et al. Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway Frontiers in Immunology 12/7/2021 [PMID: 34950139]
NC Williams, DG Ryan, ASH Costa, EL Mills, MP Jedrychows, SM Cloonan, C Frezza, LA O'Neill Signalling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1alpha in lipopolysaccharide-activated macrophages The Journal of Biological Chemistry, 2021-12-17;0(0):101501. 2021-12-17 [PMID: 34929172] (Western Blot, Mouse)	Western Blot	Mouse
Jun Zhang, Chun-Lin Mai, Ying Xiong, Zhen-Jia Lin, Ying-Tao Jie, Jie-Zhen Mai et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice Journal of Inflammation Research 12/7/2021 [PMID: 34908863]
K Yuan, J Zheng, X Shen, Y Wu, Y Han, X Jin, X Huang Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway International immunopharmacology, 2021-12-11;102(0):108426. 2021-12-11 [PMID: 34906854] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Ao Duan, Zemeng Ma, Wanshun Liu, Kai Shen, Hao Zhou, Shunbing Wang et al. 1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages Journal of Inflammation Research 12/3/2021 [PMID: 34887675]
Debabrata Chowdhury, Jason C. Gardner, Abhijit Satpati, Suba Nookala, Santhosh Mukundan, Aleksey Porollo et al. Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity Frontiers in Immunology 11/12/2021 [PMID: 34867993]
Xenia Kodji, Zizheng Kee, Robyn McKenna, Joao de Sousa Valente, Harriet Ravenscroft, Hayley McMillan et al. Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation Pharmaceuticals (Basel) 10/23/2021 [PMID: 34832855]
Xingchen Dong, Lin-Feng Chen Protocol for measuring NLRC4 inflammasome activation and pyroptosis in murine bone-marrow-derived macrophages STAR Protocols 12/1/2021 [PMID: 34723211]
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JC Santos, MS Dick, B Lagrange, D Degrandi, K Pfeffer, M Yamamoto, E Meunier, P Pelczar, T Henry, P Broz LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation EMBO J., 2018-02-19;0(0):. 2018-02-19 [PMID: 29459437] (Western Blot, Mouse)	Western Blot	Mouse
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Subo Yuan, Yuqiang Shi, Kaiwen Guo, Shao-Jun Tang Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Induce Pathological Pain through Wnt5a-Mediated Neuroinflammation in Aging Mice Journal of Neuroimmune Pharmacology 6/1/2018 [PMID: 29429030]
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Teneema Kuriakose, Min Zheng, Geoffrey Neale, Thirumala-Devi Kanneganti IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection The Journal of Immunology 2/15/2018 [PMID: 29321274]
JL Ross, LF Queme, JE Lamb, KJ Green, MP Jankowski Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury Biol Sex Differ, 2018-01-03;9(1):2. 2018-01-03 [PMID: 29298725] (Western Blot, Mouse)	Western Blot	Mouse
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Tejbeer Kaur, Kevin K. Ohlemiller, Mark E. Warchol Genetic disruption of fractalkine signaling leads to enhanced loss of cochlear afferents following ototoxic or acoustic injury Journal of Comparative Neurology 4/1/2018 [PMID: 29218724]
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Rituparna Chakraborty, Janin Chandra, Shuai Cui, Lynn Tolley, Matthew A. Cooper, Mark Kendall et al. CD 8 + lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury Experimental Dermatology 1/1/2018 [PMID: 28887852]
JC Rivera, B Noueihed, A Madaan, I Lahaie, J Pan, J Belik, S Chemtob Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina J Neuroinflammation, 2017-09-06;14(1):181. 2017-09-06 [PMID: 28874201] (IHC, Mouse)	IHC	Mouse
