Porcine IL-6 DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin 6 (IL-6) is a pleiotropic, alpha -helical, 22 - 28 kDa phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression (1-5). Mature porcine IL-6 is 183 amino acids (aa) in length and shares 58%, 39% and 39% aa sequence identity with human, mouse, and rat IL-6, respectively (6). Cells known to express IL-6 include CD8+ T cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes, endothelial cells (under the influence of endothelins), sympathetic neurons, cerebral cortex neurons, adrenal medulla chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adult astrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, B1 B cells and pancreatic islet beta cells (2, 7-29). IL-6 production is generally correlated with cell activation and is normally kept in control by glucocorticoids, catecholamines, and secondary sex steroids (2). Normal human circulating IL-6 is in the 1 pg/mL range, with slight elevations during the menstrual cycle, modest elevations in certain cancers, and large elevations after surgery (30-34). 

We have publications tested in 2 confirmed species: Mouse, Porcine.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using DY686	Applications	Species
Duarte, ME;Kim, SW; Efficacy of Saccharomyces yeast postbiotics on cell turnover, immune responses, and oxidative stress in the jejunal mucosa of young pigs Scientific reports 2024-08-20 [PMID: 39164530] (Porcine)		Porcine
Vermeire, B;Walsh, M;Cox, E;Devriendt, B; The lipopolysaccharide structure affects the detoxifying ability of intestinal alkaline phosphatases BMC veterinary research 2024-08-10 [PMID: 39127648] (Porcine)		Porcine
Deng, Z;Jang, KB;Jalukar, S;Du, X;Kim, SW; Efficacy of Feed Additive Containing Bentonite and Enzymatically Hydrolyzed Yeast on Intestinal Health and Growth of Newly Weaned Pigs under Chronic Dietary Challenges of Fumonisin and Aflatoxin Toxins 2023-06-30 [PMID: 37505702] (Porcine)		Porcine
Bahnasawy, SM;Skorup, P;Hanslin, K;Lipcsey, M;Friberg, LE;Nielsen, EI; Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli Cytokine 2023-07-17 [PMID: 37467709] (Porcine)		Porcine
P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells Heliyon, 2023-04-10;9(4):e15202. 2023-04-10 [PMID: 37123974] (Porcine)		Porcine
P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells Heliyon, 2023;9(4):e15202. 2023 [PMID: 37123974] (Porcine)		Porcine
MA Oestreich, K Seidel, W Bertrams, HH Müller, M Sassen, T Steinfeldt, H Wulf, B Schmeck Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs PLoS ONE, 2022-12-07;17(12):e0278766. 2022-12-07 [PMID: 36476845] (Porcine)		Porcine
P Geoghegan, J Clarke, G Hogan, A Keogh, H Marsh, K Donnelly, N McEvoy, A Doolan, SF Madden, I Martin-Loe, M Power, JG Laffey, GF Curley Use of a novel "Split" ventilation system in bench and porcine modeling of acute respiratory distress syndrome Physiological Reports, 2022-09-01;10(17):e15452. 2022-09-01 [PMID: 36082971] (Porcine)		Porcine
T Muk, A Brunse, NL Henriksen, K Aasmul-Ols, DN Nguyen Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis-infected preterm newborns JCI Insight, 2022-06-08;0(0):. 2022-06-08 [PMID: 35503431] (Porcine)		Porcine
M Donegà, CT Fjordbakk, J Kirk, DM Sokal, I Gupta, GE Hunsberger, A Crawford, S Cook, J Viscasilla, TR Stathopoul, JA Miranda, WJ Dopson, D Goodwin, A Rowles, P McGill, A McSloy, D Werling, J Witheringt, DJ Chew, JD Perkins Human-relevant near-organ neuromodulation of the immune system via the splenic nerve Proceedings of the National Academy of Sciences of the United States of America, 2021-05-18;118(20):. 2021-05-18 [PMID: 33972441] (Porcine)		Porcine
A Nyberg, E Gremo, J Blixt, J Sperber, A Larsson, M Lipcsey, A Pikwer, M Castegren Lung-protective ventilation increases cerebral metabolism and non-inflammatory brain injury in porcine experimental sepsis Bmc Neuroscience, 2021-04-29;22(1):31. 2021-04-29 [PMID: 33926378] (Porcine)		Porcine
