Recombinant Human beta-Galactosidase-1/GLB1 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

GLB1 is a lysosomal beta -galactosidase that hydrolyzes the terminal beta -galactose from ganglioside and keratan sulfate. Defects in this gene are the causes of lysosomal storage diseases for GM1-gangliosidosis and Morquio B syndrome (also known as mucopolysaccharidosis IVB) (1, 2, 3). In GM1 gangliosidosis, GM1 ganglioside accumulates in the neurons of the central nervous system, because of the deficiency (0±3% of normal) of lysosomal beta -galactosidase activity. GM1 gangliosidosis demonstrates varying degrees of clinical severity but is invariably fatal, and children with the most common and severe form of GM1 gangliosidosis usually die within 3 years of birth. Morquio B syndrome patients are neurologically normal, but display severe skeletal dysostosis multiplex because of an accumulation of keratan sulfate (4). More than 100 mutations have been identified for GLB1, which result in different residual activities of the mutant enzymes and a spectrum of symptoms in the two related diseases (5). In lysosome, the mature beta -galactosidase protein associates with cathepsin A and neuraminidase 1 to form the lysosomal multienzyme complex (6). An alternative splicing at the RNA level of GLB1 results a catalytically inactive beta -galactosidase (also called elastin-binding protein) that plays an important role in vascular development (7).

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: Bioassay, ELISA Standard.

Showing Publications 1 - 2 of 2.

Publications using 6464-GH	Applications	Species
T Lekva, MCP Roland, ME Estensen, ER Norwitz, T Tilburgs, T Henriksen, J Bollerslev, KR Normann, P Magnus, OK Olstad, P Aukrust, T Ueland Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence Scientific Reports, 2021-10-05;11(1):19735. 2021-10-05 [PMID: 34611223] (ELISA Standard, Human)	ELISA Standard	Human
AJ Ullal, H Pham, R Singh, P Ross, CA Graham, SM Norton, MH Nuffer, DS Burns, AE Eckhardt, M Escolar, D Bali, VK Pamula Fluorimetric assay with a novel substrate for quantification of galactocerebrosidase activity in dried blood spot specimens Pract Lab Med, 2019-10-16;18(0):e00141. 2019-10-16 [PMID: 31720353] (Bioassay, Human)	Bioassay	Human

Array 6464-GH

• beta-Galactosidase-1/GLB1 Antibodies
• beta-Galactosidase-1/GLB1 ELISA Kits
• beta-Galactosidase-1/GLB1 Lysate
• beta-Galactosidase-1/GLB1 Proteins
• beta-Galactosidase-1/GLB1 Proteins and Enzyme