F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain Front Cell Neurosci, 2017-08-08;11(0):227. 2017-08-08 [PMID: 28848393] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
Hiroshi Nakanishi, Yoshiyuki Kawashima, Kiyoto Kurima, Jae Jin Chae, Astin M. Ross, Gineth Pinto-Patarroyo et al. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy Proceedings of the National Academy of Sciences 9/12/2017 [PMID: 28847925]
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EM McDonough, CW Barrett, B Parang, MK Mittal, JJ Smith, AM Bradley, YA Choksi, LA Coburn, SP Short, JJ Thompson, B Zhang, SV Poindexter, MA Fischer, X Chen, J Li, FL Revetta, R Naik, MK Washington, MJ Rosen, SW Hiebert, KT Wilson, CS Williams MTG16 is a tumor suppressor in colitis-associated carcinoma JCI Insight, 2017-08-17;2(16):. 2017-08-17 [PMID: 28814670] (IHC, Mouse)	IHC	Mouse
J Braverman, SA Stanley Nitric Oxide Modulates Macrophage Responses to Mycobacterium tuberculosis Infection through Activation of HIF-1? and Repression of NF-?B J. Immunol., 2017-07-28;0(0):. 7/28/2017 [PMID: 28754681]
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S Yoon, A Kovalenko, K Bogdanov, D Wallach MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation Immunity, 2017-06-27;0(0):. 2017-06-27 [PMID: 28666573] (Western Blot, Mouse)	Western Blot	Mouse
Xuan Li, Sarah Thome, Xiaodan Ma, Mamta Amrute-Nayak, Alison Finigan, Lauren Kitt et al. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism Nature Communications 6/28/2017 [PMID: 28656979]
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R Domingo-Fe, RC Coll, J Kearney, S Breit, LA O'Neill The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome J. Biol. Chem., 2017-06-02;0(0):. 2017-06-02 [PMID: 28576828] (Western Blot, Mouse)	Western Blot	Mouse
Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, Tao Yang, Yin Huang et al. Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin Nature Communications 5/24/2017 [PMID: 28537251]
V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, K Biette, P Jedlicka, KS Brodsky, ME Gerich, M Mack, AAB Robertson, MA Cooper, GT Furuta, CA Dinarello, LA O'Neill, HK Eltzschig, SL Masters, EN McNamee Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome J. Exp. Med., 2017-05-09;0(0):. 2017-05-09 [PMID: 28487310] (Western Blot, Mouse)	Western Blot	Mouse
Q Zhu, TD Kanneganti Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1? J. Immunol., 2017-05-03;0(0):. 2017-05-03 [PMID: 28468974] (Western Blot, Mouse)	Western Blot	Mouse
H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production Sci Rep, 2017-05-02;7(1):1314. 2017-05-02 [PMID: 28465544] (Western Blot, Mouse)	Western Blot	Mouse
Y Kanamori, M Murakami, M Sugiyama, O Hashimoto, T Matsui, M Funaba IL-1? transcriptionally activates hepcidin by inducing C/EBP? expression in hepatocytes J. Biol. Chem., 2017-04-24;0(0):. 2017-04-24 [PMID: 28438835] (IHC, Mouse)	IHC	Mouse
L Freeman, H Guo, CN David, WJ Brickey, S Jha, JP Ting NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes J. Exp. Med., 2017-04-12;0(0):. 2017-04-12 [PMID: 28404595] (Western Blot, Mouse)	Western Blot	Mouse
MK Choo, Y Sano, C Kim, K Yasuda, XD Li, X Lin, M Stenzel-Po, L Alexopoulo, S Ghosh, E Latz, IR Rifkin, ZJ Chen, GC Stewart, H Chong, JM Park TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects J. Exp. Med., 2017-04-11;214(5):1297-1311. 2017-04-11 [PMID: 28400473] (Western Blot, Mouse)	Western Blot	Mouse
