PKC epsilon Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

PKC epsilon (protein kinase C-epsilon) is an 87 kDa member of the novel PKC subfamily, AGC Ser/Thr protein kinase family of enzymes. It is a widely-expressed Ca++‑insensitive, phospholipid-dependent enzyme that catalyzes the phosphorylation of multiple proteins. Human PKC epsilon is 737 amino acids (aa) in length. It contains two general regions: a non-Ca++-binding plus lipid binding regulatory region (aa’s 1‑99 and 169‑292, respectively), and an ATP-binding catalytic domain (aa 408‑668). Phosphorylation of PKC epsilon on Thr566, Ser368 and Ser729 activates its enzymatic activity and increases its molecular weight to 92 kDa. One potential splice form shows a 114 aa substitution for aa 118‑737. Over aa 580‑737, human PKC epsilon is 98% and 99% aa identical to mouse and canine PKC epsilon , respectively.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 2 applications: IHC-Fr, Western Blot.

Showing Publications 1 - 3 of 3.

Publications using AF5134	Applications	Species
N Erin, E Tav?an, Ö Akdeniz, VMS Isca, P Rijo Rebound increases in chemokines by CXCR2 antagonist in breast cancer can be prevented by PKC&delta and PKC&epsilon activators Cytokine, 2021-03-24;0(0):155498. 2021-03-24 [PMID: 33773907] (Western Blot, Mouse)	Western Blot	Mouse
Zhang M, Ceyhan Y, Kaftanovskaya EM et al. INPP4B protects from metabolic syndrome and associated disorders Communications biology 3/26/2021 [PMID: 33772116]
Quercetin ameliorates paclitaxel-induced neuropathic pain by stabilizing mast cells, and subsequently blocking PKC?-dependent activation of TRPV1 Acta Pharmacol. Sin., 2016-08-08;37(9):1166-77. 2016-08-08 [PMID: 27498772] (IHC-Fr, Rat)	IHC-Fr	Rat

Array AF5134

• PKC epsilon Antibodies
• PKC epsilon ELISA Kits
• PKC epsilon Lysate
• PKC epsilon Proteins