Recombinant Human CD164 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD164 is a mucin-like glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells. It is composed of a signal sequence, an extracellular domain, a transmembrane domain and an intracellular domain (1). The CD164 cDNA encodes a 178-amino acid polypeptide core, of which residues 140‑164 represent the predicted transmembrane domain and residues 165-178 form a short cytoplasmic domain (2). Biochemical and functional analyses of human hematopoietic cell lines and transfectants demonstrate that CD164 comprises a homodimeric molecule of approximately 160 kDa. It plays an important role in mediating or regulating hematopoietic precursor cell adhesion to stroma, and may serve as a potent negative regulator of hematopoietic progenitor cell proliferation (3). Moreover, recent studies have indicated that CD164 may be a basophil activation marker, potentially useful in diagnosis of allergy caused by variety of allergens, including drug allergen (4). The molecule is extensively glycosylated with sites of O-linked glycosylation clustered in two discrete mucin domains separated by a more globular cysteine-rich region (1).

Array 9679-CD

• CD164 Antibodies
• CD164 Lysate
• CD164 Protein
• CD164 Proteins and Enzyme