Z Zhong, Y Zhai, P Bu, S Shah, L Qiao Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of Apc(Min/+) mice Nat Commun, 2017-04-11;8(0):15004. 2017-04-11 [PMID: 28397782] (Western Blot, Mouse)	Western Blot	Mouse
H Youssef, P Stashenko Interleukin-1 and estrogen protect against disseminating dentoalveolar infections Int J Oral Sci, 2017-03-01;9(1):16-23. 2017-03-01 [PMID: 28358036] (Neutralization, Mouse)	Neutralization	Mouse
K Moriwaki, S Balaji, J Bertin, PJ Gough, FK Chan Distinct Kinase-Independent Role of RIPK3 in CD11c(+) Mononuclear Phagocytes in Cytokine-Induced Tissue Repair Cell Rep, 2017-03-07;18(10):2441-2451. 2017-03-07 [PMID: 28273458] (Western Blot, Mouse)	Western Blot	Mouse
TP Domiciano, D Wakita, HD Jones, TR Crother, WA Verri, M Arditi, K Shimada Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis Sci Rep, 2017-02-02;7(0):41539. 2017-02-02 [PMID: 28148962] (Western Blot, Mouse)	Western Blot	Mouse
M Tsugita, N Morimoto, M Tashiro, K Kinoshita, M Nakayama SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation Cell Rep, 2017-01-31;18(5):1298-1311. 2017-01-31 [PMID: 28147282] (Western Blot, Mouse)	Western Blot	Mouse
O Tufanli, P Telkoparan, D Acosta-Alv, B Kocaturk, UI Onat, SM Hamid, I €imen, P Walter, C Weber, E Erbay Targeting IRE1 with small molecules counteracts progression of atherosclerosis Proc. Natl. Acad. Sci. U.S.A, 2017-01-30;0(0):. 2017-01-30 [PMID: 28137856] (Western Blot, Mouse)	Western Blot	Mouse
HJ Koh, YR Kim, JS Kim, JS Yun, K Jang, CS Yang Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKC� PLoS Pathog, 2017-01-26;13(1):e1006126. 2017-01-26 [PMID: 28125719] (Western Blot, Mouse)	Western Blot	Mouse
Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis Sci Rep, 2016-12-20;6(0):39257. 2016-12-20 [PMID: 27995963] (Western Blot, Mouse)	Western Blot	Mouse
Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation PLoS Pathog, 2016-12-07;12(12):e1006052. 2016-12-07 [PMID: 27926929] (Western Blot, Human)	Western Blot	Human
TNF?-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury Proc. Natl. Acad. Sci. U.S.A., 2016-11-28;113(50):E8151-E8158. 2016-11-28 [PMID: 27911817] (Western Blot, Mouse)	Western Blot	Mouse
Jeremy S Duffield Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury J. Clin. Invest., 2016-11-21;0(0):. 2016-11-21 [PMID: 27869651] (IHC, Western Blot, Mouse)	IHC, Western Blot	Mouse
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John S. Lewis, Bridgette D. Furman, Evan Zeitler, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak et al. Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice Arthritis & Rheumatism 6/27/2013 [PMID: 23203659]
Kristina A. Hellmich, Jonathan L. Levinsohn, Rasem Fattah, Zachary L. Newman, Nolan Maier, Inka Sastalla et al. Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages PLoS ONE 11/12/2012 [PMID: 23152930]
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012-11-11;492(7427):123-7. 2012-11-11 [PMID: 23143333] (Western Blot, Mouse)	Western Blot	Mouse
Martina Proell, Motti Gerlic, Peter D. Mace, John C. Reed, Stefan J. Riedl The CARD plays a critical role in ASC foci formation and inflammasome signalling Biochemical Journal 2/1/2013 [PMID: 23110696]
Roy J. Soberman, Christopher R. MacKay, Christine A. Vaine, Glennice Bowen Ryan, Anna M. Cerny, Mikayla R. Thompson et al. CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2 PLoS ONE 10/17/2012 [PMID: 23082204]
Hana Abdalla, Lalitha Srinivasan, Swati Shah, Katrin D. Mayer-Barber, Alan Sher, Fayyaz S. Sutterwala et al. Mycobacterium tuberculosis Infection of Dendritic Cells Leads to Partially Caspase-1/11-Independent IL-1 beta and IL-18 Secretion but Not to Pyroptosis PLoS ONE 7/24/2012 [PMID: 22911706]
