Recombinant Human Ephrin-B2 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Ephrin-B2, also known as Htk-L, ELF-2, LERK-5, and NLERK-1, is a 40 kDa member of the Ephrin-B family of transmembrane ligands that bind and induce the tyrosine autophosphorylation of Eph receptors. The extracellular domains of Ephrin-B ligands are structurally related to GPI-anchored Ephrin-A ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression. Ephrin-B2 preferentially interacts with receptors in the EphB family (1, 2). Mature human Ephrin-B2 consists of a 202 amino acid (aa) extracelluar domain (ECD), a 21 aa transmembrane segment, and an 83 aa cytoplasmic domain (3). Within the ECD, human Ephrin-B2 shares 97% aa sequence identity with mouse and rat Ephrin-B2. Ephrin-B2 is expressed presynaptically on neurons (4, 5). It promotes presynaptic development, EphB2 shedding, axonal growth cone collapse, and neurite repulsion, and also regulates inflammatory and neuropathic pain (4-6). Ephrin-B2 is expressed by vascular mural cells and arterial vascular and lymphatic endothelium (7, 8). It exerts proliferative and migratory effects on these cells during angiogenesis and lymphangiogenesis in part by regulating the signaling activity of VEGF R2 and VEGF R3 (7-9). Ephrin-B2 plays a role in the immune response by mediating monocyte extravasation and T cell costimulation (10, 11). It is up‑regulated in invasive cancers and promotes tumor cell migration, invasion, and tumor angiogenesis (12-14). It functions as a cellular entry receptor for Hendra and Nipah viruses (15). Ephrin-B2 is also important for the separation of the urinary and intestinal tracts during development (16).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, Cell Culture.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using 7397-EB	Applications	Species
Kim, Y;Ahmed, S;Miller, WT; Colorectal cancer-associated mutations impair EphB1 kinase function The Journal of biological chemistry 2023-07-30 [PMID: 37527777] (Bioassay, Human)	Bioassay	Human
D Vreeken, CS Bruikman, SML Cox, H Zhang, R Lalai, A Koudijs, AJ van Zonnev, GK Hovingh, JM van Gils EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands J. Leukoc. Biol., 2020-04-26;0(0):. 2020-04-26 [PMID: 32337793] (Cell Culture, Human)	Cell Culture	Human
G Luxán, J Stewen, N Díaz, K Kato, SK Maney, A Aravamudha, F Berkenfeld, N Nagelmann, HC Drexler, D Zeuschner, C Faber, H Schillers, S Hermann, J Wiseman, JM Vaquerizas, ME Pitulescu, RH Adams Endothelial EphB4 maintains vascular integrity and transport function in adult heart Elife, 2019-11-29;8(0):. 2019-11-29 [PMID: 31782728] (Cell Culture, Human)	Cell Culture	Human
R Hilal, M Poittevin, A Pasteur-Ro, A Cogo, G Mangin, M Chevauché, Y Ziat, J Vilar, JM Launay, JF Gautier, D Broquères-, BI Levy, T Merkulova-, N Kubis Diabetic Ephrin-B2-Stimulated Peripheral Blood Mononuclear Cells Enhance Poststroke Recovery in Mice Stem Cells Int, 2018-03-15;2018(0):2431567. 2018-03-15 [PMID: 29736174] (Bioassay, Human)	Bioassay	Human
C You, K Zhao, P Dammann, K Keyvani, I Kreitschma, U Sure, Y Zhu EphB4 forward signalling mediates angiogenesis caused by CCM3/PDCD10-ablation J. Cell. Mol. Med., 2017-04-01;0(0):. 2017-04-01 [PMID: 28371279] (Bioassay, Human)	Bioassay	Human
Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol J Exp Clin Cancer Res, 2016-07-22;35(1):118. 2016-07-22 [PMID: 27448598] (Bioassay, Human)	Bioassay	Human
EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis J Clin Invest, 2016-07-11;0(0):. 2016-07-11 [PMID: 27400125] (Bioassay, Human)	Bioassay	Human
Lisle J, Mertens-Walker I, Stephens C, Stansfield S, Clements J, Herington A, Stephenson S Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer. Exp Cell Res, 2015-02-24;333(1):136-46. 2015-02-24 [PMID: 25724897] (Bioassay, Human)	Bioassay	Human
Kawasaki , Jun, Aegerter , Sandrine, Fevurly , R Dawn, Mammoto , Akiko, Mammoto , Tadanori, Sahin , Mustafa, Mably , John D, Fishman , Steven J, Chan , Joanne RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest, 2014-05-16;124(6):2774-84. 2014-05-16 [PMID: 24837431] (Bioassay, Human)	Bioassay	Human
Grafton K, Moir L, Black J, Hansbro N, Hansbro P, Burgess J, Oliver B LF-15 & T7, synthetic peptides derived from tumstatin, attenuate aspects of airway remodelling in a murine model of chronic OVA-induced allergic airway disease. PLoS ONE, 2014-01-15;9(1):e85655. 2014-01-15 [PMID: 24454912] (Bioassay, Human)	Bioassay	Human
Liu , Qian, Stone , Jacquely, Bradel-Tretheway , Birgit, Dabundo , Jeffrey, Benavides Montano , Javier A, Santos-Montanez , Jennifer, Biering , Scott B, Nicola , Anthony, Iorio , Ronald M, Lu , Xiaonan, Aguilar , Hector C Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry. PLoS Pathog, 2013-11-21;9(11):e1003770. 2013-11-21 [PMID: 24278018] (Bioassay, Human)	Bioassay	Human
Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield J EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury. J Am Soc Nephrol, 2013-03-14;24(4):559-72. 2013-03-14 [PMID: 23492730] (Bioassay, Human)	Bioassay	Human
Show All 12 Publications. Collapse Publications.

Array 7397-EB

• Ephrin-B2 Antibodies
• Ephrin-B2 ELISA Kit
• Ephrin-B2 Lysate
• Ephrin-B2 Proteins
• Ephrin-B2 Proteins and Enzymes