PI 3-Kinase p110 gamma Antibody

p110-gamma (protein kinase 110 kDa gamma; also PI3 kinase subunit gamma, Ser/Thr protein kinase PIK3CG and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma) is a 110-120 kDa Class I member of the PI3/PI4-kinase family of molecules. Schematically, PI3K (PI3 kinase) is typically thought of as a heterodimeric complex composed of one p85, p101 or p84 regulatory subunit coupled to one p110 catalytic subunit. In response to receptor tyrosine kinase ligation, PI3K is recruited to a transmembrane kinase receptor where it is activated. Active PI3K subsequently catalyzes the phosphorylation of phosphatidylinositol, generating a molecule (PIP3) that mediates downstream signaling. p110 gamma is one of four p110 genes that generates PIP3. Unlike p110 alpha ,  beta and δ, however, it neither interacts with activated Tyr kinases nor with p85. Instead, it associates with either p101 or p84, and interacts with the GPCR G beta gamma subunits to mediate downstream signaling. Human p110 gamma is 1102 amino acids in length. It contains one ABD (adaptor-binding domain) (aa 34-141), an RBD (ras-binding domain) (217-309), a C2 PI3K‑type domain (aa 357-521), a substrate presentating PIK domain (aa 549-725) and a C-terminal catalytic region (aa 830-1046). There is one utilized phosphorylation site at Ser1101. Over aa 298-467, human p110 gamma shares 94% aa sequence identity with mouse p110 gamma .

• PI 3-Kinase p110 gamma Antibodies
• PI 3-Kinase p110 gamma Lysate
• PI 3-Kinase p110 gamma Protein