Broz P, Ruby T, Belhocine K, Bouley D, Kayagaki N, Dixit V, Monack D Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1. Nature, 2012-08-15;490(7419):288-91. 2012-08-15 [PMID: 22895188] (Western Blot, Mouse)	Western Blot	Mouse
Marlies Galle, Shouguang Jin, Pieter Bogaert, Mira Haegman, Peter Vandenabeele, Rudi Beyaert The Pseudomonas aeruginosa Type III Secretion System Has an Exotoxin S/T/Y Independent Pathogenic Role during Acute Lung Infection PLoS ONE 7/23/2012 [PMID: 22844497]
Vijay A.K. Rathinam, Sivapriya Kailasan Vanaja, Lisa Waggoner, Anna Sokolovska, Christine Becker, Lynda M. Stuart et al. TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria Cell 8/3/2012 [PMID: 22819539]
Martina Kovarova, Pamela R. Hesker, Leigh Jania, MyTrang Nguyen, John N. Snouwaert, Zhidan Xiang et al. NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice The Journal of Immunology 8/15/2012 [PMID: 22753929]
Sato A, Ohtaki H, Tsumuraya T, Song D, Ohara K, Asano M, Iwakura Y, Atsumi T, Shioda S Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury. J Neuroinflammation, 2012-04-07;9(0):65. 4/7/2012 [PMID: 22483094]
Jonathan L. Levinsohn, Zachary L. Newman, Kristina A. Hellmich, Rasem Fattah, Matthew A. Getz, Shihui Liu et al. Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome PLoS Pathogens 3/29/2012 [PMID: 22479187]
Razani B, Feng C, Coleman T et al. Autophagy Links Inflammasomes to Atherosclerotic Progression Cell Metabolism 4/4/2012 [PMID: 22440612]
Thomas Enzler, Yasuyo Sano, Min-Kyung Choo, Howard B. Cottam, Michael Karin, Hensin Tsao et al. Cell-Selective Inhibition of NF-kappa B Signaling Improves Therapeutic Index in a Melanoma Chemotherapy Model Cancer Discovery 3/6/2012 [PMID: 22389871]
Kenichi Shimada, Timothy R. Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen et al. Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis Immunity 3/23/2012 [PMID: 22342844]
Nadia M Luheshi, Krisztina J Kovács, Gloria Lopez-Castejon, David Brough, Adam Denes Interleukin-1 alpha expression precedes IL-1 beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues Journal of Neuroinflammation 12/29/2011 [PMID: 22206506]
Mary K. Stewart, Lisa A. Cummings, Matthew L. Johnson, Alex B. Berezow, Brad T. Cookson Regulation of phenotypic heterogeneity permits Salmonella evasion of the host caspase-1 inflammatory response Proceedings of the National Academy of Sciences 12/20/2011 [PMID: 22143773]
Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, Steele C Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatus. Infect. Immun., 2011-10-28;80(1):410-7. 2011-10-28 [PMID: 22038916] (Neutralization, Mouse)	Neutralization	Mouse
Kim D, You B, Lim H, Lee SJ Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury. Mol Pain, 2011-09-28;7(0):74. 2011-09-28 [PMID: 21951975] (ICC, Mouse)	ICC	Mouse
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, White MR, Dinarello CA, Apte RN IL-1alpha and IL-1beta recruit different myeloid cells and promote different stages of sterile inflammation. J. Immunol., 2011-09-19;187(9):4835-43. 2011-09-19 [PMID: 21930960] (ICC, IHC-Fr, Neutralization, Mouse)	ICC, IHC-Fr, Neutralization	Mouse
Fisher DT, Chen Q, Skitzki JJ, Muhitch JB, Zhou L, Appenheimer MM, Vardam TD, Weis EL, Passanese J, Wang WC, Gollnick SO, Dewhirst MW, Rose-John S, Repasky EA, Baumann H, Evans SS IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J. Clin. Invest., 2011-09-19;121(10):3846-59. 2011-09-19 [PMID: 21926464] (Neutralization, Mouse)	Neutralization	Mouse