MH Tiba, BM McCracken, RP Dickson, JA Nemzek, CI Colmenero, DC Leander, TL Flott, RC Daniels, KE Konopka, JS VanEpps, KA Stringer, KR Ward A comprehensive assessment of multi-system responses to a renal inoculation of uropathogenic E. coli in swine PLoS ONE, 2020-12-11;15(12):e0243577. 2020-12-11 [PMID: 33306742] (Porcine)		Porcine
J Sperber, A Nyberg, A Krifors, P Skorup, M Lipcsey, M Castegren Pre-exposure to mechanical ventilation and endotoxemia increases Pseudomonas aeruginosa growth in lung tissue during experimental porcine pneumonia PLoS ONE, 2020-10-27;15(10):e0240753. 2020-10-27 [PMID: 33108383] (Porcine)		Porcine
A Barrueta T, J van der He, I Blokhin, F Massaro, HA Hansson, R Feinstein, A Larsson, A Larsson, J Tenhunen The antisecretory peptide AF-16 may modulate tissue edema but not inflammation in experimental peritonitis induced sepsis PLoS ONE, 2020-08-21;15(8):e0232302. 2020-08-21 [PMID: 32822373] (Porcine)		Porcine
A Nyberg, A Larsson, J Jylhävä, M Hurme, J Sperber, M Lipcsey, M Castegren Lung-protective ventilation suppresses systemic and hepatic vein levels of cell-free DNA in porcine experimental post-operative sepsis BMC Pulm Med, 2020-07-31;20(1):206. 2020-07-31 [PMID: 32736620] (Porcine)		Porcine
C Casaravill, Á Pittini, D Rückerl, JE Allen, Á Díaz Activation of the NLRP3 Inflammasome by Particles from the Echinococcus granulosus Laminated Layer Infect. Immun., 2020-08-19;88(9):. 2020-08-19 [PMID: 32571988] (Mouse)		Mouse
K Obremski, W Trybowski, P Wojtacha, M Gaj?cka, J Tyburski, ? Zielonka The Effect of Zearalenone on the Cytokine Environment, Oxidoreductive Balance and Metabolism in Porcine Ileal Peyer's Patches Toxins (Basel), 2020-05-27;12(6):. 2020-05-27 [PMID: 32471145] (Porcine)		Porcine
FS Hohnstein, M Meurer, N de Buhr, M von Köckri, CG Baums, G Alber, N Schütze Analysis of Porcine Pro- and Anti-Inflammatory Cytokine Induction by S. suis In Vivo and In Vitro Pathogens, 2020-01-03;9(1):. 2020-01-03 [PMID: 31947746] (Porcine)		Porcine
AMF Matthijs, G Auray, F Boyen, A Schoos, A Michiels, O García-Nic, GT Barut, C Barnier-Qu, V Jakob, N Collin, B Devriendt, A Summerfiel, F Haesebrouc, D Maes Efficacy of three innovative bacterin vaccines against experimental infection with Mycoplasma hyopneumoniae Vet. Res., 2019-11-08;50(1):91. 2019-11-08 [PMID: 31703726] (Porcine)		Porcine
Z Cao, Q Yang, M Zheng, H Lv, K Kang, Y Zhang Classical swine fever virus non-structural proteins modulate Toll-like receptor signaling pathways in porcine monocyte-derived macrophages Vet. Microbiol., 2019-01-29;230(0):101-109. 2019-01-29 [PMID: 30827374] (Porcine)		Porcine
J Sun, X Pan, LI Christians, XL Yuan, K Skovgaard, DEW Chatterton, SS Kaalund, F Gao, PT Sangild, S Pankratova Necrotizing enterocolitis is associated with acute brain responses in preterm pigs J Neuroinflammation, 2018-06-09;15(1):180. 2018-06-09 [PMID: 29885660] (Porcine)		Porcine
M Kalbitz, S Schwarz, B Weber, B Bosch, J Pressmar, FM Hoenes, CK Braun, K Horst, TP Simon, R Pfeifer, P Störmann, H Hummler, F Gebhard, HC Pape, M Huber-Lang, F Hildebrand, TREAT Rese Cardiac Depression in Pigs after Multiple Trauma - Characterization of Posttraumatic Structural and Functional Alterations Sci Rep, 2017-12-19;7(1):17861. 2017-12-19 [PMID: 29259232] (Porcine)		Porcine
A Michiels, I Arsenakis, F Boyen, R Krejci, F Haesebrouc, D Maes Efficacy of one dose vaccination against experimental infection with two Mycoplasma hyopneumoniae strains BMC Vet. Res., 2017-08-29;13(1):274. 2017-08-29 [PMID: 28851359] (Porcine)		Porcine
Y Xiao, H Yan, H Diao, B Yu, J He, J Yu, P Zheng, X Mao, Y Luo, D Chen Early Gut Microbiota Intervention Suppresses DSS-Induced Inflammatory Responses by Deactivating TLR/NLR Signalling in Pigs Sci Rep, 2017-06-12;7(1):3224. 2017-06-12 [PMID: 28607413] (Porcine)		Porcine
