Phospho-JNK Pan Specific DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Members of the MAPK family, the c-Jun N-terminal kinases (JNKs) are activated by environmental stresses and inflammatory cytokines. Ten JNK isoforms are created by alternative splicing of mRNA transcripts derived from three genes: JNK1, JNK2, and JNK3. All JNKs are activated by dual phosphorylation; at T183/Y185 for JNK1 and 2, and T221/Y223 for JNK3. Activated JNKs translocate to the nucleus where they regulate the activity of several transcription factors; including the c-Jun component of AP-1 and ATF-2.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 7 of 7.

Publications using DYC1387B-2	Applications	Species
LY Hung, JL Johnson, Y Ji, DA Christian, KR Herbine, CF Pastore, DR Herbert Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity J. Immunol., 2019-06-07;0(0):. 2019-06-07 [PMID: 31175162] (Mouse)		Mouse
Joerg Mattes TRAIL signaling is pro-inflammatory and pro-viral in a murine model of rhinovirus 1B infection Am. J. Physiol. Lung Cell Mol. Physiol., 2016-11-11;0(0):ajplung.00200. 2016-11-11 [PMID: 27836899] (Mouse)		Mouse
Ghezali L, Leger D, Limami Y, Cook-Moreau J, Beneytout J, Liagre B Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect. Exp Cell Res, 2013-01-25;319(7):1043-53. 2013-01-25 [PMID: 23357584] (Human)		Human
Yeh CC, Li H, Malhotra D, Turcato S, Nicholas S, Tu R, Zhu BQ, Cha J, Swigart PM, Myagmar BE, Baker AJ, Simpson PC, Mann MJ Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse. J. Cell. Biochem., 2010-04-15;109(6):1185-91. 2010-04-15 [PMID: 20186881] (Mouse)		Mouse
Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling. Biochem. Biophys. Res. Commun., 2007-04-02;357(2):402-7. 2007-04-02 [PMID: 17420005] (Human)		Human
Leger DY, Liagre B, Beneytout JL Low dose leflunomide activates PI3K/Akt signalling in erythroleukemia cells and reduces apoptosis induced by anticancer agents. Apoptosis, 2006-10-01;11(10):1747-60. 2006-10-01 [PMID: 16927021] (Human)		Human
Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Human)		Human

Array DYC1387B-2

• JNK1/2/3 Antibodies
• JNK1/2/3 ELISA