Bergsbaken T, Fink SL, den Hartigh AB, Loomis WP, Cookson BT Coordinated Host Responses during Pyroptosis: Caspase-1-Dependent Lysosome Exocytosis and Inflammatory Cytokine Maturation. J. Immunol., 2011-07-29;187(5):2748-54. 2011-07-29 [PMID: 21804020] (Western Blot, Mouse)	Western Blot	Mouse
Kenichi Shimada, Timothy R. Crother, Justin Karlin, Shuang Chen, Norika Chiba, V. Krishnan Ramanujan et al. Caspase-1 Dependent IL-1 beta Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection PLoS ONE 6/23/2011 [PMID: 21731762]
Jennifer V Welser-Alves, Stephen J Crocker, Richard Milner A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli Journal of Neuroinflammation 12/1/2011 [PMID: 21631912]
Jing Ying Ma, Satyanarayana Medicherla, Irene Kerr, Ruban Mangadu, Andrew A Protter, Linda S Higgins Selective p38 alpha mitogen-activated protein kinase inhibitor attenuates lung inflammation and fibrosis in IL-13 transgenic mouse model of asthma Journal of Asthma and Allergy 11/16/2008 [PMID: 21436983]
Carmi Y, Rinott G, Dotan S, Elkabets M, Rider P, Voronov E, Apte RN Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis. J. Immunol., 2011-02-07;186(6):3462-71. 2011-02-07 [PMID: 21300825] (Neutralization, Mouse)	Neutralization	Mouse
Guerriero JL, Ditsworth D, Catanzaro JM DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity. J. Immunol., 2011-02-07;186(6):3517-26. 2/7/2011 [PMID: 21300822]
Zachary L. Newman, Nicole Sirianni, Christina Mawhinney, Margaret S. Lee, Stephen H. Leppla, Mahtab Moayeri et al. Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome Antimicrobial Agents and Chemotherapy 3/1/2011 [PMID: 21149629]
Andrea J. McCoy, Yukiko Koizumi, Naomi Higa, Toshihiko Suzuki Differential Regulation of Caspase-1 Activation via NLRP3/NLRC4 Inflammasomes Mediated by Aerolysin and Type III Secretion System during Aeromonas veronii Infection The Journal of Immunology 12/1/2010 [PMID: 21037094]
Yoshida H, Russell J, Senchenkova EY, Almeida Paula LD, Granger DN Interleukin-1beta mediates the extra-intestinal thrombosis associated with experimental colitis. Am. J. Pathol., 2010-10-22;177(6):2774-81. 2010-10-22 [PMID: 20971730] (Neutralization, Mouse)	Neutralization	Mouse
Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll RC, Mills KH, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O'Neill LA Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat. Immunol., 2010-09-12;11(10):897-904. 2010-09-12 [PMID: 20835230] (Western Blot, Mouse)	Western Blot	Mouse
McCoy AJ, Koizumi Y, Toma C, Higa N, Dixit V, Taniguchi S, Tschopp J, Suzuki T Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. Eur. J. Immunol., 2010-10-01;40(10):2797-803. 2010-10-01 [PMID: 20722078] (Western Blot, Mouse)	Western Blot	Mouse
Radwan M, Stiefvater R, Grunert T, Sharif O, Miller I, Marchetti-Deschmann M, Allmaier G, Gemeiner M, Knapp S, Kovarik P, Muller M, Strobl B Tyrosine kinase 2 controls IL-1beta production at the translational level. J. Immunol., 2010-08-16;185(6):3544-53. 2010-08-16 [PMID: 20713887] (Western Blot, Mouse)	Western Blot	Mouse
Zachary L. Newman, Devorah Crown, Stephen H. Leppla, Mahtab Moayeri Anthrax lethal toxin activates the inflammasome in sensitive rat macrophages Biochemical and Biophysical Research Communications 8/6/2010 [PMID: 20638366]
Petr Broz, Kim Newton, Mohamed Lamkanfi, Sanjeev Mariathasan, Vishva M. Dixit, Denise M. Monack Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella Journal of Experimental Medicine 8/2/2010 [PMID: 20603313]
Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages. J. Immunol., 2009-12-15;183(12):7890-7. 2009-12-15 [PMID: 19933859] (MUSTag PCR Assay, Mouse)	MUSTag PCR Assay	Mouse
Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat. Med., 2009-09-20;15(10):1170-8. 2009-09-20 [PMID: 19767732] (Neutralization, Mouse)	Neutralization	Mouse
Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages. J. Immunol., 2009-08-28;183(6):4021-30. 2009-08-28 [PMID: 19717513] (Western Blot, Mouse)	Western Blot	Mouse
Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem, 2009-07-15;284(36):24035-48. 2009-07-15 [PMID: 19605353] (IHC-P, Mouse)	IHC-P	Mouse
Hyvarinen K, Tuomainen AM, Laitinen S, Bykov IL, Tormakangas L, Lindros K, Käkelä R, Alfthan G, Salminen I, Jauhiainen M, Kovanen PT, Leinonen M, Saikku P, Pussinen PJ Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect. Immun., 2009-05-18;77(8):3442-9. 2009-05-18 [PMID: 19451238] (IHC-P, Mouse)	IHC-P	Mouse
Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J. Exp. Med., 2008-08-25;205(9):1967-73. 2008-08-25 [PMID: 18725521] (Western Blot, Mouse)	Western Blot	Mouse
Das S, Mishra MK, Ghosh J, Basu A Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death. J. Neuroimmunol., 2008-03-28;195(1):60-72. 2008-03-28 [PMID: 18374991] (IHC-Fr, Western Blot, Mouse)	IHC-Fr, Western Blot	Mouse
Pozsgai G, Sandor K, Perkecz A, Szolcsanyi J, Helyes Z, Brain SD, Pinter E Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. Inflamm. Res., 2007-11-01;56(11):459-67. 2007-11-01 [PMID: 18224287] (Neutralization, Mouse)	Neutralization	Mouse
M. Galle, P. Schotte, M. Haegman, A. Wullaert, H. J. Yang, S. Jin et al. The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation Journal of Cellular and Molecular Medicine 9/1/2008 [PMID: 18081695]
Miller LS, Pietras EM, Uricchio LH, Hirano K, Rao S, Lin H, O'Connell RM, Iwakura Y, Cheung AL, Cheng G, Modlin RL Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo. J. Immunol., 2007-11-15;179(10):6933-42. 2007-11-15 [PMID: 17982084] (Western Blot, Mouse)	Western Blot	Mouse
Ogiso T, Nagaki M, Takai S, Tsukada Y, Mukai T, Kimura K, Moriwaki H Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta. J. Hepatol., 2007-08-10;47(6):816-25. 2007-08-10 [PMID: 17869372] (Neutralization, Mouse)	Neutralization	Mouse
Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol., 2007-05-31;82(3):488-96. 2007-05-31 [PMID: 17540734] (Neutralization, Mouse)	Neutralization	Mouse
Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta. Genes Dev., 2006-09-15;20(18):2527-38. 2006-09-15 [PMID: 16980582] (Neutralization, Mouse)	Neutralization	Mouse
Perrin FE, Lacroix S, Aviles-Trigueros M, David S Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration. Brain, 2005-02-02;128(0):854-66. 2005-02-02 [PMID: 15689362] (Neutralization, Mouse)	Neutralization	Mouse
Banks WA, Farr SA, La Scola ME Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exp. Ther., 2001-11-01;299(2):536-41. 2001-11-01 [PMID: 11602664] (Neutralization, Mouse)	Neutralization	Mouse
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	5 reviewed by: Verified Customer	WB	Mouse	01/08/2015	View Summary Application Western Blot Sample Tested See PMID 23160153 Species Mouse
	4 reviewed by: Verified Customer	ICC	Mouse	01/08/2015	View Summary Application Immunocytochemistry Sample Tested See PMID 23920123 Species Mouse
	4 reviewed by: Verified Customer	ELISA	Mouse	01/08/2015	View Summary Application ELISA Sample Tested See PMID 21709053 Species Mouse

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