EL Sassu, J Frömbling, JC Duvigneau, I Miller, A Müllebner, AM Gutiérrez, T Grunert, M Patzl, A Saalmüller, A von Altroc, A Menzel, M Ganter, J Spergser, M Hewicker-T, J Verspohl, M Ehling-Sch, I Hennig-Pau Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae BMC Vet. Res, 2017-02-28;13(1):64. 2017-02-28 [PMID: 28245826] (Porcine)		Porcine
De Clercq E, Devriendt B, Yin L, Chiers K, Cox E, Vanrompay D The immune response against Chlamydia suis genital tract infection partially protects against re-infection. Vet Res, 2014-09-25;45(0):95. 2014-09-25 [PMID: 25252649] (Porcine)		Porcine
Sperber J, Lipcsey M, Larsson A, Larsson A, Sjolin J, Castegren M Lung protective ventilation induces immunotolerance and nitric oxide metabolites in porcine experimental postoperative sepsis. PLoS ONE, 2013-12-12;8(12):e83182. 2013-12-12 [PMID: 24349457] (Porcine)		Porcine
Nfon , Charles, Leung , Anders, Smith , Greg, Embury-Hyatt , Carissa, Kobinger , Gary, Weingartl , Hana M Immunopathogenesis of severe acute respiratory disease in Zaire ebolavirus-infected pigs. PLoS ONE, 2013-04-23;8(4):e61904. 2013-04-23 [PMID: 23626748] (Porcine)		Porcine
Diaz I, Gimeno M, Darwich L, Navarro N, Kuzemtseva L, Lopez S, Galindo I, Segales J, Martin M, Pujols J, Mateu E Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection. Vet. Res., 2012-04-19;43(1):30. 2012-04-19 [PMID: 22515169] (Porcine)		Porcine
Husser L, Ruggli N, Summerfield A N(pro) of Classical Swine Fever Virus Prevents Type I Interferon-Mediated Priming of Conventional Dendritic Cells for Enhanced Interferon-alpha Response. J. Interferon Cytokine Res., 2012-02-07;32(5):221-9. 2012-02-07 [PMID: 22313263] (Porcine)		Porcine
Miller LC, Zanella EL, Waters WR Cytokine protein expression levels in tracheobronchial lymph node homogenates of pigs infected with pseudorabies virus. Clin. Vaccine Immunol., 2010-03-10;17(5):728-34. 2010-03-10 [PMID: 20219878] (Porcine)		Porcine
Carlsson M, Lipcsey M, Larsson A, Tano E, Rubertsson S, Eriksson M, Sjolin J Inflammatory and circulatory effects of the reduction of endotoxin concentration in established porcine endotoxemic shock--a model of endotoxin elimination. Crit. Care Med., 2009-03-01;37(3):1031-e4. 2009-03-01 [PMID: 19237914] (Porcine)		Porcine
Inci I, Arni S, Inci D, Zhai W, Hillinger S, Leskosek B, Vogt P, Weder W Impact of topical cooling solution and prediction of pulmonary graft viability from non-heart-beating donors. J. Heart Lung Transplant., 2008-07-21;27(9):1016-22. 2008-07-21 [PMID: 18765195] (Porcine)		Porcine
Siggers RH, Siggers J, Boye M, Thymann T, Molbak L, Leser T, Jensen BB, Sangild PT Early administration of probiotics alters bacterial colonization and limits diet-induced gut dysfunction and severity of necrotizing enterocolitis in preterm pigs. J. Nutr., 2008-08-01;138(8):1437-44. 2008-08-01 [PMID: 18641188] (Porcine)		Porcine
Saurer L, McCullough KC, Summerfield A In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid. J. Immunol., 2007-09-15;179(6):3504-14. 2007-09-15 [PMID: 17785784] (Porcine)		Porcine
Alves MP, Neuhaus V, Guzylack-Piriou L, Ruggli N, McCullough KC, Summerfield A Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets. Gene Ther., 2007-03-01;14(10):836-44. 2007-03-01 [PMID: 17330086] (Porcine)		Porcine
Milo LA, Correa-Matos NJ, Donovan SM, Tappenden KA Neutrophil and small intestinal lymphocyte migration after Salmonella typhimurium infection: impact of fermentable fiber. J. Pediatr. Gastroenterol. Nutr., 2004-07-01;39(1):73-9. 2004-07-01 [PMID: 15187785] (Porcine)		Porcine
Show All 37 Publications. Collapse Publications.

Array DY686

• IL-6 Antibodies
• IL-6 Antibody Pair
• IL-6 ELISA Kits
• IL-6 Lysate
• IL-6 Proteins
• IL-6 Proteins and Enzymes
• IL-6 ELISAs